Poster Session III
Saturday, May 30; 16:00-18:00
Imaging: Radiometals
126
Stability comparison study using gel electrophoresis and radio-HPLC
Heesu Ahn (National University School of Medicine, Korea)
127
Synthesis and in ovo evaluation of the neuropeptide cathelicidin 89Zr-CATH2
Gert Luurtsema (University of Groningen, Netherlands)
128
Synthesis of 99mTc(CO)3 labeled 2-(4-chloro)phenyl-imidazo[1,2-a]pyridine analog (99mTc-CB256) as a new
TSPO-selective SPECT radiotracer
Ji Young Choi (Seoul National University Bundang Hospital, Korea)
129
Evaluation of 99mTc-labelled FR-targeting Imaging Probe with Novel Linkage to Improve the Tumor Uptake
Xianzhong Zhang (Xiamen University, China)
130
Preparation and evaluation of 64Cu-labeled streptavidin/biotin-based RGD dimer for dual PET/optical
imaging of αvβ3 receptor expression
Hyunjung Kim (Samsung Medical Center, Korea)
131
68
132
203
133
Copolymer-Based Functional SPECT/MR Imaging Agent for Asialoglycoprotein Receptor Targeting
Manli Song (Xiamen University, China)
134
Synthesis and biological evaluation of new bone-seeking [Re/99mTc(CO)3(κ3-L)] complexes with [NSN] and
[NSO] bifunctional chelators
George Makris (Aristotle University Of Thessaloniki, Greece)
135
Characterization and Development of Two Phage Display Selected Anti-ErbB3 Peptides
Susan L. Deutscher (Harry S. Truman Veterans Memorial Hospital, United States)
136
99m
137
Target-Specific Radiolabeled Gold Nanoconjugates
Raghuraman Kannan (University of Missouri, United States)
138
Synthesis, Characterization and Imaging of a 99mTc(I)-Tetrazine Tridentate Ligand Complex for Bioorthogonal Chemistry
Zainab Ahmad (McMaster University, Canada)
139
Synthesis, In Vitro Evaluation, and In Vivo PET/CT of 64Cu-labeled CD11b-targeting Probe
Haixun Guo (University of Louisville, United States)
140
Synthesis and In Vitro Bacteria Binding of 68Ga-labeled Yersiniabactin
Haixun Guo (University of Louisville, United States)
141
A Novel SPECT Metalloprobe 67Galmydar for Myocardial Perfusion Imaging
Scott E. Harpstrite (Washington University School of Medicine, United States)
142
Development of ring substituted pyridine based chelates for fac-[MI(CO)3]+ (M=Re, 99mTc) based
radiopharmaceuticals
Thomas R. Hayes (Washington State University, United States)
143
Clickable bifunctional cross-bridged phosphonate-based chelator through alkyne and aldehyde modifications
Carolyn J. Anderson (University of Pittsburgh, United States)
Ga-labeled peptides for targeting phosphatidylserine (PS) in apoptosis
Amanda Perreault (University of Alberta, Canada)
Pb-labeled radiotracer targeting metastatic melanoma.
Izabela Tworowsk (1RadioMedix Inc., United States)
Tc(I) probes.
Samantha R. Slikboer (McMaster University, Canada)
144
Enhancing [64Cu]-NODAGA-Exendin-4 Uptake into GLP-1 Receptor Expressing Cells Using an Agoallosteric Modulating Quinoxaline Derivative: A Step Towards Improved β-Cell imaging.
