SUMMARY INFORMATION Applicant Information Country Afghanistan Component Funding Request Start Date April 1, 2015 Funding Request End Date Principal Recipient(s) Ministry of Public Health and United Nations Development Programme, UNDP TB December 31,2017 STANDARD CONCEPT NOTE Funding Request Summary Table A funding request summary table will be automatically generated in the online grant management platform based on the information presented in the programmatic gap table and modular templates. Investing for impact against HIV, tuberculosis, or malaria A concept note outlines the reasons for Global Fund investment. Each concept note should describe a strategy, supported by technical data that shows why this approach will be effective. Guided by a national health strategy and a national disease strategic plan, it prioritizes a country’s needs within a broader context. Further, it describes how implementation of the resulting grants can maximize the impact of the investment, by reaching the greatest number of people and by achieving the greatest possible effect on their health. A concept note is divided into the following sections: Section 1: A description of the country’s epidemiological situation, including health systems and barriers to access, as well as the national response Section 2: Information on the national funding landscape and sustainability Section 3: A funding request to the Global Fund, including a programmatic gap analysis, rationale and description, and modular template Section 4: Implementation arrangements and risk assessment IMPORTANT NOTE: Applicants should refer to the Standard Concept Note Instructions to complete this template. Standard Concept Note Template 10 March 2014│ 1 SECTION1: COUNTRY CONTEXT This section requests information on the country context, including the disease epidemiology, the health systems and community systems setting, and the human rights situation. This description is critical for justifying the choice of appropriate interventions. 1.1 Country Disease, Health ,and Community Systems Context With reference to the latest available epidemiological information, in addition to the portfolio analysis provided by the Global Fund, highlight: a. The current and evolving epidemiology of the disease(s)and any significant geographic variations in disease risk or prevalence. b. Key populations that may have disproportionately low access to prevention and treatment services (and for HIV and tuberculosis [TB], the availability of care and support services), and the contributing factors to this inequality. c. Key human rights barriers and gender inequalities that may impede access to health services. d. The health systems and community systems context in the country, including any constraints. 1. Current epidemiological features of tuberculosis According to Global Tuberculosis Report 2013 (World Health Organization [WHO], 2013) Annex 1, Afghanistan, with 27, 5 million inhabitants, ranked as one of 22 highly TB-burdened countries. The estimated incidence of TB cases in all forms is 189 in 100,000 population per year, and prevalence TB cases in all forms is 358 in 100,000 population per year. Put it simply, annually there will be approximately 56,000 new TB cases occurring in the country, and existing (prevalence) number of cases will be 110,000. Afghanistan had a steep rise in TB case notification in 2003–4 owing to integration of TB services into the general health system and rapid increase of access and implementation of the basic package of health services (BPHS). That continued through 2007, followed by steady decline in 2008 and 2009. There are several reasons for this decline, including technical and financial reasons such as interruption of Global Fund (GFATM) support after Round 4(R4) up to Round 8 (R8). However, thereafter, from 2010 to present, the National Tuberculosis Program (NTP) Afghanistan, with strong support by partners, sustained a steady increase in case notification. As a result, NTP Afghanistan has progressed substantially beyond past decades, and the number of notified cases in 2013 (31,662 TB cases in all forms) increased three fold over 2001 (9,668). There has been 6% increase in case notification yearly since 2011.In 2013, NTP notified 31,622 cases of all forms of TB (case notification rate of 115 in 100,000 population);among these, 30,507 (29,353 new and 1,154 relapse) were new TB cases. By using the number of total population by the central statistical office (27.5 million), the case detection rate still remained low (54%) and it is estimated that about 24,378 new TB cases remained undiagnosed. This low case notification rate is the same for multi-drug resistance tuberculosis (MDR-TB). According to WHO estimates, there are 1,150MDR-TB cases occurring in a year in Afghanistan that is, 750 cases among instances of new and notified pulmonary TB cases, and 400 instances among retreatment cases(Global Tuberculosis Report 2013).The 2010 sub national drug resistance survey, Standard Concept Note Template 10 March 2014│ 2 conducted in six provinces of Afghanistan, reports a higher incidence of MDR-TB in Afghanistan than WHO estimates; the survey discovered the incidence of MDR-TB at 6.8% among combined new and retreatment pulmonary sputum-smear positive cases (National TB Control Program, “Results of Drug Resistance Survey in Six Provinces of Central Region in Afghanistan” [Ministry of Public Health, 2010]) Annex 2 Although NTP has been maintaining good treatment success rate, there might have been a huge number of cases that were not properly treated in private sectors, resulting in the development of a certain number of MDR-TB cases. At this moment, NTP has notified 140 MDR-TB cases since 2011, indicating a case notification rate of MDR-TB at only 5%. For the geographic variations, the highest numbers of TB cases are accumulated in cities and provinces with large populations (“Epidemiological Review of Tuberculosis in Afghanistan and NTP Surveillance Data” ) Annex 3 .The number of TB cases from five major provinces with large population (Kabul, Herat, Nangarhar, Balkh, and Kandahar) was 12,502 in 2013, which is almost 40% of all TB cases notified in the whole country. The mean case notification rate for these provinces is 133 in 100,000 population. The mean rate for Kabul is 84; Nangarhar, 171; Balkh, 133; Herat, 139; and Kandahar, 139 in 100,000 population. Case notification rate for all forms of TB and treatment outcomesfor34 provinces in 2013 are listed in table 1 and depicted in maps 1 and 2. Table 1: Annual Case Notification and Treatment Success Rates for All Forms of Tuberculosis, per 100,000 Population, 2013 No. Province Case Notification Rate Treatment Success Rate 1 Kabul 87 74 2 Kapisa 63 95 3 Parwan 73 93 4 Panjsher 28 65 5 Wardak 39 88 6 Logar 90 93 7 Bamyan 101 93 8 Daikundi 107 95 9 Zabul 222 97 10 Ghazni 109 91 11 Paktia 144 95 12 Paktika 148 95 13 Khost 181 86 14 Nangarhar 205 89 15 Laghman 101 91 16 Kunar 175 91 17 Noristan 158 100 18 Urozgan 110 94 19 Badakhshan 113 93 20 Balkh 135 95 21 Jaozjan 168 96 22 Faryab 85 98 23 Samangan 90 95 24 Sar-E-Pul 71 95 25 Takhar 141 95 26 Baghlan 160 92 Standard Concept Note Template 10 March 2014│ 3 27 Kunduz 130 95 28 Badghis 167 96 29 heart 142 90 30 Farah 95 96 31 Ghor 126 94 32 Nimroz 141 85 33 Helmand 102 90 34 Kandahar 141 84 Note: Fifteen provinces reached the TB case notification target (70% or more); the remaining 19 provinces have not reached the target yet. NTP Surveillance data 2013 There are regional variations in case notification rate: Six out of eight provinces in the central region (nos. 1–8), three out of five in the north region (nos. 20–24), and Farah (no. 30) tended to show lower notification than the national average. For Kabul, there has been significant progress in case notification since the introduction of urban DOTS to incorporate non-NTP public health facilities and private health facilities. NTP Afghanistan has made in-depth analysis in case notification and found several possible reasons, including low suspect management, low capacity of sputum-smear diagnosis, and low out-patient department (OPD) cases. Also, NTP points out that in some provinces prevalence or incidence of TB might be significantly lower than that of national value (“TB Data Annual Analysis” [2010]) Annex 4. Thus, the reason of low case notification in other provinces in 2013 might vary; further analysis is required. There have been variations in TB case distribution by age and gender. For both genders, there exists high incidence among people aged 15–44years old, with the highest incidence among the most productive age group of 25–34 years old. Contrary to the rest of the world, Afghanistan reported a higher proportion of TB cases among women than men. For example, chronological data from NTP surveillance system (2007–13) shows that around 60% of TB cases notified were among women, especially in reproductive ages. This proportion is disseminated across the country and in all regions unanimously (Epidemiological Assessment Report, pp. 22–23). However, there are some provinces, such as Kabul, Urzgan, Kandahar, Nangarhar, and Panjshir, where the gender dissemination of TB cases was equally distributed in 2013. The gender distribution of notified MDR-TB cases is the same as that of all forms of TB, and female cases represent 63%of total cases. However, the age distribution of MDR-TB cases is different from that of all forms of TB, and cases among people less than 30 years old represent 58% of total cases. Standard Concept Note Template 10 March 2014│ 4 Map 1: Case Notification of New Episodes of Tuberculosis (New Cases and Relapse), by Province, 2012 (Central Statistics Office Data) Map 2: Population Distribution by Provinces, 2012 (Central Statistics Office Data) The multiyear data analysis (2006–13) discovered that there is seasonal variation in TB case notification in Afghanistan. Consistently, there has been a steep increase in TB case notification during the second quarter and a sharp decline during the fourth quarter of each year. On average,30% of all TB cases notified occur during the second quarter, and 20% during the fourth quarter of each year (“Epidemiological Review of Tuberculosis in Afghanistan,” p. 21). The main barrier in the Standard Concept Note Template 10 March 2014│ 5 fourth quarter is the winter season, which limits access to health services in remote and hard-to-reach areas owing to heavy snowfall, avalanches, and very cold temperatures. Thus, special intervention to cope with this issue is necessary, and NTP has introduced the slide/sputum sending system (details of which are described subsequently). NTP Afghanistan has sustained higher rates of successful treatment outcome since 2006—largely because, on average, more than 95% of notified cases have received treatment. For example, the treatment success rate for sputum-smear positive TB patients has been maintained at levels of more than 85% since 2006; it reached 90% in 2010 and has remained at this level since. The gender distribution of treatment success rate was assessed in 2012, and it shows rates of 91% and 87% for women and men, respectively (“Community Contribution in Tuberculosis Control in Afghanistan,” International Journal of Tuberculosis and Lung Disease 16.12 [Dec. 2012]: S32) Annex 5. For all forms of TB, the treatment success rate steadily improved from 82% in 2010 to 88% in 2012 (“Epidemiological Review of Tuberculosis in Afghanistan,” p. 37). The NTP surveillance data analysis for 2013 shows that the mean treatment success rate for all 34 province is 92%(95% CI=2.3%; standard deviation=6.7%), 27 provinces reached treatment success rates of more than 90%, and five provinces reached 84–89% (table 1). There are two outliers, Kabul and Panjshir, which had treatment success rates of 74% and 65%, respectively. Kabul is the capital of the country, and thus is home for most TB cases since it is the final referral for all forms of health issues, including TB. It has the highest transfer-out rate of 19%, which is five times higher than the national value of 4%. Also, the defaulter rate in Kabul is 4%, compared to 2% at the national level. It is assumed that residents of other provinces are diagnosed in Kabul and after a while travel back to their home cities in other provinces, which leads to higher transfer-out and default rates. Furthermore, there is a seasonal relocation of population from different provinces to Kabul—they travel to Kabul during spring and summer to seek job opportunities, and leave it in winter. Therefore, TB cases notified among this population resulted in higher transfer-out and default rates. To explain the lower treatment success rate for Panjshir, further analysis is required. Thus, NTP need to strengthen the referral system to reduce the transfer-out rate and to record treatment outcome of patients referred to other provinces. 2. Under-covered key populations The assessment of key affected populations supported by the Stop TB partnership (for details, see “Engaging Key Affected Population” and “People Living with Diseases”[in the Concept Note development) indicated the following groups of population as key affected populations: poor families (labor workers in urban settings and farmers in rural areas);internally displaced persons (IDPs);people living in distant areas, including nomads; females; children; and prisoners. As pointed out by the assessment, those populations have certain hindering factors to receive TB control services, such as no adequate knowledge of TB or a lack of transportation cost due to poverty; most of these populations are considered, at the same time, as under-covered populations by TB control services. The important issues regarding epidemiological figures are described here. For gender issues, detailed descriptions are in the section 3.1. Note: For the assessment, consultative workshops were held in Kabul, Herat, and Kandahar provinces, inviting ex-TB patients, TB patients among prisoners, IDPs, etc. People living in hard-to-reach areas: Although the Ministry of Public Health (MoPH) has made significant progress to expand BPHS for providing primary health care, still there are difficulties to access to health facilities especially in rural areas. For example, the proportion of population who cannot access to health facility within two hours by any means of transport varies from 17.3% in rural areas and 0.6% in urban areas (13.1% as Standard Concept Note Template 10 March 2014│ 6 the national average) (Central Statistics Organization, National Risk and Vulnerability Assessment2011–12, Afghanistan Living Condition Survey [Kabul: CSO, 2014]) Annex 6 and it is roughly estimated that about 36% people cannot access to health facility within one hour by any means of transport. IDPs, returnees, and prisoners: There are around 700,000 conflict-induced IDPs and 70,000 natural-disaster induced IDPs in whole country (United Nations High Commissioner for Refugees [UNCHR] Global Report 2012. http://www.unhcr.org/gr12/index.xml) Annex 7 .There are also more than 3 million returnees and deportees mainly from Pakistan and Iran (GulbadanHabibi and Pamela Hunte, Afghan Returnees from NWFP, Pakistan, to Nangarhar Province [Afghanistan Research and Evaluation Unit,2006], p. 3). These groups of population are most vulnerable to TB, living in poor conditions, without a nutritionally sufficient environment; indeed, they are at risk of developing infectious diseases in general, including TB. The incidence of sputum-smear positive TB cases among this population is three times that of general population (F. Delawer et al., “Identifying the Magnitude of Pulmonary TB among Internally Displaced Populations in Afghanistan,” International Journal of Tuberculosis and Lung Disease15.11 (Nov. 2011]: S255) Annex 8. However, these groups have not been continuously covered by TB-control services, as outreach programs are necessary to cover them. Only portions of these groups have been covered occasionally by support of the Rural Expansion of Afghanistan’s Community-based Healthcare (REACH) program and the Japan International Cooperation Agency (JICA). Still there are 2 million refugees outside the country, mainly Pakistan and Iran, and annually there are 20~30,000 returnees from Pakistan and 200,000 returnees and deportees from Iran. The previous screening at the border revealed nearly two times higher incidence of TB compared to that of the general population. Up to now, the screenings have been supported by JICA, but this intervention covered only part of the total number of returnees. There are about 30,000 prisoners in the country, and previous screenings revealed extremely high incidence of TB (1%). Although there are medical clinics in prisons, this extremely high incidence of TB requires special approaches, such as active screening; however, only small programs, supported by REACH and JICA, were occasionally conducted. Children: According to the central statistics office, children aged five years and younger make up 20% (5.5 million) of the total population in Afghanistan. Considering the higher rate of infection, malnutrition, and low coverage of immunization (39%) (Afghan Public Health Institute, MoPH, Afghanistan Mortality Survey 2010[Kabul, 2011]) Annex 9 , this population group is considered to be vulnerable to TB. During 2013, at least 1,283 cases of pulmonary TB among children aged five years and younger (NTP, Surveillance Data 2013) were diagnosed, and there are 4,475 cases among children aged 15 years and younger. These numbers dramatically increased after NTP started training on the standard operating procedures for pediatric TB control and utilizing tuberculin skin testing as the diagnostic tool. However, according to the health management information system (HMIS), annually there are almost 40 million outpatient attendees to health facilities, and children comprise 25% of all outpatient cases. The previous survey pointed out that a significant proportion of child TB suspects were missed for diagnosis within health facilities (F.M. Delawer et al., “Management of Pediatric Tuberculosis in Provincial and District Hospitals in Afghanistan,”Eastern Mediterranean Health Journal 19 (2014): 698–703) Annex 10. Those cases could access to health facilities, but could not access functionally to pediatric TB control. Thus, a proper screening system and appropriate diagnostic facility could lead to increased case notification among children. Standard Concept Note Template 10 March 2014│ 7 3. Key human rights barriers The concept of human rights is not pervasive in Afghanistan. This is not only in the field of TB control, but also in the entire social sector. In the field of TB control, in addition to lacking a concept of human rights, there remains a rampant stigma against TB that often hampers early consultation by TB suspect in health facilities. Sometimes, health facility staff—including doctors and nurses—are influenced by this stigma or lack a proper knowledge of the disease. In a further barrier, females are generally not decision-makers in their families, especially in remote and rural areas (although there are regional differences due to racial and cultural factors). Moreover, most of rural people prefer female health facility staff to see their female family members, but there are significant shortages of female doctors and nurses, especially in rural areas. These issues have been pointed out in several surveys, and often hamper visits to health facilities for females, resulting in failure to diagnose in the early stages of TB. Moreover, according to various researches, health care staff has been identified as a group at higher risk for contracting TB; NTP Afghanistan is working to ensure a safer working environment for health care staff, clients, and community through the implementation of TB infection control measures at various levels of the health care system. 4. Health system context The Ministry of Public Health is one of the leading ministries in the government of the Islamic Republic of Afghanistan. This ministry defined its health priorities in the national health strategic plan for 2011–15: mother and child health and communicable disease. To address these challenges, MoPH developed primary health care packages called the “basic package of health services” (BPHS) and the “essential package of health services” (EPHS). The BPHS defines the level of service delivery from community level to provincial level as follows: Health post: This level of service delivery is located deep in the community: two volunteer community health workers (CHWs), a male and a female, receive monthly kits of essential medication and other supplies, and provide basic services such as education and information on priority health problems, identifying and referring patients to health centers. As such, health posts play a role of catalyst between communities and health centers. They also refer presumptive TB cases for diagnosis to health facilities and provide DOT to TB patients in their villages. The CHWs proved to be effective and efficient in TB case identification, early diagnosis, and treatment (BPHS 2010).The health post is located in an area of approximately two hours walking distance from the upper level of health facilities and covers a population of 100–150 households, or 1,000–1,500 inhabitants. Health-post performance is monitored and supervised by community health supervision (health care staff). Currently, there are14, 130 health posts (annual health information system [HIS] publication 1392) Annex 11 and 23,000 CHWs working around the country. Sub–health center (SHC): There are 526 SHCs in Afghanistan. Sub–health centers constitute the second level of health service delivery located in the community. Sub–health centers are placed in very hard to reach and remote areas, aiming at increasing access to primary health services; they each cover a total population of 5,000–8,000. In each SHC, one nurse, one vaccinator, and one community midwife are posted. Sub–health centers provide information, education, and communication; vaccination services (fixed and outreach); outpatient attendees of primary health care; integrated management of childhood illness; family planning; and reproductive health services. In 2013, approximately 6 million clients and 44,000 presumptive TB cases attended to SHCs all over the country. Basic health center (BHC): There are823 BHCs active in Afghanistan. Basic health centers Standard Concept Note Template 10 March 2014│ 8 constitute the third level of contact between health services and patients. Each BHC covers a population of 15,000–30,000 and is staffed with one nurse, two vaccinators, one community health supervisor, and one midwife. Basic health centers do not provide laboratory services, and they act as treatment and referral centers for TB. (Some BHC+ centers do provide TB laboratory and diagnostic services.) Comprehensive health center (CHC): There are 384 CHCs in Afghanistan. This fourth level provides primary health care and also laboratory diagnostic services, including TB. Each CHC covers a population of 30,000–60,000 and is staffed with two doctors, two nurses, two midwives, two vaccinators, and two support staff. District hospitals (DH): There are 732 DHs active in Afghanistan. At this level of basic health service delivery, each DH covers a population of 60,000–100,000 and provides both primary health care and laboratory diagnostic services, including TB. Each DH is also are equipped with X-ray machines and has approximately 20 beds to accommodate patients. Additionally, a total of 159 provincial hospitals, regional hospitals, and national and specialist hospitals, along with some mobile clinics, are located at provincial and national centers. In addition, a strong private sector exists at all 34 provinces of Afghanistan. They include general physicians, private laboratories, drug stores, and private clinics and hospitals. Unfortunately, most of them are outside of the public sector and, without a strong recording and reporting system, do not report to national TB program. See table 2 for the overall performance of all health facilities in attending presumptive TB cases in 2013. At all levels of health services, approximately, 47 million individuals and 408,000 presumptive TB cases were attended. These data indicate the consultation per capita of 1.5, strengthening the case that the health system assists NTP in notifying a large number of TB cases. Table 2: Comparison of Clients and Presumptive TB Cases by Facility Type,2013 Health Facility Type Number of Clients (2013) Presumptive TB Cases Attended Health Facilities (2013) 5,599,169 44,091 Basic health centers (BHC) 15,262,819 142,535 Comprehensive health centers (CHC) 14,660,845 122,368 District hospitals (DH) 5,900,167 48,404 Provincial hospital 3,219,214 34,325 Regional and specialist hospital 2,540,948 16,627 47,183,162 408,350 Sub-health centers (SHC) Total Source: Health Information System Unit ,MoPH 2013 5. Constraints related to the health system: Current constraints related to the health system, except security problems, are summarized below; most of those are common to all three programs. 