[Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Systematic Review Electronic apex locator: A comprehensive literature review — Part I: Different generations, comparison with other techniques and different usages Hamid Mosleh, Saber Khazaei1, Hamid Razavian2, Armita Vali, Farzad Ziaei Dental Students’ Research Center, 2Department of Endodontics, Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, 1Department of Research, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran A B S T R A C T Introduction: To compare electronic apex locators (EAL) with others root canal determination techniques and evaluate other usage of this devices. Materials and Methods: “Tooth apex,” “Dental instrument,” “Odontometry,” “Electronic medical,” and “Electronic apex locator” were searched as primary identifiers via Medline/PubMed, Cochrane library, and Scopus data base up to 30 July 2013. Original articles that fulfilled the inclusion criteria were selected and reviewed. Results: Out of 402 relevant studies, 183 were selected based on the inclusion criteria. In this part, 108 studies are presented. Under the same conditions, no significant differences could be seen between different EALs of one generation. The application of EALs can result in lower patient radiation exposure, exact diagnosing of fractures, less perforation, and better retreatment. Conclusions: EALs were more accurate than other techniques in root canal length determination. Key words: Dental instrument, electronic apex locator, electronic medical, odontometry, tooth apex Introduction Ideal pulp treatment is defined as the removal of infected pulp and cleaning, shaping, and disinfecting the root canal system.[1] Subsequently, a three-dimensional filling can be provided. To achieve this goal, an essential stage is the assessment of the correct length of the root canals.[1,2] Working length is defined as the distance between the coronal/incisal reference point and the area that has been prepared and at which the filled canal should end.[1] Access this article online Quick Response Code: Website: www.dentalhypotheses.com DOI: 10.4103/2155-8213.136744 Commonly, the minor apical foramen or apical isthmus is considered the end of the area for canal preparation and filling. The minor apical foramen is the border line between the dental pulp and periodontal area, which is approximately 0.5-1 mm from the anatomic apex.[1,3] Failure to determine the root canal length can result in both over- and underestimation of the root canal length. Overestimated working length can result in preparation beyond the apical isthmus, which can damage the peri-apical region.[4] Underestimated working length and inadequate debridement can cause unsuccessful treatment and dissatisfaction of both the patient and dentist.[5] Due to the pivotal role of working length determinations in root canal therapy, several methods have been introduced as follows. A: Tactile sensation and using the mean canal length and the application of paper cones are examples of experimental methods that are used by some clinicians due to their simplicity and relative efficiency.[6] These Corresponding Author: Dr. Hamid Razavian, Department of Endodontics, School of Dentistry, Isfahan University of Medical Sciences, Hezar Jerib St, Isfahan-81746-73461, Iran. E-mail: [email protected] 84 Dental Hypotheses Jul-Sep 2014 / Vol 5 | Issue 3 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator techniques can be inaccurate in some patients, however, due to open apex teeth and apical curvature.[6] B: Radiography is a common method for determining the apical isthmus, which is 0.5-1 mm shorter than radiographic apex.[2] The radiographic method has its advantages, such as direct observation of the root canal system and the canal curvature and of the existence of peri-apical lesions, [2] but radiography cannot determine the apical isthmus, because it provides a twodimensional picture of a three-dimensional object.[2,7] In addition, a disadvantage of radiation is that it can be dangerous to both patients and dental staff. C: Owing to the advantages of electronic apex locators (EAL), such as the elimination of radiographic obstacles and EAL’s accuracy and convenience, the application of EAL has developed.