1. No category

POSTER SESSION I
Wednesday, May 27 16:00-18:00
Imaging: Radiometals
075
Evaluation of a Novel Tc-99m-Labeled HYNIC-Conjugated Lactam Bridge-Cyclized Alpha-MSH Peptide for
Human Melanoma Imaging
Yubin Miao (University of New Mexico, United States)
076
111
077
Synthesis and Biological Evaluation of a [Re/99mTc(CO)3]+-Labeled Somatostatin Receptor-Seeking
Antagonist
Lauren Radford (University of Missouri, United States)
078
PET imaging of changes in copper metabolism associated with Alzheimer's disease: potential new diagnostics
Julia B. Torres (King's College London, United Kingdom)
079
99m
080
Synthesis, Characterization and In Vitro Evaluation of New 99mTc/Re-cyclized Octreotide Analogues
Yawen Li (University of Missouri, United States)
081
Development of fluorine-18 and gallium-68 labelled aprotinin
Charlotte L. Denholt (Copenhagen University Hospital Rigshospitalet, Denmark)
082
In Vitro and In Vivo Studies Describing 68Ga/64Cu/90Y radiolabeled bivalent [RGD-Glu-(DO3A)-6-Ahx-RM2]
Targeting GRPR/αvβ3 Biomarkers on Prostate Cancer Cells.
Zongrun Jiang (Truman VA, University of Missouri, United States)
083
PET - imaging using phage display derived bicyclic peptide scaffolds
Klaus Kopka (German Cancer Research Center, Germany)
094
Linker modification of urea-based PSMA inhibitors for successful tumor-targeting in vivo
Klaus Kopka (German Cancer Research Center, Germany)
084
Monitoring Breast Cancer Resistance Protein (BCRP)-Mediated Functional Transport Activity using 68GaGalmydar
Scott E. Harpstrite (Washington University School of Medicine in St. Louis, United States)
085
[94mTc] labeled peptide targets Met in human gastric carcinoma (MKN-45, SNU-16) and glioblastoma (U87MG) cells and xenografts
Elaine M. Jagoda (National Cancer Institute, United States)
086
PET Imaging of Tenascin-C with a Radiolabeled Single-Strand DNA Aptamer
Xiaoyuan Chen (National Institutes of Health, United States)
087
DFO* - An Octadentate Bifunctional Chelating Agent for the Development of Stable Zirconium-89 Based
Molecular Imaging Probes
Thomas L. Mindt (University of Basel, Switzerland)
089
PET-MRI dual-modal iron oxide based nanoparticles for targeting asialoglycoprotein receptors and CD206
Bo Yeun Yang (Seoul National University College of Medicine, Korea)
090
2, 2'-Bipyridine Containing Peptides as β-Sheet Mimics Coordinated to Re/Tc(I)
William L. Turnbull (University of Western Ontario, Canada)
091
New zinc folate derivative useful to prepare Tc-99m radiopharmaceuticals with high specific activity
In-Labeled tetrapeptides with high affinity and selectivity for mu opioid receptors.
John R. Lever (University of Missouri, United States)
Tc/Re-tricarbonyl complexes with tridentate N-(phosphonomethyl) iminodiacetic acid: a novel approach to
new bifunctional chelating agents
Malgorzata Lipowska (Emory University, United States)
Joan Suades (Universitat Autonoma de Barcelona, Spain)
092
1,4,7-triazacyclononane ligands as versatile platform for radiocopper-labeled agents
Holger Stephan (HZDR, Germany)
093
Uptake of 89Zr-DFO by Gram-positive and Gram-negative bacteria and potential for infection imaging
Nora C. Goscinski (Washington University in St. Louis, United States)
095
Dosimetry of [68Ga]Ga-DO3A-VS-Cys40-Exendin-4 in rodents, pigs, non-human primates and human
Irina Velikyan (Uppsala University Hospital, Uppsala University, Sweden)
096
Extrapolated dosimetry of two novel 68Ga-labelled imaging agents for fibrosis: feasibility of multiple
examinations
Irina Velikyan (Uppsala University Hospital, Uppsala University, Sweden)
097
Development of a GMP compliant synthesis of 68Ga-NODAGA-E[c(RGDyK)]2
Malene Brandt-Larsen (Rigshospitalet, Denmark)
A novel cyclopentadienyl tricarbonyl 99mTc complex containing 5, 6-dimethoxyisoindoline motif – synthesis
and evaluation of a radiotracer for imaging of sigma-2 receptors in cancer
Yuanyuan Chen (Beijing Normal University, China)
098
109
Metabolically-stable 68Ga-NOTA-bombesin derivative for targeting GRP receptor in prostate cancer
xenografts
Frank Wuest (University of Alberta, Canada)
PET: F-18
147
Synthesis and comparative evaluation of a 6-carbon spacer ISO-1 vs. ISO-1 for imaging the sigma-2 receptor
status of solid tumors
Iljung Lee (University of Pennsylvania, United States)
148
(Pyridinyl-phenyl)selenoxides and (pyridinyl-phenyl)selenones as precursors for preparing
[18F]fluoropyridines from [18F]fluoride ion
Fabrice G. Siméon (National Institute of Mental Health, NIH, United States)
149
Diarylselenoxides as precursors to no-carrier-added [18F]fluoroarenes
Fabrice G. Siméon (NIMH, NIH, United States)
150
Applications of [18F]Hexafluorobenzene for Preparing Cyclized or Dimeric Radioligands
Dale O. Kiesewetter (National Institutes of Health, United States)
151
Novel approach to production of high specific-activity [18F]-Sodium Tetrafluoroborate
Alex Khoshnevisan (King's College London, United Kingdom)
152
Cerenkov luminescence imaging with PET probes for brain function analysis
Mikako Ogawa (Hamamatsu University School of Medicine, Japan)
153
Electrophilic fluorination and preclinical evaluation of a novel [18F]DPA-714 analogue, [18F]F-DPA.