1. Existence of a hard-to-reach geographical area for service delivery. 2. Lack of infrastructure and health equipment. (Back-up generators, X-ray machines, and microscopes are often not properly equipped, used according to instructions, or properly maintained.) Standard Concept Note Template 10 March 2014│ 9 3. Limitation in diagnostic services at health post, HSC, HMT, and BHC levels. 4. Lack of coordination between private and public sectors due to unregulated private sector 5. Limited mobility of women (due to the cultural issue of household decision-making and insufficient female staff in primary healthcare facilities). 6. High turnover of staff in health facilities, including CHWs, especially in remote or insecure areas. 7. Insufficient referral services and weak coordination among different levels and facilities of the health system. Among these constraints, for 5 it is difficult to cope with in this Concept Note, but for others measures to mitigate these constrains are taken into this concept note (Detail are described in the section 3.1) 6. Accuracy of data NTP assessed the data accuracy and quality in Jan-Feb 2013 in 16 provinces and in 65 health facilities. The team from central M&E unit of NTP developed the questionnaire to conduct interview with health facility staff and collect data from TB registers and compared it with the reports that already sent to NTP surveillance data. The findings revealed that the data accuracy for two key TB indicators of cases notification for sputum smear positive and all forms of TB turned to be 97.7% and 97.4% accurate. Furthermore, other data quality dimensions such as validity, integrity, timelines, reliability and precisions were assessed. The findings demonstrate validity of 65%, reliability of 76%, system integrity of 89%, precision of 89% and timeliness of 78% (data accuracy assessment report) Annex 12. The above-mentioned statement of the accuracy of data was acknowledged by the epidemiological review of Tuberculosis in Afghanistan (page 16, epidemiological review of Tuberculosis data). 1.2 National Disease Strategic Plans With clear references to the current national disease strategic plan(s)and supporting documentation (include the name of the document and specific page reference), briefly summarize: a. The key goals, objectives and priority program areas. b. Implementation to date, including the main outcomes and impact achieved. c. Limitations to implementation and any lessons learned that will inform future implementation. In particular, highlight how the inequalities and key constraints described in question1.1are being addressed. d. The main areas of linkage to the national health strategy, including how implementation of this strategy impacts relevant disease outcomes. e. For standard HIV or TB funding requests1, describe existing TB/HIV collaborative activities, including linkages between the respective national TB and HIV programs in areas such as: diagnostics, service delivery, information systems and monitoring and evaluation, capacity building, policy development and coordination processes. f. Country processes for reviewing and revising the national disease strategic plan(s) and results of these assessments. Explain the process and timeline for the development of a new plan(if current one is valid for 18 months or less from funding request start date), including how key populations will be meaningfully 1 Countries with high co-infection rates of HIV and TB must submit a TB and HIV Concept Note. Countries with high burden of TB/HIV are considered to have a high estimated TB/HIV incidence (in numbers) as well as high HIV positivity rate among people infected with TB. Standard Concept Note Template 10 March 2014│ 10 engaged. Standard Concept Note Template 10 March 2014│ 11 1. Key goals, objectives, and priority program areas The program goal, objectives, and key strategic areas of the national strategic plan for 2014–18, according to NTP, are summarized below: Goal: To reduce TB mortality by 50% at the end of 2018 compared to 2013 Objectives: To increase the case notification of all TB cases at least 6% by year and to at least maintain treatment success rate 90% by 2018 To detect and treat at least 50% of estimated MDR-TB cases by 2018 Key strategic areas and directions: The following key areas were considered to develop the strategic directions: 1. Improving accessibility to TB care and control services 2. Enhancing contact management and suspect management 3. Enhancing screening for high-risk groups 4. Introducing concepts of human rights 5. Obtaining reliable data for the prevalence, incidence, and mortality of TB (For details, see “General Situation Analysis of Tuberculosis Control Program, ”National Strategic Plan, 2014–18, pp. 11)All strategic directions have been defined based on the general situation analysis, including epidemiological analysis. Strategic interventions and relevant activities were defined by detailed situation analysis on each area of the TB-control program. (For details, see situation analysis under each strategic direction of “NTP Vision, Goal, Objectives, Strategic Directions, Strategic Interventions and Activities, “National Strategic Plan, 2014–18, pp. 14–28.) NTP, National Strategic Plan 2014-2018 Annex 13 The national strategic plan for 2014–18 identifies nine strategic directions to respond the diseases in country, which include: Strategic direction1: Enhancing political commitment and DOTS expansion 1. Sustain political commitment for TB control at all levels. 2. Strengthen collaboration mechanisms with different departments of MoPH. Strategic direction 2: Strengthen human resource development 1. Render NTP leaders more capable and enable them for day-to-day human resource management and development to address all TB-related human resources needs for implementation of the strategic plan at all levels in the health system. 2. Update curricula for all pre-service training in medical faculties and HSIs, according to the revised NTP national guidelines, and train lecturers for implementation. 3. Provide needs-based quality in-service training and continuing education for all staff (technical and nontechnical) involved in TB-control activities at all levels. Strategic direction 3: Strengthening surveillance, monitoring, and evaluation Standard Concept Note Template 10 March 2014│ 12 1.Strengthen the surveillance system by introducing a new electronic surveillance system, termed the TB information system (TBIS). 2.Ensure regular supervision and monitoring at all levels. 3.Enhance internal or self-evaluation mechanism through quarterly review meetings and annual evaluation workshops. Strategic direction 4: Drug supply and management system Ensure effective, uninterrupted drug supply and management system at all levels. Strategic direction 5: Strengthening laboratory network 1.Improve accessibility for TB diagnosis. 2.Maintain laboratory network and improve quality control for sputum-smear examinations. 3. Improve access to laboratory diagnosis by culture and drug susceptibility testing (DST) for MDR-TB diagnosis and establish the capacity of rapid diagnosis for MDR-TB management. 4. Introduce an innovative approach to enhance quality of TB diagnosis. 5.Ensure bio safety and TB infection control for TB diagnostic laboratory services. Strategic direction 6: Address TB/HIV, MDR-TB, child TB, and the needs of poor and vulnerable populations (IDPs, prisoners, refugees, etc.) and strengthening TB diagnosis and treatment among the household contacts of patients with all forms of TB. 1. Strengthen collaboration mechanisms among NTP, the National AIDS Control Program (NACP), and partners. 2. Scale up of HIV testing among TB patients. 3. Scale up TB screening and providing prophylaxis for people living with HIV. 4. Enhance pediatric TB-control program in all provinces. 5. Scale up case detection and access to effective treatment for MDR-TBat the national and provincial levels. 6. Strengthen coordination and collaboration among the MDR-TB team, public hospital, and the Ministry of Public Health. 7. Scale up TB-infection control in MDR-TB hospital wards and outpatient clinics. 8. Enhance TB detection in selected high-risk groups (nomads, IDPs/returnees, prisoners, and refugees). 9. Develop cross-border mechanisms on TB control for returnees. 10.Strengthen TB diagnosis and treatment among household contacts for patients with all forms of TB. 11.Increase early detection of female TB patients during pregnancy and postpartum. 12.Expand contact management of TB among women. 13.Increase community awareness and advocacy to reduce reproductive health factors as risks for TB. 14.Provide preventative treatment for high-risk females regarding reproductive factors. Strategic direction 7: Engage all care providers 1. Continue private public mix (PPM)-DOTS expansion to public and private healthcare facilities nationwide. 2. Develop a monitoring and evaluation mechanism for PPM. 3. Involve private health care providers in raising TB awareness. Strategic direction 8: Empower people with TB and communities through partnership 1. Expand partnership for advocacy communication and social monitoring. 2. Introduce the concept of the patient charter into healthcare services. 3. Pursue advocacy, communication, and social mobilization at all levels. Standard Concept Note Template 10 March 2014│ 13 4. Strengthen community participation in TB care, prevention, and health promotion. Strategic direction 9: Enable and promote research 1. Strengthen the capacity of research teams to conduct operational research at national and provincial levels. 2. Assess research needs and conduct operational research to enhance case finding and to improve service delivery and health services. The previous national strategic plan for TB control for the years 2009–13 was designed to guide the national TB-control efforts at the country level; it was developed in line with components of Stop TB strategy in order to achieve the United Nations’ Millennium Development Goals targets for TB. The key strategies are summarized as follows: Strategy 1:Pursue quality DOTS expansion and enhancement Strategy 2:Adapt DOTS to respond to TB/HIV, MDR-TB, and other challenges Strategy 3:Contribute to health-system strengthening Strategy 4:Engage all health care providers Strategy 5:Empower patients and communities Strategy 6:Enable and promote operational research 2. Implementation to date, including the main outcomes and impact achieved As a result of NTP strategies, at the end of 2013, there are 1,197 public and private DOTS centers that can provide TB services and care according to international standards for TB care.The estimated population that has access to DOTS facilities in Afghanistan has steadily increased to 96% by the end of 2013. However, this is a generous estimate of population coverage; it assumes the whole population of a district is physically covered, even if only one health facility in a district provides DOTS, regardless of the actual number of people that have access to that facility. As described in the previous section, 13.1% of the population on average cannot access health facilities within two hours by any means of transport. The case notification rate has significantly increased during the period 1997–2013 from 7 to 115 per 100,000 population per year for all TB cases respectively. The treatment success rate is also increased from 84% (2001) to 90% (2012) cohort. However, still around 50% of all TB cases and an estimated 95% of MDR-TB cases remain undetected. TB service is not universally accessible, particularly in remote, hard-to-reach areas and for vulnerable population such IDPs, nomads, prisoners, etc.; the community is not fully involved in TB care; and the subcomponents of Stop TB strategies have not been fully implemented. These results of the national strategic plan implementation have been externally evaluated periodically by the Eastern Mediterranean Regional Office of the WHO. The latest evaluation was conducted in 2012, Annex A which confirmed most of the achievements described here. 3. Limitations to implementation and lessons learned There have been a number of obstacles and limitations for the implementation of the strategic plan, but the major technical weakness lies in focusing on passive case findings in the previous national strategic plan. In the previous plan, expansion of high-quality DOTS was the main focus, and passive case findings in health facilities were the main interventions of DOTS strategy. This resulted in a significant proportion of under-covered population, as noted in section 1.1, due to inaccessibility to TB-control services. NTP Afghanistan has realized the significance of this weakness and the necessity to change strategies to cope with these under-covered populations. Thus, NTP has started to evaluate effectiveness of active case findings in various settings through Standard Concept Note Template 10 March 2014│ 14 several small pilots, such as screening for IDPs and prisoners. With some favourable results of these pilots, NTP has included various interventions for active case findings in the current strategic plan, which covers 2014–18, mainly to cope with inequalities and geographical constraints found in the epidemiological and general situation analysis, as described in the section 1.1. The second issue was the weak capacity of NTP for program management. With weak capacity for financial management, MoPH/NTP relies on donors for the operational budget to implement most important interventions of the program; the GFATM is the main source of support. MoPH/NTP asks other partners to work as principal recipients. To implement the strategic plan smoothly and effectively in these difficult settings, NTP has needed a strong capacity for program management. As a result, NTP has not been able to take initiatives in the implementation of the strategic plan due to weak capacity for program management. Weak financial management by the principal recipients also hampered smooth disbursement of the budget to implement necessary interventions. In 2011, most of the activities supported by the GFATM, including key activities for the program management, were canceled due to weak capacity for financial management. In addition to these obstacles and limitations in general areas to the implementation of the national strategic plan, there are certain obstacles and limitations in each program areas such as high turnover of staff in health facilities, weak quality-control mechanisms for several interventions, and weak collaborating mechanisms with stakeholders at peripheral levels. These are addressed with their effect on the implementation of the national strategic plan in the section for situation analysis and interventions to cope with obstacles are developed in the current plan for 2014–18.(For details, see situation analysis under each strategic direction of “NTP Vision, Goal, Objectives, Strategic Directions,” pp. 14–28.) In addition to the significance of active case findings, there are several other lessons learned from the implementation of the previous strategy. 3.1 Enhancing collaboration with other departments of MoPH Integrating TB services in the health system, as defined by both BPHS and EPHS, was a valuable public health practices in Afghanistan.There has been progress in improving collaboration mechanisms between departments within MoPH; during these process, NTP has learned the importance of collaboration to change the approach from narrow-vertical to wide-multisectorial, especially with departments such as Health Finance and Economy, HMIS, M&E, and Grant and Contract Management—this is true not only for technical issues, but also for effective usage of the limited budget. Thus, NTP will act to enhance these collaboration mechanisms in the current national strategic plan. 3.2 Reducing stigma The NTP has introduced the Afghan TB Patient Association, aiming at promoting TB-control programs at community levels along with a pervading concept of human rights. As the results of pilot activities, this intervention provided encouraging results in case notification and support to ensure treatment (details are described in the section 3.2).One of the important factors of these interventions is that they have helped to reduce rampant stigma in communities, which often hampered interventions of the national strategic plan at community levels. Thus, NTP has come to focus on reducing stigma and enhancing human rights to improve TB-control program, and several interventions are included in the current plan for2014–2018. 4. Linkage to the national health strategy Standard Concept Note Template 10 March 2014│ 15 The MoPH strategic plan for2011–15 Annex F has been developed through a highly participatory process . In addition to the active participation of a multi-stakeholder working group, a number of consultations were carried out by the “new” planning team in the Strategic Planning Department. Input was also invited and consensus built at a national workshop held in Kabul in December 2010, from which the following ten strategic directions emerged: These strategies of the TB-control program are linked to the national health strategy’s strategic direction 3, strategic objective-3 (SO-3), and priority intervention 2. Strategic directions: 1. Improve the nutritional status of the Afghan population 2. Strengthen human resource management and development 3. Increase equitable access to quality health services 4. Strengthen the stewardship role of MoPH and governance in the health sector 5. Improve health financing 6. Enhance evidence-based decision-making by establishing a culture that uses data for improvement 7. Support regulation and standardization of the private sector to provide quality health services 8. Support health promotion and community empowerment 9. Advocate for and promote healthy environments 10. Create an enabling environment for the production and availability of quality pharmaceuticals. Strategic objective-3 (SO-3): To increase the coverage of services to prevent and treat communicable diseases and malnutrition Priority interventions: 1. Expand and sustain the expanded program for immunization (EPI) coverage, with special emphasis on hard-to-reach areas 2. Expand appropriate and effective interventions to combat TB, malaria, and HIV/AIDS 3. Support implementation of the Public Health Nutrition Strategy and Policy, 2009–13 4. Initiate and strengthen interventions for reducing demand-side barriers (e.g., health education and community involvement) 5. Impact of health system strengthening (HSS) in the national health strategy on the TBcontrol program The TB-control program is an important part of health-service delivery in Afghanistan, and it integrated into the general health system, especially at the point-of-service delivery. The HSS in the national health strategy has contributed substantially in various ways. As the TB-control program is part of BPHS and EPHS, the HSS strategies to enhance the entire profile of BPHS and EPHS Standard Concept Note Template 10 March 2014│ 16 subsequently enhanced the TB-control program. These include developing health facilities in rural areas and ensuring human resources such as community nurses, especially in distant areas. Also, investment in laboratory infrastructure (expansion of laboratories in some BHCs, provision of laboratory materials and equipment for regional reference labs) in the country level enhanced diagnostic capacity of the TB-control program. Furthermore the HSS strategy has enhanced health information system by increasing the routine use of health data, as well as integrating programs’ information systems (TB, malaria, and HIV) into the national HMIS. 6.TB/HIV collaborative mechanism Although prevalence of HIV (0.01% in adult population, Afghanistan Health Fact Sheet 2014) Annex 14 is low in Afghanistan, the HIV prevalence among TB patients is 0.2%; around 1,250 HIV-positive cases have been diagnosed in the country to date. NTP Afghanistan in collaboration with NACP has started interventions to cope with TB/HIV co-infection. NTP and NACP developed collaboration mechanisms by conducting working-group meetings. National policy, strategy, and operational guidelines on TB/HIV have been developed. Also, the training curriculum was finalized based on the guideline to train voluntary counseling and testing (VCT) staff and TB-center staff. The referral system between TB and VCT centers was developed, and 10,033 TB cases in the highrisk groups were screened for HIV and 227 HIV cases were screened for TB, resulting in reporting of 12 TB/HIV co-infected cases. However, still NTP and NACP need to enhance collaborative mechanisms, especially for screening for both TB and HIV, including provision of IPT for those cases. 