Gregory D. Bowden (Eberhard Karls Universität Tübingen,Germany)
145
Isothiocyanate-functionalized bifunctional chelates for 99mTc and Re complexes for uPAR targeting in
prostate cancer
Paul D. Benny (Washington State University, United States)
146
Clickable cross-bridged chelator to prepare dimeric peptide for targeted PET imaging
Marie-Caline Abadjian (San Diego State University, United States)
100
Synthesis of [123I]Iodoaniracetam, a SPECT agent for Brain Imaging
David W. Blevins (University of Tennessee, United States)
088
Influence of chelators on targeting properties of 111In and 68Ga labeled GRPR antagonist
Irina Velikyan (Uppsala University, Sweden)
PET: F-18
235
Identification and in vivo evaluation of [18F]MNI-617 as a radioligand for PDE4 imaging in non human
primate
Caroline Papin (Molecular NeuroImaging, United States)
236
In vitro evaluation of new tau PET tracer candidates using [ 18F]T808 and [18F]T808 AD brain slice
autoradiography binding inhibition studies
Guy Bormans (KU Leuven, Belgium)
237
Optimisation of the synthesis and purification of 18F-4-fluorobenzaldehyde on a FASTlab cassette for
labelling of macromolecules
Julian Grigg (GE Healthcare, United Kingdom)
239
Using Biotransformations for Radioligand Discovery and Validation – Preparative Liver Microsome
Incubations Shed Further Light on the Impact of Radiometabolites on In Vivo Imaging
Magnus Schou (AstraZeneca, Sweden)
240
Synthesis and Biological Evaluation of 18F-labeled FMTPD as a Focal Adhesion Kinase-Targeted Tumor
Imaging Agent
Yu Fang (Beijing Normal University, China)
241
First radiosynthesis of 18F-labeled anle138b a potential tracer for imaging of neurodegenerative diseases
associated with protein deposition in brain
Bernd Neumaier (University Clinic Cologne, Germany)
242
Construction of 18F-labeled molecules via metal-free cross-coupling reactions of radiofluorinated
tosylhydrazones
Bernd Neumaier (University Clinic Cologne, Germany)
243
Radiosynthesis and preclinical evaluation of new Al18F-labelled Urea-based PSMA inhibitors for PET
imaging of prostate cancer
Frederik W. Cleeren (University of Leuven, Belgium)
245
Synthesis and pharmacological evaluation of hydrophilic [F-18]-labeled GBR12935 derivatives as novel PET
imaging agents for dopamine transporter
Ling-Wei Hsin (National Taiwan University, Taiwan)
246
Synthesis of deuterium-substituted [18F]fluoromethyl-PBR28 and its initial PET evaluation compared with
[18F]fluoromethyl-PBR28 in a rat model of neuroinflammation
Byung Chul Lee (Seoul National University Bundang Hospital, Korea)
248
Synthesis, characterization, and in vivo evaluation of 18F-labeled 2-phenyl-imidazo[1,2-a]pyridine analog (18FCB251) as a new TSPO PET radiotracer
Byung Chul Lee (Seoul National University Bundang Hospital, Korea)
247
A simplified production method of 18F-FMISO using a cation exchange resin for the deprotection reaction.
Yuji Kuge (Hokkaido University, Japan)
249
Development of 18F-labeled PET Probes for C-MET Imaging
Zhen Cheng (Stanford University, United States)
250
Evaluation of Trehalose Derivatives as Radiotracers Specific for Tuberculosis in Animal Models of Disease
Gwendolyn A. Marriner (National Institutes of Health, United States)
251
Synthesis and First ex-vivo Results of [19F]-Fluoroethyl-resorufin for Imaging of Cerebral Amyloid
Angiopathy in APP23 Mice
Andreas Maurer (Eberhard Karls University Tübingen, Germany)
252
The Automated Production of 18F-Labeled PET Molecular Imaging Probes using a Microfluidic Chip-based
Synthesizer
Mingwei Wang (Fudan University Shanghai Cancer Center, China)
253
Clinical grade [18F]FTC-146: Radiosynthesis of sigma-1 receptor ligand for human PET studies
Bin Shen (Stanford University, United States)
254
Microfluidic optimization and production of [18F]FP-TZTP
Giancarlo Pascali (ANSTO, Australia)
255
Synthesis of [18F]Tetrafluoroborate via Radiofluorination of BF 3
Huailei Jiang (Mayo Clinic, United States)
256