[3,8] The principal design and development of the early apex locators dates back to Suzuki (1942)[9] whom investigated on dogs and found out that the electrical resistance between the periodontal membrane and the oral mucosa was a constant value. This point was introduced into clinical practice by Sunada[10] (1962) which almost measured the electrical resistance between oral mucosa and periodontal ligament. Over the last decade, different versions of EAL have been released. Table 1 shows and compares the different versions of these devices, based on the functions of each generation. The aim of the present study was to investigate and compare the accuracy of EALs in determining the working length through root canal therapy. Materials and Methods English language only. Systematic reviews, case reports, letter to editors, editorials, and congress abstracts were excluded. The title and abstract of each article were reviewed by three of the authors (HM, AV, and FZ), and articles that fulfilled the inclusion criteria were selected. Data extraction Extraction of data from studies and assessment of validity was independently performed by two authors (HM and AV) and checked by a third author (FZ). In the case of disagreement between evaluators, it reassessed by discussion between two reviewers and a final consensus was agreed on (HR and SKh). Figure 1 provides information on the number of papers identified through the search strategy. Information of the authors, their institutions, and result of primary studies were removed before assessment of the validity. Information on the first author, year of publication, study design, study population and sample size, and the outcome measurements (main results) were extracted. Results Out of 402 articles, 183 studies were reviewed and 108 studies were selected for this part. The studies were categorized as follows. Comparison of different EALs In this part of the present study, 38 articles, consisting of 14 in vitro,[11-24] 9 ex vivo,[25-33] and 15 in vivo studies [34-48] were reviewed. Of the in vitro studies, four articles did not report significant differences between various devices[12,13,16,19] [Table 2]. All of the ex vivo studies showed significant differences between different devices, except for the study by Comin Chiaramonti et al.[31] and Baginska et al.[32][Table 2]. Among the Search strategy Electronic searches were performed using “tooth apex,” “dental instrument,” “odontometry,” “electronic medical,” and “electronic apex locator” as keywords. Moreover, cross-references were screened to identify further study that probably missed through the search strategy. Electronic databases Electronic searches were performed in Medline/PubMed, Cochrane library, and Scopus data base up to 30 July 2013. Four hundred and two articles were found. Inclusion criteria The inclusion criteria were articles, clinical trials in humans and cohort and case-control studies in the Jul-Sep 2014 / Vol 5 | Issue 3 Figure 1: Flow chart of selected articles Dental Hypotheses 85 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 1: Different generations of electrical apex locator devices and their operation base[86] Generation Operation base First Second Third Fourth Fifth Device samples Measurement of electrical resistance Root canal meter (Onuki medical Co.tokyo, Japan) Endodontic meter(Onuki medical Co.tokyo, Japan) Dentometer (Dahlin ectromedicine, Copenhagen, Denmark) Endo Radar (Electronica liarre, Imola, Italy) Measurements of electrical impedance Sono-Explorer (Hayashi Dental Supply, Tokyo, Japan) Endo Cater (Yamaura Seisokushu, Tokyo, Japan) Digipex (Mada Equipment Co.Carlstadt, NJ, USA) Exact-A-Pex (Ellman International Hewlett, NY, USA) Formatron IV (Parkell Dental, Farmingdale, NY, USA) Endodontic Meter S II (Onuki Medical Co., Tokyo, Japan) Sono-Explorer Mark II (Hayashi Dental Supply, Tokyo, Japan). Sono-Explorer Mark II Junior (Hayashi Dental Supply, Tokyo, Japan) Using two different frequencies at the same Endex/Apit (Osada Electrica Co. Tokyo, Japan) time in order to measure the difference or ratio Root ZX (J.Morita, Tokyo, Japan) between two currents Neosono Ultima EZ (Satelec Inc, Mount Lourel, Nj, USA) TCM Endo V (Nouvag Ag, Goldach, Switzerland) Apex Pointer (MicroMega, Besanc¸on, France) Dat Apex (Dentsply Maillerfer, Ballaiques, Switzerland) Just or Justy II (Yoshida Co.Yokyo, Japan) Mark V Plus (Moyco/Union Broach, Bethpage, NY, USA) Apex pointer Endy 5000 (Loser, Leverkusen, Germany) Mini Apex Locator (Sybron Endo, Anaheim, CA, USA) Dentaport ZX (J. Morita MFG Corp., Osaka, Japan) Endo Analyzer Model 8005 (Analytic/Endo, Orange, CA, USA) Apex Finder AFA (Analytic Technologies, Redmond, WA) Mark V Plus (Moyco/Union Broach, Bethpage, New York, USA) Endox (Co. Lysis, Milan, Italy). Endy (Loser, Leverkusen, Germany) Apex Finder (Endo Analyzer 8001; Analytic Technology, Redmond, WA, USA) Foramatron D10 (Parkell Electronic Division, Farmingdale, New York, USA). Using two or more non-simultaneous Bingo1020/Raypex4 (Foroum Engineering Technologies Rishon Lezion, Israel) continuous frequencies in order to measure Raypex4 (VDW, Munich, Germany) the difference or ratio between two currents Element Dianostic Unit & Apex Locator (Sybron Endo, Anaheim, CA, USA) Neosono MC (Amadent Medical and Dental, Co., Cherry Hill, New Jersey, USA). Propex (Dentsply Maillerfer, Ballaiques, Switzerland) Novapex (Foroum Engineering Technologies Rishon Lezion, Israel) Apex NRG XFR (Medic NRG Ltd, Tel Aviv, Israel) Apex DSP (Septodont, Saint-Maur des Fosse´s, Cedex, France) AFA Apex Finder, Model 7005 (Ana-lytic Endodontics, Orange, CA) iPex (NSK Ltd, Tokyo, Japan) Romi Apex D-30 (Romidan LTD, Kiryat-ono, Israel) Measures the capacitance and resistance Propex II (Dentsply Maillerfer, Ballaiques, Switzerland) of the circuit separately Top of Form Bottom of Form Apex Locator Joypex 5 (Henan, CBD Neihuan Road, Zhengzhou, China) I-ROOT (E-Magic Finder)(S-Denti SEoul, South Korea) Raypex 5 (VDW, Munich, Germany) in vivo studies, Welk et al.