7. Country process to review and revise the national strategic plan For developing the current national strategic plan for 2014–18, NTP started to review the previous strategic plan with all technical stakeholders in 2012. After careful review of the achievements and constraints of the previous national strategic plan through SWOT analysis and the project-cycle management method, NTP has determined a new national strategy for 2014–18. The technical working group, including a member of the ex-patient association, mainly worked on drafting the plan; after review by WHO or other technical partners, the national strategic plan was endorsed by MoPH in early 2013. Thereafter, there were several opportunities, such as international workshops, to review the plan and occasionally to make minor revisions. Also, the consultants from international technical partners made extensive review; EPI assessment by country visits and recommendations by them were incorporated in the final plan. The final version was endorsed in January 2014 and has been approved by MoPH as the national strategic plan for2014–18.(Stop TB partnership/community consultations.) SECTION 2: FUNDING LANDSCAPE, ADDITIONALITY AND SUSTAINABILITY To achieve lasting impact against the three diseases, financial commitments from domestic sources must play a key role in a national strategy. Global Fund allocates resources that are far from sufficient to address the full cost of a technically sound program. It is therefore critical to assess how the funding requested fits within the overall funding landscape and how the national government plans to commit increased resources to the national disease program and health sector each year. 2.1 Overall Funding Landscape for Upcoming Implementation Period In order to understand the overall funding landscape of the national program and how this funding request fits within this, briefly describe: a. The availability of funds for each program area and the source of such funding (government and/or donor). Highlight any program areas that are adequately Standard Concept Note Template 10 March 2014│ 17 resourced (and are therefore not included in the request to the Global Fund). b. How the proposed Global Fund investment has leveraged other donor resources. c. For program areas that have significant funding gaps, planned actions to address these gaps. a. During 2012 ~ 14, there have been a lot of sources for funding. For years 2012 and 2013, actual expenditure of National TB Control Program (NTP) was reported US$ 14,432,719 (US$ 1,325,752 by government, US$ 5,699,488 by external donors (WHO, JICA, TB CARE and TB REACH) and US$ 7,407,479 by GF-R8 and R10) and the same years MOPH spent US$ 88,825,100 as ordinary budget for its overall health expenditure. Allocated budget for year 2014 is US$ 7,139,864 to conduct National TB Control Program (NTP) activities (US$ 784,071 by government, US$ 1,970,291 by external donors (WHO, JICA, TB CARE and TB REACH) and US$ 4,385,502 by GFATM R8 and R10 funding, in 2012 the grant agreement of (grant #AFG012-G13-T) was signed and existed for 2 months in 2012. Despite this grant having such a short lifespan, the amount of US$ 289,853 for AFG-012-G13-T was considered as past Global Fund resources in this concept note, therefore the total past GFAMTM amount reached to US$ 4,675,355and the same year MOPH allocated US $61,000,000 as ordinary budget for its overall heath expenditure. The supported program areas by each funding source are summarized below: o Government contribution: MoPH has mainly supported management cost (heating, infrastructure, communication and transportation). Also, MOPH has supported BPHS/EPHS, through donors’, support where TB control program has been included as the component and certain amount of budget such as salaries of health facility staffs and infrastructure of health facilities are supported by the cost for BPHS/EPHS. This budget for BPHS/EPHS is not included into the expenditure here, as it is very difficult to estimate proportion of allocated budget to TB control care services. (Roughly estimated, the allocation is US$ 2.1 per a capita and yearly average of government resources towards national strategic plan in current and previous years is US$ 703,274. The World Health Organization(including Italian cooperation and the Canadian International Cooperation Agency) has supported program-management cost (including staff salaries); laboratory network; M&E; advocacy, communication and social mobilization(ACSM); and research. The Japan International Cooperation Agency has supported general capacity development for program management, laboratory network (including culture and DST and molecular diagnosis), MDR-TB, pediatric TB, PPM, ACSM, and research. TB CARE has supported areas of M&E, operational research, ACSM, infection control, community-based DOTS, and urban DOTS in Kabul. TB REACH has supported contact management, active case findings for vulnerable populations, including procurement of a digital X-ray machine. The Stop TB Partnership–Global Drug Facility provided an emergency grant of about USD$2 million for first-line drugs to cover those lost by the fire of the central warehouse. The GFATM R8 and R10 programs have supported most of program areas, including program management cost (including staff salary), all TB medicines, chemicals for sputumsmear examinations, external quality assurance (EQA), and training of health facility staff, M&E, MDR-TB, pediatric TB, PPM, ACSM, and research. Standard Concept Note Template 10 March 2014│ 18 For the next three years (2015–17) a US$44,214,219 budget is proposed to cover the NTPplanned activities, based on the national strategic plan for 2014–18. o Government contribution to TB control program for the next three years (2015-2017) covers US$ 2,908,693 (US$ 870,319 for 2015, US$ 966,054 for 2016 and US$ 1,072,320 for 2017) to cover management cost in addition to the NSP proposed budget and these annual amount corresponds to 18-27% of total funding request in this concept note. o Government of Japan granted to pay US$ 12,000,000 to procure TB medicines (First line drugs (FLDs) and Second line drugs (SLDs), lab-consumables (except sputum caps, LED consumables and consumables for culture and DST), related capacity building and supervisions, some small renovations/ rehabilitation of central and provincial drug stocks and establishing drug information system (DMIS).For FLD, about US$ 4.8 million shall be allocated and this will be enough to cover all cases expected to be found with 25% buffer stocks. For SLD, US$ 2.7 million shall be allocated and this will cover more than half of targets (Considering to avoid unspent medicine, only limited amount of SLD, compared o the targets, were approved,). For diagnostic kit (sputum smear examinations) and developing DMIS, 38,000 USD and 43,000 USD shall be allocated, respectively. Also, the budget for TA (one international (60%) and one national expert) is included in this grant. Other external funding partners have no commitment for years 2015–17 (to date). Thus, about US$ 16,902,553 remains as the financial gap for implementing NTP-planned activities; all program areas, except drug supply and drug management, remain unfunded. In this Concept Note, US $12,402,973 (the full amount of indicative funding for years 2015– 2017) is requested to cover the most prioritized/vital activities among unfunded areas. This amount covers the top priorities of TB-control activities. Prioritization was done through following principals: Interventions/activities that fill the programmatic gap, especially to increase case notification(including MDR-TB), and have the potential of saving more lives Interventions/activities that maintain the basic framework of the program, such as program management, monitoring and evaluation, and human resource development. Details for selected program areas and interventions are described in section 3.2. b. Government has covered the cost of human resource development, infrastructure, maintenance and operational costs; BPHS implementers have introduced-control activities in the field; GFATM grants have covered the cost of the most crucial activities of TB-control program; and NTP partners have covered the gaps of activities not covered by government. However, in the coming three years, only the Japanese government has pledged to procure necessary TB drugs and lab-consumables. Thus, although the government and BPHS implementers will cover the above-mentioned areas, there exist significant funding gaps. As there is no pledge to cover these gaps at this moment, NTP has to request the budget from the GFATM (the only funding source at this moment) to cover basic interventions to maintain the framework of the program and interventions with top priorities to achieve the targets in the national strategic plan’s programmatic gaps analyzed by NTP and NTP partners. The table of this workshop is summarized in Annex 15 XVII. The top and some of high prioritized activities that are not Standard Concept Note Template 10 March 2014│ 19 supported by government and other donors have been addressed to this Concept Note. c. For unfunded program areas and interventions (as described in section 3.2), MoPH will continuously try to increase the budget allocation to the TB program. Possibly the US Agency for International Development (USAID) and JICA will launch new technical cooperation project in 2015, and MoPH/NTP will negotiate with those two donors to incorporate unfunded interventions with high priority in the national strategic plan into the context of their projects. 2.2 Counterpart Financing Requirements Complete the Financial Gap Analysis and Counterpart Financing Table (Table1).The counterpart financing requirements are set forth in the Global Fund Eligibility and Counterpart Financing Policy. a. Indicate below whether the counterpart financing requirements have been met. If not, provide a justification that includes actions planned during implementation to reach compliance. Counterpart Financing Requirements i. Availability of reliable data to assess compliance ii. Minimum threshold government contribution to disease program (low income-5%, lower lowermiddle income-20%, upper lower-middle income-40%, upper middle income-60%) Standard Concept Note Template Compliant? ☐Yes ☐ Yes ☒ No ☒ No If not, provide a brief justification and planned actions There is no national disease account in place ; a detailed calculation per disease area is not possible currently. The programs and HSS with close coordination of Health Economics and Financing Directorate (HEFD)/ MoPH will work to provide reliable data on the specific contribution of the country domestic resources for each disease components and HSS in long term programs sustainability. Afghanistan, health expenditures may not be categorized as domestic funding, thus could not be regarded as meeting the counted as counterpart financing requirement, as they originate in large extend from international funding. However, as most of the funds originate from international pooled funding, the interpretation as domestic funding is inadequate. 10 March 2014│ 20 iii. Increasing government contribution to disease program Though the amount seems small, given the exceptional economic and political crisis, the weakened fiscal and health budget outlook in Afghanistan, and the fact that major health funding comes from international donors, it is unlikely that Afghanistan will meet the WTP requirements in the short/medium term. ☐ Yes ☒ No However the application of 85% indicative budget rule due to non-compliance to WTP requirements may affect the priorities that are requested for funding under the indicative funding, which potentially affects the achievement of major program objectives as well as impact. b. Compared to previous years, what additional government investments are committed to the national programs (TB and HIV) in the next implementation period that counts towards accessing the willingness-to-pay allocation from the Global Fund. Clearly specify the interventions or activities that are expected to be financed by the additional government resources and indicate how realization of these commitments will be tracked and reported. c. Provide an assessment of the completeness and reliability of financial data reported, including any assumptions and caveats associated with the figures. b. Based on the plan of MoPH, total budget needed from ordinary budget for health sector for the years of 2015 and 2016 are US$69,000,000 and US$78,000,000, respectively. Also, it is expected that US$88,000,000 will be allocated in 2017. This indicates a 15% annual increase as the average. As discussed in the previous section, the government has plan to increase its expenditure to the TB-control program by 11% annually, corresponding to the incremental increase of overall expenditures .These amounts correspond to more than 18~27% of the requested funding annually, and will continue to cover management cost (staff salaries, infrastructure, communication, and transportation). They will also cover the management cost for renovated hospitals for MDR-TB, which will be supported by this funding request. c. A standard financial assessment tool was developed by the NTP central unit and was circulated to all provincial TB coordinators to collect the government expenditure for the TB-control program for the years 2012 – 2013 and the budget allocation for 2014. The data was collected from below sources: • Actual expenditure of the NTP central unit. All data were collected to fill the tool by NTP Standard Concept Note Template 10 March 2014│ 21 admin/finance section. The report is verified by the NTP manager, relevant MOPH section, and the local funding agency. • Actual expenditure of TB control at provincial levels. All necessary data were collected to fill the tool, and thereafter the reports are verified by relevant department at provincial level (finance unit) and approved by provincial health directorate (PHD). • Overall government health expenditure for the years 2012–2013 allocated budget for 2014 and plan for 2015 –2017 reported by MoPH National Health Account. The reports were verified by MOPH National Health Account and the local funding agency. At the end, summary of information received from provinces including NTP central unit were submitted to financial unit of MOPH for their approval. Note: Government expenditures at the MoPH/NTP central unit and provincial levels include followings; staff salaries, infrastructure (electricity or heating), communication, transportation and stationary. For infrastructure at provincial levels, 10% of total expenditure for related buildings was counted as expenditure to TB-control service. • Other external health contribution (WHO, JICA, TB CARE1, and TB REACH) reported by them. These were verified by their authorities accordingly. • Expenditures by the GFATM R8 and R10 programs, reported by relevant principal recipients (BRAC and JICA).These were verified by principal recipients and the local funding agency as well. SECTION 3: FUNDING REQUEST TO THE GLOBAL FUND This section details the request for funding and how the investment is strategically targeted to achieve greater impact on the disease and health systems .It requests an analysis of the key programmatic gaps, which forms the basis upon which the request is prioritized. The modular template (Table 3) organizes the request to clearly link the selected modules of interventions to the goals and objectives of the program, and associates these with indicators, targets, and costs. 3.1 Programmatic Gap Analysis A programmatic gap analysis needs to be conducted for the three to six priority modules within the applicant’s funding request. Complete a programmatic gap table (Table2) detailing the quantifiable priority modules within the applicant’s funding request. Ensure that the coverage levels for the priority modules selected are consistent with the coverage targets in section D of the modular template (Table3). For any selected priority modules that are difficult to quantify (i.e. not service delivery modules), explain the gaps, the types of activities in place, the populations or groups involved, and the current funding sources and gaps. 1. Key modules As described in section 1, NTP faces two major technical gaps: low TB case notification and insufficient MDR-TB program management. Thus, by considering that these are prioritized areas for funding, detailed programmatic gap analysis is done for the two modules (TB care and Standard Concept Note Template 10 March 2014│ 22 prevention—case detection and diagnosis and MDR-TB-case detection and diagnosis). In both modules, for filling programmatic gaps by GFATM support (this means to achieve the targets in the national strategic plan for 2014–18), to fill technical gaps including those based on the epidemiological findings is crucial. Detailed explanations on technical gaps are described. <MODULE: TB Care and prevention> TB case detection and diagnosis For low case detection, the epidemiological findings in section 1.1 indicate that the following points be considered: 1. Generally, there low case detection all over the country with little geographical variations, except in Kabul, the capital province, where the rate of case detection is even lower. 2. The highest numbers of TB cases are accumulated in cities and provinces with higher populations. 3. There are seasonal variations in cases detection, with lower detection rates in winter due to weather-impeded accessibility to health facilities. 4. There are key under-covered populations, especially: People in hard-to-reach areas IDPs, returnees, and prisoners Children In addition to these epidemiological findings, there are other important factors to be considered to develop the programmatic interventions. Suspect management in health facilities: Qualitative analysis of routine TB surveillance data and findings from quarterly review workshops notify and generate hypotheses that approximately higher number of undetected TB cases missed within the health system .For example, the presumptive TB cases identification rate is only 2.4%, which should be up to 5% of outpatient attendees. In 2013, in total 216,744 (2.4%) presumptive TB cases identified by health system out of outpatient attendees and leaves a programmatic gap of unexamined presumptive TB cases of at least 200,000.This is owing to a significant number of untrained health care workers, as only onethird of health care staff are trained on standard operating procedure for case detection and treatment and there is a high turnover rate for front-line health care staff, especially in remote and hard-to-reach areas. Addressing this challenge could lead to significant increases for TB-case notification, especially pulmonary TB cases. Thus, the strategy to address this issue is providing continuous opportunities for training on TB control, especially newly recruited staff in health facilities. Accessibility to diagnosis of TB: BHC, SHC, and health posts (at the community level) do not have laboratory diagnostic facilities, which results in a large number of missed TB cases at these levels. In total, there are 2,356 facilities of various types; of them, 1,100 (47%) are covered by DOTS; thus, 1,256 facilities, mainly BHCs and SHCs, are still to be covered by DOTS. The presumptive TB cases identified at BHC and SHC levels have to travel to the upper level of comprehensive health centers or district hospitals for sputum-smear examinations or other types of diagnosis, such as X-ray and TB/HIV screening. During this process, it is estimated that a Standard Concept Note Template 10 March 2014│ 23 significant number of presumptive TB cases, especially among people living in remote areas (including nomads) become initial defaulters. Thus, strategies to address this challenge are enhancement and improvement of the slide/sputum sending mechanism and engagement of communities such as CHWs and patient association. Insufficient contact management: Currently only passive management at health facilities is conducted. In this intervention, index TB cases are asked to bring TB suspects among their family members to health facilities.In 2013, 14,277 new infectious cases plus 2,269 previously treated cases (16,546 sputum-smear positive) were notified; at least 99,276 individuals have contacted with these infectious cases as the average number of household is 7. However, only 48,122 household contacts (48.5%) were registered by this approach and 8,274 (80%) screened for tuberculosis. Among screened people, 788 (9.5%) were diagnosed as active tuberculosis, and 390 (4.7%) were diagnosed as pulmonary smear positive tuberculosis. The incidence for all types of TB among contacts is 1.64%, and for smear-positive TB is 0.81%.During 2011, by the support of TB REACH Wave 1, active household contact management was implemented in selected areas. In this intervention, health facility staffs visited homes of index smear positive TB cases and directly screened all family members. As a result, 16,145 household contacts were screened, and 822 TB cases in all forms, including 606 sputum-smear positive cases, were found. This result indicates that the incidence of all forms of TB among household contacts was about 5%. Thus, it is strongly indicated that expanding active contact management through home visits could increase case findings in early stages of the disease. Missed cases in private sectors: According to research conducted in 2004, for 65% of patients the first point of health-services contact is the private sector. Unfortunately, lack of recording and reporting within private sectors resulted in not reporting TB cases to national program, and they diagnosed and treated with non-recommended procedures. Thus, NTP has introduced PPM into 8 major provincial capitals that notified approximately 1,500 TB cases annually in 2013 and 2012. The enhancement of this model will lead to increased TB-case notification and treatment adherence. For Kabul, the biggest city with dense population of more than 4million, in 2013, the total number of TB cases notified was 3,548, which represents only 17% of all estimated cases. Urban DOTS projects supported by TBCARE dramatically improved the situation, but still30% of facilities, mainly private sectors, are not covered by DOTS in Kabul city. Thus, it is crucial to enhance urban DOTS of which PPM is the main component. Quality of laboratory network for sputum-smear examinations: Improving the quality of established network for sputum-smear examinations is crucial. For this purpose, several efforts should be made as there has been a high turnover rate for laboratory technicians, especially in remote areas. Thus, in addition to conducting training on sputum-smear examinations for laboratory technicians based on needs, enhancing quality-control mechanisms is crucial for better diagnosis and subsequent increased case notification. For blind cross-checking