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Hyoscine Butylbromide
Anticholinergic
C21H30BrNO4 = 440.4
CAS—149­64­4
IUPAC Name [7(S)­(1α,2β,4β,5α,7β)]­9­Butyl­7­(3­hydroxy­1­oxo­2­
phenylpropoxy)­9­methyl­3­oxa­9­azoniatricyclo[3.3.1.02,4]nonane bromide
Synonyms Butylscopolamonii bromidum; hyoscine­N­butyl bromide;
scopolamine butylbromide.
Proprietary Name Buscopan
Chemical Properties A white crystalline powder. Mp 140° to 144°. Soluble 1 in 1
of water, 1 in 50 of ethanol and 1 in 5 of chloroform; practically insoluble in ether.
Log P (octanol/water), −1.1.
Colour Tests Aromaticity (method 2)—colourless/yellow; Liebermann's reagent—
orange.
Thin­layer Chromatography System TA—Rf 0.08 (acidified iodoplatinate
solution, positive).
High Performance Liquid Chromatography System HY—RI 294.
Ultraviolet Spectrum Aqueous acid—252 (A11 =3.7a), 258 (A11 =4.6a), 264 nm
(A11 =3.6a).
Infrared Spectrum Principal peaks at wavenumbers 1175, 1721, 1052, 874,
1072, 709 cm−1 (Nujol mull).
M Account
Disposition in the Body Poorly absorbed after oral administration. About 90% of
an oral dose is eliminated in the faeces and <10% is excreted in the urine. After
IV administration, about 40% of a dose is excreted in the urine.
Half­life Plasma half­life, about 8 h.
Protein Binding About 10%.
Dose 20 mg given parenterally, repeated if necessary; 80 mg daily, orally.
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(2)
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Handbook on
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Scopolamine
Butylbromide
Scopolamine
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Injectable Drugs Guide
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Hyoscine
butylbromide
(scopolamine
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Hyoscine
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hydrobromide)
Papaveretum with
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Remington: The
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Scopolamine
Hydrobromide
Stockley's Herbal
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Angel's trumpet
Henbane
Stockley's Drug
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Interactions of
Hyoscine
Drug Administration via
Enteral Feeding Tubes
(2)
Hyoscine
butylbromide
Hyoscine
hydrobromide
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