Synthesis of radiobrominated amino acid derivatives via silicon-bromine exchange reaction
Shigeki Watanabe (Japan Atomic Energy Agency, Japan)
257
A F-18 Labeled Enantiomeric PET Radiotracer for σ1 Receptors
Xuyi Yue (Washington University in St. Louis, United States)
258
Development of 18F-Labeled Peptides for Imaging EGFL7 in Prostate Cancer
Leonard Luyt (University of Western Ontario, Canada)
259
Novel Microscale Automated System for F-18 Radiopharmaceutical Synthesis
Joe O. Armstrong (University of Washington, United States)
260
Synthesis of 18F-TH302 for PET hypoxic tumor imaging
Dhanabalan Murali (University of Wisconsin, United States)
261
Synthesis and biological evaluation of [18F]DOPP for FAAH imaging
Yu-Shin Ding (NYUMC, United States)
262
Improved Syntheses of Reference Standard and Precursors for Tau Imaging Agent, [18F]AV-1451
Carey L. Horchler (Avid Radiopharmaceuticals, United States)
263
Intricacies of 18F-labelling of exendin-4 via click chemistry
Cheng-Bin Yim (University of Turku and Åbo Akademi University, Finland)
264
Facile 18F radiosynthesis of olaparib derivatives as potential poly[ADP-ribose] polymerase 1 (PARP-1)
imaging agents
Dong Zhou (Washington University in Saint Louis, United States)
265
A Perfluoroaryl-Cysteine SNAr Chemistry Approach towards F-18 labeling of Bioactive Peptides
Jitendra K. Mishra (St. Jude Children's Research Hospital, United States)
266
Rapid, microfluidic radiosynthesis of a [18F]F-Py-GnRH peptide
Robin C. Cumming (University of California Davis, United States)
267
Synthesis and biological evaluation of a novel α,α-diakyl amino acid PET tracer for brain tumor and prostate
cancer imaging.
Ahlem Bouhlel (Washington University in St Louis, United States)
268
Radiolabelling of a α-synuclein PET radioligand candidate using a copper-mediated nucleophilic fluorination
reaction
Christophe Plisson (Imanova, United Kingdom)
269
Modelling Reactions for F-18 Labeling of Chitosan Nanoparticles
Ana Lima Oubina (University of Debrecen, Hungary)
270
A 18F Labeling Strategy for Near Infrared Fluorophores. Multi-Modal Probes for Reactive Oxygen Species
Salma Al-karmi (McMaster University, Canada)
271
Production of [F-18]THK-5117 using Siemens Explora chemistry module
Tobey J. Betthauser (University of Wisconsin - Madison, United States)
272
PET imaging and ex vivo brain autoradiography in a mouse model of Alzheimers disease using the TSPO
tracers [18F]DPA-714 and [18F]F-DPA
Merja Haaparanta-Solin (University of Turku, Finland)
213
Automated synthesis of a 18F-labeled lysine-urea-glutamate for PSMA imaging
Frank Wuest (University of Alberta, Canada)
410
Radiosynthesis and In Vitro Evaluation of [18F] FP-PEAQX as a Potential PET Radioligand for Imaging the
GluN2A Subunit of the NMDA Receptor
Simon Ametamey (ETH Switzerland)
411
Preliminary Evaluation of Dual 18F- and 125I-Labeled Benzyloxybenzenes for Comparative Imaging ofβAmyloid Plaques
H. Jia (Beijing Normal University, China)
PET: C-11 and Other
321
Cellular uptakes of novel gold nanoparticle conjugates via radioactivity analysis and photoacoustic imaging
Xia Shao (University of Michigan, United States)
327
Radiosynthesis of [11C]Allyl Amides by Amidation of a [11C]Carboxylate Intermediateintermediate
Xia Shao (University of Michigan, United States)
322
Radiosynthesis of the auxin class plant growth hormone 4-chloro-3-indolyl[1-11C]acetic acid
Paul Ellison (University of Wisconsin, United States)
323
11
324
Radiosynthesis and Selective Purification of [11C]Palmitic Acid (PA) using a Single Disposable Cartridge
James M. Kelly (Weill Cornell Medical College, United States)
325
Synthesis of Radiolabeled Glycogen Synthase Kinase 3β Inhibitors for CNS imaging
Peter J. Scott (University of Michigan, United States)
326
Evaluation of Bioorthogonal Reactive Pairs for Cathepsin B Imaging
Patricia Edem (McMaster University, Canada)
328
Rapid Synthesis of [11C]Urea derivatives by [11C]CO2 Incorporation: Application to novel mGluR1 brain
imaging probes.
