MARCH 26e29, 2015
statistically lower number of abnormal aortic stiffness index than the
ischemia group (p<0.001)
Conclusion: Aortic stiffness index and distensibility, parameters
measuring aortic elasticity, may improve diagnostic accuracy of singlephoton emission computed tomography MPS, especially in suspected
cases with the equivocal results.
O
R
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L
A
B
S
T
R
A
C
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- OP-178
Galectin-3 Levels in Hypertrophic Cardiomyopathy and
the Relationship with Left Ventricular Mass Index and
Function. Selcen Yakar Tuluce1, Kamil Tuluce2,
Sadık Volkan Emren1, Zehra Ilke Akyildiz1. 1Izmir Katip
Celebi University Ataturk Training and Research Hospital,
Department of Cardiology, Izmir, Turkey; 2Karsiyaka State
Hospital, Department of Cardiology, Izmir, Turkey.
Figure. ROC curve for sensitivity and spesiﬁcity of aortic stiffness index value in discriminating ischemia on myocardial perfusion
scintigraphy.
Table
Normal
Group
(n¼55)
Age
Gender (F/M)
BMI
DM n (%)
HT n (%)
Cigarette smoking n (%)
Family history of premature
CAD n (%)
Hyperlipidemia n (%)
SBP (mmHg)
DBP (mmHg)
LVEF (%)
Mitral E/A ratio
Mitral anulus TDI Em/Am
Diastolic Function
Normal (%)
Grade I DD (%)
Grade II DD (%)
Grade III DD (%)
ASI
AD (1/(103xmmHg))
Equivocal
Group
(n¼54)
Ischemia
Group
(n¼40)
5611
5511
569
35/20 (64/36) 32/22 (59/41) 20/16 (60/40)
305
30 6
314
16 (29)
12 (22)
11 (27)
30 (54)
27 (50)
18 (45)
9 (16)
10 (19)
9 (22)
8 (14)
4 (7)
4 (10)
p value
0.596
0.884
0.154
0.669
0.654
0.750
0.483
8 (14)
12415
786
633
1.150.52
1.160.60
4 (7)
12410
795
634
1.240.42
1.370.59
6 (15)
13213
786
623
0.760.16
0.690.27
0.404
<0.005
0.200
0.237
<0.001
<0.001
27 (49)
26 (47)
2 (4)
0 (0)
2.610.48
5.983.05
32 (59)
18 (33)
4 (8)
0 (0)
2.600.49
5.962.75
6(15)
34 (85)
0 (0)
0 (0)
3.800.38
1.590.98
<0.001
<0.001
Background: In hypertrophic cardiomyopathy (HCM) cardiac ﬁbrosis
is an important contributor of adverse left ventricular (LV) remodelling
and arrhythmias. Galectin-3 (Gal-3) is a novel marker of cardiac ﬁbrosis
and inﬂamation. In this study we investigated the levels of Gal-3 in
patients with HCM and control subjects and assessed the relationship
between Gal-3 levels and echocardiographic indices using strain
echocardiography.
Methods: Forty patients with HCM and 35 healthy control subjects
were enrolled. Global LV strain and strain rates, LV mass index (LVMI)
of all subjects were assessed by echocardiography. Galectin-3 levels of
all subjects were measured.
Results: Global LV longitudinal strain (13.374.6% vs.
18.932.5%, p<0.001) and strain rate (0.660.22 vs. 1.080.14,
respectively; p<0.001) values were lower in patients with HCM than in
those of controls. Levels of Gal-3 were signiﬁcantly higher in patients
with HCM than in controls (16.36.74 ng/mL vs. 13.213.42 ng/mL,
p¼0.017). The Gal-3 levels were associated with thickness of interventricular septum (r¼0.444, p¼ 0.004) and LVMI (r¼ 0.365,
p¼0.021) (Fig.1) however were not associated with global LV longitudinal strain (p¼0.42) and strain rate (p¼0.28).
Conclusion: Galectin-3 levels are increased and related with the
degree of LV hypertrophy in patients with HCM. In patients with
HCM, Gal-3 seems to be not a good marker of decreased myocardial
functions.
Clinical, echocardiographic and demographic data of the groups.
BMI: Body mass index; DM: Diabetes mellitus; HT: Hypertension;
CAD: Coronary artery disease; SBP: Systolic blood pressure; DBP:
Diastolic blood pressure; ASI: Aortic stiffness index; AD: Aortic
distensibility; LVEF: Left ventricle ejection fraction; TDI: Tissue
Doppler imaging; DD: Diastolic dysfunction.
accepted as abnormal, frequency of abnormal aortic stiffness index in
the normal, equivocal, and ischemia groups were 11%, 19%, and 98%
respectively. The equivocal group had similar frequency of abnormal
aortic stiffness index compared to the normal group (p¼0.262) while
Figure. Correlation between Galectin-3 level and left ventricular mass
index.
S80 The American Journal of Cardiologyâ MARCH 26e29, 2015 11th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY
AND CARDIOVASCULAR SURGERY ABSTRACTS / Oral