DNA is amazing stuff one molecule with a 4-letter code that holds the instructions for every living thing in Earth’s history. Today, DNA can help us solve a crime or diagnose a disease - but not long ago, nobody knew it existed. This is the story of the first known person to see DNA, Friedrich Miescher. Friedrich Miescher: The First Person To See DNA Friedrich Miescher is a quiet, shy boy who loves music and art. 1854 Father, I think I might like to be a musician. Well, I’m off to start my medical studies. I know you’ll make us proud, son. Take care of yourself, dear. Nonsense, Friedrich. You will be a scientist. It is the legacy of our family! 1861 He will survive, but the fever has damaged his hearing. While Miescher is studying medicine, he contracts typhoid fever. 1865 How can I practice medicine now? But of course... I’ll go into research! It’s no use! I’ll never be a doctor! biotechhistory.org © Copyright 2015 Life Sciences Foundation All rights reserved Friedrich joins the laboratory of Felix HoppeSeyler, one of the first scientists to focus on molecular biology and biochemistry. The laboratory is in the cellar of the castle at Tubingen, Germany. 1868 Ho I have chosen you as my only student. Together we will unravel the mysteries of the life of cells! ppe-Seyler I know that chemistry can answer those questions, and I’m excited to work with you, sir! These independent cells hold the key... But how will we get enough to study? I I have have an idea! an idea! Why does he want those used bandages? The pus in these bandages is filled with white blood cells, which can teach us how cells work! Look at this, sir! 1869 No, it’s another substance, completely unknown to science! biotechhistory.org Is it another protein? Let’s call it nuclein! Today, ‘nuclein’ is called DNA. Miescher was fascinated by it and continued to work on it for the rest of his career. But he never knew how important it was. Most scientists thought that proteins provided instructions to make living things. It wasn’t until 1952, more than 80 years after Miescher’s experiments, that scientists determined that DNA was the instruction book for life. © Copyright 2015 Life Sciences Foundation All rights reserved
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