Abdul Karim Haji Dheere (King's College London, United Kingdom)
329
Synthesis of C-11 and F-18 labeled NOP 46 - A potential marker for chronic pain
Shunichi Oya (Columbia University, United States)
330
Radiosynthesis and evaluation of the 5-HT2A inverse agonist: [11C]pimavanserin
Matthias Herth (University of Copenhagen, Denmark)
331
Synthesis of Dipeptide [11C]Phe-Phe-NH2, a High Affinity Ligand for the Substance P 1-7 Specific Binding
Site
Aleksandra Pekošak (VU Medical Center, Netherlands)
C ammonium thiocyanate: a novel 11C synthon for PET radiolabelling
Tom Haywood (Imperial College London, United Kingdom)
332
Radiolabelling and initial in vivo evaluation of 11C N-methyl Linsitinib (OSI 906) targeting IGF-1 and insulin
receptors
Dirk A. Bender (Aarhus University Hospital, Denmark)
333
Development of efficient construction of [11C]carbamate moiety using [11C]COCl2
Masayuki Fujinaga (National Institute of Radiological Sciences, Japan)
334
Selective O-[11C]methylation of 1-(3-hydroxyphenyl)piperazine
Szabolcs Lehel (Copenhagen University Hospital, Denmark)
335
Synthesis and preclinical evaluation of [11C]/[3H]Alisertib, an aurora kinase A (AURKA) inhibitor
Joost Verbeek (VU University medical center, Netherlands)
336
The introduction of an useful organic strong base, 1,8-bis(tetramethylguanidino)naphthalene for
[11C]methylation: a preparation of [11C]raclopride
Sang-Yoon Lee (Gachon University, Korea)
337
A Simple Method for Evaluation of [11C]PBR28 Partitioning Within Blood
Mark A. Green (Indiana University, United States)
338
GMP compliant synthesis of [11C]phenytoin by rhodium mediated [11C]carbon monoxide carbonylation
performed in disposable glass vials
Jonas Eriksson (Uppsala University Hospital, Sweden)
339
Synthesis of N-succinimidyl-3-fluoro-4-[124I]-iodobenzoate (S-FIB), a novel protein iodination analogue
Christina L. Brown (3DImaging, LLC., United States)
Radiopharmacy
369
High output [18F]FDOPA production on AllInOne (Trasis) at commercial scale.
Muhammad Otabashi (Trasis SA, Belgium)
370
Azeotropic drying free FDG synthesis and its application to a microfluidic platform
Simon K. Lindner (University of Munich LMU, Germany)
371
4S-(3-[18F]Fluoropropyl)-L-glutamic acid (FSPG): Biodistribution and tumor uptake in SLC7A11-KO mice
Matthias Friebe (Piramal Imaging, Germany)
374
Comparative biodistribution of 99mTc-duramycin: influence of species, purification and kit composition
Luca Palmieri (University Hospital Antwerp, Belgium)
375
Reproducibility of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in brain tumors and influence of dexamethasone
therapy: A PET study in rat gliomas
Johannes Ermert (Forschungszentrum Jülich, Germany)
376
Radiochemical stability of 68Ga- and 177Lu-labeled high-affinity DOTATATE (DOTA-3-iodo-Tyr3-octreotate)
Dirk Mueller (University Hospital Halle(Saale), Germany)
377
Synthesis and evaluation of 99mTc labeled metronidazole analogs HYNIC-ADIBO-MN via copper-free click
chemistry for tumor hypoxia imaging
Liqin Liu (University of Science and Technology Beijing, China)
378
[99mTc]ZOL - First in vivo imaging in dogs
Daniela Haeusler (Medical University of Vienna, Austria)
379
Synthesis and evaluation of two novel Tc-99m-labeled lactam bridge-cyclized melanocortin peptides for
melanoma SPECT imaging
Thomas P. Quinn (University of Missouri, United States)
380
Reactivity and structure relations in Mn(I), Re(I) and Tc(I)-tricarbonyl complexes – impact on drug design.