Thomas Keller (University of Turku and Turku University Central Hospital, Turku, Finland)
154
Synthesis and evaluation of two novel 18F-labeled acetamidobenzoxazolone radioligands for PET imaging of
translocator protein (18 kDa)
Ming-Rong Zhang (National Institute of Radiological Sciences, Japan)
155
Automation of [18F]-radiotracers on the AllinOne
Robert H. Mach (University of Pennsylvania, United States)
156
Copper-mediated Late-Stage Radiofluorination of Electron-rich Arenes
Peter J. Scott (University of Michigan, United States)
157
Development of a novel 18F-labelled tetrazine with low lipophilicity
Outi M. Keinänen (University of Helsinki, Finland)
158
Copper-mediated aromatic radiofluorination revisited: efficient production of PET-Tracers on a preparative
Scale
Bernd Neumaier (University Clinic Cologne, Germany)
244
Less is more: Preparation of 18F-labeled arenes without azeotropic drying, base and other additives
Bernd Neumaier (University Clinic Cologne, Germany)
159
Radiosynthesis of [18F]cabozantinib and [18F]fluoroethyl-sunitinib: two RTK-inhibitors of VEGFR-2
Torsten Kniess (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
169
Fast 18F-fluoroethylation without azeotropic drying in the radiosynthesis of cyclooxygenase-2 inhibitors
Torsten Kniess (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
160
Rapid strain induced sydnone-alkyne cycloaddition reactions for bioorthogonal PET imaging
Jennifer M. Murphy (University of California Los Angeles, United States)
161
Automated concentration of 18F-fluoride into microliter volumes
Mark S. Lazari (UCLA, United States)
162
Site-specific Labelling of Active Site Inhibited Factor Seven (ASIS) with fluorine-18 by Oxime Coupling
Troels E. Jeppesen (Rigshospitalet and University of Copenhagen, Denmark)
163
Molecular Imaging of Neuroinflamation and b-amyloid density in Alzheimer’s disease
Johnny Vercouillie (CERRP, U930, France)
164
Synthesis of 18F-FDOPA via Nucleophilic Pathway on IBA's Synthera®
David Goblet (IBA, Belgium)
165
18
166
18
167
Design and Synthesis of Novel F-18 PET probes for early detection of Alzheimer’s disease
Sundaram S. Guruswami (Washington University, United States)
171
Interrogation of status of Thioflavin T in human epidermal carcinoma cells using fluorescence imaging
Sundaram S. Guruswami (Washington University, United States)
168
Direct 18F-labelling of tosylated Pluronic® F127 and first in vivo animal PET imaging
Johannes M. Postema (Medizinische Hochschule Hannover, Germany)
170
Improved Radiosynthesis and Whole-body Biodistribution of PHF-tau Tracer [18F]T807 in Mice
Ya-Yao Huang (National Taiwan University, Taiwan)
172
Radiosynthesis of [18F]-FAZA on Trasis AllinOne for tumor hypoxia PET imaging in patients suffering from
chordoma of the skull base and spine
Emilie Da Costa Branquinho (Institut Curie, France)
173
On the development of a novel non-peptidic 18F-labeled radiotracer for in vivo imaging of oxytocin receptors
with PET
Barbara Wenzel (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
174
Continuous-Flow Microfluidic [18F]Radiofluorination of Spirocyclic Iodonium(III) Ylides
Samuel B. Calderwood (University of Oxford, United Kingdom)
175
[18F]FP-DTBZ : Radiosynthesis on a TRACERLab module and its use in PET imaging of beta-cell mass in pig
Frédéric Dollé (Service Hospitalier Frédéric Joliot, France)
F-Labeling and Radiopharmacological Evaluation of Novel Purinedione Multi-Eph Inhibitors
Constantin Mamat (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
F-Radiolabeling of Second Generation EphB4 Inhibitors Based on Bis-anilinopyrimidines
Constantin Mamat (Helmholtz-Zentrum Dresden-Rossendorf, Germany)
176
Nucleophilic radiofluorination at the alpha-carbon of an acetamide motif: preparation of a novel fluorine-18labeled analogue of SSR180575
Annelaure Damont (Service Hospitalier Frédéric Joliot, France)
180
The pyrazolo[1,5-a]pyrimidine F-DPA: synthesis, in vitro characterization and radiolabeling with fluorine-18
using a nucleophilic approach
Annelaure Damont (Service Hospitalier Frédéric Joliot, France)
177