for EQA, the participation rate still remained around 70%. Percentages of poor laboratories declined to 15% in 2008, but thereafter increased up to around 20% in 2009–11. There still exists predominant high false negative among major errors. Thus, it is crucial to improve performance of blind crosschecking. To scale up EQA, the NTP’s national reference laboratory has planned to conduct blind cross-checking at the provincial level; this is currently conducted at the regional level. For this purpose, the NTP’s national reference laboratory (NTP/NRL) conducted the operational research in the central region and got favourable results in participant rate. Thereafter NTP/NRL has developed a plan to introduce this new system to whole provinces. Based on this plan, NTP/NRL has started training for assessors and cross-checkers in each province; by the end of 2014, NTP/NRL’s new Standard Concept Note Template 10 March 2014│ 24 system will be available in all provinces. Thus, it is crucial for NTP/NRL to maintain the newly reformed EQA system. Also, for sputum-smear examinations, WHO has strongly recommended replacing light microscopes with LED microscopes; however, at this moment NTP/NRL distributed only ten LED microscopes by support of TB CARE. Thus, it is also crucial to introduce more LED microscopes into laboratories with high workloads. Management of paediatric TB control: Children are defined as one of the under-covered populations (see section 1). This is due largely to weak diagnostic capacity for pediatric TB, because of at least two factors: (1) a shortage of skilled pediatricians or general practitioners in the health facilities and (2) a lack or shortage of essential diagnostic tools, such X-rays and tuberculin skin testing (TST). For proper diagnosis and management of TB among children, it is necessary to provide essential diagnostic tools and train the existence health workers at the health-facility level. For this purpose, to manage pediatric TB cases under integrated medical care, NTP developed a standard operating procedure and diagnostic algorithm for pediatric TB. In this algorithm, especially for children under five years old, both X-ray examinations and TST are mandated. Based on this strategy, NTP conducted training on the management of pediatric TB for key health facility staffs, including pediatric specialists in key hospitals in the country by support of the GFATM R10 program in 2012 and 2013. Simultaneously, NTP started to provide TST, also supported by GFATM R10 program. These measures have resulted in increased number of pediatric cases in 2013 (4,809 smear positive cases and 3,181 other types of TB) compared to 2011 (4,206 and 1,989, respectively); however, NTP still needs to enhance case notification of pediatric TB cases by introducing active case findings in hospitals as a whole, since there are possibly TB suspects in departments other than pediatric outpatient (such as nutrition). Also, NTP needs to provide adequate tools for diagnosis of pediatric TB, which are not covered by BPHS/EPHS, such as TST. For X-ray examinations, BPHS/EPHS have the responsibility to provide quality X-ray machines; but due to limited budgets, most X-ray machines in public health facilities are old and cannot provide quality pictures. So, NTP provided digital X-ray machines to three major provinces by support of the GFATM R10 program, JICA, and TBREACH; it would like to provide more. These may eventually result not only in increased diagnostic capacity of TB, but also health system strengthening. At the same time, NTP needs to strengthen the connections between the pediatric TB program and other programs for the integrated management of childhood illness (IMCI) and reproductive, maternal, newborn, and child health (RMNCH), as TB is often misclassified in children as pneumonia, malnutrition, brucellosis, or some other infectious diseases. For this purpose, the following interventions/activities are necessary Coordination meeting with public nutrition, IMCI, and RMNCH programs Updating current standard operating procedures for pediatric TB management based on the latest WHO guidelines and integrated with public nutrition, IMCI, and RMNCH programs. Conducting refresher training on revised standard operating procedures for pediatric TB management <MODULE:MDR-TB case notification and diagnosis> As seen in the section 1, although NTP has successfully initiated the MDR-TB program, case Standard Concept Note Template 10 March 2014│ 25 notification of MDR-TB is far below the target. One of the main reasons for this gap is the limited opportunity for MDR-TB diagnosis. To improve case notification, with support of the GFATM R10 program, NTP has trained staff in health facilities on sample collection from MDR-TB suspects—such as failure of category 1 and exposure to known MDR-TB cases, as defined in the national guidelines (National Guidelines for the Management of Drug-Resistant Tuberculosis, p. 15) Annex 16 —and established sample transportation system from peripheral health facilities to diagnostic centers for MDR-TB. However, at this moment, there are only three laboratories for culture examination; another two laboratories are expected to start culture examinations. It is expected that NRL can implement drug susceptibility testing as routine work soon, and yet NTP/NRL still relies on the supranational reference laboratory, Agha Khan University. Thus, it is crucial to improve and speed-up diagnostic procedures; a rapid molecular diagnostic system is required in this regard with the maintenance of a nationwide sample collection/transportations system. At the same time, NTP needs to enhance quality control on culture examinations with support of the Agha Khan University. For treatment of MDR-TB, up to now, NTP showed relatively good performance. (A total of 123 cases have been enrolled at the end of March 2014, and there are 27 cured cases and 39 cases in the continuous phase with negative conversion. There are 13 death cases, 4 transfer-out cases, and 5 defaulters.) At this moment, NTP would focus on hospitalized care during the initial phase (at least several months) to ensure treatment and better case management, while NTP plans to introduce ambulatory care for the initial phase in the near future. For hospitalized treatment, there are only 56 beds in the newly constructed communicable disease hospital in Kabul, and NTP plans to provide at least another 100 beds in five main provinces. This was planned previously, and the budget was included in the GFATM R10 program; however, due to some administrative issues, the construction and renovation of MDR-TB wards in five provinces were suspended. For nearly two years, another crucial issue to providing adequate treatment has been the lack of social welfare system. There is no social welfare system to support sick people, including MDRTB, in Afghanistan; as NTP has conducted ambulatory treatment in Kabul, patients shoulder a huge cost for transportation that surpasses their monthly income. Thus, to launch the program successfully and avoiding defaulters, JICA provided monetary patient support. Thereafter, this support has been included in the GFATM R10 program (the extension period) instead of support by JICA. 2. Other supporting modules In addition to these two key modules, there are other important supporting modules. While focusing on those two modules, simultaneously NTP needs to keep the basic framework of the program and continue current important measures not only for case findings, but also for treatment and prevention. These include areas of monitoring and evaluation and program management; quantification of these modules is difficult, but as for the previous two modules, the programmatic gaps in these areas are also nearly 100%. Explanations of these measures are addressed in two supporting modules (HIS and M&E, program management) in this section. <MODULE: HIS and M&E (routine reporting)> Interventions in this supporting module regarding M&E that does not directly bring impacts on the TB program, but are essential to concrete the framework of the program. NTP Afghanistan has introduced an electronic information system (i.e., TBIS), but TBIS serves above the provincial level, and the entire reporting system still relies on the older paper-based system. The electronic reporting system (TBIS) was developed with assistance from USAID funded TB CAP and TB Standard Concept Note Template 10 March 2014│ 26 CARE I projects. Currently, this system is fully integrated into national HMIS and NTP with assistance from TB CARE I and its follow on project (2015-2019) will continue its assistance with NTP to maintain electronic reporting system. The coordination, training, supervisionand monitoring of the system and periodic evaluation and data quality assessment will be assisted through upcoming USAID TB project. HMIS unit of MOPH will ensure the sustainabilityof this system along with national HMIS. For MDR TB patient NTP maintained an excell based nominal recording that developed by NTP In these settings, quarterly review meetings at various levels play key roles in adequate data collection, verifying quality and providing feedback to health facilities (technical details to conduct those meetings are defined in the guideline [NTP, “Province Level of Monitoring Event Guideline”]) Annex 17. These meetings have been implemented in all provinces with support by the GFATM FundR8 program, resulting in significant reduction in missing data and errors in reporting. Thus, it is crucial to continue these activities. Supervisory visits to health facilities also play key roles not only in M&E, but also in improving the quality of services of TB control; technical instructions for supervisory visits are defined in the guideline as well[NTP, “Facility Level of Monitoring Event Guideline”] Annex 17.These supervisory visits have also been supported largely by the GFATM R8 program. To strengthen the surveillance system, research through several key surveys is necessary. As in the national strategic plan, NTP would like to conduct a national prevalence survey; however, at this moment and for the foreseeable future, this is not feasible due to the security situation. Thus, at least, NTP needs to conduct alternatives such as capture-recapture study to obtain more accurate incidence of TB cases. Also, an inventory survey is required to evaluate the current surveillance system. The drug resistance survey was conducted in 2010, but in only limited regions, and a nationwide survey is necessary to obtain full estimates of the MDR-TB burden. To improve the quality of the program, several operational researches should also be done based on the needs assessment. <MODLE: Program management> While the government of Afghanistan is increasing its expenditure for the health sector, NTP (like other programs or departments) has little budget for providing basic management costs such as consumables for office work or basic communications, resulting in hampering the performance of NTP program management. Thus, in the GFAMT R10 program, the budget to support basic management was incorporated. This includes the cost for providing IT equipment, Internet maintenance and communication fee, etc. Also the government of Afghanistan is increasing its staff salary scales by the support of the World Bank; still MOPH needs to budget for salary to ensure its key staff with a decent livelihood. The GFATMR8 program has been supporting salaries to NTP staffs at the central and provincial levels. Although there is some progress in the government expenditure, there is no significant change in the situation mentioned above; support for these areas shall be continued in the next funding request by the GFATM. 3. Cross-cutting issues to fill programmatic gaps In addition to those areas for programmatic gaps, there are important issues that also affect the quality of the entire program. These concern gender issue and human rights, and are considered as cross-cutting issues to define the strategic overview and select interventions. Gender issue: As noted in section 1, there is a marked predominance of TB cases for females, especially for women at reproductive ages. Therefore, NTP prioritized activities to reach women in various ways as planned in the national strategic plan. The purpose of intervention for the gender Standard Concept Note Template 10 March 2014│ 27 issue is not to enhance case detection, but to decrease the burden of TB among females, although efforts to increase case detection among females will be done in a comprehensive manner common to those for males. Based on the results of the two surveys, and given the susceptibility of women of childbearing ages, it is highly possible that reproductive factors such as early age marriage or short birth interval might be important risk factors to developing TB among females. There are also other risk factors, including nutrition and cultural issues such as limited morbidity and decisionmaking for females, but it is difficult to address these in the short term, and a multi-sectorial approach is necessary. However, immediate actions should be taken to reduce the burden of TB among females; NTP would start to conduct training on TB risks among pregnant female for midwives and gynecological doctors for prevention and early diagnosis in collaboration with the reproductive health department of MOPH. This content shall be included in routine training curricula for pre-service and in-service training for midwives and gynecological doctors. For other interventions, defined in the national strategic plan, contact management among females will be done in the comprehensive manner of the contact management and activities to increase community awareness regarding reproductive health factors as risk factors will be done in line with comprehensive awareness activities. For creating direct impact to female predominance, NTP has started to discuss the feasibility of isoniazid preventive therapy (IPT) for females at high risk regarding reproductive health. As described before, the recently conducted surveys indicated that reproductive factors such as early age marriage, high fertility rate, or short-term birth intervals might be important risk factors for females to develop TB, although malnutrition or other factors might also be responsible for this. The surveys indicated that significant number of pregnant females develop TB within 6~12monthsafter delivery. This condition may provide the possibility of IPT for high-risk female after delivery, although further discussion is required. Thus, with intensive discussion with technical partners, NTP will develop plans of piloting of IPT in several provinces with extremely high predominance of female cases. Human rights: The concept of human rights is not pervasive in Afghanistan. This is not only in the field of the TB-control program, but in the entire social sector. In the health sector, few health facility staff can understand the concept of medical ethics, and the human rights of patients are not respected. Also, there is very limited social support for patients with chronic illness or disabled patients. Thus, necessary actions should be taken to enhance human rights through a multisectorial approach, but possible measures in the field of TB-control program should also be initiated. 3.2 Applicant Funding Request Provide a strategic overview of the applicant’s funding request to the Global Fund, including both the proposed investment of the allocation amount and the request above this amount. Describe how it addresses the gaps and constraints described in questions 1, 2 and 3.1. If the Global Fund is supporting existing programs, explain how they will be adapted to maximize impact. 1. Strategy of funding request To achieve the overall goal of the current national strategic plan for 2014–18, the main technical gaps exist in insufficient case finding and weak management of MDR-TB program, as described in sections 1 and 3.1.Thus, this Concept Note presents a funding request for interventions and activities to address these gaps while maintaining the basic essential framework of the TB-control program. Standard Concept Note Template 10 March 2014│ 28 Since there are huge financial gaps, as described in section 2, those interventions and activities that have potential to bring maximum outcome were selected based on the previous achievement. At the same time, measures to detect cases in the early stages have priority for reducing TB mortality, which is the goal of the current plan. Also, concepts of gender and human rights were considered as important factors. Thus, among three core modules and four supportive modules, the requests are made for intervention in two key modules (TB care and prevention, and MDR-TB) and two supporting modules (M&E and program management). Among the module for TB care and prevention, “treatment and prevention” is an important area, but the programmatic gap of this area is very limited, as described below, and there is no standalone funding request in the intervention of “treatment.” All first- and second-line medicines, including those for prophylactic use and laboratory kit for sputum-smear examinations, shall be covered for three years (2015–17 Funding Proposal for Japan Government) Annex 18 by the grant-aid assistance by the government of Japan. The planned amount of procurement can cover estimated new cases as in the target of this Concept Note. To ensure and maintain current treatment outcome, several measures should be taken. For uninterrupted provision of medicine and reagents, capacity development of related staff on drug management is crucial, and the plans to introduce an electronic drug management system and to train related staff in drug management are included in the grant-aid support by the government of Japan. In addition to the uninterrupted supply of medicine, NTP Afghanistan ensures the strategies to maintain and improve higher treatment success rate. These include implementation of communitybased DOTS, especially in rural areas, and strengthening TB patients association, in both urban and rural areas (detailed description regarding these two interventions are described subsequently).Also, other measures such as training of health staffs and supervisory visits to health facilities are crucial to maintain current treatment outcome. The budget for all these interventions is included in this funding request in the related areas in the other modules. The budget to maintain health facilities that provide TB-control programs is covered by the government and donor support. This is the same for “prevention,” and budget such as for ITP is included in the related areas. Among three core modules, no funding request shall be made for TB/HIV. Although there exist significant technical gaps, as indicated in the section 1.2, the total amount of the necessary budget is little, and NTP can find other resources for funding, in collaboration with NACP. <Coordination and integration among three programs and HSS for interventions at primary health care facilities> There is integration and coordination mechanisms among three programs at health facilities, and these mechanisms work to reduce cost for program implementation for each other and subsequently to reduce the funding request of this Concept Note. According to the Afghan health system, all activities for three programs such as TB, HIV and malaria are integrated into the general health system (i.e., BPHS) Annex 19. All these activities are conducted under one roof at health facilities, especially in primary health care facilities, all over Afghanistan. There is one microscope and a laboratory technician at each health facility supported by BPHS to conduct test for malaria and TB. Thus, the collaborative activities could result in reducing the cost of a laboratory system at the health-facility level. In addition, HIV testing is also conducted at primary health care facilities. This could result in improved testing and screening of Standard Concept Note Template 10 March 2014│ 29 TB patients for HIV (and vice versa) at the primary health care facility level. Health system strengthening is a cross-cutting issue that benefits all three programs. For instance, the reference laboratory system assists malaria and HIV programs with complicated testing, while the TB program has reference laboratories in different settings due to infection control. Also, HSS could integrate the case notification standard operation procedure for case detection of all three programs into its curriculum to teach community midwifery and nursing education that will help all three programs in case notification of tuberculosis, HIV, and malaria at the health-facility level. <Strategic overview on TB case notification and diagnosis> Based on the epidemiological findings and other important technical constraints in the section 3.1, following strategic directions are taken in this Concept Note to define the interventions and activities for funding request. Enhancing case detection by: 1. Strengthening PPM and urban DOTS in Kabul. 2. Enhancing contact management. 3. Enhancing suspect management in all clinics and hospitals. 4. Improving accessibility in remote areas and in winter. 5. Enhancing active case findings among key affected (under-covered) populations. 6. Improving diagnosis and management of paediatric TB cases through integration of paediatric TB control intoIMCI and RMNCH. 7. Enhancing the quality of laboratory network, including introduction of LED microscopes. 8. Decreasing stigma and introducing concepts of human rights. Thus, the selected activities based on this strategic overview are classified into the six interventions under the module of “TB care and prevention” as follows. <MODULE: TB care and prevention> 1.1 Case detection and diagnosis Improving accessibility for TB diagnosis through conduction of slide/sputum sending system Strengthening EQA for enhancing quality of sputum-smear examinations Procurement of LED microscopes Conducting screening/triage for child TB suspects in hospitals Procurement of TST 1.2 Key affected populations Standard Concept Note Template 10 March 2014│ 30 Introducing active case finding among IDPs Introducing active case finding among prisoners Introducing active case finding among household contacts 1.3 Engaging all care providers Expanding PPM-DOTS into other big cities and enhancing existing PPM, including urban DOTS in Kabul city 1.4 Community TB care and prevention Expansion of community DOTS supported by community health workers Expanding the TB Patient Association Introducing the concept of the patient charter Conducting awareness activities 1.5 Collaborative activities with other programs Improving coordination and collaboration with reproductive departments at the national and provincial levels Introducing IPT to high-risk pregnant female 1.6 Others Training on health care providers Printing and distribution of the package of NTP documents (guidelines, standard operating procedures, training materials, etc.) <MODULE: Strategic overview on MDR-TB case notification and diagnosis> At this moment, special epidemiological characteristics in low case detection are unclear, as the MDR-TB control program has been just initiated. The following strategic directions, which are generally to develop the system for diagnosis and treatment for MDR-TB, are taken in this Concept Note to define the interventions based on the general situation analysis on the MDR-TB control program. In this module, interventions regarding treatment are necessarily included, as the MDRTB control program still needs to develop an adequate treatment system. While NTP aims at developing collaboration mechanisms with private sectors and civil service organization on MDRTB management, especially for case notification, during these three years, NTP focuses on establishing good program management in public sectors. If possible, NTP shall involve private sectors in Kabul city for case notification as a part of the urban DOTS project. Enhancing case detection by: Enhancing diagnostic network on MDR-TB including rapid diagnostic methods Preparing adequate treatment system by: Providing MDR-TB wards to for hospitalized treatment in the initial phase Providing social welfare for MDR-TB patients Thus, the selected activities based on this strategic overview are classified into the interventions under this module as follows. 