Hendrik G. Visser (University of the Free State, South Africa)
381
In vivo imaging and characterization of [ 18F]DPA-714, a potential new TSPO ligand, in mouse brain and
peripheral tissues using small-animal PET
Mariarosaria Panico (CNR, Italy)
382
Metabolism study of radiolabeled hydrazinocurcumin derivative
Sarah Shin (Samsung Medical Center, Korea)
363
A 99mTc-labeled antibody for the dog EGF-receptor - a preclinical evaluation
Christina Rami-Mark (Medical University of Vienna, Austria)
Targetry, Production and Separations
383
Chemical Conversion of 11CO2 to 11CO via Silacarboxylic Acids: Applications in Palladium-Mediated
Carbonylations
Patrik Nordeman (Uppsala University, Sweden)
385
Improved Production of Zr-89 from Cyclotron using a Second-Generation Solution Target
Mukesh K. Pandey (Mayo Clinic, United States)
386
82
387
Improved elution procedure of 3’-Deoxy-3’-[18F]fluorothymidine [18F]FLT for safer human injectable
radiotracer
Mohammed H. Al Qahtani (King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia)
388
A study on remote production of 43Sc from natCaO target via the natCa(α,x)-reaction
Kotaro Nagatsu (National Institute of Radiological Sciences, Japan)
389
A feasibility study on 68Ge production from elemental natGa by in-situ extraction process
Kotaro Nagatsu (National Institute of Radiological Sciences, Japan)
390
Application of Compton-suppressed Gamma-Ray Spectroscopy for Improved Quality Control for production
of 82Sr.
Suzanne V. Smith (Brookhaven National Lab, United States)
Alternative Methods for the Production of Mo-99: non-Fission Based Solid-State, Mo-100 (g,n) Mo-99, and
sub-Critical Solution-State, U-235 (n,f) Mo-99
David A. Rotsch (Argonne National Laboratory, United States)
391
Sr/82Rb production with an SR resin®: characterization and quantification by mass spectrometry of
radiation-induced degradation of various 18-crown-6 crow-ethers
Sandrine C. Huclier-Markai (SUBATECH/ARRONAX, France)
Therapy
401
Promising anti-Gram-negative antimicrobial peptides (AMPs): Radiolabeling and biodistribution profiles
Unai Cossío (CIC biomaGUNE , Spain)
402
Production and In Vivo Evaluation of Radioactive MGF-198AuNPs for Prostate Cancer Treatment
Amal Y. Al-Yasiri (University of Missouri, United States)
403
Radiosynthesis and Quality Control of Nanosized Resveratrol-Au-198
T M. Sakr (Egyptian Atomic Energy Authority, Egypt)
404
Synthesis of radiolabelled boron-rich functionalized NPs as boron carriers for boron neutron capture therapy
Kiran B. Gona (CICbiomaGUNE, Spain)
405
Strategies to Probe the Chemistry of Actinium
Justin J. Wilson (Los Alamos National Laboratory, United States)
406
Hypoxia imaging biomarker, Tc-99m-HL91, in injectable in situ forming thermosensitive implant at a murine
tumor mode
Bi-Fang Lee (National Cheng Kung University Hospital, Taiwan)
407
cGMP Kit Production of CycloSam® (Sm-153-DOTMP), A New Therapeutic Bone Agent
R K. Frank (IsoTherapeutics Group LLC, United States)
408
Treatment with Samarium-153-DOTMP in Dogs with Naturally Occurring Osteosarcoma for Therapeutic
Benefit and as a Translational Model
Kimberly A. Selting (University of Missouri, United States)