Program Sunday 17th November 2013 ASPREE Community Event 2:00pm - 4:00pm Registration 3:00pm - 7:30pm Convention Centre Pre Function Opening Forum 4:10pm - 5:10pm Convention Centre Part 1 David Le Couteur & Stephen Simpson Older but Wiser: The Science of Healthy Ageing abs# 1 Expert Panel Q&A Session 5:10pm - 5:30pm Chair: Andrew McLachlan Firkin Oration 5:30pm - 6:30pm Chair: Naomi Rogers Convention Centre Part 1 Session sponsored by: 5:30 PM Rafael de Cabo Dietary interventions for healthy aging Welcome Reception 6:30pm - 7:30pm abs# 2 Eureka Ballroom ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 1 Monday 18th November 2013 Registration 7:00am - 6:30pm Convention Centre Pre Function Session 1 - The Ageing Body 8:30am - 10:30am Chairs: Aisling McMahon & Rafael de Cabo Convention Centre Part 1 Session co sponsored by: 8:30 AM 9:00 AM 9:30 AM 9:50 AM 10:15 AM John Headrick Ageing in the myocardium: Dysfunctional stress-resistance & cytoprotective signalling Andrew McLachlan Not available Victoria Cogger The Ageing Liver Kirsty Walters Androgens and ovarian aging Jonathan Stone The mechanical cause of age-related dementia: the brain is destroyed by the pulse Morning Tea 10:30am - 11:00am 11:30 AM 11:45 AM 12:00 PM 12:15 PM 12:30 PM 12:45 PM abs# 4 abs# 5 abs# 6 abs# 7 Convention Centre Pre Function Session 2 - Skeletal Muscle 11:00am - 1:00pm Chairs: Kristen Nowak & Anna Wong Shee 11:00 AM abs# 3 Convention Centre Part 1 Miranda Grounds Targeting sarcopenia: molecular changes associated with loss of innervation of old myofibres are prevented by benefits of life-long exercise abs# 8 Naomi Rogers Ageing & Sleep abs# 9 Jez Supreme Identifying the genetics of a novel naturally occurring muscular dystrophy in Western Australian sheep using bioinformatics and molecular biology abs# 10 Fleur Garton Alpha-actinin-3 deficiency alters muscle adaptation in response to denervation and immobilisation abs# 11 Victoria Wyckelsma The effects of high-intensity interval training on aerobic power and skeletal muscle Na +, K+ATPase in single fibres of healthy older adults abs# 12 Peter Houweling Alpha-actinin-3: a novel genetic modifier of Duchenne muscular dystrophy (DMD) abs# 13 Joshua Denham Leukocyte DNA methylation changes caused by high-intensity exercise training abs# 14 Lunch 1:00pm - 2:00pm Convention Centre Pre Function ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 2 Session 3 - Diabetes/Obesity 2:00pm - 4:00pm Chairs: Jonathan Hodgson & Lauren Fortington 2:00 PM 2:25 PM 2:50 PM 3:15 PM 3:30 PM 3:45 PM Convention Centre Part 1 Mark Febbraio Heat shock protein 72: a panacea for disease prevention? abs# Greg Cooney How does excess lipid availability decrease insulin action in muscle? abs# Tony Tiganis Hepatic oxidative stress, selective insulin resistance & obesity abs# Tara Brennan-Speranza Glucocorticoid effects on bone and energy metabolism abs# Guohui Cai Early life diet programs long-term neuroimmune function; a role for the hypothalamicpituitary-adrenal axis abs# Tina Bianco-Miotto Obesity and prostate cancer risk: evidence from animal models. abs# Afternoon Tea 4:00pm - 4:30pm Convention Centre Pre Function Poster Session 4:30pm - 6:30pm Convention Centre Pre Function ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 3 15 16 17 18 19 20 Tuesday 19th November 2013 Registration 8:00am - 5:30pm Convention Centre Pre Function Session 4 - Cardiovascular 8:30am - 10:30am Chairs: Joshua Lewis & Fadi Charchar Convention Centre Part 1 Session co- sponsored by: 8:30 AM 9:00 AM 9:30 AM 9:45 AM 10:00 AM 10:15 AM Juliana Hamzah Novel strategies to deliver imaging reagents and therapeutics into atherosclerotic plaques in vivo abs# 21 Jonathan Hodgson Effects of black tea on blood pressure and its variation abs# 22 Warrick Chilton Acute cardiorespiratory exercise leads to regulation of telomere-associated genes and microRNA expression in white blood cells abs# 23 Yuen Ting Lam Age-related impairment in vasculogenesis is characterised by failure of mobilisation of bone marrow-derived progenitors abs# 24 Laura Lecce Aging is associated with an impairment in androgen-mediated paracrine regulation of angiogenesis abs# 25 Joshua Lewis The effects of 3 years of calcium supplementation on common carotid artery intimal