2.1 Case detection and diagnosis of MDR-TB Standard Concept Note Template 10 March 2014│ 31 Establishing and maintaining sample transportation system for MDR-diagnosis Procurement consumables for culture examinations and DST Enhancing quality control of culture examinations and DST Introducing GeneXpert with diagnostic kits 2.2 Treatment Renovation of TB wards for treatment of MDR-TB cases in five provinces Providing living support for MDR-TB patients <MODULE: Strategic Overview on HIS and M&E (routine reporting)> As described in section 3.1, it is crucial to maintain the current HIS and M&E system; quarterly review meetings at provincial and national levels and supervisory visits are key activities for this purpose. Also, operational research to improve quality of the TB-control program is required, based on the needs. Ensuring the M&E mechanism, including routine reporting and surveillance by: Sustaining the M&E system by conducting quarterly review meetings and supervisory visits at various levels Conducting necessary operational researches or surveys(inventory survey, DRS, female) Thus, the selected activities based on this strategic overview are classified into the interventions under this module as follows. 3. HIS & M&E 3.1 Routine reporting Revision of record and reporting forms Conducting quarterly meetings Conducting supervisory visits 3.2 Survey/operational research Conducting operational researches or surveys to strengthening surveillance system <MODULE: Program management> 4. Program management As in section 3.1, while the government of Afghanistan is increasing its expenditure for the health sector (as for other programs or departments), there has been little improvement and support for staff salary incentives and areas for good communications is still necessary for NTP as in the previous funding programs by the GFATM as the cost for program management in addition to routine grant management cost. 4.1 Policy, planning, coordination and management Staff salaries at National and provincial level, the staffs salaries will be adjusted based on Standard Concept Note Template 10 March 2014│ 32 National Technical Assistance (NTA) Remuneration policy Routine operational cost for NTP, including provision of IT equipment and other communication materials 4.2 Grant management Principal recipient management cost Mid-term review for the national strategic plan (30,000) The following major interventions/activities are not included in this funding request due to relatively low priorities: Human resource development: o Introduction of TB program into pre-service education curriculum o Evaluation of training courses, including post-training monitoring o Introduction of competency assessment o Refresher training for several targets M&E: Introduction of electronic system for supervisory checklists Laboratory network: Introduction of liquid culture and DST by line-probe assay Conducting the National Prevalence Survey The following major interventions/activities are not included as supports by other donors are expected: Expansion of mechanisms for TB infection control TB/HIV Urban DOTS in Kabul and its extension Also, there are several interventions/activities that are included with significant reduction of quantity, such as ACSM activities. 3.3 Modular Template Complete the modular template (Table3).To accompany the modular template, for both the allocation amount and the request above this amount, briefly: a. Explain the rationale for the selection and prioritization of modules and interventions. b. Describe the expected impact and outcomes, referring to evidence of effectiveness of the interventions being proposed. Highlight the additional gains expected from the funding requested above the allocation amount. The rationale for the selection and prioritization of modules and interventions are described in section 3.2. Following is a summary of the results: Standard Concept Note Template 10 March 2014│ 33 Among three core modules and four supportive modules, no funding request shall be made in TB/HIV. No stand-alone requested budget for interventions for TB care and prevention: treatment and prevention in the module of TB care and prevention. The expected outcome of activities under the selected interventions and their rationale areas follows, with brief explanation of budgeting. 1. TB care and prevention 1.1Case detection and diagnosis Conducting slide/sputum sending systems This intervention has been introduced by support of JICA and the GFATM R10 program to improve accessibility to TB diagnosis for people living in hard-to-reach areas, including nomads. NTP Afghanistan has gradually introduced this system in 23 provinces. For the other 11 provinces, NTP did not plan to introduce this system for several reasons, which include geographical difficulties or few numbers of basic health facilities without laboratories. After the introduction to 23 provinces, around 200 smear-positive TB cases per quarter were found. Although counter-factual effect should be considered, this system could work to improve suspect management in remote areas where a significant proportion of TB suspects defaulted before receiving diagnostic examinations. Given that 30% of TB suspects are missing, 60 smear positive TB cases per quarter (240 per year) are found by this intervention as the additional gain. Also, this system could work to reduce the financial burden on poor people in remote areas to access TB diagnosis. Thus, NTP plans to continue this system; but considering huge cost to manage this system, NTP has revised the implementation strategy of and reduced the number of health facilities for slide/sputum sending systems, which are more costly to manage. Briefly, this system will be continued in 20 provinces excluding three provinces with low performance, and the slide sending system will be continued in six provinces with significant hard-to-reach areas and severe weather conditions in winter. Thus, the budget request for this activity includes the operational cost of this system—mainly the transportation cost for slide/sample sending and the management cost, including training in case of staff turnover. Strengthening EQA for enhancing quality of sputum-smear examinations EQA has been implemented countrywide through blind cross-checking and subsequent supervision and trainings based on the results of EQA. However, participants rate for blind cross-checking still remain around 70%, and the percentage of poor laboratories also remains around 20%. There still exists predominant high false negative among major errors. Thus, it is crucial to improve performance of blind cross-checking to increase case notification, and explained in section 3.1. For this purpose, based on the results of the operational research, NTP/NRL has shifted blind cross-checking to provincial levels from regional levels in 2014. Thus, the requested budget for EQA is to maintain this revised EQA system, including an honorarium for cross-checkers and urgent supervision for EQA and microscopes for cross checkers. Slide collection shall be done in the quarterly meetings. Procurement of LED microscopes. NTP plans to introduce 50more LED microscopes to laboratories with high workload, and the budget for procurement of microscopes with reagent and training on staffs are requested. (Procurement of sputum cups is classified into Standard Concept Note Template 10 March 2014│ 34 this intervention based on the convenience of the budgeting.) Conducting screening/triage for child TB suspects in hospitals Procurement of TST Procurement of digital X-ray machines This activity aims to enhance the diagnostic capacity for pediatric TB cases. As explained in section 3.1, there has been certain progress in pediatric TB management by the introduction of standard operating procedure for training and utilization of TST, but NTP needs to introduce more active measures to find child TB cases. For this purpose NTP will introduce screening in hospitals as a new intervention. NTP Afghanistan will recruit one staff member in provincial and district hospitals to screen and triage TB suspects not only in pediatric OPD, but also in all related OPD, such as EPI and nutrition departments. This intervention has been initiated recently in the children’s hospital in Kabul by support of TBREACH, and early results with the combination of introducing digital X-ray machine were encouraging, though there has been no official report yet. Preliminary experiences of utilizing digital X-ray machines in Nangarhar and Kabul have resulted in increased case notification, especially for pediatric cases (no official report is available at this moment), indicating necessity of quality X-ray pictures. Thus, NTP plans to provide two more digital X-ray machines to Maiwand hospital in Kabul, which has a large pediatric OPD, and Herat regional hospital. NTP Afghanistan will conduct the following interventions to integrate with IMCI and RMNCH only through the support of other donors such as USAID and JICA, as these will work only indirectly to increase case notification. Coordination meetings with public nutrition, IMCI, and RMNCH programs; establishment consultative committees in each hospital for diagnosis and management of pediatric TB cases. Updating current standard operating procedures for childhood TB management based on the latest WHO guidelines and integrated with public nutrition, IMCI, and RMNCH. Conducting refresher training on revised standard operating procedures of pediatric TB management Thus, the requested budget includes the cost for incentives to hospital staffs (one per hospital) for screening/triage of childhood TB suspects and uninterrupted provision of TST and two digital X-ray machines(with maintenance). 1.2 Key affected populations Introducing active case findings among IDPs Under TB REACH Wave 1 in 2011, NTP along with partners has initiated active TB case finding among IDPs by designated mobile teams in eight provinces. In these activities, sputumsmear examinations after verbal interviews to identify TB suspects were the routine diagnostic method. As the result, among about 220,000 IDPs, 5,139 suspects were found, and subsequently 358 smear-positive TB cases were identified. This intervention identified twotimes higher amounts of TB cases among this group of population than the general population. Also, by a similar concurrent intervention among 22,463 IDPs (utilizing a mobile digital X-ray Standard Concept Note Template 10 March 2014│ 35 unit in Nangarhar in 2012), 848 TB suspects were found, and subsequently 41 TB cases in all forms were identified. These results also indicate considerably higher incidence of TB in all forms among IDPs. However, these interventions to utilize the mobile teams are not cost effective to screen the general population, considering the number of TB cases detected. Thus, NTP will change the methodology to screen IDPs through less costly means. There are around 570,000 conflict-induced IDPs and 7,000 natural-disaster induced IDPs in whole country (UNCHR Global Report 2012). According to UNHCR data, the majority of IDPs accumulated in large camps in several provinces: Herat (106,000), Kandahar (46,000), Nangarhar (70,000), Helmand (99,000), and Kabul (20,000). Thus, NTP will focus on these five provinces. In these five provinces, NTP will recruit one staff member in the provincial hospitals to manage screening of IDPs. They will further recruit staffs inside the camps and train them to conduct health education and to encourage TB suspects to visit health facilities as ordinary CHW in rural areas. The number of staff in camps depends on the size of the camp, but as the average one staffs per a 5,000 population will be recruited. The expected numbers of TB cases detected by this intervention are listed in table 3. Table 3. Expected Detection of TB Cases by Screening of Internally Displaced Persons in Five Provincial Hospitals Provinces Total No. of IDPs Targets to Be Covered in 2015 Targets to Be Covered in 2016 Targets to Be Covered in 2017 Kabul 20,000 18,000 18,000 18,000 (90%) Nangarhar 70,000 63,000 63,000 63,000(90%) 106, 000 30,000 70,000 90,000(90%) Kandahar## 46,000 0 10,000 20,000(44%) Helmand## 99,000 0 20,000 40,000 (40%) Total 341,000 111,000 18,1000 23,1000 (68%) Heart Expected TB cases 220 360 460 of all forms# #The incidence is estimated as 0.2% as the minimum based on the previous experiences described above. ## Targets in Helmand and Kandahar are set at the low level due to security constraints. The requested budget includes incentives to staff to manage the interventions, cost for initial training for recruited CHW and incentives for CHWs. There have been several large natural disasters in recent years; among them, severe flooding often created huge numbers of IDPs, especially in spring and summer, resulting in an epidemic of TB among IDPs. Thus, NTP will conduct urgent screening in this regard by utilizing existing staff. Budget for these screenings is included. Introducing active case findings among prisoners: Through TB REACH Wave 1 in 2011, NTP along with the partner has initiated active TB case finding among prisoners in eight provinces and among 3,000 prisoners,233 (8%) were Standard Concept Note Template 10 March 2014│ 36 identified as TB suspects and finally 5 (1%) were diagnosed as smear positive TB cases. Also, current similar interventions in Nangarhar by utilizing a mobile digital X-ray unit, totally 18 all form of TB cases, including extra-pulmonary TB and smear negative were found among 1,783 prisoners (1%). These findings clearly indicate the extremely high incidence of TB among prisoners compared to general population and encourage to expand for further case notification. There are around 30,000 prisoners in the entire country (Afghanistan 2013 Human Rights Report) Annex 20.NTP Afghanistan will focus on the larger prisons, such as Kabul (8,000), Nangarhar (1,500), Herat (3.500), Kandahar (3,500), Balkh (2,000), Kunduz (2,000), and Baghlan (2,000). The total expected prisoners are 22,500.In other prisons, there are fewer prisoners, who are incarcerated for shorter periods and are thereafter forwarded to other prisons or released. In each prison, a team consisting at least two staff from provincial hospitals will visit three times per a month, on average, and conduct screening for prisoners by collaboration with staff in prison clinics. Sputum samples from TB suspects will be transported to provincial hospital for examinations. In Kabul and Nangarhar prisons, mobile digital X-ray facilities will be utilized for screening. Throughout this intervention, NTP will train staff in prison clinics to develop a screening system for incoming prisoners to enhance efficiency of screening. Thus, it is expected that about 20,000 prisoners will be screened every year in the funding period and that 200 TB cases will be found as additional cases. The requested budget includes operational cost for this screening such as per-diem and transportation cost for staff to visit prisons. Note: For active case findings among returnees, the budget is not requested in this Concept Note, considering the relatively small number of TB cases detected. Introducing active case findings in household contacts For contact management, as described in the section 3.1, currently only passive management at health facilities is conducted, and introduction of active contact management by home visits required for enhancing case findings in the early stages of disease. Thus, NTP will start home visits for contact management, and it is expected that health facilities will make two visits per month and as the average 144 contact, as the average, will be directly screened per a health facility per a year with the assumption of average number of family members as 7.This intervention will be applied to all 34 provinces, and it is planned to involve at least 400 TB diagnostic centers in 2015, 600 in 2016, and 800 in 2017, including some TB treatment centers. For the incidence of TB among household contacts, the results of passive contact management in 2013 showed 1.6% for all forms of TB and 0.8% of smear-positive TB, while active contact management in 2011 revealed 1.6% as the incidence for smear-positive TB cases (268 cases among 16,645 contacts). Considering the feasibility, the estimation of additional TB cases, in table 4, is presented using incidence of all forms of TB and smear-positive TB as 2% and 1%, respectively. Table 4. Additional TB Cases among Household Contacts Criteria 2015 2016 2017 No. of health facilities (HFs) conduct contact management* 400 600 800 No. of contacts screened 57,600 86,400 115,200 Standard Concept Note Template 10 March 2014│ 37 Incidence of all TB cases among contacts 2% 2% 2% No. of all TB cases 1,152 1,720 2,304 Incidence of sputum smear positive TB cases 1% 1% 1% No. of sputum smear positive TB cases 576 864 1,152 The requested budget includes per-diem and transportation cost for health facility staffs to visit homes of index cases. 1.3 Engaging all care providers Expanding PPM-DOTS into other big cities and enhancing existing PPM, including urban DOTS in Kabul city As in the national strategic plan and previous sections, NTP expanded PPM into capital cities in eight provinces, resulting in finding about 3,500 TB cases yearly through referrals from private practitioners. In addition to expansion of PPM in these eight provinces, urban DOTS in Kabul have been implemented. This brought significant results in case finding (from 1,934 in 2009 to 3,555 in 2013). For other areas, it is difficult to estimate how many of these cases were diagnosed as additional cases due to counterfactual effect, but early data suggest that introduced PPM in Balkh resulted in 10% increase of total TB cases in the related area. Thus, it might be estimated that among 3,500 notified cases through PPM about 350 cases are considered as additional cases by this intervention. Now, NTP plans to expand to another seven provinces (Kandahar, Takhar, Kunduz, Badakhshan, Parwan, Baghlan, and Faryab). Considering several conditions, including population of the capital city, more than 1,000,000 populations will be covered by PPM expansion. Thus, a total of 5,808,000 population in these 16 provincial capitals will be covered by PPM.(This number represents only people living within capital cities and more populations will be covered in actuality.)It is expected that around 3,000 TB cases in all forms will be notified through PPM in these 15 provincial capitals (although Kabul and about 300 cases might be counted as additional cases to the current case notification through PPM). Also, incremental increases of notified cases might be expected in Kabul by scaling up urban DOTS. At the same time, it is essential to increase the participation rate in provinces where PPM has been already introduced and to enhance M&E mechanism on the PPM program. Thus, the requested budget includes cost for expansion in remaining provinces and scaling-up in provinces where PPM is already in place, including urban DOTS in Kabul such as cost for training for private practitioners, pharmacists and laboratory technicians for expansion to new provinces and scaling-up in ongoing provinces including urban DOTS in Kabul and cost for M&E to conduct regular workshops for M&E and recruit one focal point in a province to manage and monitor activities by PPM. 1.4 Community TB care and prevention As the assessment of key affected population indicated, generally, current ACSM activities utilizing mass media are not effective, and high incidence of illiteracy among poor and rural populations hinders acquiring adequate knowledge for TB. Thus, approaches to deliver messages and knowledge directly to key affected populations are required. Thus, NTP will enhance community approaches in these regards. Standard Concept Note Template 10 March 2014│ 38 Expanding community DOTS supported by CHWs Roles of CHWs are very important not only in case finding and treatment support, but also in mitigating the barriers for females to access health service, especially in rural areas as described in the section1. Thus, NTP has promoted community DOTS by support of the GFATM R8 program USAID funded TBCAP and and TBCARE I projects. The supported budget both from GFATM and USAID has covered the cost for training of CHW and CHS and monetary incentives on case findings and treatment support for CHW. According to data from six selected provinces, Jowzjan, Herat, Bahghlan, Takhar, Badakhshan and Faryab, 1,482 and 1,089 cases were notified by CHW in 2012 and 2013, respectively. In 2013, nearly 7,000 CHW received monetary incentives for case finding and treatment support in aforementioned six 4 provinces and rest of country through GF R 8 and USAID. As a result, for example, treatment cure rate among those TB patients who received their DOT from CHWs (community DOTS) were 96%, compared to 87% among those who received facility-based DOTS (“Identifying the contribution of community health workers to the treatment outcome of Tuberculosis patients in four provinces of Afghanistan, 2010, P.S88) Annex 21. Based on these encouraging results, NTP and partners will expand this intervention to all provinces in the same manner, and only the budget for incentives for CHWs is requested, given that NTP and partners have finished training on CHW by GFATM R8 support. Expanding the Afghan TB Patient Association (introduction of the patient charter) The Afghan TB Patient Association was established as a profiting organization that implements activities previously supported by WHO/Canadian International Cooperation Agency in December 2009 and gradually expanded into provinces (Kabul, Parwan, MaidanWardak, Bamiyan, Ghor, Daikundi, Takhar, and Herat).This association has been working with a set of following objectives. o Establishment of relation between patient and HF. o o o o Strengthening of patient care according to international standards. To promote patients’ rights. Establishing strong coordination mechanism in community to fight against TB. Ensure that every Afghan TB patient has access to effective diagnosis, treatment and cure To refer patient from community to health facilities. o By this association, up to now, a total of 5,122 TB suspect cases have been referred, 427 sputum-smear positive cases have been notified, and also 468 TB cases have been supported for their DOT by members of the association. Although counterfactual effect should be considered and actual additional case notification is not clear, it is judged that activities by this association could make a significant impact on TB cases management at the community level. Also, this association might work to reduce stigma at the community. Thus, NTP and partners plan to expand this intervention to another four provinces with significantly bigger populations (Nangarhar, Kandahar, Balkh, and Lagman), considering feasibility. In these 12 provinces, NTP plans to recruit enough ex-patients to cover most districts. Also, NTP plans to introduce the concept of the patient charter not only in these 12 provinces, but also in other 22 provinces through training of health-facility staff. The budget request for this intervention includes cost for training/workshops to establish the association in other 26 provinces and the training of health-facility staff on the patient charter. Also, to increase community awareness, including gender issues, the budget to develop Standard Concept Note Template 10 March 2014│ 39 materials used by CHW or ex-patients and the cost for some campaigns is included. Conducting awareness activities These activities are important to increase awareness for TB and reduce stigma among the general population. However, effectiveness and impact by most approaches have not thoroughly evaluated. Some of these activities have been conducted with the design to evaluate effect by JICA, such as involvement of religious leaders, teachers, and community committee leaders in Nangarhar and Panshijir provinces with significant effects on changing knowledge and subsequent case notification (here is no published document on this). Thus, NTP plans these kinds of activities, including concept of the patient charter in addition to awareness activities on World TB day or some special campaign. The requested budget includes cost for these activities and cost for developing materials for these purposes. 