[34] and Arora et al.[47] found a significant difference between EALs [Table 2]. Comparison of EALs with different working length determination methods Thirty-one studies evaluated different methods of working length determination. Among these studies, eleven compared different EALs and conventional and digital radiography as three different methods of working length determination.[7,35-46,49-59] Among the studies that compared EALs to radiographic method, six studies 86 Dental Hypotheses did not report any significant differences, [7,35,36,43,53,54] three studies concluded that radiography method was more accurate,[49,55,59] and the remainder reported greater accuracy with the EAL [Table 3]. Three studies that compared digital radiography to EAL showed that EAL was more accurate[37,54,60] [Table 3]. Shanmugaraj et al.[6] compared three methods of measuring root canal length (apex locator, radiography, tactile sense) and reported that EAL was the most reliable method, but Ounsi et al.[61] showed that EAL and radiography method have Jul-Sep 2014 / Vol 5 | Issue 3 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 2: Comparison of different electronic apex locators (EALs) in working length determination Authors Type of Publication Sample (n) Types of studied study year ELA Comin Chiaramonti et al.[31] Ex vivo 2012 40 teeth Baginska et al.[32] Ex vivo 2012 40 teeth Somma et al.[89] In vivo 2012 30 teeth Paludo et al.[48] In vivo 2012 100 root Canals Jung et al.[15] In vitro 2011 104 teeth Stober et al. [90] In vivo 2011 40 root canals Stober et al.[87] In vivo 2011 40 root canals Miletic et al.[91] In vivo 2011 48 root canals Silveira et al. [88] In vivo 2011 23 teeth deVasconcelos et al. [28] Ex vivo 2010 38 teeth Guise et al.[17] In vitro 2010 40 teeth D’Assuncao et al. [33] Ex vivo 2010 31 teeth Pascon et al. [92] In vivo 2009 831 root canals Higa et al.[13] In vitro 2009 12 teeth Siu et al. [93] In vivo 2009 29 teeth Pascon et al.[25] Ex vivo 2009 60 teeth Ebrahim et al.[16] In vitro 2007 32 teeth D’Assuncao et al.[18] Invitro 2007 40 teeth Bernardes et al.[12] 2007 40 teeth Invitro Jul-Sep 2014 / Vol 5 | Issue 3 Aim of study Bingo 1020 Propex Comparing operation of different apex locator devices Raypex 5, Apex Comparing operation D.S.P and Locapex of different apex Five locator devices Dentaport ZX, Comparing operation Raypex 5, of different apex ProPex II locator devices Apex and iPex Comparing the accuracy of EALs in length measurement Root ZX, I-Root Comparing operation of different apex locator devices Raypex 5 Comparing operation Mini Apex Locator of different apex locator devices Root ZX and iPex Comparing operation of different apex locator devices Dentaport ZX, Comparing operation RomiApex A-15 and of different apex Raypex 5 locator devices Root ZX, Comparing operation Novapex of different apex locator devices Root ZX, RomiApex Comparing operation D-30, and Ipex of different apex locator devices Comparing operation Root ZX II, of different apex Elements AL, locator devices Precision AL Root ZX-II, Novapex, Comparing operation Mini AL of different apex locator devices DentaPort ZX, Comparing operation Raypex 5 of different apex locator devices Justylll, Dentaport, Comparing operation E-Magic Finder of different apex locator devices Root ZX II, Apex Comparing operation NRG of different apex XFR, Mini Apex locator devices Locator Dentaport ZX, Comparing operation Raypex 5 Elements of different apex Diagnostic Unit and locator devices AL Dentaport ZX, Comparing operation ProPex, of different apex Foramatron D10, locator devices Apex NRG, Apit 7 Mini AL, Root ZX II Comparing operation of different apex locator devices Root ZX, Elements Comparing operation Diagnostic Unit and of different apex A L, RomiAPEX locator devices D-30 Main study result Type of generation No significant difference Fourth No significant difference Fifth No significant difference Third and Fourth There weren’t significant differences and both devices were accurate No significant difference Fourth No significant difference Fourth No significant difference Third and Fourth No significant difference Third and Fourth No significant difference Third and Fourth Root ZX was more accurate Third and Fourth Third Root ZX II was more Fourth accurate Root ZX II was more Fourth accurate No significant difference Third and Fourth Justylll was more accurate Third and Fourth No significant difference Third Elements Diagnostic Unit and A L was not accurate than others Dentaport ZX, ProPex, Foramatron D10 were more accurate Third and Fourth No significant difference Fourth No significant difference Third and Fourth Third and Fourth (Continued ) Dental Hypotheses 87 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 2: (Continued) Authors Type of Publication Sample (n) Types of studied study year ELA Aim of study Main study result Type of generation Wrbas et al.