Development of High Affinity Ghrelin (1-8) Analogues for [18F] Imaging of GHSR-1a
Carlie Charlton (The University of Western Ontario, Canada)
178
[18F]THK-523, [18F]T808 and [18F]T807: Radiosynthesis on a TRACERLab FX N Pro synthesizer
Yann Bramoulle (Molecular Imaging Research Center, France)
179
Fully automated radiosynthesis of 1-[18F]FETrp, a potential substrate for indoleamine 2,3-dioxygenase PET
imaging
Jean Henrottin (Université de Liège, Belgium)
181
Modified Resin-Supported Silicon-Based Precursors for Kit-Like F-18 Labeling
Norio Yasui (University of Illinois, United States)
182
Synthesis and evaluation of novel 18F-labelled P2X7 receptor antagonists
Enrico R. Fantoni (King's College London, United Kingdom)
183
Improving the SRA of [18F]-tracers with easy-to-implement solutions: the experience at the Service
Hospitalier Frédéric Joliot
Bertrand Kuhnast (Service Hospitalier Frédéric Joliot, France)
184
Customization of the TRACERLab FxN Pro for the simultaneous double synthesis of [ 18F]-labelled
radiotracers
Bertrand Kuhnast (Service Hospitalier Frédéric Joliot, France)
185
The presence of oxygen stabilizes [F-18]FLT against radiolytic degradation
Joseph Walsh (PETNET, United States)
186
Regiospecific radiolabeling of Nanofitin on Ni Magnetic Beads with 18F-FBEM and in vivo PET studies
Sylvestre Dammicco (Cyclotron Research Center, Belgium)
226
Evaluation of the novel radiotracer 18F-DBT-10 for imaging the α7 nicotinic acetylcholine receptor in nonhuman primates
Henry Huang (Yale University, United States)
227
Microfluidic Synthesis of [18F]FPyTFP Using a Novel Bicyclic Triflate Precursor
David W. Blevins (The University of Tennessee, United States)
228
Evaluation of precursors for the production of a potential Tau imaging agent, 18F-AV-1451
Kuo-Hsien Fan (Avid Radiopharmaceuticals Inc., United States)
229
Readily accessible heteroaromatic silanes as fluoride acceptors in a mild 18F–19F isotopic exchange
Christopher M. Waldmann (University of California Los Angeles, United States)
217
Stability of [18F]FMeNER-D2: correlation of in vivo behavior with in vitro enzymes
Christina Rami-Mark (Medical University of Vienna, Austria)
412
Preliminary Evaluation of Dual 18F- and 125I-Labeled Benzyloxybenzenes for Comparative Imaging of βAmyloid Plaques
H. Jia (Beijing Normal University, China)
PET: C-11 and Other
273
Synthesis of [11C]GSK1482160 as a new potential PET radiopharmaceutical for targeting the P2X 7 receptor
Qi-Huang Zheng (Indiana University, United States)
274
Radiolabeling of small peptides with L-[11C]alanine.
Ulrike Filp (VU Medical Center, Netherlands)
279
Use of phase-transfer catalysis for the enantioselective synthesis of [11C]alanine.
Ulrike Filp (VU Medical Center, Netherlands)
275
Syntheses of 1-[11C]Methyl-4-aryloxy-1,2,3,6-tetrahydropyridines as In Vivo Metabolic Trapping
Radiotracers for Monoamine Oxidase-A and –B
Allen F. Brooks (University of Michigan, United States)
299
The synthesis of [11C]PBD150, a glutaminyl cyclase inhibitor for the early detection of Alzheimer’s Disease,
via the selective methylation of a phenol in the presence of a thiourea.
Allen F. Brooks (University of Michigan, United States)
276
Novel radiosynthetic approaches applying carbon-11 labeled isobutanol and isobutyl iodide
Lonneke Rotteveel (VU University Medical Centre, Netherlands)
277
Initial evaluation of P2X7R antagonists [11C]A-740003 and [11C]SMW64-D16 as PET tracers of microglial
activation in neuroinflammation
Bieneke Janssen (VU University Medical Center, Netherlands)
278
Synthesis and in vitro evaluation of radiobrominated adenosine A1 receptor ligand [*Br]CPBPX
Heinz H. Coenen (Institut für Neurowissenschaften und Medizin, Germany)
280
Towards the Stereoselective Synthesis of [11C]Phenylalanine and Obtaining Carbon-11 Labeled Peptidic PET
Tracers
Aleksandra Pekošak (VU Medical Center, Netherlands)
282
Improved Synthesis and Application of [11C]Benzyl Iodide as Synthon for PET Radiotracer Production
Aleksandra Pekošak (VU University Medical Center, Netherlands)
281
Synthesis of [11C]vemurafenib via a unique [11C]CO carbonylative Stille coupling to image V600E mutated BRaf in cancer.
