Finally... A Proven comprehensive treatment for the appearance of cellulite has arrived! A pain free procedure with no adverse events or side affects. Verjú BY ERCHONIA® — A Revolutionary Evidence Based Cellulite Treatment Erchonia, driven by our commitment to research, has significantly contributed to the global body of knowledge Erchonia changed the medical community when it discovered 635 nm laser effects on fat cells, and with this foundation, concerning low level lasers. In addition to the empirical evidence substantiating our claims, each new level (1) clinical trial Erchonia examined different ways to affect adipocytes and their surrounding tissue, and Verjú was born. we sponsor provides us with a more unique understanding of the diverse biological responses that occur when low level laser therapy (3LT®) is applied to living tissue. The new knowledge gained becomes the foundation for our future studies. The Verjú is a multi-facted approach to treat the appearance of Cellulite, and is the only device to be backed by a level (1), Our application of low level laser therapy in the GREEN spectrum is no exception. placebo controlled study to prove its efficacy. The Verjú is a transdermal laser that penetrates the skin to treat hypertrophic adipocytes while increasing dermal collagen and stabilizing the fibrotic septae collagen. Cellulite Reduction & Documented Results According to the doctors that performed the Verjú cellulite clinical trial using the green laser, the 4 measurement points in the Nurnberger-Muller scale that was implemented, may not be sensitive enough to measure the changes the doctors were seeing with their eyes and that by using a 10 point scale, it may have even produced better results. Laser Surgery Medicine 2013 Mar, 45(3); 14-17 Below is an electromagnetic chart of radiation and was the basis for our theory. This chart indicates that there is more energy in a green photon than a red photon. What is interesting to note is that according to so-called experts, everything in the electromagnetic radiation chart penetrates through or deep into the body except visible light. This theory we believe may be flawed based on the fact the energy in the visible spectrum has about 40% more energy per photon than infrared light and this has nothing to do with power of the laser which is measured in milliwatts or watts. If low level laser therapy works by cell transfer and not power, then our theory could be correct. 49 48 Green Test Red Test 47 More than a dozen clinical trials have demonstrated the utility of 635 nm (red ) laser to safely and effectively collapse 46 Placebo 45 enlarged fat cells. Verjú delivers a wavelength that carries more energy 532 nm (green) and as a result liberates more lipid 44 material while stimulating the synthesis of type I and III collagen. 43 Baseline LT Week 1 LT Week 2 LT 2 Weeks Post 49 Did you know? 48 Prueba verde Prueba de Red 47 The Verjú laser system also proves as an effective 46 45 treatment for the circumference reduction of the waist, 44 hips and thighs. 43 Base LT Semana1 LT Semana2 Placebo LT 2 Semanas Mensaje LASER RADIATION DO NOT STARE INTO BEAM CLASS 2 LASER 532nm 16.00 ± 2mW IEC 60825-1:2001 Complies with 21 CFR 1040,10 and 1040,11 except for deviations pursuant to Laser Notice No. 50, dated July 26, 2001 CLS Nurnberger-Muller CELLULITE DEFINITION Scale The Nurnberger-Muller scale has been published in many papers but not many, if any, have implemented this scale in a level (1) blinded and controlled clinical trial. The reason is that there are only 4 grades of cellulite Results of the clinical trial Changes in Nurnberger-Muller Scale Stages, Per-Protocol Population LLLT TREATMENT (N=23) and to change from 1 grade to another would be a 25% difference based on the doctor’s perception of cellulite reduction. Please see an example of the scale below. Stage 0 No dimpling or apparent visible alterations to the skin surface upon standing or lying down or upon pinching the skin. Stage 1 No dimpling or apparent visible alterations to the skin surface upon standing or lying down. Dimpling appears with the pinch WEEK 2, N(%) • DECREASE OF 2 STAGES 2 (9%) --- • DECREASE OF 1 STAGE 13 (56%) 1(3%) • NO CHANGE 8 (35%) 27(94%) --- 1(3%) • DECREASE OF 2 STAGES 4(17%) --- • DECREASE OF 1 STAGE 13(57%) 4(14%) • NO CHANGE 6(26%) 27(83%) --- 1(3%) • INCREASE OF 1 STAGE WEEK 6, N (%) • INCREASE OF 1 STAGE Subjects Achieving Individual Success test or muscular contraction. Stage 2 Dimpling appears spontaneously when standing but not when lying down. The orange peel appearance of the skin is evident to the naked eye, without need for manipulation. Stage 3 SHAM TREATMENT (N=29) SUBJECTS (5) LLLT TREATMENT (N=34) SHAM TREATMENT (N=34) SIGNIFICANCE* 19 (55.88) 3 (8.82) P < 0.0001 PRIMARY OUTCOME MEASURE Nineteen subjects in the LLLT group achieved the individual success criteria (55.88%) versus three subjects (8.82%) in the sham-treated group (P < 0.0001; Table 2). Dimpling is spontaneously present when both standing and lying down, evident to the naked eye without need for Changes in BSA Affecting Cellulite manipulation; Orange peel skin surface appearance with raised areas and nodules. LLLT TREATMENT (N=23) SHAM TREATMENT (N=29) 16.65 (6.23) 14.74 (6.92) 12.76 (6.47)* 14.08 (6.55) 12.33 (6.77)* 13.58 (6.59) BSA (%), MEAN (SD) • PRE-TREATMENT (BASELINE) In addition to classifying cellulite severity, the Nurnberger-Muller scale can be used to assess changes in severity following treatment intervention. Assessments using the Nurnberger-Muller scale were made at baseline, 2 weeks (following the last treatment session) and 6 weeks (4 weeks after the last treatment session) for the Erchonia clinical study. • POST-TREATMENT (WEEK 2) FOLLOW-UP (WEEK 6) *P <0.0005, one-way ANOVA for correlated samples ƚP <0.001, one way ANOVA for correlated samples This chart was implemented to support the Nurnberger-Muller scale and shows reduction of body surface analysis based on total body cellulite. CLINICAL MEANINGFUL RESULTS IN AS LITTLE AS TWO WEEKS! BEFORE AFTER Erchonia’s Verjú laser system is a new revolutionary device designed specifically for the treatment of cellulite. The Verjú utilizes Erchonia’s patented line generated low level lasers to target pockets of uneven fat in the thighs, buttocks and lower abdomen. The Erchonia Verjú laser system was proven through a doubleblind, multi-site, placebo controlled study. It is the only low level laser device on the market to receive FDA market clearance for the appearance of cellulite. Verjú Laser System Verjú Massager www.verju.com LASER RADIATION DO NOT STARE INTO BEAM CLASS 2 LASER 532nm 16.00 ± 2mW IEC 60825-1:2001 888.242.0571 Toll Free or 214.544.2227 Complies with 21 CFR 1040,10 and 1040,11 except for deviations pursuant to Laser Notice No. 50, dated July 26, 2001 CLS Verjú™ is a product of ERCHONIA® Corporation - 2021 Commerce Drive, McKinney, TX 75069 Patented, US and international patents and patent pending. For more information go to www.erchonia.com. Verju Cellulite English US Rev_1