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Scopolamine Hydrobromide
BAN: Hyoscine Hydrobromide [BANM]
Chemical name Benzeneacetic acid, [7(S)­(1a,2b,4b,5a,7b)]­a­
(hydroxymethyl)­, 9­methyl­3­oxa­9­azatricyclo[3.3.1.02,4]non­7­yl ester,
hydrobromide, trihydrate
Synonyms Bromhidrato de Escopolamina; Escopolamina, Bromhidrato de;
Escopolamina, hidrobromuro de; Hidrobromuro de hioscina; Hioscino
hidrobromidas; Hioscyny bromowodorek; Hioszcin­hidrobromid; Hiyosin
Hidrobromür; Hyoscinhydrobromid; Hyoscini Hydrobromidum;
Hyoskiinihydrobromidi; Ioscina Bromidrato; Scopolamine Bromhydrate;
Scopolamine Hydrobromide; Scopolamine, bromhydrate de; Bromhydrate de
scopolamine; Scopolaminhydrobromid; Scopolamini Hydrobromidum; Scopolamini
Hydrobromidum Trihydricum; Skopolamiinihydrobromidi; Skopolamin­bromid
trihydrát; Skopolaminhydrobromid; Skopolamino hidrobromidas; Szkopolamin­
butilbromid; スコポラミン臭化水素酸塩; Гиосцина Гидробромид
Structure
Chemical Structure of Hyoscine
CAS 114­49­8 (anhydrous hyoscine hydrobromide); 6533­68­2 (hyoscine
hydrobromide trihydrate)
Molecular formula C17H21NO4·HBr.3H2O = 438.3
Description Colorless or white crystals or white, granular powder; odorless;
slightly efflorescent in dry air; the anhydrous salt melts about 195–199°C; pH (1
in 10 solution) 4–5.5; has a pKa = 8.01.
Solubility 1 gm in 1.5 mL water or 20 mL alcohol; slightly soluble in chloroform;
insoluble in ether.
Stability Store at controlled room temperature (between 68°F and 77°F); protect
parenteral solution from light.
Packaging Oral tablets, supplied in opaque plastic bottles of 100 Scopolamine
HBr 0.4 mg tablets; ophthalmic solution, dropper bottle, 5 ml Scopolamine HBr
0.25%, ophthalmic solution; parenteral solution for injection, supplied in 1 ml vials
containing Scopolamine HBr 0.4 mg/1mL; and transdermal patch, boxes of 10 or
24 Scopolamine 1mg/72h, patch.
History Scopolamine or hyoscine is an anticholinergic or solanaceous alkaloid in
species of the plant genuses Datura, Duboisia, Hyoscyamus, and Scopolia.
Scopolamine was available for years, prior to FDA approval in 1939. Under the
General Agreement on Tariffs and Trade (GATT), the patent for Transderm­Scop
expired in 1995. In 1997, the FDA approved scopolamine soluble tablets.
Therapeutic categories of use CNS agents, antimuscarinic
antiemetic/antivertigo agents for prevention of nausea and vomiting associated
with motion sickness and prevention of postoperative nausea and vomiting.
Incompatibilities It may precipitate at pH values > 6.0 that create >1% of the
non­ionized or free­base form, B. It may form insoluble salts with aromatic
organic anions, depending on concentration.
Comments/Notes It differs from other antimuscarinic drugs in that, in
therapeutic doses, it is a sedative and tranquilizing depressant to the CNS. In its
peripheral actions, it differs from atropine in that it is a stronger blocking agent for
the iris, ciliary body, and salivary, bronchial, and sweat glands but is weaker in its
action on the heart, in which it is incapable of exerting actions in tolerated doses,
the intestinal tract, and the bronchial musculature. It is sometimes given as a pre­
anesthetic medication for both its sedative­tranquilizing and antisecretory actions.
It is effective as a prophylactic against motion sickness, for which slow­release
transdermal dosage forms have been devised. Transdermal systems provide
sustained release for 3 days. It is also used sometimes in other types of vertigo. It
is occasionally used to suppress delirium. As a mydriatic and cycloplegic, it has a
somewhat shorter duration (3–7 days), and intraocular pressure is affected less
markedly than with atropine.