Paul Slobbe (VU University Medical Center, Netherlands)
283
Carbon-11 Labeled Fumaric Acid Esters
Marc S. Berridge (3D Imaging LLC, United States)
284
A two-step, one-pot synthesis of indole-3-[1-11C]acetic acid ([11C]auxin) using tetraethylene glycol solvent
So Jeong Lee (Stony Brook University, United States)
285
Simplified radiochemical synthesis of [11C]clozapine
Patrick Lao (University of Wisconsin, United States)
286
Synthesis of a candidate 11C-labeled ligand for imaging brain oxytocin receptors in rhesus monkey
Victor W. Pike (NIMH, NIH, United States)
287
Direct and Efficient Cobalt Carbonyl-Mediated Aryl Acetylation using [11C]Methyl Iodide
Kenneth Dahl (Karolinska Institutet, Sweden)
288
Gas-Liquid Segmented Microfluidics: 11C-Carbonylation Reactions Made Easy
Kenneth Dahl (Karolinska Institutet, Sweden)
290
Radiosynthesis and evaluation of [11C]BU99008 with ultra-high specific activity as a PET ligand for imaging
I2-imidazoline receptors.
Kazunori Kawamura (National Institute of Radiological Sciences, Japan)
292
Direct radiolabelling with [11C]carbon disulfide: synthesis of thioureas and the progesterone receptor agonist
Tanaproget
Tom Haywood (Imperial College London, United Kingdom)
293
Robust [11C]methylation of a terminal alkyne: the BACE-1 PET tracer [11C]RO6807936
Idriss Bennacef (Imaging, Merck & Co., United States)
294
Preparation of 13N-labelled polysubstituted triazoles via Huisgen cycloaddition
Sameer M. Joshi (CIC biomaGUNE, Spain)
295
Synthesis and preclinical evaluation of two novel radioligands for PDE7 imaging in the brain
David Thomae (University of Antwerp, Belgium)
296
An Improved Radiolabelling Strategy for the 5-HT2A Agonist, [11C]Cimbi-36
Nic Gillings (Copenhagen University, Denmark)
297
Synthesis of [11CO]Raclopride and a Comparison with [11CH3]Raclopride in a Monkey PET Study
Obaidur Rahman (Karolinska Institutet, Sweden)
298
Radiosynthesis and evaluation of [11C]isradipine, a calcium channel antagonist, for PET neuroimaging
Neil Vasdev (Harvard Medical School, United States)
300
Optimization of tumor targeting using liposome-carried radiotracer at various conditions
Woonghee Lee (Kyungpook National University, Korea)
308
Exploration of analogs of [11C]dLop as potential probes for measuring increased P-gp function
Lisheng Cai (National Institute of Mental Health, United States)
319
Synthesis of a novel 125I-labelled radiotracer for molecular imaging of cyclooxygenase-2 (COX-2)
Ole Tietz (University of Alberta, Canada)
Radiopharmacy
341
77
342
One-pot radiosynthesis of [11C]formic acid as labelling agent for heterocycles via cyclization reaction using a
GE Tracerlab FX C Pro synthesis module
Severin Mairinger (AIT Austrian Institute of Technology GmbH, Austria)
343
Evaluation of carbon-11 labelled H4R antagonists as potential PET tracers of neuroinflammation
Uta Funke (BV Cyclotron VU, Netherlands)
344
SPECT/CT imaging and ex vivo biodistribution of peptide modified 111In-labelled Silicon nanoparticles in a
rat model of myocardial infarction
Sanjeev Ranjan (University of Helsinki, Finland)
345
(Radio)pharmacological characterization of novel α-MSH derivatives
Feng Gao (Institute of Radiopharmaceutical Cancer Research, Germany)
346
Imaging atherosclerotic plaque inflammation with the CD80/CD86-specific 111In-DOTA-Belatacept
Roger Schibli (ETH Zurich, Switzerland)
352
Evaluation of the Chick Embryo as a Test System for Radiopharmaceuticals
Roger Schibli (ETH Zurich, Switzerland)
347
Studies on minimal required specific activities (SA) of 177Lu for labeling a typical clinical dose of 0.2 mg
DOTATATE with 7.4 or 11.1 GBq 177Lu for Peptide Receptor Radionuclide Therapy (PRRT)
Wouter A. Breeman (Erasmus MC, Netherlands)
348
Quality of Animal Experiments – Problems and Pitfalls
P. A. Schubiger (Swiss Federal Institute of Technology, Switzerland)
As Complexes for Potential PET and Radiotherapy
Yutian Feng (University of Missouri-Columbia, United States)
349
In vivo evaluation of syn- and anti-[123I]IVACBC as potential SPECT tumor imaging agents
Weiping Yu (Emory University, United States)
350
Radiochemical stability study of [methyl-11C]choline by HPLC method
István Jószai (University of Debrecen, Hungary)
351
Synthesis and Evaluation of a new 18F-Synthon for copper-free click Labeling of Biomolecules
Kathrin Kettenbach (Johannes Gutenberg-University, Germany)
353
44
354
Synthesis and biodistribution of novel 99mTc labeled chitosan modified metronidazole analogs as a potential