[94] In vivo 2007 20 teeth Root ZX Raypex5 No significant difference Third Stavrianos et al.[24] In vivo 2007 80 root canals Dentaport ZX,RayPex 4 No significant difference Third and Fourth Venturi et al.[26] Ex vivo 2007 60 root canals Root ZX, Apex Finder Root ZX was more accurate Third Topuz et al.[19] In vitro 2007 47 teeth TCM Endo V Root ZX Comparing operation of different apex locator devices Comparing operation of different apex locator devices Comparing operation of different apex locator devices evaluating the accuracy of the apex-locating function of the TCM Endo V and to compare the results to these of the Root ZX Third and Fourth Ebrahim et al.[27] Ex vivo 2006 36 teeth Plotino et al.[30] Ex vivo 2006 40 teeth D’Assunco et al. [20] In vitro 2006 40 teeth Root ZX, Foramatron D10, Apex NRG and Apit 7 Root ZX, Elements Diagnostic Unit and A L, ProPex Novapex Root-ZX TCM Endo V proved to be as reliable as Root ZX but the use of the device to determine the working length was not easy as Root ZX Root ZX and Foramatron D10 were more ProPex was not accurate than others Hor et al.[29] Ex vivo 2005 193 teeth Justy II Raypex4 Haffner et al.[95] In vivo 2005 40 teeth ElAyouti et al.[14] Ex vivo 2005 182 root canals Root ZX Endy Justy II EndoxLysis Raypex 4, Apex pointer, Root ZX Venturi et al.[96] Invivo 2005 64 teeth Apex Finder, Root ZX Lucena-Martin et al.[11] In vitro 2004 20 teeth Hoer et al.[46] In vivo 2004 75 teeth Justy II, Root ZX, NeosonoUltima EZ Justy II, Endy 5000 Welk et al. [34] In vivo 2003 32 teeth Root ZX Endo Analyzer Model 8005 De Moor et al. [21] In vitro 1999 15 single canal teeth Apex Finder AFA Model 7005, Apex-Finder, Neosono Ultima EZ and Apit 2 88 Dental Hypotheses Comparing operation of different apex locator devices Comparing operation of different apex locator devices to compare the accuracy of the RootZX and Novapex electronic apex locators (EALs) in locating the apical foramen Comparing operation of different apex locator devices Comparing operation of different apex locator devices Third and Fourth Third and Fourth Root-ZX and Third and Novapex are Fourth useful and accurate devices for the apical foramen location Raypex4 was more accurate Third and Fourth No significant difference Third Comparing operation Root ZX was more of different apex accurate locator devices Comparing operation No significant of different apex difference locator devices Comparing operation No significant of different apex difference locator devices Comparing operation No significant of different apex difference locator devices Comparing Root ZX was more operation of accurate different apex locator devices The accuracy Apex Finder AFA and operator Model 7005 was the dependency of four most electronic accurate canal length measuring devices were compared under a set of specified conditions Third and Fourth Third Third Third Third Third (Continued ) Jul-Sep 2014 / Vol 5 | Issue 3 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 2: (Continued) Authors Weiger et al. [22] Type of Publication Sample (n) Types of studied study year ELA In vitro 1999 41 teeth Root ZX Apit Lauper et al.[97] Ex vivo 1996 130 root canals Apit and Odontometer Arora et al. [47] In vivo 1995 61 root canals ENDEX and RCM Mark II Pallares and Faus [98] Ex vivo 1994 116 root canals Odontometer and Endo Cater Nahmias et al. [23] 1987 60 single root teeth Sono-Explorer, C. L. Meter and Neosono-D In vitro Aim of study Main study result Two apex locators In the presence of were compared NaOCl, Root ZX regarding their ability to provides the most accurately locate the accurate apical constriction in EWL measurements the presence of various canal fluids at different meter readings. Evaluated the accuracy Apit was more of EAL in length Accurate measurement Comparison the ENDEX was higher accuracy of EALs accuracy than the in canal length RCM Mark II measurement in present of different contents(vital pulp, necrotic pulp, pus/ exudates, sodium hypochlorite, and water) Compared the Endo Cater was accuracy of EAL in higher accuracy than length measurement the Odontometer Compared the All EALs were accuracy of EAL in accurate length measurement Type of generation Third First and Third Third First and Second Second and Third same accuracy and significantly were more accurate than tactile method. In the study by Subramaniam et al.