PROGRAM Sunday 14th July 2013 (s) Student Presentation Registration 12:00pm - 3:00pm Hotel Lobby Afternoon Tea 2:30pm - 3:00pm Pioneers (Exhibition Hall) Sponsored by Alchemia Opening Ceremony 3:00pm - 3:10pm Wentworth Session 1 Wentworth 3:10pm - 4:50pm Chair: Renate Griffith 3:10PM Lisa Marcaurelle Diversity-oriented synthesis for oncology drug discovery abs# 1 4:00 PM Christopher Burns Discovery of new treatments for Acute Myeloid Leukaemia abs# 2 4:30 PM Guillaume Lessene Discovery, structure-guided design and validation of WEHI-539, a novel, potent and selective inhibitor of the pro-survival BCL-2 family member BCL-XL abs# 3 Annual General Meeting 4:50pm - 5:45pm Wentworth Welcome Function Dinner 6:00pm - 7:30pm Poster Session (odd number abstract presentations) 7:30pm - 9:30pm Pre Function Area Sponsored by FB Rice RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 th th 17 July 2013 12 Monday 15th July 2013 (s) Student Presentation Session 2 Wentworth 8:30am - 10:40am Chair: Michela Simone 8:30 AM Ben Davis Sugars & proteins: towards a synthetic biology abs# 4 9:20 AM Christopher Gordon Advancing Flow Chemistry: Towards Total Flow Synthesis abs# 5 (s) 9:40 AM Prarthana Devi Synthetic Approaches to a Peptide Isostere to Study Enzyme Mechanism abs# 6 10:00 AM Rebecca Pouwer Natural products as starting points for drug discovery: The total synthesis and antimalarial activity of thiaplakortone A and analogues abs# 7 10:20 AM Naresh Kumar Synthesis of novel biologically active scaffolds based on flavones and isoflavones abs# 8 Morning Tea 10:40am - 11:00am Pre Function Area Sponsored by AMRI Session 3 Wentworth 11:00am - 1:20pm Chair: Jonathan Morris 11:00 AM Stefan Knapp Modulating transcription by selective targeting protein interactions mediated by epigenetic effector domains abs# 9 11:50 AM Sally-Ann Poulsen Medicinal chemistry of carbonic anhydrase inhibitors targeting tumour hypoxia abs# 10 12:20 PM Elizabeth New Chemical approaches to studying oxidative stress in biology abs# 11 12:40 PM Tim Quach Design and synthesis of lipid prodrugs for the improved treatment of autoimmune diseases by targeted delivery to the lymphatic system abs# 12 1:00 PM Michael Davies Tetraethyl- and tetramethyl- nitroxides are potent inhibitors of the key neutrophil-derived inflammatory enzyme myeloperoxidase abs# 13 Lunch 1:20pm - 2:30pm Pre Function Area Sponsored by BioScientific RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 th th 17 July 2013 13 Session 4 Wentworth 2:30pm - 4:10pm Chair: Michael Kassiou 2:30 PM Edward Holson Targeting Chromatin Modulators as a Novel Treatment for Cognitive Impairment: Development of Isoform Selective Inhibitors of Histone Daecetylases (HDACs) abs# 14 3:20 PM Mary Collins Chebib Trapped in the act: The - interface of nicotinic acetylcholine receptors is an additional binding site for methyllycaconitine abs# 15 3:50 PM Shane Wilkinson Synthetic Strategies on Polycyclic Frameworks for Blood-Brain Barrier Penetration abs# 16 Afternoon Tea 4:10pm - 4:30pm Pre Function Area Session 5 4:30pm - 5:50pm Chair: Michael Kassiou 4:30 PM 4:50 PM 5:10 PM 5:30 PM Wentworth Sponsored by AMRI Matthew Isherwood Discovery of a new series of 5-ht6 antagonists with potential for treatment of diseases associated with cognitive dysfunction abs# 17 (s) Madeline Kavanagh Design and synthesis of metabolically s abs# 18 (s) Jeppe Olsen Additive modulation of nicotinic acetylcholine receptors by positive allosteric modulators binding in two distinct sites abs# 19 Shailesh Mistry Textured Drug Discovery: Uncovering Enriched SAR of M1 Muscarinic Receptor Allosteric Modulators abs# 20 Monday Night Dinner 6:15pm - 7:30pm Blaxland & Lawson Poster Session (even number abstract presentations) 7:30pm - 9:30pm Pre Function Area Sponsored by FB Rice RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 th th 17 July 2013 14 Tuesday 16th July 2013 (s) Student Presentation (i) Industry Award Presentation Session 6 Wentworth 8:30am - 10:40am Chair: Shelli McAlpine 8:30 AM John Flygare Antibody-Drug Conjugates for the Treatment of Cancer abs# 21 9:20 AM Pat Sharp Towards the Development of Bromodomain Inhibitors as Potential Cancer Therapeutics abs# 22 (s) 9:40 AM Hamish Toop Examining AAL(S) as a New Lead for the Treatment of Leukaemia abs# 23 10:00 AM Michael Kelso Towards Hypoxia-Activated Anti-tumour Mutual Prodrugs: Progress and Discoveries en Route abs# 24 10:20 AM Mark Gorrell Towards developing selective inhibitors of the protease Fibroblast Activation Protein (FAP) as a potential therapeutic for cancer and chronic liver injury abs# 25 Morning Tea 10:40am - 11:00am Pioneers (Exhibition Hall) Sponsored by United Bioresearch Session 7 11:00am - 1:20pm Chair: Rachel Codd 11:00 AM 11:50 AM 12:20 PM 12:40 PM 1:00 PM Wentworth Sponsored by FB Rice Ronald Quinn Natural Products in a Drug Discovery Environment abs# 26 Adam McCluskey Rings, helices, macromolecular structures and the inhibition of dynamin GTPase as a novel therapeutic target abs# 27 Joel Tyndall Identification of an antifungal inhibitor of the riboflavin synthesis pathway by in silico screening abs# 28 (s) Anh Thu Tran Synthesis and evaluation of novel enzyme inhibitors as tuberculosis drug leads abs# 29 Rohan Davis Exploiting Fungal Chemistry for Antimalarial Lead Discovery abs# 30 Lunch 1:20pm - 2:30pm Pioneers (Exhibition Hall) Sponsored by Waters Australia RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 th th 17 July 2013 15 Session 8 2:30pm - 4:10pm Chair: Renate Griffith Wentworth 2:30 PM Andrew Abell Bio-heterocyclic chemistry, from Adrien Albert to the University of Adelaide abs# 31 3:20 PM Matthew Piggott abs# 32 3:50 PM Pall Thordarson A functional nanoreactor based on a Ru(II)bisterpyridine-cytochrome c bioconjugate light driven proton pump abs# 33 Afternoon Tea 4:10pm - 4:40pm Wentworth Session 9 Wentworth 4:40pm - 6:00pm Chair: Wim Meutermans 4:40 PM Chris Parkinson A new perspective on ATP: Implications of ATP structure on the design of ATP site kinase inhibitors abs# 34 (i) 5:00 PM Andrew Donohue Development of levofloxacin releasing intravitreal implants for the treatment of ocular disease abs# 35 (i) 5:20 PM Alison Findlay Development of mechanism-based inhibitors of amine oxidases abs# 36 (i) 5:40 PM Martine Keenan Scaffold hops to a pre-clinical candidate to treat Chagas Disease abs# 37 Conference Dinner 7:00pm - 10:00pm Blaxland & Lawson Sponsored by FB Rice Wednesday 17th July 2013 (s) Student Presentation Session 10 9:00am - 10:50am Chair: Rachel Codd Wentworth Sponsored by CSIRO 9:00 AM Martina Stenzel Micelle design for the efficient delivery of anti-cancer drugs abs# 38 RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 th th 17 July 2013 16 9:30 AM 9:50 AM 10:10 AM 10:30 AM Sheshanath V Bhosale Yoctowells as a simple model system for the encapsulation and control release of biomolecules abs#39 (s) Seong Jong Kim Effectively delivering a drug using star polymers: Improving solubility of a unique hsp90 inhibitor abs# 40 Luke Adams Targeting DsbA, a key Player in Bacterial Virulence, through the Evolution of a Phenylthiazole Fragment Hit abs# 41 Louise Whittell Tetrahydrocarbazoles as Fragment Leads Against the b-sliding clamp: Towards Antibacterials with A Novel Mechanism of Action abs# 42 Morning Tea 10:50am - 11:10am Pioneers (Exhibition Hall) Session 11 Wentworth 11:10am - 1:10pm Chair: William Bret Church 11:10 AM Emily Parker Aldolase Mechanism, Inhibition and Allostery abs# 43 11:40 AM Richard Payne Natural Product Analogues as New Tuberculosis and Malaria Drug Leads abs# 44 12:00 PM Brad Sleebs Transition state mimetic inhibitors of Plasmepsin V from Plasmodium falciparum and Plasmodium vivax abs# 45 12:20 PM Jennifer Martin Towards antibacterials without resistance: development of DSB inhibitors to block virulence using a combination of approaches abs# 46 Closing 1:10pm - 1:20pm RACI Biomolecular Division Conference, Fairmont Resort Blue Mountains, NSW 14 Wentworth th th 17 July 2013 17