probe for tumor hypoxia imaging
Liqin Liu (University of Science and Technology Beijing, China)
357
Cerebral uptake of FET after tumor resection in a F98 rat glioma model
Johannes Ermert (Institut für Neurowissenschaften und Medizin, Germany)
361
Simple and highly efficient automatic synthesis of [ 18F]LBT-999 with protic solvent
Cheol-min Yook (Asan Medical Center, Korea)
Sc and 177Lu-labeling of DOTA-PSMA DKFZ-617 for dosimetry and therapy of prostate cancer
Elisabeth Eppard (University Hospital Bonn, Germany)
Targetry, Production and Separations
393
Separation of Cu-67 from an irradiated zinc target by electrolysis
Donald E. Wycoff (University of Missouri, United States)
394
Investigation of Accelerator-Based Production of High Specific Activity 186Re
Matthew D. Gott (University of Missouri, United States)
395
Design of a multi-functional automated 68Ga-synthesis program
Karin M. Nielsen (Aalborg University Hospital, Denmark)
Poster Session III
Saturday, May 30; 16:00-18:00
Imaging: Radiometals
126
Stability comparison study using gel electrophoresis and radio-HPLC
Heesu Ahn (National University School of Medicine, Korea)
127
Synthesis and in ovo evaluation of the neuropeptide cathelicidin 89Zr-CATH2
Gert Luurtsema (University of Groningen, Netherlands)
128
Synthesis of 99mTc(CO)3 labeled 2-(4-chloro)phenyl-imidazo[1,2-a]pyridine analog (99mTc-CB256) as a new
TSPO-selective SPECT radiotracer
Ji Young Choi (Seoul National University Bundang Hospital, Korea)
129
Evaluation of 99mTc-labelled FR-targeting Imaging Probe with Novel Linkage to Improve the Tumor Uptake
Xianzhong Zhang (Xiamen University, China)
130
Preparation and evaluation of 64Cu-labeled streptavidin/biotin-based RGD dimer for dual PET/optical
imaging of αvβ3 receptor expression
Hyunjung Kim (Samsung Medical Center, Korea)
131
68
132
203
133
Copolymer-Based Functional SPECT/MR Imaging Agent for Asialoglycoprotein Receptor Targeting
Manli Song (Xiamen University, China)
134
Synthesis and biological evaluation of new bone-seeking [Re/99mTc(CO)3(κ3-L)] complexes with [NSN] and
[NSO] bifunctional chelators
George Makris (Aristotle University Of Thessaloniki, Greece)
135
Characterization and Development of Two Phage Display Selected Anti-ErbB3 Peptides
Susan L. Deutscher (Harry S. Truman Veterans Memorial Hospital, United States)
136
99m
137
Target-Specific Radiolabeled Gold Nanoconjugates
Raghuraman Kannan (University of Missouri, United States)
138
Synthesis, Characterization and Imaging of a 99mTc(I)-Tetrazine Tridentate Ligand Complex for Bioorthogonal Chemistry
Zainab Ahmad (McMaster University, Canada)
139
Synthesis, In Vitro Evaluation, and In Vivo PET/CT of 64Cu-labeled CD11b-targeting Probe
Haixun Guo (University of Louisville, United States)
140
Synthesis and In Vitro Bacteria Binding of 68Ga-labeled Yersiniabactin
Haixun Guo (University of Louisville, United States)
141
A Novel SPECT Metalloprobe 67Galmydar for Myocardial Perfusion Imaging
Scott E. Harpstrite (Washington University School of Medicine, United States)
142
Development of ring substituted pyridine based chelates for fac-[MI(CO)3]+ (M=Re, 99mTc) based
radiopharmaceuticals
Thomas R. Hayes (Washington State University, United States)
143
Clickable bifunctional cross-bridged phosphonate-based chelator through alkyne and aldehyde modifications
Carolyn J. Anderson (University of Pittsburgh, United States)
144
Enhancing [64Cu]-NODAGA-Exendin-4 Uptake into GLP-1 Receptor Expressing Cells Using an Agoallosteric Modulating Quinoxaline Derivative: A Step Towards Improved β-Cell imaging.
Gregory D. Bowden (Eberhard Karls Universität Tübingen,Germany)
145
Isothiocyanate-functionalized bifunctional chelates for 99mTc and Re complexes for uPAR targeting in
prostate cancer
Paul D. Benny (Washington State University, United States)
146
Clickable cross-bridged chelator to prepare dimeric peptide for targeted PET imaging
Marie-Caline Abadjian (San Diego State University, United States)
100
Synthesis of [123I]Iodoaniracetam, a SPECT agent for Brain Imaging
David W. Blevins (University of Tennessee, United States)
088
Influence of chelators on targeting properties of 111In and 68Ga labeled GRPR antagonist
Irina Velikyan (Uppsala University, Sweden)
PET: F-18
Ga-labeled peptides for targeting phosphatidylserine (PS) in apoptosis
Amanda Perreault (University of Alberta, Canada)
Pb-labeled radiotracer targeting metastatic melanoma.
Izabela Tworowsk (1RadioMedix Inc., United States)
Tc(I) probes.
