东南大学生物科学与医学工程学院 生物电子学国家重点实验室邀请 加州圣地亚哥大学国际著名教授来校讲学 Professor Andrew McCulloch Distinguished Professor of Bioengineering and Medicine University of California San Diego Dr. Andrew McCulloch served as Chair of the Bioengineering Department from 2005 to 2008. He is currently chair of the Physiome and Systems Biology Committee of the International Union of Physiological Sciences. He directs the HHMI-NIBIB Interfaces Graduate Training Program and the UCSD Interdisciplinary Ph.D. Specialization in Multi-Scale Biology. Dr. McCulloch is a Principal Investigator of the National Biomedical Computation Resource and the Cardiac Atlas Project, and Co-Director of the Cardiac Biomedical Science and Engineering Center at UCSD. He is member of the UCSD Institute for Engineering in Medicine, the Qualcomm Institute and a Senior Fellow of the San Diego Supercomputer Center. He was educated at the University of Auckland, New Zealand in Engineering Science and Physiology receiving his Ph.D. in 1986. Dr. McCulloch was an NSF Presidential Young Investigator and is a Fellow of the American Institute for Medical and Biological Engineering and a Fellow of the Cardiovascular Section of the American Physiological Society. He is currently Associate Editor of PLoS Computational Biology and co-Editor-in-Chief of Drug Discovery Today: Disease Models. He is on the editorial boards of four other journals. Dr. McCulloch’s lab uses experimental and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the whole heart during ventricular remodeling, heart failure and arrhythmia. 学术报告一 Multi-Scale Mechanisms of Heart Failure: From Mouse to Man 时间:2015.5.19 16:00-17:30 地点:东南大学丁家桥校区 中大医院新大楼 五楼学术报告厅 We use multi-scale computational modeling, magnetic resonance imaging and biophysical studies in genetically engineered mice to investigate how cellular and molecular defects can give rise to heart failure at the organ and system scales. Here I will show recent studies on the mechanisms by which gene defects in the contractile regulatory protein myosin regulatory light chain and the cytoskeletal protein vinculin can lead to dilated cardiomyopathy and heart failure. Recent progress in using patient-specific models of dyssynchronous heart failure to understand clinical responses to cardiac resynchronization therapy will also be presented. 学术报告 二 Multi-Scale Modeling of the Heart: From Cell to Organ System 时间:2015.5.20 10:00-12:00 地点:四牌楼校区逸夫科技馆3楼 生物电子学国家重点实验室会议室 We are developing multi-scale models of the heart that integrate both functionally across biomechanical, electrophysiological and regulatory functions and structurally across physical scales of organization from molecule to organ system. Biomechanics models integrate from the level of the crossbridge to the myofilament lattice to the cell, tissue, organ and circulatory system. Electrophysiological models start at the scale of the individual ion channel, then integrate their currents into the whole cell action potential, which then propagates in threedimensions through the myocardium and gives rise to electrocardiograms on the body surface. These models can then be used to investigate electrical alterations in arrhythmia and mechanical alterations in heart failure and other disorders. Here, we illustrate the development of these computational models to using several examples including: Microanatomically detailed models of subcellular and cellular biophysics generated from 3D electron tomograms; multi-scale models of murine ventricular mechanics derived from mouse cardiac magnetic resonance imaging; and patient-specific computational models of human atrial fibrillation and dyssynchronous heart failure to improve diagnosis and treatment efficacy.
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