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Amphotericin B
BAN: Amphotericin B [BANM]
INN: Amphotericin B [rINN (en)]
INN: Amfotericina B [rINN (es)]
INN: Amphotéricine B [rINN (fr)]
INN: Amphotericinum B [rINN (la)]
INN: Амфотерицин B [rINN (ru)]
INN: ‫ﺏ‬ ‫ﺃﻣﻔﻭﺗﺭﻳﺳﻳﻥ‬ [rINN (ar)]
INN: 两性霉素b [rINN (cn)]
Chemical name [1R (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,
25E,27E,29E,31E,33R,35S,36S,37S)]­33­[(3­Amino­3,6­dideoxy­β­D­
mannopyranosyl)­oxy]­1,3,5,6,9,11,17,37­octahydroxy­15,16,18­trimethyl ­ 13 ­
oxo ­ 14,39 ­ dioxabicyclo[33 . 3 . 1]nonatriaconta ­ 19,21,23,25,27, 29,31­
heptaene­36­carboxylic acid
Synonyms Amfotericin; Amfotericin B; Amfotericina B; Amfotericinas B;
Amfoterisiini; Amfoterisiini B; Amfoterisin; Amfoterisin B; Amfoterycyna
b; Amphotericin; Amphotericin B Cholesteryl Sulfate Complex;
Amphotericin B Lipid Complex; Amphotericin B Liposome; Amphotericin B
Phospholipid Complex; Amphotericin B­Sodium Cholesteryl Sulfate
Complex; Amphotéricine B; Amphotericinum; Amphotericinum B;
Anfotericina B; Liposomal Amphotericin B; アムホテリシン B; アムホテリシンB
Structure
Chemical Structure of Amphotericin B
CAS 1397­89­3
Molecular formula C47H73NO17 = 924.1
M Account
Description Antifungal; yellow to orange powder; odorless or practically
odorless.
Solubility Insoluble in water, alcohol, and ether; soluble in propylene glycol;
insoluble in benzene and toluene; soluble in dimethylformamide and dimethyl
sulfoxide; slightly soluble in methanol; practically insoluble in aqueous media at
neutral pH values; 1 gram dissolves in 25 to 30mL of DMSO and 12–15mL acidic
dimethylformamide.
Stability Store 2–8ºC; decomposes gradually above 170ºC without melting; in
aqueous solution, trans­cis isomerization and epoxidation are the most likely
routes of degradation; amphotericin is solubilized by micelle formation and prone
to photlytic degradation; protect from light.
Packaging Light resistant and airtight container; refrigerate.
Therapeutic categories of use Antifungal; antiprotozoal.
Incompatibilities Follow manufacturer's directives.
Comments/Notes It is administered by IV, nasal instillation, inhalation, topically
in the treatment of superficial monilial infections and by nasal spray in the
prophylaxis of aspergillosis in immunocompromised patients. Amphotec is
Amphotericin B Cholesterol Sulfate Complex for Injection, a liposomal product
for IV adm. Upon reconstitution, Amphotec forms a colloidal dispersion of
microscopic disc­shaped particles. Label: to be administered intravenously or
topically. Used in Leishmaniasis in animals. Under no circumstances should a total
daily dose of 1.5 mg/kg be exceeded. Amphotericin B overdoses can result in
potentially fatal cardiac or cardiorespiratory arrest. Although some patients may
tolerate full intravenous doses of amphotericin B without difficulty, most will
exhibit some intolerance, often at less than the full therapeutic dose.
Amphotericin B Inhalation Powder (ABIP) has been granted orphan medicinal
product designation by the European Commission for the prevention of pulmonary
infections; in the United States, the FDA granted Fast Track designation and
Orphan Drug designation for the prevention of pulmonary fungal infections by
inhalation treatment.
Preparation
Single­ingredient preparations The symbol ¤ denotes a preparation which is
discontinued or no longer actively marketed.
Argentina: Abelcet; AmBisome; Amfostat¤; Amphotec; Anfogen¤. Australia:
Abelcet; AmBisome; Amphocil¤; Fungilin; Fungizone. Austria.: Abelcet;
AmBisome; Ampho­Moronal; Amphocil. Belgium: Abelcet; AmBisome; Fungizone
¤. Brazil: Abelcet; AmBisome¤; Amphocil; Anforicin B; Fungi B; Fungizon.