Samantha R. Slikboer (McMaster University, Canada)
235
Identification and in vivo evaluation of [18F]MNI-617 as a radioligand for PDE4 imaging in non human
primate
Caroline Papin (Molecular NeuroImaging, United States)
236
In vitro evaluation of new tau PET tracer candidates using [ 18F]T808 and [18F]T808 AD brain slice
autoradiography binding inhibition studies
Guy Bormans (KU Leuven, Belgium)
237
Optimisation of the synthesis and purification of 18F-4-fluorobenzaldehyde on a FASTlab cassette for
labelling of macromolecules
Julian Grigg (GE Healthcare, United Kingdom)
239
Using Biotransformations for Radioligand Discovery and Validation – Preparative Liver Microsome
Incubations Shed Further Light on the Impact of Radiometabolites on In Vivo Imaging
Magnus Schou (AstraZeneca, Sweden)
240
Synthesis and Biological Evaluation of 18F-labeled FMTPD as a Focal Adhesion Kinase-Targeted Tumor
Imaging Agent
Yu Fang (Beijing Normal University, China)
241
First radiosynthesis of 18F-labeled anle138b a potential tracer for imaging of neurodegenerative diseases
associated with protein deposition in brain
Bernd Neumaier (University Clinic Cologne, Germany)
242
Construction of 18F-labeled molecules via metal-free cross-coupling reactions of radiofluorinated
tosylhydrazones
Bernd Neumaier (University Clinic Cologne, Germany)
243
Radiosynthesis and preclinical evaluation of new Al18F-labelled Urea-based PSMA inhibitors for PET
imaging of prostate cancer
Frederik W. Cleeren (University of Leuven, Belgium)
245
Synthesis and pharmacological evaluation of hydrophilic [F-18]-labeled GBR12935 derivatives as novel PET
imaging agents for dopamine transporter
Ling-Wei Hsin (National Taiwan University, Taiwan)
246
Synthesis of deuterium-substituted [18F]fluoromethyl-PBR28 and its initial PET evaluation compared with
[18F]fluoromethyl-PBR28 in a rat model of neuroinflammation
Byung Chul Lee (Seoul National University Bundang Hospital, Korea)
248
Synthesis, characterization, and in vivo evaluation of 18F-labeled 2-phenyl-imidazo[1,2-a]pyridine analog (18FCB251) as a new TSPO PET radiotracer
Byung Chul Lee (Seoul National University Bundang Hospital, Korea)
247
A simplified production method of 18F-FMISO using a cation exchange resin for the deprotection reaction.
Yuji Kuge (Hokkaido University, Japan)
249
Development of 18F-labeled PET Probes for C-MET Imaging
Zhen Cheng (Stanford University, United States)
250
Evaluation of Trehalose Derivatives as Radiotracers Specific for Tuberculosis in Animal Models of Disease
Gwendolyn A. Marriner (National Institutes of Health, United States)
251
Synthesis and First ex-vivo Results of [19F]-Fluoroethyl-resorufin for Imaging of Cerebral Amyloid
Angiopathy in APP23 Mice
Andreas Maurer (Eberhard Karls University Tübingen, Germany)
252
The Automated Production of 18F-Labeled PET Molecular Imaging Probes using a Microfluidic Chip-based
Synthesizer
Mingwei Wang (Fudan University Shanghai Cancer Center, China)
253
Clinical grade [18F]FTC-146: Radiosynthesis of sigma-1 receptor ligand for human PET studies
Bin Shen (Stanford University, United States)
254
Microfluidic optimization and production of [18F]FP-TZTP
Giancarlo Pascali (ANSTO, Australia)
255
Synthesis of [18F]Tetrafluoroborate via Radiofluorination of BF 3
Huailei Jiang (Mayo Clinic, United States)
256
Synthesis of radiobrominated amino acid derivatives via silicon-bromine exchange reaction
Shigeki Watanabe (Japan Atomic Energy Agency, Japan)
257
A F-18 Labeled Enantiomeric PET Radiotracer for σ1 Receptors
Xuyi Yue (Washington University in St. Louis, United States)
258
Development of 18F-Labeled Peptides for Imaging EGFL7 in Prostate Cancer
Leonard Luyt (University of Western Ontario, Canada)
259
Novel Microscale Automated System for F-18 Radiopharmaceutical Synthesis
Joe O. Armstrong (University of Washington, United States)
260
Synthesis of 18F-TH302 for PET hypoxic tumor imaging
Dhanabalan Murali (University of Wisconsin, United States)
261
Synthesis and biological evaluation of [18F]DOPP for FAAH imaging
Yu-Shin Ding (NYUMC, United States)
262
Improved Syntheses of Reference Standard and Precursors for Tau Imaging Agent, [18F]AV-1451
Carey L. Horchler (Avid Radiopharmaceuticals, United States)
263
Intricacies of 18F-labelling of exendin-4 via click chemistry
Cheng-Bin Yim (University of Turku and Åbo Akademi University, Finland)
264
Facile 18F radiosynthesis of olaparib derivatives as potential poly[ADP-ribose] polymerase 1 (PARP-1)
imaging agents
Dong Zhou (Washington University in Saint Louis, United States)
265
A Perfluoroaryl-Cysteine SNAr Chemistry Approach towards F-18 labeling of Bioactive Peptides
Jitendra K. Mishra (St. Jude Children's Research Hospital, United States)
266
Rapid, microfluidic radiosynthesis of a [18F]F-Py-GnRH peptide
Robin C. Cumming (University of California Davis, United States)
267
Synthesis and biological evaluation of a novel α,α-diakyl amino acid PET tracer for brain tumor and prostate
cancer imaging.
