1. No category

Department of
Anesthesia and
Perioperative Care
Anesthesia
News
2015 | Vol. 13
Preparing for Ebola
Matt Aldrich, MD
Also in this issue:
■■ Message
from the Interim Chair
■■ Pediatric
Cardiac Anesthesia
■■ The
Ronald D. Miller Distinguished
Professorship of Anesthesia
■■ Resident
“Houses”
■■ Acute
Respiratory Distress
Syndrome
■■ The
Anesthesia Staff Support
Engagement Team
■■ Farewell
to Chuck Hajek and
Lorenzo Woo
■■ Resident
Profiles, New Faculty,
Publications, Grants, and more
M
att Aldrich, MD, interim director of adult critical care medicine at UCSF
Medical Center, is part of the core group at UCSF leading preparations
for a potential Ebola Virus Disease patient. In December 2014, the U.S.
Department of Health & Human Services designated UCSF Medical Center as an
Ebola treatment center – the only hospital in San Francisco to earn this designation
and one of 35 such hospitals nationwide.
He understands the event may never occur – to date, there has not been one
documented case of Ebola in California – but says, “What’s the alternative to fully
preparing? We’re putting processes in place for better emergency response and
preparedness; that’s important not just because of Ebola, but because we don’t
know what the next infectious disease outbreak will be.”
A Long, Thoughtful Process
By late August of 2014, epidemiology and infection control groups at UCSF had
already developed a web site and put in place guidelines for screening, personal
protective equipment (PPE) and patient isolation. At that point, approximately 30 key
stakeholders from Infection Control, Nursing, Critical Care Medicine, Emergency
Medicine, Lab Medicine, the Safety Office and the Department of Emergency
Management met for the first time.
continued on next page
Anesthesia
News
is published by the UCSF
Department of Anesthesia
and Perioperative Care
521 Parnassus Avenue
Room C 450, Box 0648
San Francisco, CA 94143-0648
415/476-2131
“Taking the time to
go through this
process is valuable.
Even if it never
involves taking care
of an Ebola patient.”
— Matt Aldrich, MD
http://anesthesia.ucsf.edu
Send all inquiries to
UCSFAnesthesiaNews
@ucsf.edu
DEPARTMENT
INTERIM CHAIR AND
EDITOR-IN-CHIEF:
Michael Gropper, MD, PhD
EDITOR:
Morgen Ahearn
DESIGNER:
Laura Myers Design
PRINCIPAL WRITER:
Andrew Schwartz
PHOTOGRAPHERS:
Noah Berger, Cindy Chew,
Adam Jacobson, Christine
Jegan, Susan Merrell,
Marco Sanchez (UCSF
Documents, Media and Mail),
Richard Schlobohm
©2015 The Regents of the
University of California
Preparing for Ebola
continued from previous page
Their work was quickly colored – the
team galvanized – by events at Texas
Health Presbyterian Hospital in
September, when a patient arriving from
Liberia was initially sent home and
ultimately died of the disease, but not
before infecting two nurses.
The work, however, posed a set of
significant challenges. Beyond creation
of an isolation unit and training in the use
of PPE, they would need to create clear
and detailed processes for everything
from the use of diagnostic equipment to
lab testing, waste disposal and rapid
response to an Ebola patient in distress.
This multidisciplinary effort has been
lead by Adrienne Green, Associate Chief
Medical Officer for UCSF Health.
Creating the Unit and Processes
Drawing on CDC guidelines and best
practices from Emory University and
Nebraska Medical Center, which had
successfully handled Ebola cases,
the UCSF team decided to create an
isolation unit in an existing intensive care
(ICU) unit on its Mount Zion campus.
The core clinical teams include nurses,
clinical lab scientists, respiratory
therapists and faculty physicians from
critical care, infectious disease, and
hospital medicine who have volunteered
to train and provide care for Ebola virus
infected patients. The School of
Medicine and Medical Center decided
that no trainees would be involved in
direct care.
UCSF Department of Anesthesia and Perioperative Care |
“A guiding principle has been to limit
patient contact to a core group of
providers and – as we think broadly
about what we can accomplish clinically
– to also do everything we can to
minimize risks to staff,” says Aldrich.
Among other things, this has meant
developing new workflows to address
the risk of procedures – such as
continuous renal replacement therapy –
that have been effective in treating
Ebola patients, but have the potential
for significant blood exposure. The
group is also planning to make use of
telemedicine to limit the number of
providers in the room.
The Role of Critical Care
Aldrich has been unsurprised, though
pleased, by the response of critical care
staff in both adult and pediatric units.
These individuals know that should an
Ebola patient arrive, the clinical teams
will be isolated and away from their
normal lives for at least the entire
treatment period.
“We have a sizeable group of
volunteers from both Anesthesia and
Pulmonary Critical Care,” says Aldrich.
“We will work together with the
volunteers from critical care nursing, as
well as Pediatric Critical Care, Infectious
Disease, Hospital Medicine, and
Obstetrics to provide the best care
possible to patients of all ages.”