Preparation
Single­ingredient preparations The symbol ¤ denotes a preparation which is
discontinued or no longer actively marketed.
Argentina: Buscapina; Cifespasmo; Colobolina; Excelentia Antiespasmodico;
Luar­G; Pasmodina; Rupe­N. Australia: Buscopan; Kwells; Pamine¤; Scop¤;
Setacol; Travacalm HO. Austria.: Buscapina; Buscopan; Scopoderm¤. Belgium:
Aspasmine¤; Buscopan. Brazil: Buscopan; Hiospan; Uni Hioscin. Canada:
Buscopan; Transderm­V. Chile.: Buscapina. Czech Republic: Buscolysin¤;
Buscopan. Denmark: Buscopan; Scopoderm. Finland: Buscopan; Scopoderm.
France: Buscopan¤; Genoscopolamine¤; Scoburen; Scopoderm TTS; Scopos¤.
Germany: Boro­Scopol; BS Carino; BS­ratiopharm; Buscolysin¤; Buscopan; espa­
butyl¤; Holopon¤; Scopoderm TTS¤; Skopyl¤; Spasman scop; Spasmowern¤.
Greece: Buscopan; Naftex. Hong Kong.: Ariel; BF­Horloten¤; Buscopalamin¤;
Buscopan; Busopin; Colospan¤; Copan¤; Dhacopan; Holomine¤; Holopon¤;
Hyomide; Hysopan¤; Scopoderm TTS¤; Spasmoliv¤; Vidaspan¤. Hungary:
Buscopan. India.: Buscopan; Hyospan. Indonesia: Buscopan; Dormi; Gitas;
Hyscopan; Scobutrin; Scopamin; Scopma; Spashi; Spasmolit. Ireland: Buscopan;
Kwells. Italy: Addofix; Buscopan; Transcop. Jpn.: Buscopan. Malaysia.:
Buscopan; Buston; Colospan¤; Copan; Dhacopan; Encodex; Fucon; Hyomide;
Spasmoliv¤; Vacopan; Vascopan¤. Mexico: Alpin; Biomesina; Bipasmin N;
Bipasmin; Brolamina; Buscapina; Busina¤; Busprina­S; Buticina¤; Butiral;
Cryopina; Espacil; Espasantral¤; Excosine­S; Grafin; Hiosinotil¤; Hiosultrina;
Lemophar; Liliam¤; Selpiran­S; Serralpina; Tilosin¤. Netherlands: Buscopan;
Scopoderm TTS. Norway: Buscopan; Scopoderm. NZ.: Buscopan; Gastro­Soothe;
Scopoderm TTS. Philippines: Amucin; Ascopen; Buscin; Buscomed; Buscopan;
Busopin; Fucon; Gascopan; Gastride; Rotomide; Scolmin; Spasmosan; Xspas.
Poland: Buscolysin; Buscopan; Scopolan. Portugal: Buscopan; Vagotrope­S¤.
Russia: Buscopan (Бускопан). South Africa: Buscopan; Hyospasmol; Scopaject;
Scopex; Scopoderm TTS¤. Singapore.: Buscopalamin; Buscopan; Colospan;
Copan; Cospan; Dhacopan; Dividol; Fucon; Hyomide; Hyosun; Scopoderm TTS;
SP­Anspaz; Spasmoliv; Vacopan. Spain.: Buscapina; Vorigeno¤. Sweden:
Buscopan; Scopoderm. Switzerland: Buscopan; Scopoderm TTS¤. Thailand:
Amcopan; Antispa Plus; Antispa; Bacotan; Buscono; Buscopan; Butyl; Cencopan;
Eralgavvv¤; Fucon; Higan; Hy­Spa; Hybutyl; Hyosman; Hyosmed; Hyospan;
Hyostan; Hyozin; Hytic¤; Kanin; Myspa; Scopas; Spalox¤; Spascopan; Spasgone­
H; Spasmo; Spatab¤; U­Oscine; Uospan; Uricine; Vacopan; Vescopolamine.