Ahlem Bouhlel (Washington University in St Louis, United States)
268
Radiolabelling of a α-synuclein PET radioligand candidate using a copper-mediated nucleophilic fluorination
reaction
Christophe Plisson (Imanova, United Kingdom)
269
Modelling Reactions for F-18 Labeling of Chitosan Nanoparticles
Ana Lima Oubina (University of Debrecen, Hungary)
270
A 18F Labeling Strategy for Near Infrared Fluorophores. Multi-Modal Probes for Reactive Oxygen Species
Salma Al-karmi (McMaster University, Canada)
271
Production of [F-18]THK-5117 using Siemens Explora chemistry module
Tobey J. Betthauser (University of Wisconsin - Madison, United States)
272
PET imaging and ex vivo brain autoradiography in a mouse model of Alzheimers disease using the TSPO
tracers [18F]DPA-714 and [18F]F-DPA
Merja Haaparanta-Solin (University of Turku, Finland)
213
Automated synthesis of a 18F-labeled lysine-urea-glutamate for PSMA imaging
Frank Wuest (University of Alberta, Canada)
PET: C-11 and Other
321
Cellular uptakes of novel gold nanoparticle conjugates via radioactivity analysis and photoacoustic imaging
Xia Shao (University of Michigan, United States)
327
Radiosynthesis of [11C]Allyl Amides by Amidation of a [11C]Carboxylate Intermediateintermediate
Xia Shao (University of Michigan, United States)
322
Radiosynthesis of the auxin class plant growth hormone 4-chloro-3-indolyl[1-11C]acetic acid
Paul Ellison (University of Wisconsin, United States)
323
11
324
Radiosynthesis and Selective Purification of [11C]Palmitic Acid (PA) using a Single Disposable Cartridge
James M. Kelly (Weill Cornell Medical College, United States)
325
Synthesis of Radiolabeled Glycogen Synthase Kinase 3β Inhibitors for CNS imaging
Peter J. Scott (University of Michigan, United States)
326
Evaluation of Bioorthogonal Reactive Pairs for Cathepsin B Imaging
Patricia Edem (McMaster University, Canada)
328
Rapid Synthesis of [11C]Urea derivatives by [11C]CO2 Incorporation: Application to novel mGluR1 brain
imaging probes.
Abdul Karim Haji Dheere (King's College London, United Kingdom)
329
Synthesis of C-11 and F-18 labeled NOP 46 - A potential marker for chronic pain
Shunichi Oya (Columbia University, United States)
330
Radiosynthesis and evaluation of the 5-HT2A inverse agonist: [11C]pimavanserin
Matthias Herth (University of Copenhagen, Denmark)
331
Synthesis of Dipeptide [11C]Phe-Phe-NH2, a High Affinity Ligand for the Substance P 1-7 Specific Binding
Site
Aleksandra Pekošak (VU Medical Center, Netherlands)
332
Radiolabelling and initial in vivo evaluation of 11C N-methyl Linsitinib (OSI 906) targeting IGF-1 and insulin
receptors
Dirk A. Bender (Aarhus University Hospital, Denmark)
333
Development of efficient construction of [11C]carbamate moiety using [11C]COCl2
Masayuki Fujinaga (National Institute of Radiological Sciences, Japan)
334
Selective O-[11C]methylation of 1-(3-hydroxyphenyl)piperazine
Szabolcs Lehel (Copenhagen University Hospital, Denmark)
335
Synthesis and preclinical evaluation of [11C]/[3H]Alisertib, an aurora kinase A (AURKA) inhibitor
Joost Verbeek (VU University medical center, Netherlands)
336
The introduction of an useful organic strong base, 1,8-bis(tetramethylguanidino)naphthalene for
[11C]methylation: a preparation of [11C]raclopride
Sang-Yoon Lee (Gachon University, Korea)
337
A Simple Method for Evaluation of [11C]PBR28 Partitioning Within Blood
Mark A. Green (Indiana University, United States)
338
GMP compliant synthesis of [11C]phenytoin by rhodium mediated [11C]carbon monoxide carbonylation
performed in disposable glass vials
Jonas Eriksson (Uppsala University Hospital, Sweden)
339
Synthesis of N-succinimidyl-3-fluoro-4-[124I]-iodobenzoate (S-FIB), a novel protein iodination analogue
Christina L. Brown (3DImaging, LLC., United States)
C ammonium thiocyanate: a novel 11C synthon for PET radiolabelling
Tom Haywood (Imperial College London, United Kingdom)
Radiopharmacy
369
High output [18F]FDOPA production on AllInOne (Trasis) at commercial scale.