medial thickness and carotid atherosclerosis in older women: an ancillary study of the CAIFOS randomized controlled trial abs# 26 Morning Tea 10:30am - 11:00am Convention Centre Pre Function Edwards Oration 11:00am - 12:00pm Chair: Roger Yazbek Convention Centre Part 1 Stephen Simpson Not available abs# 27 Lunch 12:00pm - 1:00pm Convention Centre Pre Function ASMR AGM 12:00pm - 1:00pm Please pick up a plate of food and bring it with you to the AGM ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 4 Convention Centre Part 1 Session 5 - Brain 1:00pm - 3:00pm Chairs: Juliet Taylor & Peter Crack 1:00 PM 1:30 PM 2:00 PM 2:15 PM 2:30 PM 2:45 PM Convention Centre Part 1 Saul Villeda Young blood reverses age-related cognitive impairments abs# 28 Tony Broe High dementia rates in urban Aboriginal people: implications for ageing abs# 29 Alan Rembach The Australian Imaging and Biomarker (AIBL) study and Alzheimer’s disease: an update on blood-based biomarker progress abs# 30 Bevan Main Targeting type-1 interferon signalling is neuroprotective in the mptp mouse model of Parkinson’s disease abs# 31 Belal Chami Oxidative damage in the early stages of Alzheimer’s Disease abs# 32 Dan Johnstone Indirect application of near-infrared light induces neuroprotection in a mouse model of Parkinson’s disease – an abscopal neuroprotective effect abs# 33 Afternoon Tea 3:00pm - 3:30pm Convention Centre Pre Function ASMR Research Fund Meeting 3:15pm - 3:30pm Convention Centre Part 1 Session 6 - Mixed Free Communications 3:30pm - 5:30pm Chairs: Rosemary Keogh & Steven Polyak 3:30 PM 3:45 PM 4:00 PM 4:15 PM 4:30 PM 4:45 PM 5:00 PM 5:15 PM Convention Centre Part 1 Myles Minter Type-1 interferons modulate glial phenotype in response to Aβ. abs# 34 Allan Wiseman A prospective study of television viewing time and adiposity amongst postmenopausal women abs# 35 Mani Grover Identification of novel therapeutics for complex diseases from genome-wide association data abs# 36 Sivaraman Purushothuman Photobiomodulation is neuroprotective in transgenic mouse models of age-related dementias abs# 37 Cedric Lamboley Sarcoplasmic reticulum Ca2+ leak in human skeletal muscle fibres is not altered with age abs# 38 Ghanim Almahbobi Down-regulation of BMP action may alleviate the negative impact of age-related menopause abs# 39 Mark Yates The Dementia Care in Hospitals Program (DCHP)- a re-evaluation in the private sector abs# 40 Priscilla Prestes Whole genome DNA sequencing of a genetic model of cardiac hypertrophy identifies two candidate genes in cardiac mass QTL 22 abs# 41 Conference Dinner 7:00pm - 11:00pm Sovereign Hill ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 5 Wednesday 20th November 2013 Registration 8:00am - 1:30pm Convention Centre Pre Function Session 7 - Nutrition 8:30am - 10:30am Chairs: Alice Owen & Rachel Burt 8:30 AM 8:55 AM 9:20 AM 9:45 AM 10:00 AM 10:15 AM Convention Centre Part 1 Gary Wittert Testosterone for the prevention of type 2 diabetes in men: The T4DM Trial abs# 42 Anna Peeters The impact of obesity trends on healthy ageing abs# 43 Neville Owen Too little exercise and too much sitting: implications for chronic disease prevention abs# 44 Josephine Forbes Linking kidneys and blood sugar - An unlikely couple out for dinner? abs# 45 Lindsay Wu NAD+ biology in ageing, senescence and cancer abs# 46 Rosilene Waern A snapshot of the nutritional adequacy of men participating in the Concord Health and Ageing in Men Project (CHAMP) abs# 47 Morning Tea 10:30am - 11:00am Convention Centre Pre Function Session 8 - Bone 11:00am - 1:00pm Chairs: Nathan J. Pavlos & Tara Brennan-Speranza 11:00 AM 11:30 AM 11:55 AM 12:20 PM 12:45 PM Convention Centre Part 1 Ego Seeman Challenges in the detection, prevention and reversal of bone fragility abs# 48 Natalie Sims Delving into osteocytes to find new treatments for aging bone abs# 49 Gustavo Duque Old bone new fat: what ageing means to bone? abs# 50 David Findlay Osteocytes: All things to all persons abs# 51 Vasant Hirani Vitamin D status and associations with intrusive and chronic pain in older Australian men: The Concord Health and Ageing in Men Project. abs# 52 Awards and Close 1:00pm - 1:30pm Convention Centre Part 1 ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 6 Poster Listing