[62], there were no significant differences among conventional radiography, digital radiography, and tactile sense in primary teeth. Janner et al.[63] compared cone beam computed tomography to EAL in root canal length determination and concluded that both two methods were comparable [Table 3]. determining the canal length of 79 teeth (93 canals). They showed that these devices can specify the sites of the minor and major apical foramen, but they cannot determine apical constriction with sufficient accuracy. Also, Oishi et al.[77] investigated the accuracy of EALs in determining apical constriction, and they were accurate [Table 4]. Use of EAL in root perforations, fractures, and apical foramen widening Six articles were published on this topic.[78-81] Two of them evaluated the accuracy of EALs before and after canal filling and showed that, in most cases, EALs were accurate in root canal retreatment.[78,80] In the study by Aggarwal et al.[80], the accuracy of Root ZX and Protaper devices was evaluated in the retreatment of filled canals with: 1) gutta-percha+ zinc oxide ogenol sealer; 2) gutta-percha+ AH plus sealer; and 3) Resilon+ Epiphany sealer. Both devices showed high accuracy in the first and second treatments, and no significant differences were reported in the presence of different filling materials. Uzun et al.[79] studied the precision of two apex locators (tri auto ZX TCM, locating handpieces endo apex) in root canal retreatment with root-end-cured teeth evaluated. They demonstrated that both devices could be used for determining apical area, but for root canal retreatment, accuracy of 0.0 mm is required, which these devices could not accomplish [Table 4]. Ten studies reported other uses of EALs, such as identification of root perforation sites and the location of horizontal and vertical fractures. EALs were only accurate in horizontal fracture diagnosis[64,65] although Topez et al.[66] reported that EALs were accurate in both vertical and horizontal root fractures. Furthermore, Goldberg et al.[67] studied the consistency of EALs in teeth with simulated horizontal root fractures, and they showed that EALs were accurate and consistent. Several studies showed that EALs were able to detect perforation sites [Table 4].[68-71] There were five studies that evaluated EALs’ ability to control apical foramen widening with rotary files, and they both concluded that use of EALs in root canals that were prepared with rotary instruments was not sufficiently accurate to control apical extensions.[72-75] Hoer et al.[76] evaluated the ability of the Justy II and Endy 5000 devices in Jul-Sep 2014 / Vol 5 | Issue 3 Use of EAL in root canal retreatment Dental Hypotheses 89 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 3: Comparison of electronic apex locators (EALs) and different other techniques in working length determination Authors Orosco et al.[60] Type of study In vivo Publication Sample (n) year 2012 25 teeth Kishor[99] In vitro 2012 Chougule et al.[58] In vivo 2012 Zand et al.[100] In vivo/ Ex vivo In vivo 2011 Parekh and Taluja[101] Janner et al.[63] Ex vivo 2011 In vivo 2011 Neena et al.[54] In vivo 2011 Singh et al.[57] In vivo 2011 Real et al.[51] In vitro 2011 Patino-Marin et al.[45] Kqiku et al.[7] In vivo 2011 Ex vivo 2011 Vieyra et al.[38] In vivo/In vitro 2011 Mancini et al.[44] Ex vivo 2011 Cianconi et al.[37] Ex vivo 2010 Sharma and Arora[102] Vieyra et al.[46] In vivo/ Ex vivo In vivo 2010 Javidi et al.[40] In vitro 2009 Kim et al.[43] In vivo 2008 Krajczar et al.[39] In vitro 2008 Hassanien et al.[50] In vivo 2008 Jarad et al.[36] 2011 2010 Shanmugaraj et al.[6] In vivo/In vitro 2007 Smadi et al.[51] In vivo 2006 Subramaniam et al.[62] In vitro 2005 90 Dental Hypotheses Types of studied ELA Root ZX Aim of study Main study result Comparison of EAL and radiography Conventional and EAL in determination of working length were comparable and better than digital 35 teeth Foramatron D10 Comparison of EAL and radiography, EAL are more accurate radiovisography in determination of working length 13 primary teeth Dentaport ZX Comparison of EAL and radiography EAL are more accurate in determination of working length 75 teeth Root ZX Comparison of EAL and radiography No significant difference in determination of working length 46 teeth Raypex 5 Comparison of EAL and radiography No significant difference in determination of working length 20 patients Root ZX Comparison of EAL and radiography Radiography and EAL in determination of working length can be used together 3 patients Root ZX Compared CBCT method to EAL Two methods were comparable 30 teeth — Comparison of EAL and No significant difference radiography in determination of working length 20 teeth Propex II Comparison of EAL and radiography EALs are more accurate