1.5 Collaborative activities with other programs Improving coordination and collaboration with reproductive departments at the national and provincial levels Introducing IPT to high-risk pregnant females As described in the section 3.1, NTP would like to start immediate measures to reduce the burden of TB among females. Among several activities, the requested budget in this intervention includes the cost to improve coordination mechanisms with the reproductive department at the national and provincial levels. For preventive therapy for females with high risks regarding reproductive health, NTP will conduct pilots in several provinces to prove the effectiveness of these interventions within these three years, and the budget for this is also included in this Concept Note. For other interventions, the budget is not included for following reasons: contact management among females will be done in the comprehensive manner of the contact management; training of midwives and gynecological doctors on reproductive risk factors for TB will be incorporated into the current curricula in collaboration with reproductive health department and information; education; and communication materials will be developed by the budget of conducting community awareness. 1.6 Others Training of health facility staffs As mentioned in section 3.1, remediating suspect training of health facility staffs is crucial to acquire proper knowledge on TB and standard operating procedures for case management. Also, training of laboratory technicians is essential to maintain capacity of diagnosis by sputum-smear examinations. Thus, the requested budget includes cost for training doctors, nurses, and laboratory technicians in health facilities. The requested budget will cover minimum numbers of training courses, considering high turnover rate of staff. This budget can cover two trainings for eight regions in the country per year (i.e., 16 trainings total) for each category. These batches will focus on the newly recruited staff (due to staff turnover), and all new contents such as gender, pediatric TB, and the patient charter will be included. It is assumed that 20 persons will participate per batch. These may result in training ten staff members in each province every year for each category, Standard Concept Note Template 10 March 2014│ 40 which is enough to cover turnover of staff on average. Printing and distribution of the guidelines, standard operating procedures, training materials, etc. NTP has provided all necessary documents such as the guidelines and standard operating procedures to all health facilities as the DOTS packages so that all-important documents are easily reviewed by all health care staff. NTP would like to continue the distribution of these packages as some procedures or guidelines must be revised according to international standards. In summary, during year one, 2,500 additional cases will be found, compared to the baseline, and 500 additional cases shall be expected in each year following. Finally during year 3, an additional 3,500 TB cases are expected to be added to the baseline as the direct outcome of slide/sputum sending, screening of child TB, contact management, screening of IDPs and prisoners, and PPM. Other interventions such as EQA, LED microscopes, community approaches, and routine training may bring certain additional gain, and it is expected that about 4,500 additional cases shall be found compared to the baseline and that 1,500 additional cases shall be expected in each year. Finally during year 3, an additional 7,500 TB cases will be added compared to the baseline as the minimum scenario by this funding program. 2. MDR-TB 2.1 Case detection and diagnosis of MDR-TB Establishing and maintaining sample transportation system for MDR-diagnosis Procurement consumables for culture and DST Enhancing quality control for culture examinations and DST Introducing GeneXpert (five units) with diagnostic kits As already described, NTP has successfully launched the MDR-TB program, but still case notification is far below the target. To increase case notification, enhancing current diagnostic methods (culture and DST) is crucial, including sample collection system from targets at peripheral health facilities to reference laboratories. (Targets for MDR-TB screening submit sputum samples slides with reagents for GeneXpert and culture/DST while they receive routine diagnostic procedures with sputum smear examinations.)NTP has already conducted training on sample collection and transportation by support of GFATM R10 support, and key staffs at peripheral health facilities have already received training. Given that is the fundamental of case notification for MDR-TB to ensure access to diagnosis and driven that developing this system brought increased case notification of MDR-TB, proper implementation to maintain this system is crucial. Also, introducing new innovative measures for rapid diagnosis are required to provide treatment in early stages of the disease. In early 2014, NTP introduced GeneXpert for the diagnosis of MDR-TB in NRL, resulting in increased case notification of MDR-TB. Now,NTP plans to introduce GeneXpert into five provinces (Herat in west, Nangarhar in east, Kandahar in south, Balkh in north, and Paktia in southeast). The first four provinces have or will have regional reference laboratories that conduct culture examinations, and staff in those reference laboratories have been or shall be well trained for culture examinations and utilization of GeneXpert. Thus, by this introduction, most of these provinces will have access to Standard Concept Note Template 10 March 2014│ 41 examinations by GeneXpert. Thus, the requested budget includes cost for sample collection and transportation, procuring five GeneXpert and diagnostic kits, and cost for reagents for culture and DST. The system for sample transportation was developed, and most of key staffs at peripheral health facilities have already received training under the GFATM R10 program. Also, cost for quality control of culture and DST by the NRL and SNRL is included. 2.2 Treatment Renovation of TB wards for treatment of MDR-TB cases in five provinces Providing living support for MDR-TB patients For treatment of MDR-TB, as described in the section 3.1, NTP plans to provide 100 beds for MDR-TB treatment in five provinces (Nangarhar, Herat, Balkh, Kunduz, and Kandahar). In addition to the existing 56 beds in Kabul, NTP will be able to provide hospitalized treatment for at least 300 MDR-TB cases per year.(This was already approved in GFATM R10, but due to administrative constraints, the implementation was postponed.) For patient support, NTP provides a fixed amount of support as living support for MDR-TB patients in continuous phase. Patients do not need to spend money for transportation and daily foods in the initial phase as hospitalized service is provided as free of charge. This support will avoid defaulters and work as nutritional support and eventually bring favorable outcome for patients. Thus, the requested budget includes cost for these two activities; a small budget to develop training material on MDR-TB and conducting training for doctors and operational cost mainly for laboratories in MDR-TB hospitals and wards are also included 3. HIS & M&E 3.1 Routine reporting Revision of record and reporting forms Conducting quarterly meetings Conducting supervisory visits Conducting survey This supporting module includes interventions regarding M&E. These interventions do not directly bring impacts on the TB program, but are essential to support the framework of the program. First, NTP must revise all recording and reporting formats, including the electronic reporting system (TBIS). The entire reporting system still relies on the paper, though TBIS serves as an electronic system above the provincial level. In these settings, quarterly review meetings at various levels play key roles in adequate data collection with good quality and providing feedback to health facilities; technical details to conduct those meetings are defined in the guidelines. These meetings have been implemented in all provinces with support by the GFATMR8 program, resulting in significant reduction in missing data and errors in reporting. Thus, it is crucial to continue these activities. Supervisory visits to health facilities also play key roles not only in M&E, but also in improving quality of services of TB control; technical instructions for supervisory visits are defined in the guidelines as well. Standard Concept Note Template 10 March 2014│ 42 Thus, the requested budget in this module includes cost for conducting those interventions and cost for supervisory visits, including visits for urgent supervision in the EQA and visits for other purposes such as management of slide sputum/sending transportation system. Also, as in the section 3.1, the budget to conduct surveys and operational researches is included. 4. Program management 4.1 Policy, planning, coordination, and management As in the section 3.1, MOPH still needs support for basic operational cost of NTP and incentives to NTP staff. Thus, the following budget is requested as the cost for program management. Staff salaries: the staff’s salaries will be adjusted based on National Technical Assistance (NTA) Remuneration policy and the same scales are used among all programs funded by GFATM. Routine operational cost for NTP: This include provision of IT equipment, Internet maintenance cost for sustaining better communication among NTP staff, including provincial levels. The amount is less than that currently supported by the GFATM R10 program. 4.2 Grant management Principal-recipient management costs are requested as 10% of total requested budget; budget for the external mid-term review of the national strategic plan is also included. 5. Measures to mitigate risks for effective program implementation There are certain anticipated risks for effective program implementation. These are described as follows, with measures to mitigate them. In general, as most of interventions and activities shall be implemented at primary health care facilities NTP will strengthen the coordination mechanism with NGOs that are implementers of BPHS. Weak management capacity for implementation of interventions at field level As there is limited number of staff in the NTP central unit and one PTC and one PLC at each province, it is very difficult to manage and monitor all interventions at field level. To mitigate stagnation of interventions and maintain quality, the request of funding includes recruiting focal points to manage and monitor some important interventions, such as PPM, screening of IDPs, and screening of pediatric TB in hospitals. Also, enough budgets are allocated for onsite supervisions for certain activities. Turnover of staff in health facilities To cope with turnover of staff in health facilities, in addition to ordinary training for health facility staff, additional training courses shall be provided as key interventions for which ordinary training course is difficult to cover, such as slide/sputum sending and PPM. Standard Concept Note Template 10 March 2014│ 43 3.4 Focus on Key Populations and/or Highest-impact Interventions This question is not applicable for low-income countries. Describe whether the focus of the funding request meets the Global Fund’s Eligibility and Counterpart Financing Policy requirements as listed below: a. If the applicant is a lower-middle-income country, describe how the funding request focuses at least 50 percent of the budget on underserved and key populations and/or highest-impact interventions. b. If the applicant is an upper-middle-income country, describe how the funding request focuses 100 percent of the budget on underserved and key populations and/or highest-impact interventions. ½ PAGE SUGGESTED SECTION 4: IMPLEMENTATION ARRANGEMENTS AND RISK ASSESSMENT 4.1 Overview of Implementation Arrangements Provide an overview of the proposed implementation arrangements for the funding request. In the response, describe: a. If applicable, the reason why the proposed implementation arrangement does not reflect a dual-track financing arrangement (i.e. both government and nongovernment sector Principal Recipient(s). b. If more than one Principal Recipient is nominated, how coordination will occur between Principal Recipients. c. The type of sub-recipient management arrangements likely to be put into place and whether sub-recipients have been identified. d. How coordination will occur between each nominated Principal Recipient and its respective sub-recipients. e. How representatives of women’s organizations, people living with the three diseases, and other key populations will actively participate in the implementation of this funding request. a. Civil society organizations submitted an Expression of Interest, however following an assessment by the CCM PR Selection Committee against agreed criteria the CCM nominated the MoPH and UNDP as Co-Principal Recipient (PR) (the Co-PRs) of this grant. The minutes of the CCM meeting of 14 July 2014 nominating the Co’PRs was shared with GFATM through CCM secretariat. The Grant Agreement will commence on 1 April 2015 and will be consolidated with the HSS grant under the NFM. b. UNDP and the MoPH will nominate a focal point responsible for coordination. Monthly coordination meetings will be held with UNDP, NTP/HSS/MoPH, SRs and technical partners. A quarterly meeting will be dedicated to reviewing and providing feedback on Progress Updates (PUs), and six monthly meetings will be designated to review management letters from GFATM and examine and refine implementation arrangements. Annual review meetings will be held after receipt of Sub-Recipient (SR) audit reports to prepare and submit Annual Commitment Disbursements Decision request to the GFATM and review implementation arrangements. The Co’PRs will coordinate preparation of joint reports to the GFATM as per the requirements of the grant agreement and the CCM. In addition, the Co’PRs will prepare a joint M&E Plan, and Training and Technical Assistance Plans to ensure synergies and avoid duplication. Joint monitoring missions will be held with the NTP/MoPH, UNDP and the CCM. It will be critical for Standard Concept Note Template 10 March 2014│ 44 the NTP/MoPH and UNDP to engage with the writing teams of the CN for Malaria and HIV to ensure synergies, efficiencies and avoid duplication of activities, as they have already done for the HSS CN. UNDP will coordinate with the MoPH on leveraging additional domestic and international resources for the TB and HSS programme and shall focus on capacity development activities for the transition of the PR’ship to MoPH. c. UNDP has completed a preliminary mapping of the current SRs and PRs under TB grants funded by the GFATM with prospective SRs identified. As far as possible, there will be no change in SRs from the current GFATM grants with the exception of the addition of the current PRs (AFG-809G07-T; AFG-011-G12-T) subject to satisfactory capacity assessments, approved programme activities, value for money and willingness of SRs to continue in their designated function. UNDP, NTP/MoPH and the current PRs, will work together to ensure a smooth transition to the new implementation arrangements. The SRs identified will be those under the BPHS, including MOVE Welfare Organization, Agency for Assistance and Development of Afghanistan, Aga Khan Foundation, Afghan Health and Development Services, Bakhtar Development Network, Afghanistan Center for Training and Development, Humanitarian Assistance and Development Association for Afghanistan (HADAAF), International Medical Corps UK, and Solidarity for Afghan Families. In addition, BRAC and Health NETPro. To ensure a smooth transition to the new implementation arrangements the CO’PRs will request the CCM to appointing a PR transition committee. SR management arrangements - MoPH The proposed implementation arrangements for this grant are based on the standard procedures established by the GoIRA and the MoPH as well as the past recommendations of the GFATM. The SRs involved in the health sector include national and international NGOs with proven experience and capacity having demonstrated expertise under the BPHS. The SRs have been selected through approved transparent procedures established by the MoPH. SR management arrangements - UNDP UNDP has strong systems which ensure requisite resources are available for identifying and assessing SRs and for overseeing the SRs once engaged. Additionally, UNDP carefully addresses and manages potential risks involved in working with SRs, while supporting SRs in implementing effective and sustainable programmes, based on an understanding of their needs and challenges. UNDP will work to build the skills, knowledge and experience of its SRs so that they can successfully implement GFATM programme activities. The capacity building work will focus on the priorities, policies and desired results that have been mutually identified with the NTP/HSS/MoPH and the SR(s) and are in step with other donor funded programmes (e.g., BPHS, SEHAT). A SR Operating Manual will be developed in consultation with national stakeholders drawing on lessons learnt from prior rounds. UNDP Afghanistan will conduct capacity assessments of proposed SRs prior to signing of SR Grant Agreements and transfer of funds. The assessments of SRs capacity and discussions with the SRs will feed into Capacity Development Plans (CDP), to be annexed to the SR Agreements, or included in the SR Annual Work Plans. The CDPs will define a clear and practical plan, schedule, and budget to build capacity in the identified areas of weakness, while maintaining and strengthening capacity in other areas. For more information on UNDP Capacity Development Initiatives please refer to the CD Toolkit. UNDP’s SR agreements will be consistent with the terms and conditions of UNDP's Grant Agreement with the Global Fund. Routine monitoring and evaluation of SR activities will provide UNDP with a strong evidence-baseto inform decision making and propose changes to programming as well as appraise SR funding requests. These reports will be shared during the quarterly meetings with the NTP/MoPH. d. UNDP will nominate a focal point within the Programme Management Unit (PMU) for SR coordination (programme and operations) and will develop the SR Operating Manual in addition to holding regular SR trainings, based on feedback from SRs and performance reviews by UNDP. In addition, as outlined in the previous section UNDP will hold monthly coordinating meetings with the NTP/HSS/MoPH, SRs, and technical partners, to review PUs and implementation arrangements, six monthly performance review and annual review meetings following receipt of Standard Concept Note Template 10 March 2014│ 45 SR audit reports. Coordination of SRs - MoPH Considerable experience with previous GFATM grants ensures close coordination among these relevant units of the MoPH leading to frequent technical and administrative support to monitor project performance in accordance with GFATM grant procedures and the MoPH Terms of Reference. Constant efforts are made to ensure responsible implementation and performance in accordance with GFATM protocols and consistent with MoPH policies, strategies, rules and regulations and in conformance with contractual obligations to achieve planned progress toward stated targets. e. The Co’PRs will strongly encourage the direct involvement of representatives of women’s organizations, people living with the disease and other Key Affected Populations in the design and implementation of programmes. NTP/HSS/MoPH and other national programmes receiving GFATM funding under the NFM (malaria and HIV) and UNDP and partners will request the CCM to convene a sub-committee of representatives of women's organizations, KAPs and people living with the three diseases to be engaged in the review of programme implementation. In the past, a wide range of BPHS implementing NGOs, Provincial Councils, local communities, grass-roots women’s organizations, religious leaders and community leaders have been actively involved in the planning and implementation of GFATM-supported activities and policy discussions. Efforts will be made to ensure similar active participation in future GFATM grant activities. 