Sumaya Allami Heat therapy effects on skeletal muscle heat shock proteins in the elderly abs# 101 Mark Bigland Evidence for perturbations in ion homeostasis in the inner ear vestibular (balance) system of the aged rat abs# 102 Scott Booth Telomere length and microRNA-34a expression in a polygenic model of cardiac abs# 103 Rachel Burt Death of a hair cell: how is the auditory apoptosis that causes age-related hearing loss regulated? abs# 104 Emma Callegari Improving vitamin D status and related health in young women (the Safe-D study) abs# 105 Caitlin Doogan Investigating the role of long non-coding RNA in essential hypertension through the use of RNA-Seq abs# 106 Jerzy Dyczynski The decreased activity of ADRB2 gene and COMT, the genetic component of stress correlate with elevated stress level measured as Cardio Stress Index (CSI) based on Heart Rate Variability (HRV). abs# 107 Faeza Ebrahimi Investigating the role of miR-126 in colorectal cancer abs# 108 Divya Eratte Development of composite microcapsule containing omega-3 fatty acids and probiotics - a new concept in the nutraceuticals and functional food delivery for human health abs# 109 Victor H. H. Goh Associations of age and physical exercise as a lifestyle habit with handgrip strength and regional distribution of lean body mass in Asian men abs# 110 Vasant Hirani Optimum serum 25-hydroxyvitamin D concentrations for multiple health conditions, physical performance, reduced risk of disability, falls and all-cause mortality: The Concord Health and Ageing in Men Project. abs# 111 Sae Rom Jo Insulin Growth Factor-1 qctivation of Early Growth Response-1 (Egr-1) via receptor cross-talk abs# 112 Dan Johnstone Brain iron accumulation during ageing in the haemochromatosis mouse model and wildtype mice abs# 113 Usha Kalluri GCMS-HS-SPME analysis of volatile metabolites produced by a lung cancer cell line abs# 114 Myung-Jin Kang Inhibition of the mitochondrial unfolded protein response and longevity by Wnt signalling abs# 115 Niamh Lynn The place we thought we would never be - HIV complex care and ageing abs# 116 Francine Marques Droplet digital PCR measurement of copy number variation in genome-wide association regions for blood pressure reveal association with essential hypertension abs# 117 Catherine Milte Diet quality is associated with physical and mental health status of older Australians abs# 118 Hassina Massudi Evidence for non-cell autonomous regulation of mitochondrial biogenesis by SIRT1 abs# 119 Mashani Mohamad Effect of liver endothelial cells defenestration on glucose metabolism and insulin resistance abs# 120 Elsa Molina Y chromosome-linked long non-coding RNA: function and involvement in diabetes with implications for coronary artery disease. abs# 121 Alex Nield The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells abs# 122 Kristen Nowak Harnessing a powerful mouse resource to better diagnose, understand and treat skeletal muscle and cardiac muscle diseases abs# 123 Gemma Parkinson Age-related increase in the abundance of mitochondrial DNA deletions in substantia nigra dopamine ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 7 neurons of the rat. abs# 124 Steven Polyak Biotin protein ligase: a novel anti-TB drug target abs# 125 Withdrawn abs# 126 Indrajeetsinh Rana Role of microRNA in cardioprotection of the renin angiotensin system inhibitor in animal model of renal injury abs# 127 Shajjia Razi Serum induced SIRT1 expression and longevity in older men abs# 128 Samantha Solon-Biet The role of macronutrient balance on appetite, metabolic health and ageing in a mouse model abs# 129 Joanna Skommer Changes in microRNA expression in the ageing human heart abs# 130 Ilona Tay Tap4Bone: An exploratory randomized-controlled trial using mobile-phone intervention in young women to improve their longterm bone health abs# 131 Thien Tra Is H9C2 a valid cardiomyocyte model? abs# 132 Alessandra Warren Lack of vitamin C in mice (Gulo-/-) associated with less mitochondria in hepatocytes and increased sinusoidal endothelial porosity. abs# 133 Evelyn Zacharewicz Regulation of skeletal muscle micrornas in young and old adults following acute resistance exercise abs# 134 ASMR 52nd National Scientific Conference Ballarat Lodge 17th – 20th November 2013 page 8