in determination of working length 37 root canals Root ZX Comparison of EAL and radiography EALs are more accurate Just II in determination of working length Elements Diagnostic 61 root canals of Root ZX and Comparison of EAL and radiography EALs are more accurate primary teeth ProPex in determination of working length 30 teeth Root ZX Comparison of EAL and radiography No significant difference in determination of working length 245 teeth (693 Root ZX, Comparison of EAL and other EALs are more accurate root canals) Elementsmethods in determination of working Diagnostic, length Precision AL and Raypex 5 120 teeth Endex, Propexll Comparison of EAL and other EALs are more accurate and Root ZX methods in determination of working length 101 teeth Endex Comparison of EAL and radiography EALs are more accurate ProPex II in determination of working length Root ZX 100 teeth Root ZX Comparison of EAL and radiography EALs are more accurate in determination of working length 160 teeth Root ZX and Comparison of EAL and radiography EALs are more accurate Elementsin determination of working length Diagnostic 30 teeth Root ZX Comparison of EAL and radiography Radiography and EAL in determination of working length can be used together 25 teeth Root ZX Evaluating EAL with or without No significant difference radiography in determination of working length 70 teeth ProPex Comparison of EAL and radiography EAL are more accurate in determination of working length 20 patients Root ZX Comparison of EAL and radiography EAL are more accurate in determination of working 30 teeth Foramatron-IV Comparison of EAL and other EAL are more accurate methods in determination of working length 151 root canals Tri Auto ZX Comparison of EAL and radiography Use of EAL could reduce in determination of working length need for additional radiography 20 teeth Formatron D10 Comparison of EAL and other No significant difference methods in determination of working length (Continued ) Jul-Sep 2014 / Vol 5 | Issue 3 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 3: (Continued) Authors Type of study Publication Sample (n) year Types of studied ELA Aim of study Main study result ElAyouti et al.[41] In vitro 2002 30 teeth Root ZX EAL are more accurate Brunton et al.[42] In vitro 2002 50 teeth - Martinez-Lozano et al.[35] In vitro 2001 70 teeth Apit EM-S3 Saad et al.[103] In vivo 2000 14 teeth Root ZX Ounsi et al.[61] In vitro 1998 37 teeth Endex Comparison of EAL and radiography in determination of working length Effect of apex locator on reduction X-ray exposure Comparison of EAL and radiography in determination of working length Effect of apex locator combining Root ZX and a digital imaging system (RadioVisioGraphy]on reduction X-ray exposure Comparison of EAL and radiography, tactile sense method in determination of working length Himel et al.[55] In vivo 1993 96 root canals Formatron IV Hembrough et al.[49] In vivo 1993 26 maxillary molar teeth Sono-Explorer Mark III Frank et al.[56] In vivo 1993 185 root canal Endex Trope et al.[59] In vivo 1985 Murakami et al.[104] In vivo 2002 127 root canals Sono-Explorer Mark III 66 infected Sono-Explorer canals Comparison of EAL and radiography in determination of working length To retrospectively assess the success of endodontic treatment that had been guided by audiometric (electronic) measurement. Stavrianos et al.[105] Ounsi et al.[106] In vivo 2007 85 teeth Raypex 5 In vitro 1999 39single root teeth Root ZX Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in length measurement Vajrabhaya et al.[107] Shabahang et al.[108] Wu et al.[109] In vivo 1997 In vivo 1996 20 Root ZX Single root teeth 26 root canals Root ZX In vivo 1992 Ricard et al.[110] In vivo Compared EAL with radiography method in length measurement 1991 20 single root teeth 37 teeth Sono-Explorer type Y-III RCM Mark II McDonald et al.[111] In vivo 1990 47 teeth Endocater Berman et al.[112] In vivo 1984 Busch et al.[113] In vitro 1976 24 mature Neosono-D and 5 immature root canals 77 teeth (46 vital Sono-Explorer and 26 necrotic) Use of EAL in patients with pacemakers Wilson et al.[82] investigated the operation of the Endo Analyzer Model 8005 in patients with pacemakers and cardioverter/defibrillator devices. They demonstrated that there was no interference between the apex locator and pacemaker function. Jul-Sep 2014 / Vol 5 | Issue 3 Comparing the accuracy of EALs and radiography method in length measurement Compared the accuracy of EAL and radiography method in length measurement Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in detecting apical constriction Evaluated the accuracy of EAL in length measurement Evaluated the accuracy of EAL in length measurement Use of EAL reduced patients X-ray exposure No significant difference This technique was useful Tactile sense method was inaccurate, but other two methods were same