Muhammad Otabashi (Trasis SA, Belgium)
370
Azeotropic drying free FDG synthesis and its application to a microfluidic platform
Simon K. Lindner (University of Munich LMU, Germany)
371
4S-(3-[18F]Fluoropropyl)-L-glutamic acid (FSPG): Biodistribution and tumor uptake in SLC7A11-KO mice
Matthias Friebe (Piramal Imaging, Germany)
374
Comparative biodistribution of 99mTc-duramycin: influence of species, purification and kit composition
Luca Palmieri (University Hospital Antwerp, Belgium)
375
Reproducibility of O-(2-[18F]fluoroethyl)-L-tyrosine kinetics in brain tumors and influence of dexamethasone
therapy: A PET study in rat gliomas
Johannes Ermert (Forschungszentrum Jülich, Germany)
376
Radiochemical stability of 68Ga- and 177Lu-labeled high-affinity DOTATATE (DOTA-3-iodo-Tyr3-octreotate)
Dirk Mueller (University Hospital Halle(Saale), Germany)
377
Synthesis and evaluation of 99mTc labeled metronidazole analogs HYNIC-ADIBO-MN via copper-free click
chemistry for tumor hypoxia imaging
Liqin Liu (University of Science and Technology Beijing, China)
378
[99mTc]ZOL - First in vivo imaging in dogs
Daniela Haeusler (Medical University of Vienna, Austria)
379
Synthesis and evaluation of two novel Tc-99m-labeled lactam bridge-cyclized melanocortin peptides for
melanoma SPECT imaging
Thomas P. Quinn (University of Missouri, United States)
380
Reactivity and structure relations in Mn(I), Re(I) and Tc(I)-tricarbonyl complexes – impact on drug design.
Hendrik G. Visser (University of the Free State, South Africa)
381
In vivo imaging and characterization of [18F]DPA-714, a potential new TSPO ligand, in mouse brain and
peripheral tissues using small-animal PET
Mariarosaria Panico (CNR, Italy)
382
Metabolism study of radiolabeled hydrazinocurcumin derivative
Sarah Shin (Samsung Medical Center, Korea)
363
A 99mTc-labeled antibody for the dog EGF-receptor - a preclinical evaluation
Christina Rami-Mark (Medical University of Vienna, Austria)
Targetry, Production and Separations
383
Chemical Conversion of 11CO2 to 11CO via Silacarboxylic Acids: Applications in Palladium-Mediated
Carbonylations
Patrik Nordeman (Uppsala University, Sweden)
385
Improved Production of Zr-89 from Cyclotron using a Second-Generation Solution Target
Mukesh K. Pandey (Mayo Clinic, United States)
386
82
387
Improved elution procedure of 3’-Deoxy-3’-[18F]fluorothymidine [18F]FLT for safer human injectable
radiotracer
Mohammed H. Al Qahtani (King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia)
388
A study on remote production of 43Sc from natCaO target via the natCa(α,x)-reaction
Kotaro Nagatsu (National Institute of Radiological Sciences, Japan)
389
A feasibility study on 68Ge production from elemental natGa by in-situ extraction process
Sr/82Rb production with an SR resin®: characterization and quantification by mass spectrometry of
radiation-induced degradation of various 18-crown-6 crow-ethers
Sandrine C. Huclier-Markai (SUBATECH/ARRONAX, France)
Kotaro Nagatsu (National Institute of Radiological Sciences, Japan)
390
391
Application of Compton-suppressed Gamma-Ray Spectroscopy for Improved Quality Control for production
of 82Sr.
Suzanne V. Smith (Brookhaven National Lab, United States)
Alternative Methods for the Production of Mo-99: non-Fission Based Solid-State, Mo-100 (g,n) Mo-99, and
sub-Critical Solution-State, U-235 (n,f) Mo-99
David A. Rotsch (Argonne National Laboratory, United States)
Therapy
401
Promising anti-Gram-negative antimicrobial peptides (AMPs): Radiolabeling and biodistribution profiles
Unai Cossío (CIC biomaGUNE , Spain)
402
Production and In Vivo Evaluation of Radioactive MGF-198AuNPs for Prostate Cancer Treatment
Amal Y. Al-Yasiri (University of Missouri, United States)
403
Radiosynthesis and Quality Control of Nanosized Resveratrol-Au-198
T M. Sakr (Egyptian Atomic Energy Authority, Egypt)
404
Synthesis of radiolabelled boron-rich functionalized NPs as boron carriers for boron neutron capture therapy
Kiran B. Gona (CICbiomaGUNE, Spain)
405
Strategies to Probe the Chemistry of Actinium
Justin J. Wilson (Los Alamos National Laboratory, United States)
406
Hypoxia imaging biomarker, Tc-99m-HL91, in injectable in situ forming thermosensitive implant at a murine
tumor mode
Bi-Fang Lee (National Cheng Kung University Hospital, Taiwan)
407
cGMP Kit Production of CycloSam® (Sm-153-DOTMP), A New Therapeutic Bone Agent
R K. Frank (IsoTherapeutics Group LLC, United States)
408
Treatment with Samarium-153-DOTMP in Dogs with Naturally Occurring Osteosarcoma for Therapeutic
Benefit and as a Translational Model
Kimberly A. Selting (University of Missouri, United States)