4.2 Ensuring Implementation Efficiencies Complete this question only if the Country Coordinating Mechanism (CCM) is overseeing other Global Fund grants. Describe how the funding requested links to existing Global Fund grants or other funding requests being submitted by the CCM. In particular, from a program management perspective, explain how this request complements (and does not duplicate) any human resources, training, monitoring and evaluation, and supervision activities. This grant will be a continuation of Rd 8 and 10 GFATM TB grants (AFG-809-G07-T, AFG-011G12-T). The grant will be implemented by MoPH and UNDP in a Co-PR’ship role, which will facilitate coordination with national programmes and key stakeholders (e.g., technical partners, bilaterals). CN development has been coordinated with the strong engagement of all national programmes to ensure synergies and avoid duplication. Compo nent Round HIV Rd 7, TFM (AFG-708G04-H; AFG-708G05-H) TB Rd 8 AFG-809-G07-T Rd 10 AFG-011-G12T BRAC JICA Malari a AFG-809-G09-M AFG-809-G10-M AFG-812-G14-M BRAC, HealthNetPro, Mop Standard Concept Note Template Current PRs MoPH, GIZ CCM Nomination Grant End Dates and Start Dates CN Submission Date UNDP/MoPH 30 Sept 2015 Start Date 1 October 2015 April 2015 31 March 2015, 30 Sept August 2014 2014 UNDP/MoPH Start Date 1 April 2015 30 June 2015 October 2014 TBC UNDP/MoPH 31 January 1 February 2015 2012 10 March 2014│ 46 HSS AFG-S-Mop Mop MoPH, UNDP 31 March 2014 Start Date 1 April 2015 August 2014 The TB and HSS activities of the NFM will be consolidated under one grant agreement, thereby reducing the administrative burden on the PRs, GFATM and LFA (e.g., reporting etc), which will decrease the number of staff required. The CCM and the Co’PRs will discuss with the GFATM Secretariat opportunities for further simplification of grant implementation arrangements in line with GFATM policies (e.g., number of grant agreements, reporting etc) during the preparation of the CNs for malaria and HIV and the grant making process. To avoid duplication of activities and ensure synergies for the three disease components and HSS grants UNDP will work to ensure there is a: 1. Consolidated M&E plan 2. Consolidated PSM plan 3. Consolidated training plan 4. Consolidated technical assistance plan 5. Consolidated capacity development plan 6. Consolidated human resource compensation plan (e.g., incentives, top-ups, salaries) 7. Focal point appointed from each of the national disease programmes (TB, malaria, HIV) and Health Services Strengthening Coordination Unit (MoPH) 8. Joint SR Operating Manual As detailed in Section 4. ‘Implementation Arrangements’ UNDP and the MoPH and partners have acknowledged the need to enhance the coordination between SRs, national disease programmes and other funded programmes, which will be facilitated through the following mechanisms: 1. Monthly coordinating meetings will be held with UNDP and NTP/MoPH, SRs and technical partners; 2. Quarterly meeting will be dedicated to reviewing and providing feedback on PUs; 3. Six monthly meetings will be designated to review management letters from GFATM and examine and refine implementation arrangements; 4. Annual review meetings will be held after receipt of SR audit reports to prepare and submit Annual Commitment Disbursements Decision request to the GFATM; 5. NTP/MoPH and UNDP will coordinate preparation of joint reports to the GFATM as per the requirements of the grant agreement and the CCM; and 6. Standard Operating Procedure (SPO), to ensure maximum impact and engagement of national programmes on HSS, malaria and HIV. To enhance the transparency of GFATM funded activities, the Co-PRs will use a web-based KM platform (Share point) to share key documents with CCM and national partners, donors etc, and to produce a quarterly newsletter. 4.3 Minimum Standards for Principal Recipients and Program Delivery Complete this table for each nominated Principal Recipient. For more information on minimum standards, please refer to the concept note instructions. Principal Recipient 1 Name Ministry of Public Health Gov’t Sector Does this Principal Recipient currently manage a Global Fund grant(s) for this disease component or a cross-cutting HSS grant(s)? X Yes ☐No AFG-S-MOPH grant (EUR 15.8 million) AFG-708-G04-H grant (USD 2.4 million) AFG-809-G09-M grant (USD 1.7 million) Minimum Standards CCM assessment Standard Concept Note Template 10 March 2014│ 47 1. The Principal Recipient demonstrates effective management structures and planning MOPH is responsible for coordinating and managing all financial issues of the Global Fund Grants to Ministry of Public Health, overall including management of grant activities and agreements; disbursement of funds; consolidation of information available on grants and to coordinate all efforts through other relevant departments of MoPH, and to report on consolidated expenditures from the funds provided by the donor. Through this approach, the following results can be expected: 1. Having a well-professional and capable staff inside the MOPH to smoothly implement the grants. 2. Strengthened capacity of the National Programs to effectively and efficiently manage the GF grants. 3. Strengthened health system including TB, HIV/AIDs and Malaria In order to have proper mechanism for grant management, on behalf of MOPH, HSS Coordination Program will be responsible for the entire GF grants in MOPH; therefore Technical and financial staff who are currently involved in grant implementation in MOPH will be part of this team as per the scope and load of work; meanwhile, this team shall be having close coordination and communication with national programs and relevant departments. The team who are currently managing almost USD 20 million of GF HSS grant will be responsible for NFM grant as well and this team is composed of; Senior Technical Consultant with more than 8 years experiences in the Global Fund grant, Technical Officers, finance team (having Master degrees in finance), procurement staff, M&E Experts and Grant Consultants. To effectively implement the Global Fund grants in MOPH, a team of few members will be working as Co-PR for all Global Fund grants under the Health System Strengthening Coordination Program. This team will be led by a team leader and the team leader will be reported to the head of HSS Coordination Program 2. The Principal Recipient has the capacity and systems for effective management and oversight of sub-recipients (and relevant sub-sub-recipients) Standard Concept Note Template MOPH has rich technical experience and developed an extensive network of sub-recipients (NGOs) for training of community health nurses, provision of Laboratory services and bringing improvement in national HMIS through GFR support, which is clear from the number of projects implemented and managed by HSS Department of MOPH. MOPH has extensive knowledge about the requirements set by the Global Fund and on the roles assigned to the PR. MoPH M&E staff are well trained and experienced in monitoring and evaluating HSS component in the country. The teams – including finance, logistic and program staff – have attended a number of GF related meetings in the 10 March 2014│ 48 region. MoPH is aware of the reporting requirements and formats, the role of LFA and how to communicate with them. MoPH is familiar and has direct experience with the mechanisms for monitoring sub-recipients. MoPH understands that the selected PR will be legally responsible for program results, financially accountable, manage a number of sub-recipients, receive periodic disbursements of funds directly from the GF Trustee accounts and these funds towards the implementation of the proposed activities. MoPH also understands that the PR should provide periodical reports to LFA and monitor the performance of SR(s). MoPH proposes to use the existing resources within ministry while adding to its strength to fulfill its role as PR. a. Sound financial management is critical to project implementation and hence the achievement of the desired development objectives. Relevant, reliable and timely financial information provides a basis for better decision-making, improved management of physical and financial resources, and efficient implementation of project activities. An effective financial management system is vital for development projects because of the need to deliver services to target groups/people quickly over a large geographic area. Following are some points, which a smooth Financial Management System provides: b. Essential information to those who manage, implement and supervise projects; Comfort to stakeholders (SRs and SSRs) and the donor community that funds have been used efficiently and for the purpose intended; and a deterrent (discourage) to fraud and corruption, because the incorporate strong internal control and transparent financial reporting systems which identify unusual occurrences and deviations. c. Financial management, procurement and audit functions for the government Development Projects (discretionary) will be undertaken through the agents contracted under the Public Administration Capacity Building project and non-discretionary project will be undertaken through the donor agent (LFA) respectively. This is the primary instrument for continuing to strengthen the fiduciary (involving trust) measures put in place for ensuring transparency and accountability of funds provided by donor (Global Fund). d. MOPH technical staff is responsible for planning, coordination of stakeholders (amongst the MOPH departments, SRs LFA and donor), HR related issue, decision making related to GF and SRs technical areas and the finance team of HSS grant funded by the Global Fund is responsible for Standard Concept Note Template 10 March 2014│ 49 e. f. g. h. maintaining all financial records of the project based on all contracts signed by both parties of contract. Any financial record/transaction is processing under the government of Afghanistan laws and regulations. HSS finance team of DBD has managed USD 34 million of GAVI project for 5 years and currently managing USD 20 million from the ongoing Global Fund HSS grant (single stream funding). Each grant was audited at the end of each year and the reports of audit have been shared with the GAVI, Global Fund and LFA. To build or strengthen financial management and other fiduciary capacity has been prepared, the Project will make sufficient resources available in Special Account to successfully implement the action plan within the agreed timetable and before project implementation begins. HSS Project will normally use a Special Bank A/C in central bank of Afghanistan for the smoothly running of Project transactions. DBD section of HSS project (funded by the Global Fund) are visiting from SRs offices in capital to verify the expenses reports of any SRs (vouchers checking), while SRs are reporting to PR. MoPH development projects, Financial Managements Unit are gathering under the deputy minister of Finance and admin meetings each month. It discusses the problems and obstacles in financial documentation and record as well as finds the solutions for its problems. The Budget Department of the Ministry of Finance has the responsibility to work with the Line Ministries to develop and formulate the annual budget for Afghanistan. They manage the budget process by providing guidance to Line Ministries through Budget Circulars and other instructions. The Accounting Information System (or Treasury) is not used in the budget formulation process other than to provide historical expenditure data and other financial reports. However, the Accounting Information System is essential to budget execution after the annual budget has been approved by Parliament and the Budget department of MoF. 3. The internal control system of the Principal Recipient is effective to prevent and detect misuse or fraud Standard Concept Note Template A key internal control process under the cash basis of accounting is the reconciliation of bank Statements with accounting records. Internal control procedures of all MoF and other policies are keys to eliminate waste, abuse and fraud in the GoIRA. A key tool in the budget execution process is AFMIS as it is used to record budget transactions including appropriations, allotments and sub-allotments. Commitment is 10 March 2014│ 50 recorded for projects in the development budget. In addition, AFMIS has several internal controls built into its design and use. Specifically, each level of budget execution (appropriation, allotment, expenditure, etc.) cannot be processed unless the previous level has been completed and recorded in AFMIS. For example, no allotments can be made unless an appropriation has been approved and recorded in AFMIS or no expenditure can be made without an allotment. In addition, total transactions of one budget execution level cannot exceed the recorded amount of the previous level, e.g. sub-allotments cannot exceed allotments. Each step of budget execution is processed using a budget form. They are as follows: B‐3 –Approved Budget (Appropriations) B‐20 – Sub-allotments B‐23 – Request for Budget Transfer B‐27 ‐ Allotments And other forms such as PCS (project coding sheet), B2 (Commitment) Since AFMIS has enabled the Ministry of Finance to centralize budget execution process as per the requirements of the PEFML (Public Finance and Expenditure Management Law), much of budget execution is the responsibility of the Treasury, specifically the Allotments and Commitments Unit. Primary and secondary budget units also play an important role in budget execution. Non‐salary expenditures in the Ordinary Budget are the most common and typical type of transactions and all other transaction types are a variation of the processes detailed in this Section. Specifically, the roles and responsibilities identified in each step of the scenarios and the different internal controls will be the same or similar for other procedures with modifications. In addition, internal controls and procedure steps will vary between transactions completed at the Treasury and those completed at the Mustofiats (Provincial Finance office). Therefore, additional steps and internal control requirements for Mustofiats are highlighted. Disbursements of expenditure can either be made using direct deposits from Treasury bank accounts or the issue of checks directly to bonded trustees. However, the accounting procedure will be same in either case until the disbursement step. Therefore each scenario is applicable to both types of payments (i.e. checks or direct deposit). The most vital toolkit of control system reconciliation is performing in various conditions. Each financial institution is reconciling monthly, quarterly, semi-annual and annually reports of Ministry of Finance along with Bank Statements and line ministries expenditure reports. Standard Concept Note Template 10 March 2014│ 51 4. The financial management system of the Principal Recipient is effective and accurate 5. Central warehousing and regional warehouse have capacity, and are aligned with good storage practices to ensure adequate condition, integrity and security of health products Standard Concept Note Template Financial management under the scope of MOPH through the Global Fund NFM grants would be the responsibility of the assigned finance team who are working under the Global Fund HSS current grants. In order to further ensure transparency and accountability, the head of relevant program/department will sign the relevant documents prior to processing by finance team. All financial procedures should be complied with rules, regulations and agreed working procedures of the Government of Afghanistan, Global Fund requirements and approved budget/work plan. Project financial management is a process which brings together planning, budgeting, accounting, financial reporting, internal control, auditing, procurement, disbursement, and the physical performance of the project’s activities with the aim of managing resources to achieve the planned/targeted objectives. Development Budget Department (DBD) of The Global Fund which is headed by the Finance Manager that will provide all the support and guidance for establishing a proper financial management and accounting system within the frame work of Government of Islamic Republic of Afghanistan and with The Global Fund rule and regulation. MoF has introduced a financial database (Budget & Expenditure Tracking database) especially designed for the financial management of the entire development project within all ministries of Afghanistan. The financial database is a kind of software that can produce basic books of cash book, ledgers, different allotment, expenditure disbursement forms (M16, B27 etc.) and different kinds of financial reports to MoF and donors (rarely, because every donor required different form of report). MoPH has developed ample in-house capacity and has put standard procedures into practice for procurement. Besides, MoPH is well aware of and knowledgeable about the content of the policy documents of the GFATM including Procurement and Supply Management, Performance Based Funding, and Fiduciary Arrangements for Grant Recipients. These policy documents will be the guides for playing the role of PR for the GF NFM grants. Upon renovating the regional labs, warehouse was considered not only to have enough space, but also to be equipped with refrigerators and freezers to keep all health products in good conditions until used. The Central Lab, although it has reliable facility, but it will need to expand to accommodate the newly established network demands’ i.e. more health products will be ordered for the regional and provincial labs. These products may need more space than the available. Currently, it can absorb the needs. Future use will need some rehabilitation and space expansion. 10 March 2014│ 52 6. The distribution systems and transportation arrangements are efficient to ensure continued and secured supply of health products to end users to avoid treatment/program disruptions 7. Data-collection capacity and tools are in place to monitor program performance 8. A functional routine reporting system with reasonable coverage is in place to report program performance timely and accurately MoPH has developed ample in-house capacity and has put standard procedures into practice for procurement. Besides, MoPH is well aware of and knowledgeable about the content of the policy documents of the GFATM including Procurement and Supply Management, Performance Based Funding, and Fiduciary Arrangements for Grant Recipients. These policy documents will be the guides for playing the role of PR for the GF NFM grants. Upon renovating the regional labs, warehouse was considered not only to have enough space, but also to be equipped with refrigerators and freezers to keep all health products in good conditions until used. The Central Lab, although it has reliable facility, but it will need to expand to accommodate the newly established network demands’ i.e. more health products will be ordered for the regional and provincial labs. These products may need more space than the available. Currently, it can absorb the needs. Future use will need some rehabilitation and space expansion. Health products will be flowing swiftly from the central level to the regional level which in turn will take the responsibility to distribute the products to the provincial and district lab levels. Transportation is available either by road or by flights, namely UN domestic flight through WHO pouch. Cold chain of Polio Eradication Program is now everywhere in Afghanistan and if need be, this polio eradication network will be used to cover remote areas as necessary. Data Collection Capacity and Tools: Two main capacities are exist: At central level the M&E focal points collecting, analyzing, interpreting and using the data, and preparing report on the base of analysis. Data entry is also one of the tasks. At provincial level the PPHOs, are doing the same activities. The M&E Directorate developed several checklists for monitoring of Health facilities, like: NMC (National Monitoring Checklist), HNCM (Hospital National Monitoring Checklist), Lab Checklist, CHNE Checklist (Community Health Nursing Education Checklist) HMIS tools (several monthly reports like; MIAR, HMIAR, MAAR, MAR… HFA tools for Balance score card A functional routine reporting system with reasonable coverage is in place to report program performance timely and accurately. HMIS is covering 93 % of Public Health Facilities which 97 % of which provide timely reporting, the quality of HMIS for Standard Concept Note Template 10 March 2014│ 53 specific indicators, assessed by third party is more than 90%, but for complete system the quality of data need to be improved. The utilization also there are some good evidence that could show us how well HMIS data utilized but at programs level there are huge gap and need some efforts and investment to strengthen data use. 9. Implementers have capacity to comply with quality requirements and to monitor product quality throughout the in-country supply chain The whole process of supply chain will be carried out by MoPH Lab Staff with minor support from WHO as necessary. Lab staffs are well trained in sample collection and transportation which will reflect positively on the distribution of goods and kits. In case of shipping bulky items or pouch is sent by air, lab technicians will prepare the shipment and also lab staff at the other end will be responsible of collecting the goods to keep it at the optimum conditions. The key aim of this approach is to provide joint efforts and venture to the National Control Programs including TB, HIV/AIDs, Malaria and HSS and further opportunity to build their capacity in technical management of the grants, including financial management, M&E, PSM and. In order to realize a full integration of the GF grants in health system, it was envisaged that eventually programmatic and financial aspects would be brought down at the level of the individual programs. The available human resources who are funded by the Global Fund and GAVI grants will be used for the better implementation of the NFM grants and they will be fully involved with national programs/departments in grant implementation. As HSS will be responsible for the entire NFM grants of MOPH; therefore technical, financial and procurement staff who are currently involved in grant implementation will be part of this team; meanwhile, this team shall be having close coordination and communication with national programs and relevant departments. Ultimately this approach will assist the national programs and HSS to have better understanding with other PR in order to effectively manage the M&E, PSM and financial activities of the grant. 10. 