accurate EALs weren’t accurate EAL is useful only combined with radiography and couldn’t replace it EAL was comparable with radiography method EAL wasn’t accuracy same as radiography Use of the SonoExplorer aided successful treatment of infected root canals EAL was accurate Root ZX couldn’t detect apical constriction and should only use to detecting major foramen In clinical acceptable range its accurate In clinical acceptable range its accurate In clinical acceptable range its accurate In clinical acceptable range its accurate It was accurate EAL only in mature canal was accurate EAL was accurate in both groups Discussion Different generations of EALs, with improved functions and greater clinical applications, have entered the market over these past few decades. Our results indicate that there are no significant differences between different Dental Hypotheses 91 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 4: Other usage of electronic apex locators (EALs) Authors Aggarwal et al.[80] Type of study In vitro Publication Sample (n) year 2010 60 teeth Types of studied ELA Root ZX and ProPex Stavrianos et al.[114] In vitro 2008 40 teeth Alves et al.[78] Ex vivo 2005 62 teeth Dentaport ZX, RayPex 5, Endo Master and Bingo-1020 Tri Auto ZX Goldberg et al.[115] In vitro 2005 Uzun et al.[79] Ex vivo 2008 Uzun et al.[81] In vitro 2007 Fadel et al.[74] In vivo 2012 Jakobson et al.[73] In vivo 2008 Felippe et al.[72] Ex vivo 2008 Campbell et al.[75] In vitro 1998 Goldberg et al.[67] In vitro 2008 Topuz et al.[66] In vitro 2008 Ebrahim et al.[65] In vitro 2006 al Kadi et al.[116] In vitro 2006 Azabal et al.[64] In vitro 2004 Hoer et al.[76] In vitro/ In vivo 2004 Oishi et al.[77] In vitro 2002 Pratten and Mc Donald [117] In vitro 1996 Aim of study Main study result Application of apex locator devices in root canal retreatment Application of apex locator devices in root canal retreatment Both devices had high accuracy in retreatment All device were reliable, but Dentaport ZX and Endo Master were more accurate In most cases EAL was accurate in retreatment Application of apex locator devices in root canal retreatment 20 teeth ProPex, NovApex, Application of apex locator Third devices had high and Root ZX devices in root canal accuracy in retreatment retreatment 40 teeth TCM Endo V and Devices should be used Evaluation the accuracy of Tri Auto ZX with caution apex locator device along with rotary files in root canal length measurement in retreatment 40 root TCM Endo V and Evaluation the accuracy of These devices are resected teeth Tri Auto ZX apex locator device along with not appropriate for rotary files in root canal length retreating. measurement in retreatment 30 single root Root ZX II Use of apex locator in Not appropriate premolar controlled canal widening 24 teeth Root ZX II Evaluation of apex locator EAL with rotary ability control apical fromen instruments was not widening with rotary files accurate to controlling apical extension 67 single root Root ZX II Use of apex locator in Not appropriate teeth controlled canal widening 60 teeth Tri Auto ZX to examine the apical Instrumentation with extent of rotary canal the automatic apical instrumentation and the ability reverse feature set to maintain apical constriction at 1 consistently with the Tri Auto ZX at approximated the apical different automated settings constriction; however, the constriction was frequently enlarged 20 teeth ProPex Evaluation apex locatordevice All devices are reliable NovApex operation in diagnosis root Root ZX fractures Elements AL 40 teeth TCM Endo V Evaluation apex locator Both devices identified and Tri Auto ZX device operation in diagnosis different root fracture in root fractures an acceptable range 90 teeth Root ZX, Evaluation apex locatordevice Device works accurately Foramatron D10, operation in diagnosis root in teeth with horizontal Apex NRG fractures root fractures 100 teeeth Evaluation apex locatordevice Device works accurately Propex and operation in diagnosis root in teeth with horizontal Raypex-4 fractures and vertical root fractures Justy II Evaluation apex locatordevice Device works accurately 64 teeth operation in diagnosis root in teeth with horizontal fractures root fractures 93 root canals Justy II, Endy 5000 Evaluation apex locators Devices cannot ability in determination apical determine apical constriction constriction ROOT ZX Evaluation apex locators Device 771 teeth ability in detremination apical can determine apical constriction constriction — Apit Evaluation apex locators Device ability in detremination apical can determine apical constriction constriction (Continued ) 92 Dental Hypotheses Jul-Sep 2014 / Vol 5 | Issue 3 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator Table 4: (Continued) Authors Publication Sample (n) year 1991 99 canals Types of studied ELA Endocater Aim of study Main study result Keller et al.