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ANTI-DANDRUFF
trikenol
TM
Natural synergic
complex for the
treatment of
dandruff
www.provitalgroup.com
trikenolTM
Natural synergic complex for the treatment of dandruff
Dandruff is an annoying problem that affects millions of men and
women around the world.
It is a condition of the scalp, marked by itching, which causes flakes
of skin to appear.
One of the main factors that increases the likelihood of dandruff to
appear are microorganisms.
In some cases, suffering from dandruff can be embarrassing and not
easy to treat, originating low self-esteem and complexes.
trikenolTM is a natural active ingredient for anti-dandruff treatment,
acting also against several factors involved in both dry and oily dandruff.
trikenolTM is a synergistic complex of two botanical ingredients:
Manuka concentrate, rich in triketones, with inhibitory
activity on the proliferation of Malassezia globosa and M.
furfur.
Willow extract, rich in polyphenols and salicylic derivatives
(salicylic acid), has anti-irritant, anti-seborrhea and
keratolytic actions.
In vitro tests
Antifungal activity
Anti-irritant activity
trikenolTM activity on Malassezia globosa and
Malassezia furfur:
M. globosa
MIC
Inhibition
% COX INHIBITION
MIC
LI
Inhibition
0.25%
0.25%
Fungicide
ASA 1mM
trikenolTM was more active against Malassezia
ASA 0.1mM
0.06%
LI
M. furfur
Anti-irritant activity of 0.1% willow extract,
contained in trikenolTM, by measuring the
inhibition of cyclooxygenase (COX):
0.003% Fungicide
globosa, the primary dandruff-causing agent
MIC: Minimum Inhibitory Concentration (complete inhibition of
microorganisms growth).
LI: Large Inhibition (reduces growth without inhibiting it
completely).
63.9%
49.9%
WILLOW
EXTRACT
0.1%
43.5%
0
10
20
30
40
50
ASA: acetylsalicylic acid as the positive control.
60
70
ANTI-DANDRUFF
In vivo efficacy
TM
20 volunteers during 1 month. Shampoo containing 1% trikenol vs. placebo. Measurements were taken at the beginning and at the
end of the treatment.
Measurement of the amount of scalp oil
Scalp observation and evaluation
trikenolTM improved the general health of scalp:
SD
dandruff
trikenolTM significantly reduced seborrhoea by
57.4%, measured with Sebumetry.
Microscopic examination of scales
Wounds
produced by
scratching
Flaking
dandruff
Itching
After trikenolTM treatment, there is an absence
of microorganisms (Malassezia) in the scales.
Seborrhoea
Redness
trikenol
TM
PLACEBO
Observation with micro-camera
trikenolTM showed very satisfactory progress,
with less scales and a reduction of
seborrhoea.
T0
T30
trikenolTM features and benefits:
T0
Inhibition of bacterial
proliferation: Malassezia globosa
and Malassezia furfur.
Anti-irritant: cyclooxygenase
inhibition.
Keratolytic effect: restore the scalp
with a 45% scale reduction.
T30
Anti-seborrhea: reduces 57% of
sebum production.
trikenol
ANTI-DANDRUFF
TM
Natural synergic complex for the treatment of dandruff
cosmetic applications
• Anti-dandruff specific treatments
• Daily hair care products: shampoo, conditioners, etc.
Technical specifications
Formulation
trikenol 75800
Anti-dandruff Shampoo for Oily Hair
TM
PROPERTIES
Anti-dandruff treatment from
natural origin
Acts also against the several
factors involved in both dry and
oily dandruff
ACTIVES MOLECULES
Triketones
Polyphenols
Salicylic derivatives
APPEARANCE
Transparent liquid
Yellow - dark yellow color
SOLUBILITY
Soluble in aqueous solutions
RECOMMENDED DOSE
0.25 - 1 %
INCI / PCPC
A Aqua (Water)
Aqua (Water), Sodium Laureth Sulfate
Methyldibromo Glutaronitrile, Phenoxyethanol
Tetrasodium EDTA
trikenolTM
Glycerin
% (w/w)
51.96
30.00
0.15
0.10
0.50
0.50
B Parfum (Fragrance)
Coco Glucoside, Aqua (Water)
0.40
5.00
C Cocamidopropyl Beatine, Aqua (Water)
Cocamide DEA
Polyquaternium-39
6.00
1.50
2.50
D Citric Acid
Aqua (Water)
0.08
0.32
E CI 42090
CI 19140
q.s.
q.s.
F Sodium Chloride
0.70
V01-2013