4.3 Minimum Standards for Principal Recipient (PR) and Program Delivery Complete this table for each nominated PR. For more information on Minimum Standards refer to the Concept Note Instructions. PR 2 Name UNDP Standard Concept Note Template Sector Multilateral 10 March 2014│ 54 Organization Does this principal recipient currently manage a Global Fund stand-alone crosscutting HSS or a disease component grant(s)? X Yes ☐No UNDP is PR in 25 countries and a regional programme (South Asia, 7 countries), managing 53 grants Minimum Standards CCM assessment 1. The principal recipient demonstrates effective management structures and planning 2. The principal recipient has the capacity and systems for effective management and oversight of Sub-Recipients (and relevant Sub-Sub-Recipients) 3. The internal controlsystem of the principal recipient is effective to prevent and detect misuse or fraud 4. The financial management system of the principal recipient is effective and accurate 5. Central warehousing and regional warehouse have capacity, and are aligned with good storage practices to ensure adequate condition, integrity Standard Concept Note Template UNDP will implement programmes in accordance with its rules and procedures (Article 2 Standard Terms and Conditions of the Grant Agreement). The Programme and Operations Policies and Procedures (POPP) are the basis for all aspects of UNDP operations. UNDP' systems are designed to ensure transparency, accountability, cost effectiveness and value-for-money. A Programme Management Unit (PMU) will be established under supervision of UNDP senior management, with support from UNDP's Global Fund Partnership Team and other UNDP Country Offices bringing in global experience to the PR role. UNDP has strong systems which ensure resources are available to identify and assess SRs and to oversee the SRs once engaged. Additionally, UNDP carefully addresses and manages potential risks associated with working with SRs, while supporting SRs in implementing effective and sustainable programmes, based on an understanding of their needs and challenges. UNDP's internal control system (ICS) is effective in preventing and detecting misuse or fraud. The ICS ensures consistent adherence to policies and procedures and compliance with its grant agreement with the Fund. UNDP's risk management tools and processes have been integrated into one comprehensive system, enabling the organization to identify, prioritize and manage risks from all sources, to inform decision making related to programme management, serve partners and achieve development results. UNDP has a special audit regime for GFATM funded grants, which has been agreed to with the GFATM. All audit reports are available on UNDP's public website. As detailed above, UNDP financial managements systems for the implementation of GFATM funded programmes are been approved by GFATM and no additional capacity assessment is required. As detailed above, UNDP procurement systems for the implementation of GFATM funded programmes have been approved by GFATM and no additional capacity assessment is required. Under this programme, UNDP has a 10 March 2014│ 55 and security of health products 6. The distribution systems and transportation arrangements are efficient to ensure continued and secured supply of health products to end users to avoid treatment / program disruptions 7. Data-collection capacity and tools are in place to monitor program performance 8. A functional routine reporting system with reasonable coverage is in place to report program performance timely and accurately 9. Implementers have capacity to comply with quality requirements and to monitor product quality throughout the Standard Concept Note Template limited volume of procurement of health commodities. Although UNDP currently does not have warehousing services dedicated to pharmaceutical and health commodities, UNDP will sub-contract such facilities and ensure they adhere to UNDP standards, which are in line with the WHO. See Section 5 UNDP has extensive experience in obtaining reliable data for monitoring programme performance, which is part of routine processes in its programming practice as well as in the technical and capacity development support UNDP provides to government and CSO partners. Ideally, monitoring data originates or is collected from national sources dependent on data availability and quality. In an increasing number of countries, analytical data comes from national development information systems. Specific attention is given to establishing baselines, identifying trends and data gaps, and highlighting constraints in country statistical and monitoring systems. In Afghanistan, UNDP assists regularly in Household Income and Expenditure surveys analysis in partnership with stakeholders. All monitoring efforts in UNDP address the following at a minimum: - Progress towards outcomes; - Factors contributing to impeding achievement of the outcomes (this necessitates monitoring the country context and closely link to risk management); and - Individual partner contribution to the outcome through outputs. UNDP has an extensive monitoring and evaluation capacity and works towards a robust monitoring system through effective policies, tools, processes and systems so that it can meet the multiple monitoring challenges it faces. While the prime objective of monitoring in UNDP is achievement of results, it is also necessary to monitor the appropriate use of resources at all levels. UNDP does this through monitoring at three levels: outputs and projects, outcomes and programme alignment with the key reference for monitoring which is the M&E framework associated with the grant documents. UNDP has extensive knowledge of the GFATM Quality Assurance policy and has systems in place to comply with it, including procurement 10 March 2014│ 56 in-country supply chain 10. Capacity building of programme staff and SRs systems that ensure supply of quality-assured products. A quality assurance plan will be developed to ensure that all aspects of quality assurance will be monitored, it will cover the following areas: product selection, international transport, transit, reception, quality control, central storage, peripheral storage, distribution, waste management, pharmacovigilance, rational use and development of capacities. Quality control will be performed at reception of the medicines in country and along the supply chain. The national medicines regulatory authority will be the key national partner in this area. UNDP’s role as Principal Recipient is an interim arrangement that lasts until one or several national entities (i.e.: government entities and/or CSOs) are ready and able to take over grant implementation. While supporting countries in implementing grants and ensuring timely delivery of services, UNDP also helps develop the capacity of national entities to take over this PR role. UNDP has robust systems and processes for CD work in the context of GFATM programmes. For more information on UNDP Capacity Development Initiatives please refer to the CD Toolkit. 4.4 Current or Anticipated Risks to Program Delivery and Principal Recipient(s) Performance a. With reference to the portfolio analysis, describe any major risks in the country and implementation environment that might negatively affect the performance of the proposed interventions including external risks, Principal Recipient and key implementers’ capacity, and past and current performance issues. measures (including technical Type Risk Mitigation Strategic b. Describe the proposed risk-mitigation assistance)included in the funding request. Dependency on donor funding: despite strong commitment of the Government and MoPH, the total government expenditures on the national TB control program (NTP) were less than 9% of total amount of the necessary budget as reported in the TB Global Report (2014). The TB control budget heavily relies on partners such as GFATM, USAID, JICA, WHO, CIDA and Italian cooperation. Such dependency poses risks associated with sustainability of funding and So far, significant external funding has been secured for NTP in Afghanistan. Advocacy efforts will continue to ensure donors’ pledges and timely disbursements of funds. International support is being withdrawn slowly to allow gradual increase of domestic funds. NTP is a priority for the Government. In line with the NSP Strategic Direction 1 (Enhancing Political Commitment and DOTS expansion), NTP along with stakeholders continues advocating for an increase of the domestic funding for TB care. The MoPH in consultation with the stakeholders will prepare accurate budget plans with allocations for prioritized interventions/projects. NTP will implement the initiatives with proven costefficiency. Standard Concept Note Template 10 March 2014│ 57 Programmatic timely availability of funds in the country. Insufficient budget allocation for NTP. The funding gap (45% NSP 20152017) adversely impacts implementation of the National Strategic Plan for 2014-2018, especially with regard to costly MDR-TB interventions. Insufficient funding poses a risk for sustainability and consolidation of the recent gains of the Afghan NTP. Weak coordination between stakeholders involved in TB control activities including the NTP central and provincial teams. Weak coordination poses the risk of duplication of activities and ineffective use of resources. Low implementation capacity of health facility staff. The low implementation capacity is due to different factors including: lack of qualified staff; high turnover of health workers; and lack of mechanisms to ensure adherence to the SOPs and guidelines. The risk correlates with remoteness of the service delivery point. Standard Concept Note Template It has been acknowledged that efficient coordination and information mechanisms exist in MoPH Afghanistan, which help with avoiding duplication of efforts and resources by various partners. The TB-TEAM is working in the country, and some members of the CCM are also on the team. In addition, the NTP is conducting national and provincial meetings at the end of each quarter and there is also the monthly Provincial Health Coordination meeting. The TB Task Force meets regularly at the NTP; the meetings are attended by relevant NTP managers and stakeholders. On the community level the TB Patients Association helps with coordination of community-based activities and partnership building. With regard to the GFATM grant, coordination mechanism between UNDP, MoPH, SRs, donors and other stakeholders (women’s groups and KAPs) will be established by: Clearly defining the roles and responsibilities of all parties (refer Section 4.1. and 4.2 above) With regard to strengthening the coordination between NTP central and provincial levels, the current CN includes funding for NTP operational costs, including internet communication, and for systematic monitoring visits and follow-up meetings. In line with the NSP Strategic Direction 2 (Strengthen the Human Resource Development), the current CN includes a series of capacity development activities: Initial and Refresher DOTs trainings (medical doctors and nurses) Trainings for diagnostic facilities staff (LED-FM, DST, etc.) Drug management trainings Community-based DOTs trainings for community health workers MDR-TB case management NTP recently developed a decentralized training system and updated training curricula based on a needs assessment. Quality of trainings will be improved through the use of standard (e.g. WHO) 10 March 2014│ 58 Potential for high staff turnover within the MoPH due to the ministry’s compliance with GFATM conditions regarding implementation of national salary scales for all programmes. This risk could extend to have an impact on the achievement of programme targets. Lack of involvement from the private sector, due to factors such as reluctance, and no mechanisms for monitoring private sector activities and performance. NTP’s capacity to provide adequate coverage of supervision visits (due to remote areas, logistics, and safety) so as to ensure quality of TB services in all service delivery points. The quality of MDR-TB case management might be affected due to insufficient capacity of the TB doctors, and inadequate laboratory support for treatment monitoring and timely detection of side effects, especially during out-patient treatment. High default rates among MDR-TB cases over 2 year period of treatment. As experience from other countries has shown, it is extremely challenging to keep MDR-TB patients in treatment over the 2 year period necessary for successful completion of treatment, especially when providing out-patient care. The reasons are various, and include: cost of transportation to health Standard Concept Note Template modules, engagement of master-trainers, and M&E. Funding is requested for salary top-ups as means of retaining health workers. Also funding is requested for M&E of the programme, which will contribute to ensuring adequate implementation. Monitoring implications of compliance with GFATM conditions and developing mitigation plan in consultation with NTP/MoPH, GFATM and other donors. Required staff for health facilities will be recruited from the local community. Involvement of the private sector will be executed in line with the NSP Strategic Direction 7: Engage all care providers, with strong support from the MoPH. Funding is requested to hire M&E personnel in each province. Regular M&E workshops will be conducted to identify issues in a timely manner Policy engagement between MoPH (Private Health Directorate), Afghan Private Health Association and other relevant ministries. Funding is requested to cover the cost of an adequate number of supervision visits, and programme activities will take place in relatively easy to access areas to ensure adequate monitoring of grant implementation. Funding is requested for trainings of health workers on MDR-TB case management as well as trainings for diagnostic facilities staff, refurbishing of laboratories and new diagnostic equipment. 5 wards will be renovated in five main provinces by this grant. Funding is requested for patient living support. Strengthening the reference system. Considering high defaulter rate in NTP quarterly review meetings. 10 March 2014│ 59 PSM facility, psychological considerations, development of side effects, need to work, family support etc. Timely and consistent availability of health products and pharmaceuticals. Relevant factors for consideration include: Complicated preexisting financial and procurement systems in the MoPH. All 1st and 2nd line TB drugs as well as laboratory kits for sputum microscopy will be procured by the NTP through the Government of Japan funding. An intricate financial and procurement process may delay the arrival of the health products on which GFATM grant activities depend. Capacity to accurately calculate needs Lack of experience in ordering luminescent kits and Xpert cartridges with short shelf life (estimated need is2 orders per year) taking into account buffer stocks and expiry dates Capacity for development of specifications, e.g. for new lab equipment may be lengthy Capacity to monitor stocks and provide early notification of potential shortage and expiration, as well as notification of excess stocks Shortage of quality assured 2nd line TB drugs on the global market due to high demand. This may lead to delays or interruption in supply flow, or availability of drugs with a short shelf life, which might not be utilized before expiry date Storage conditions for reagents and TST, especially in remote facilities Standard Concept Note Template This will be mitigated through: Coordination and information sharing between GFATM grant and other programmes Early initiation of the procurement cases Ensuring buffer stocks are in place Enhancing capacity of NTP for demand forecasting Monitoring stocks of TB drugs and lab reagents on a quarterly basis Training on drug management for all provinces (Gov’t of Japan). Establishment of the DMIS (Gov’t of Japan). Regular in field visits (Gov’t of Japan). Drug inventory in health facilities will be reviewed in ¼ ‘ly NTP meeting. Based on lessons learned in other countries, procurement of 2nd line TB drugs should be initiated approximately 1.5 years in advance of the required delivery to NTP. Special attention will be given to shelf life of the 2nd line drugs. Terms shall be agreed with the procurement agent. See above item for other mitigation measures. Allocation of proper storage facilities for anti TB drugs will be reviewed and reflected in the PSM Plan in accordance with international standards. 10 March 2014│ 60 Country context TSD reagents will be stored at DHC and upper level facilities where refrigeration is available. This risk will be mitigated through: Careful development of specifications for procurement of appropriate medical equipment Capacity building on use of the procured equipment, e.g. LED microscopy trainings The equipment purchased through the GFATM grant will be procured by the PR through its procurement agent, and the contracts will include the cost of calibration and maintenance The fund requested for maintenance of LED and GeneExpert. Challenges associated with maintenance and repair of procured medical equipment. This might be due to: Lack of capacity to develop specifications which may result in procurement of inappropriate equipment that is either too sophisticated or unsuitable for the room size or national electricity parameters. Lack of capacity to use equipment, e.g. annual calibration of Xpert machines Insufficient local market for maintenance and repair of medical equipment Renovation work, which is The following factors are considered for risk scheduled to take place in 5 mitigation: provinces. Associated risks Careful estimates of the budget for include poor building renovation conditions, logistical delays, Early initiation of the renovation work and unforeseen expenses. Strict monitoring by the PR throughout Untimely completion of In the case of insufficient funds, reallocation renovation work may cause will be considered within the current grant subsequent delays with enrolment of MDR-TB cases. Logistical and safety Comply with considerations for UNDSS security arrangements implementation of activities Contract security e.g. - slide collection and services for physical security. transportation, home visits, Obtain security and active case findings clearances for internal travel among IDPs. Risks include: Conduct conflict Potential risk of injury or assessment as part of selection of districts death to project staff and Contract external contractors organizations where required Delayed or rescheduled activities Lack of security in provinces and districts in which UNDP-JHRA will carry out programming. This impedes project implementation and impacts the ability to monitor activities through field Standard Concept Note Template 10 March 2014│ 61 assessment. Leadership and organisational change among GoA and partners, caused by political campaigning, Presidential and PC elections, and subsequent appointments Weak capacity of national Sub-recipients (SRs) to comply with GFATM reporting requirements PR’s capacity to ensure adequate coverage with monitoring visits (e.g. to remote areas, given safety considerations) for supervisory and verification purposes Support organizational and individual capacity development for sub national partners and a broad range of technical specialist and tashkeel personnel, to minimize the impact. The following factors are considered for risk mitigation: Coordination mechanism between co-PRs, through proposed PMU structure Robust capacity assessment process and contracting process UNDP’s strong experience with management of SRs, including the development of an SR Management Manual, trainings, and a robust audit process Develop and implement SR Institutional Development and Capacity Building plans The grant budget provides for monitoring staff. There will be strong coordination of monitoring between PR, other UNDP programmes, and other donors. The MoPH and UNDP have agreed to have one monitoring plan for all grants, to ensure synergy and efficiency. A plan to ensure monitoring visits to remote and priority areas will be completed. CORE TABLES, CCM ELIGIBILITY AND ENDORSEMENT OF THE CONCEPT NOTE Before submitting the concept note, ensure that all the core tables, CCM eligibility and endorsement of the concept note shown below have been filled in using the online grant management platform or, in exceptional cases, attached to the application using the offline templates provided. These documents can only be submitted by email if the applicant receives Secretariat permission to do so. ☐ Table 1: Financial Gap Analysis and Counterpart Financing Table Standard Concept Note Template 10 March 2014│ 62 ☐ Table 2: Programmatic Gap Table(s) ☐ Table 3: Modular Template ☐ Table 4: List of Abbreviations and Annexes ☐ CCM Eligibility Requirements ☐ CCM Endorsement of Concept Note Standard Concept Note Template 10 March 2014│ 63 ANNEX 1: ACRONYMS ACSM BHC BPHS BRAC CHC CHW DH DMIS DOTS DST EPHS EPI EQA HF HIS HMIS HIS HSS IDP IMCI IPT JICA M&E MDR-TB MOPH NACP NRL NTP OPD PPM R4 R8 R10 REACH RMNCH SHC SS+ TB TBIS TST UN UNCHR USAID VCT WHO Advocacy, communication and social mobilization Basic health center Basic package of health services Bangladesh Rural Advancement Committee Comprehensive health center Community health worker District hospital Drug information system Directly observed treatment, short course Drug susceptibility testing Essential package of health services Expanded program for immunization External quality assurance Health facility Health information system Health management information system Health Information System Health system strengthening Internally displaced person Integrated management of childhood illness Isoniazid preventive therapy Japan International Cooperation Agency Monitoring and evaluation Multi-drug resistance tuberculosis Ministry of Public Health National AIDS Control Program National Reference Laboratory National Tuberculosis Program Out-patient department Public private mix Round 4 Round 8 Round 10 Rural Expansion of Afghanistan’s Community-based Healthcare Reproductive, maternal, newborn, and child health Sub–health center Sputum smear positive Tuberculosis TB information system Tuberculin skin testing United Nations United Nations High Commissioner for Refugees United States Agency for International Development Voluntary counseling and testing World Health Organization Standard Concept Note Template 10 March 2014│ 64 UNDP United Nations Development Program Standard Concept Note Template 10 March 2014│ 65 ANNEX 2: REFERENCE LIST NTP, National Strategic Plan 2014-2018 Detail budget plan of Concept note TB Epi Assessment report ,2013 Assessment report of Key Affected Population (KAP) and People Living With Diseases (PLWD) Standard Concept Note Template 10 March 2014│ 66
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