Turkey: Buscopan; Butopan; Molit; Spazmol; Spazmotek. UAE.: Scopinal. UK.:
Buscopan; Joy­Rides; Kwells; Scopoderm TTS; Travel Calm¤. Ukraine:
Spasmobru (Спазмобрю). USA.: Pamine; Scopace; Transderm Scop. Venezuela:
Buscapina; Hiocin.
Multi­ingredient Preparations The symbol ¤ denotes a preparation which is
discontinued or no longer actively marketed.
Argentina: 6­Copin¤; 6­Copin; Buscapina Compositum N; Buscapina
Compositum; Buscapina Fem; Cavodan¤; Cifespasmo Compuesto; Colobolina D;
Dislembral¤; Espasmo Biotenk; Espasmol; Feminity; Gastrolina Compuesta;
Hioscina Compuesta; Ibu­Buscapina; Ibuxim Fem; Labsyna Fem; Lisalgil
Compuesto; Luar­G Compositum; Novopasmil Compuesto; Pasmodina Compuesta;
Rupe­N Compuesto; Tafirol Mujer. Australia: Benacine¤; Contac¤; Donnagel;
Donnalix; Donnatab; Donnatal¤; Travacalm. Austria.: Asthma¤; Buscopamol¤;
Buscopan Compositum; Modiscop¤. Belgium: Buscopan Compositum; Spasma¤;
Tranquo­Buscopan¤. Brazil: Algexin; Analverin Composto¤; Analverin Plus¤;
Binospan¤; Bioscina Composta¤; Buscopan Composto; Buscopan Plus; Buscoveran
Composto; Butilamin; Disbuspan; Dorspan Composto; Ductopan¤; Espasmodid
Composto; Hioariston; Hiospan Composto; Inib­Dor¤; Kindpasm; Neocopan;
Sedabel¤; Sedobion¤; Tropinal; Uzara¤; Vagoplex¤; Veratropan Composto.
Canada: Diban¤; Donnagel¤; Donnatal¤; Donnazyme¤. Chile.: Algion¤; Buscapina
Compositum; Crotalgina; Dolcopin; Kordinol Compuesto¤; Novalona. France:
Algo­Buscopan¤; Sedol¤; Supposedol¤; Vagantyl¤. Germany: B1­Neurischian¤;
bella sanol¤; Brox­Aerosol N¤; Buscopan Compositum¤; Buscopan Plus;
Circovegetalin compositum¤; Febenol¤; Felsolyn N¤; Ichthospasmin N¤; Oragallin S
¤; Seda­Stenocrat­N¤; Spasmo­Bilicura¤; Tranquo­Buscopan¤. Greece: Buscopan
Plus; Colik; Spasmo­Apotel. Hong Kong.: Crema­U¤; Epilon; Unigan; Virulex
Forte. Indonesia: Aludonna; Aludonna; Buscopan Plus; Dormi Comp; Gitas Plus;
Procolic; Scopamin Plus; Scopma Plus; Spashi Plus; Spaslic; Spasmacine;
Unthecol. Ireland: Feminax. Italy: Buscopan Compositum; Spasmeridan¤;
Tranquo­Buscopan¤. Mexico: Algosfar; Anadil; Benfol¤; Biomesina Compuesta;
Bipasmin Compuesto NF¤; Bipasmin Compuesto; Buscapina Compositum N;
Buscapina Compositum; Buscapina Fem; Busconet; Busepan; Busprina; Colepren;
Doltrix; Donodol Compuesto; Escapin­N; Espacil Compuesto; Espasmogress;
Hiosinotil Compuesto¤; Hiosultrina­F; Infafren Compuesto; Mebuxina; Neo­
Pasmonal; Ortran¤; Pasmodil; Pirobutil; Precicol; Prestodol Compuesto; Retodol
Compositum; Selpiran Compuesto; Selpiran; Serralpina Compuesta; Viladol Plus;
Viladol­Met. Philippines: Buscopan Plus; Unigan. Poland: Scopolan Compositum;
Vegantalgin H. Portugal: Buscopan Compositum N. South Africa: Allertac¤;
Bellatard¤; Bellavern¤; Buscopan Compositum; Donnatal¤; Dyka­D¤; Dykatuss¤;
Millerspas; Respinol Compound¤; Respinol¤; Scopex Co; Tropax¤; Virobis¤.
