1. No category

2015 Winter Meeting on
Translational Heart Failure Research
Organized by the
Heart Failure Association (HFA) and the
Working Group on Myocardial Function of the ESC
Les Diablerets, Switzerland, January 21 – 24, 2015
1
Day 1
Thursday, 22.01.2015
08:00 – 08:10
Gerasimos Filippatos
Welcome from the President of the HFA
Session 1
Chairs:
Genome Biology in Myocardial Research
Johannes Backs (DE), Emilio Hirsch (IT)
08:10 – 08:35
Gianluigi Condorelli
Epigenetic signature of cardiac hypertrophy
Lutz Hein
Dynamic DNA methylation in the heart
Tobias Merkel
Regulation of cardiac metabolism by a
histone methyltransferase
Timothy McKinsey
Chromatin-based therapeutics for heart failure
08:35 – 09:00
09:00 – 09:25
09:25 – 09:50
09:50 – 10:20
Coffee Break
Session 2
Chairs:
Hypertrophic cardiomyopathy
Nazha Hamdani (DE/NL), Zoltán Papp (HU)
10:20 – 10:40
Burkert Pieske
The clinical problem
Björn Knollmann
Focal energy deprivation as a new mechanism
for arrhythmias
Jolanda van der Velden
Tension cost in HCM
Thomas Eschenhagen
How Ca2+ sensitivity affects mitochondrial redox
Lucie Carrier
Gene therapy
10:40 – 11:05
11:05 – 11:30
11:30 – 11:55
11:55 – 12:20
12:30
Lunch
17:00 – 19:45
Poster Session
Poster Judges
Denise Hilfiker-Kleiner (Chair)
Rodolphe Fischmeister
Mauro Giacca
Adelino Leite-Moreira
Frank Heinzel
Lars S. Maier
20:00
Dinner
(GR)
(IT)
(DE)
(DE)
(US)
(AT)
(US)
(NL)
(DE)
(DE)
(DE)
(FR)
(IT)
(PT)
(AT)
(DE)
2
Day 2
Friday, 23.01.2015
Session 3
Chairs:
Ageing: Hallmarks and Principles
Mauro Giacca (IT), Eva van Rooij (NL)
08:00 – 08:25
Christian Bar
Hallmarks of Ageing
Nilesh Samani
Shortening of telomeres during cardiac ageing
Giovanni Camici
Age-related endothelial dysfunction
Reinier Boon
Therapeutic approaches of cardiac ageing
08:25 – 08:50
08:50 – 09:15
09:15 – 09:40
(ES)
(UK)
(CH)
(DE)
09:40– 10:10
Coffee Break
Session 4
Chairs:
Mitochondria: Dynamics, autophagy and redox control
Christoph Maack (DE), Gerald Dorn (US)
10:10 – 10:35
Elena Ziviani
Eat me! Mitochondrial morphology and
mitophagy in health and disease
Gerald Dorn
Novel functions of mitofusin-2 for mitophagy
Michael Ristow
The concept of mitohormesis in aging
Michael P. Murphy
Succinate accumulation during ischaemia
drives mitochondrial ROS upon reperfusion
10:35 – 11:00
11:00 – 11:25
11:25 – 11:50
11:55 – 12:30
Chairs:
(IT)
(US)
(CH)
(UK)
Brutsaert Lecture
Dirk Brutsaert (BE), Gerd Hasenfuß (DE)
Introduction: Gerd Hasenfuß (DE)
Walter Paulus
Heart Failure with preserved ejection fraction
12:30
Group Photograph
12:45
Lunch
16:30 – 17:15
Poster viewing with coffee
(NL)
3
Session 5
Chairs:
Vascular aspects of cardiac disease
Jean-Luc Balligand (BE), Frank Ruschitzka (CH)
17:00 – 17:25
Christian Weber
Chemokine ligand/receptor axis in endothelial
dysfunction and cardiovascular disease
Andreas Papapetropoulos
The role of gasotransmitters NO, CO, H2S in
cardiovascular diseases
Dirk J. Duncker
Microvascular dysfunction underlying cardiovascular
diseases: lessons from large animal models
Frank Ruschitzka
PARADIGM – why does neprilysin inhibition work?
17:25 – 17:50
17:50 – 18:15
18:15 – 18:40
Debate Session:
Stem Cells in Heart Failure trials
Do they have a future?
18:45 – 19:05
19:05 – 19:25
No!
Yes!
19:25 – 20:00
General debate
Moderators:
Alexander Lyon (UK), Gerasimos Filippatos (GR)
Discussion panel:
Karin Sipido
Wolfram H. Zimmermann
from 20:15
Dinner and announcement of poster prize winners
Loren Field
Stefan Janssens
(DE)
(GR)
(NL)
(SU)
(US)
(BE)
(BE)
(DE)
4
Day 3
Saturday, 24.01.2015
Session 6
Chairs:
Long non-coding RNAs
Manuel Mayr (UK), Thomas Thum (DE)
08:30 – 08:55
Thierry Pedrazzini
Enhancer derived lncRNAs
Thomas Thum
lncRNAs in cardiac remodeling
Yvan Devaux
lncRNS as biomarkers
Ching-Pin Chang
Protective lncRNAS in hypertrophy
08:55 – 09:20
09:20 – 09:45
09:45 – 10:05
10:05 – 10:25
Coffee Break
Session 7
Chairs:
Fibrosis: Biology and clinical impact
Adelino Leite-Moreira (PT), Guido Tarone (IT)
10:25 – 10:45
Johann Bauersachs
Fibrosis as a clinical target
Micheletti Rudi (Abstract)
Cardiac fibroblast-specific long non-coding
RNAs modulate expression of pro-fibrotic genes
Hans J. de Haas
Molecular imaging of the cardiac extracellular matrix
Rudolf A. de Boer
Revival of galectin-3: Biomarker and therapeutic target!
10:45 – 11:10
11:10 – 11:35
11:35 – 12:00
12:00 – 12:10
Concluding remarks (Christoph Maack)
12:30
Lunch
13:15
Departure of bus to Geneva
(CH)
(DE)
(LU)
(US)
(DE)
(SU)
(NL)
(NL)
N=54 faculty
5