Fast, effective treatment for inflammatory skin conditions Designed and developed by 28 Years of Laser Innovation. INTRODUCING REGENLITETM TRANSFORM Fast, effective treatment for inflammatory skin conditions Chromogenex has developed a truly novel laser technology, RegenliteTM Transform, that enables the management of inflammatory skin conditions without any discomfort, downtime or residual cell necrosis. Regenlite Transform is clinically proven to treat a number of common inflammatory skin conditions, including • Acne vulgaris (all grades) • Psoriasis can support downregulation of any localised inflammatory cascade and resolve active dermatological disorder. These cytokines, which can increase by up to 1500% above normal tissue levels, have been measured as soon as 3 hours after the laser treatment, demonstrating the ability for rapid relief of these inflammatory conditions. This unique biostimulatory effect in the tissue enhances the skins wound healing response over and above the normal levels of response without having to create a trauma unlike the mechanism of most laser and light therapies. • Eczema • Rosacea • Wound healing • Scar Improvement RegenliteTM Transform can also be used for other applications to include vascular lesions, warts verrucas, molluscum contagosum and skin rejuvenation. Biostimulatory effect Using a unique and patented laser cavity design, laser parameters are produced that can initiate a biostimulatory effect in the tissue, stimulating important cytokines that Data from reference 1. n=8; p=0.093 (3h), p=0.012 (24h). Reference: 1. Seaton ED et al. Investigation of the mechanism of action of nonablative pulsed-dye laser therapy in photorejuvenation and inflammatory acne vulgaris. Br J Dermatol 2006; 155(4): 748-755. HOW DOES REGENLITE TRANSFORM WORK? SmartpulseTM Technology Regenlite Transform 585nm laser light is preferentially absorbed by oxyhemoglobin, creating a minute low-grade heating of the microcapillary walls. Fenestration of these walls releases inflammatory mediators such as TGF-ß. 585nm laser light is preferentially absorbed by oxyhemoglobin SmartPulse technology maximizes collagen stimulation without causing long-term impairment. Regenlite Transform requires less energy and is less painful than other aesthetic devices in treating a wide range of skin conditions. With Regenlite SmartPulse, 80% of the energy is delivered in the first 150μs The importance of TGF-ß in the dermis TGF-ß is the messenger that stimulates the fibroblast cells for neocollagenesis. In tissue where an inflammatory cascade is active, TGF-ß downregulates this cascade, quickly resolving the inflammation, such as found in active acne lesions or underlying psoriatic plaques. TGF-ß has a pivotal role in acquiring an immune response in the tissue, which can allow the re-establishment of the skin’s normal negative feedback mechanism to cause normal lesion resolution rather than the progression into inflammatory acne. It is this mechanism that is overstimulated or faulty as a result of increased androgen levels, and why a teenager can develop acne. The ‘re-boot’ of this mechanism can prevent microcomedone formation prevent future acne outbreaks. In non-inflammatory tissue, the TGF-ß is able to use its full potential in fibroblast stimulation, creating new collagen production to remodel the dermis where unwanted lines or scars are present. This collagen remodelling occurs without detriment to existing healthy connective tissue fibres as is often seen in other ‘thermal’ light based methods. REGENLITE TRANSFORM: CLINICALLY PROVEN IN ACNE 50% Reduction in acne lesion counts A single Regenlite Transform treatment on acne vulgaris has been shown to decrease the average number of acne lesions by 50%. Improvement has been observed to last longer than 12 weeks after a single laser session. Acne studies • • • • 3 87% of patients demonstrated substantial improvement 58% exhibited greater than 50% improvement The most rapid improvements were seen in first 4 weeks There were no reported side effects Improves and prevents scarring, as well as clears acne. “Over 92% of patients reviewed after a single treatment had a significant improvement” 3 Seaton, ED et al. The Lancet Vol 362, 2003 3 REGENLITE TRANSFORM: CLINICALLY PROVEN IN ACNE Scientific evidence published in the British Journal of Dermatology showed RegenliteTransform treatments:1 • Stimulates fibroblast activity to produce new collagen • Rapid wound healing • Improves wrinkles & scarring • Induces regulatory T-cells • Reduces inflammation • Initiates an immune response • Prevents further outbreaks of acne & other conditions Regenlite Transform significantly increases collagen production Before 30 days later Epidermis Dermis Increased collagen production 30 days later EVIDENCE: BEFORE AND AFTER PHOTOS Rosacea 59 year old before after 2 treatments 48 days Rosacea – blood image before/after 2 treatments 48 days Before After 1 treatment Eczema 61 year old before after 2 treatments Eczema – blood image before/after 5 treatments Acne 20 year old before Psoriasis After 3 treatments Before treatment After 4 treatments Vascular Before treatment After 2 treatments Before treatment After 2 treatments Before 3 months after 8 treatments Before After 2 treatments REGENLITE TRANSFORM: FAST, EFFECTIVE TREATMENT FOR INFLAMMATORY SKIN CONDITIONS Regenlite Transform is easy to use. Treatments can be delivered simply and quickly with minimal intra-operative discomfort or post-operative effects, enabling fast patient turn-around times. Good for Patients • • • • • Rapid results No side effects Pain free – no need for analgesia Treats all skin types Effective in cases resistant to traditional medications Great for Practices • Easy to use (touch-screen controls, ergonomic handpiece) • Fast patient turnaround times • Excellent versatility • Proven effectiveness • Highly profitable system for your clinic • Extensive patient recruitment PR and Marketing campaign TESTIMONIALS “The biggest breakthrough in acne in the last 30 years.” Prof. Chu, Dermatologist, Hammersmith Hospital, UK. “As awareness for laser treatment of scars continues to grow with patients, the quest for laser treatment of scars also increases. When used in the early stage of wound healing, the Regenlite has proven to prevent further abnormal scar proliferation and to effect speedier improvement.” Dr. Christine Dierickx, Dermatologist, Belgium “Regenlite is one of the most used lasers in my practice. We have also conducted our own clinical studies and found the laser to be both versatile and effective with minimal side effects. Its unique mechanism allows us to achieve impressive results with inflammatory skin conditions as we well as vascular and viral skin conditions.” Dr. Tokuya Omi, Dermatologist, Japan “The most versatile laser you will ever purchase.” Dr. Steve Shapiro, Dermatologist, University of Miami “Bottom line for my practice: It works. The Regenlite is also painless, affordable to a greater variety of patients, and has become a workhorse that exceeds my expectation.” Dr. Edward Zimmerman, Las Vegas, NV The Company Chromogenex Technologies Limited has been manufacturing lasers for the medical industry since 1986. We are a global business offering expertise in clinical training, design and development, manufacturing, research and customer support. Commitment to Quality Chromogenex devices meet all product, system and regulatory requirements for a worldwide market. We apply a Medical Device Quality System that meets United States FDA and GMP Medical Device Regulations. “Better results than my fraxional laser and without the side effects.” Dr. Kopleston, Dermatologist Beverly Hills, CA “Regenlite is a paradigm shift, using low fluence laser to treat inflammatory disorders such as acne and psoriasis” Dr. Steve Eubanks, Dermatologist, Denver, CO Contact Us Chromogenex US Inc. 5872 Sterling Drive Howell, MI 48843 Email inquiries to: [email protected] Additional information may be found at: www.chromogenex.com www.regenlite.com Phone: 1.855.438.4547 All other international enquiries: +44 (0)1554 755 444 Made in Great Britain F20-1265A facebook.com/chromogenex