Spain.: Brom Hioscin Espasmoliti¤; Buscalide¤; Buscapina Compositum; Buscopax
¤; Frenespan¤; Furantoina Sedante¤; Gestadramina¤; Lotanal¤; Midriati; Nolotil
Compositum¤; Oportunin¤; Oragalin Espasmolitico; PH 3 Compuesto¤; Psico
Blocan; Uro Hubber¤; Urogobens Antiespasmo¤. Sweden: Spasmofen.
Switzerland: Buscopan Compositum¤; Nardyl¤; Viaggio¤. Thailand: Amcopan
Plus; Buscopan Plus¤; Donnatal¤; Hyosman Plus; Pacopan; Spasgone; Unigan.
Turkey: Buscopan Compositum¤; Buscopan Plus; Molit Plus; Skopolin¤; Spazmol
Plus; Spazmotek Plus; Tanko­Buskas¤; Tranko­Buskas. UK.: Feminax. USA.:
Accuhist LA¤; AeroHist Plus; AeroKid; AH­chew; Alkabel; AllePak; AlleRx DF;
AlleRx; Antispasmodic Elixir; Atrohist Plus¤; Barbidonna¤; Bellahist­D; Bellatal;
Chlor­Mes D; Chlor­Mes; CPM PSE MSC; CPM/PE/MSC; DA Chewable; DA II;
Dallergy PE; Dallergy; Deconhist LA¤; Dehistine; Dexphen M; Donna­Sed¤;
Donnagel­PG¤; Donnamor¤; Donnapine¤; Donnatal; DriHist; DryMax; Dura­
Vent/DA; Durahist D¤; Durahist¤; Ex­Histine; Extendryl DM; Extendryl PEM;
Extendryl; Hista­Vent DA¤; Histaspan­D¤; Histatab D; Histor­D Timecelles;
Hyosophen; Kinesed¤; Malatal¤; Mescolor¤; Murocoll­2¤; Nacon; NoHist Plus;
Omnihist LA; Pamine FQ Kit; Pannaz; PB­Hyos; PCM; PE­CPM­MSN; PE­HCL­CPM­
MSN; Phenacon¤; Phenahist­TR¤; Phenchlor SHA¤; Prehist D; PSE MSC; Ralix;
Redur­PCM¤; Relaxadon¤; RelCof CPM; RelCof DN PE; RelCof DN PSE; RelCof PSE;
Rescon; Rhinolar¤; Ru­Tuss¤; Ryneze; Servira; Spasmophen¤; Spasquid¤; Stahist;
Susano; SymPak II; SymPak PDX; SymPak; Xiral¤. Venezuela: Brugesina;
Buscapina Compositum; Buscapina Plus; Butilamina Compuesta; Diezol
Compuesto¤; Fenopol¤; Hioscinol Compuesto¤; Sarifan Compuesto¤; Vuscobras.
◄ Previous: Saxagliptin Monohydrate | Top | Next: Secobarbital ►
See Also
AHFS Drug Information
(2)
Scopolamine,
Scopolamine
Hydrobromide
Scopolamine
Hydrobromide (EENT)
British National
Formulary (9)
Symptom control
Continuous
subcutaneous
infusions
4.6 Drugs used in
nausea and vertigo
see all (9)
BNF for Children (7)
Symptom control
Continuous
subcutaneous
infusions
4.6 Drugs used in
nausea and vertigo
see all (7)
Clarke's Analysis of
Drugs and Poisons
Hyoscine
Handbook on
Injectable Drugs
Scopolamine
Hydrobromide
Injectable Drugs Guide
(2)
Hyoscine
hydrobromide
(scopolamine
hydrobromide)
Papaveretum with
hyoscine
hydrobromide
Martindale: The
Complete Drug
Reference
Hyoscine
Drug Administration via
Enteral Feeding Tubes
Hyoscine
hydrobromide
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