[118] Type of study In vivo Device was not accurate Zmener et al.[71] In vitro 1999 40 teeth Tri Auto ZX Evaluated the ability of EAL in detecting apical constriction and cemento dentinal junction Detection and measurement of endodontic root perforations using a newly designed apex-locating handpiece Kaufman et al.[70] In vitro 1997 Fuss et al.[68] In vitro 1996 Hulsmann et al.[69] In vivo 1989 30 teeth with perforation in middle third 32 teeth with perforation in midle third 21 teeth Root ZX , Sono Explorer Mark II Junior and Apit III Sono Explorer Mark 2 Junior and Apit 2 Exact-A-Pex The Tri Auto ZX detected and measured endodontic root perforations within a range of clinically acceptable variations Evaluated the ability of EALs Regardless of the in locatin perforation perforation size all EALs were accurate Evaluated the ability of EALs Both device were in locatin perforation accurate EALs of the same generation. The first generation apex locator was supplied by single frequency of direct current in order to measurement of electrical resistance. Pain and discomfort were often felt with using this type of apex locator.[83] The second generation apex locator known as impedance apex locators was measured opposition to the flow of alternating current or impedance.[84] The disadvantage of this generation is that electro-conductive materials in canal affect on its accuracy.[83] The third generation apex locator (frequency dependent apex locators) was supplied by two frequencies to measure the impedance in the canal. The disadvantage of this generation sensitivity to canal fluid and the machine needs a fully charged battery.[85] The fourth generation apex locator measures the impedance characteristics using more than two frequencies.[3] The disadvantage includes needing to perform in relatively dry or in partially dried canals.[84] The fifth generation apex locator was developed in 2003 which measure the capacitance and resistance of the circuit separately.[86] Many studies compared the ability of various generations of EALs in determining root canal length. Most of these studies showed that EALs were accurate for canal length measurement, within a clinically acceptable range of ± 0.5. Some studies indicated that the most recent generation of these devices had enhanced accuracy, better patient acceptance and greater ease of use for dentists.[31,87,88] but other studies mentioned that some EALs of the third generation were more accurate than those of the fourth generation.[20,27,28] Jul-Sep 2014 / Vol 5 | Issue 3 Evaluated the ability of EAL in Was accurate control apical bridge formation in the treatment of teeth with incomplete root formation Although most of the previous studies reported that EALs were more accurate, compared to radiography, some of the studies noted no significant differences between the two methods due to small sample sizes. However, a recent randomized, controlled clinical trial study showed no significant differences between these two methods.[2] To consider the advantages of conventional radiography, such as the ability to observe the root canal system and the canal curvature directly and to determine the existence of peri-apical lesions, the decision of which method to use should be different in each case. It should be noted that EALs could decrease the patient’s radiation exposure.[42,51] There is controversy in the diagnosis of the horizontal and vertical root fractures by EALs. Some studies have reported that EALs have the capacity to diagnose horizontal and lateral root fractures,[66,67] and others studies have indicated that horizontal fractures and perforation sites can be better diagnosed by EALs than vertical fractures.[64,65] Few studies have investigated the ability of apex locators to detect root fractures and perforations. Due to limited information on this subject, a general conclusion could not be achieved. More studies are required on this subject. The present review has some limitations. First, only relevant articles were searched in Medline/PubMed, Cochrane library, and Scopus, which might have restricted the results. Second, our keywords were limited to “Tooth apex,” “Dental instrument,” “Odontometry,” “Electronic medical,” and “Electronic apex locator” to focus on EALs. More prospective, randomized clinical Dental Hypotheses 93 [Downloaded free from http://www.dentalhypotheses.com on Sunday, May 24, 2015, IP: 213.147.158.15] Mosleh, et al.: Electronic apex locator trials are needed to determine various conditions that affect EALs’ accuracy. Conclusion The results of the present study showed that EAL is an appropriate technique for root canal length measurements. References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 94 Renner D, Grazziotin-Soares R, Gavini G, Barletta FB. 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