Canada: Abelcet; AmBisome; Amphotec; Fungizone. Chile.: Fungizon. Czech
Republic: Abelcet; Amphocil. Denmark: Abelcet; AmBisome; Amphocil; Fungilin
¤; Fungizone. Finland: Abelcet; AmBisome; Fungizone. France: Abelcet;
AmBisome; Fungizone. Germany: Abelcet; AmBisome; Ampho­Moronal. Greece:
Abelcet; Aglutin; AmBisome; Amphiprol; Amphocil; Fungizone. Hong Kong.:
Abelcet¤; AmBisome; Amphocil¤; Fungilin¤; Fungizone. Hungary: Abelcet;
AmBisome; Amphocil; Fungizone. India.: Fungizone. Indonesia: Fungizone.
Ireland: Abelcet; AmBisome; Amphocil; Fungizone. Israel.: AmBisome;
Amphocil; Amphotec; Fungilin¤; Fungizone¤. Italy: Abelcet; AmBisome; Amphocil;
Fungilin; Fungizone. Jpn.: AmBisome. Malaysia.: Abelcet¤; Amphocil; Fungizone.
Mexico: Abelcet; Amfostat; Amphocil; Candipres; Terix. Netherlands: Abelcet;
AmBisome; Amphocil; Fungizone. Norway: Abelcet; AmBisome; Fungizone. NZ.:
Abelcet; AmBisome; Fungilin; Fungizone. Philippines: Fungizone. Poland:
Abelcet; AmBisome; Amphocil. Portugal: Abelcet; AmBisome; Amphocil;
Fungizone¤. Russia: AmBisome (АмБизом)¤; Amphoglucamin (Амфоглюкамин)¤;
Fungizone (Фунгизон). South Africa: AmBisome; Fungizone. Singapore.:
Abelcet; AmBisome; Amphocil; Fungizone. Spain.: Abelcet; AmBisome; Amphocil;
Funganiline¤; Fungizona. Sweden: Abelcet; AmBisome; Amphocil¤; Fungizone.
Switzerland: Abelcet¤; AmBisome; Ampho­Moronal; Fungizone. Thailand:
ADPHO; AmBisome; Amphocil; Ampholin; Amphotret; Fungizone¤. Turkey:
Abelcet; AmBisome; Amphotec; Fungizone. UK.: Abelcet; AmBisome; Amphocil¤;
Fungilin¤; Fungizone. USA.: Abelcet; AmBisome; Amphotec; Fungizone¤.
Venezuela: Amphotec; Fungizone.
Multi­ingredient Preparations The symbol ¤ denotes a preparation which is
discontinued or no longer actively marketed.
Austria.: Mysteclin. Belgium: Fungispec¤. Brazil: Anfoterin¤; Gino­Teracin;
Novasutin; Talsutin; Tericin AT; Tricocilin B; Vagiklin. Canada: Resteclin¤. Chile.:
Talseclin¤. France: Amphocycline¤. Germany: Ampho­Moronal V L¤; Ampho­
Moronal V¤; Mysteclin¤; Mysteclin. Hong Kong.: Talsutin¤. Indonesia: Talsutin.
Ireland: Mysteclin­F¤. Italy: Anfocort¤; Talsutin¤. Malaysia.: Talsutin¤.
Netherlands: Amphocycline¤. Philippines: Vagimycin. South Africa: Mysteclin­
V¤; Vagmycin¤. Spain.: Gine Heyden¤; Novicort¤; Sanicel¤; Trigon Topico¤.
Switzerland: Amphocycline¤; Neo Amphocort¤. Venezuela: Talsutin¤.
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See Also
AHFS Drug Information
Amphotericin B
Stockley's Interaction
Alerts
Interactions of
Amphotericin b
British National
Formulary (12)
Treatment of fungal
infections
5.2.3 Polyene
antifungals
AMPHOTERICIN
see all (12)
BNF for Children (7)
Treatment of fungal
infections
5.2.3 Polyene
antifungals
AMPHOTERICIN
see all (7)
Clarke's Analysis of
Drugs and Poisons
Amphotericin B
Handbook on
Injectable Drugs (4)
Amphotericin B
Cholesteryl Sulfate
Complex
Amphotericin B Lipid
Complex
Amphotericin B
Liposomal
see all (4)
Injectable Drugs Guide
(4)
Abelcet (Amphotericin
B­phospholipid
complex)
AmBisome (liposomal
amphotericin B)
Amphocil
(amphotericin B­
sodium cholesteryl
sulfate complex)
see all (4)
Kucers' the Use of
Antibiotics (7)
Description
Antimicrobial activity
Mechanism of drug
action
see all (7)
Martindale: The
Complete Drug
Reference
Amphotericin B
Remington: The
Science and Practice of
Pharmacy
Emulsions
Stockley's Drug
Interactions
Interactions of
Amphotericin B
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