Despite the demands of the
preparation effort, Aldrich believes,
“Taking the time to go through this
process is valuable. Even if it never
involves taking care of an Ebola patient,
the Medical Center has done the right
thing by making it a priority. I’m grateful
for the very strong support of both
UCSF Health and School of Medicine
leadership.”
Anesthesia News | 2015 | 2
Message from the Interim Chair
Changes in the Healthcare Landscape: Challenges and Opportunities
O
n Sunday, February 1st, 40
ambulances arrived at Moffitt/
Long Hospital to begin the
challenging task of safely transporting
131 patients from the Moffitt/Long and
Mount Zion hospitals to the new hospitals
at the Mission Bay campus. The patients
included newborns, a baby on ECMO,
triplets, laboring mothers, and many
others. Due to extensive planning, and
the hard work of 300 personnel, the
process went smoothly. I was particularly
proud watching our residents and faculty,
who provided critical support at both
hospitals during the transition. By early
afternoon, all patients were safely
admitted to the new hospitals: The
UCSF Benioff Children’s Hospital San
Francisco, UCSF Betty Irene Moore
Women’s Hospital, and the UCSF Bakar
Cancer Hospital. Combined, these three
hospitals add nearly 300 beds and
20 operating rooms to UCSF Health.
Starting February 2nd, Mount Zion
Hospital became an Ambulatory Surgery
Center (ASC), with 6 OR’s and various
non-OR anesthetizing locations.
Staffing 20 new ORs and a 14 bed
ICU at Mission Bay, in addition to the
ASC at Mount Zion, has created both
challenges and opportunities for the
Department. Over the last year and
into the next, we will have added
approximately 14 new faculty members
to provide coverage in the new hospitals,
in addition to providing for expansion in
pain management, critical care, and
other areas. Additional faculty are being
recruited to San Francisco General
Hospital, which will open its new facility,
the Priscilla and Mark Zuckerberg San
Francisco General Hospital and Trauma
Center (please “like” it on Facebook!). Of
note, Priscilla Zuckerberg, MD is a UCSF
graduate, and recently completed her
pediatrics residency at UCSF. This will
be a state of the art hospital, with an
expansion from 27 to 58 beds in the
trauma center, increase in ORs from
10 to 20 (including 8 adult, 8 pediatric
and 4 shared adult/pediatric ORs), and
doubling of ICU beds (31 single and
13 double intensive care nursery rooms,
14 intensive care unit rooms for adults,
10 pediatric intensive care unit rooms,
12 pediatric cardiac intensive care unit
rooms, and 12 transitional pediatric
intensive care rooms). James Marks,
MD, PhD, Chief of the Anesthesia
Service at SFGH and current Chief of
Staff, has also been adding faculty in
anticipation of having to staff additional
ORs and ICU beds.
One of the challenges faced by the
Department is the spread of faculty
and trainees across the city. It is with
mixed feelings that we will begin to
videoconference our traditional
Grand Rounds and QI conferences on
Wednesday mornings, as an effort to
reduce the stress of having to cross
San Francisco in the peak of commute
hour to reach SFGH, the VA, Mount Zion,
and Mission Bay in order to start OR
cases on Wednesday mornings. In order
to minimize the impact of this dispersion,
we have started the “Houses” concept,
described in this newsletter. These
groups will bring residents, fellows,
and faculty together in a social
environment for mentoring, teambuilding,
and camaraderie. In spite of these
changes, our residency is viewed as the
best in the country, at least according
to the recently released Doximity and
US News & World Report rankings
(http://tinyurl.com/UCSFrank). While
many argue with the methodology, I
personally believe it is sound.
UCSF Department of Anesthesia and Perioperative Care |
Speaking of rankings, for a number
of years, UCSF has been ranked #1
in terms of NIH funding. However, it is
increasingly difficult to fund the research
that has been an essential part of our
success. I am encouraged by the recent
success of our faculty in obtaining
funding, but increasingly, academic
departments need to provide long-term
funding in the form of endowed chairs
and distinguished professorships. In
addition to providing stability, these
endowments are a crucial tool for
recruiting top talent to UCSF, where
the cost of living serves as a major
disadvantage. As many of you are aware,
we are in the process of fundraising for
the Ronald D. Miller Distinguished
Professorship. This Professorship will
honor Dr. Miller, our 3rd Chair, who led
the Department for 26 years. It will
support a clinical/translational researcher
in the mold of Dr. Miller, whose critical
contributions to transfusion medicine
and neuromuscular blockade
transformed our specialty. While I don’t
expect our alumni to be as generous as
Priscilla Zuckerberg, I do hope you will
contribute to help assure that we remain
the #1 department in the world.
Michael Gropper, MD, PhD
Professor and Interim Chair
Anesthesia News | 2015 | 3
Ask the Expert: Scott Schulman, MD, MHS
Pediatric Cardiac Anesthesia
Now that surgical advances have dramatically
improved survival rates for children with congenital
heart disease, how can research in pediatric cardiac
anesthesia improve the quality of these patients’ lives?
W
hen I did my cardiac
anesthesia rotation, we lost a
lot of congenital heart disease
patients on the table. Now, thanks to
advances in cardiac surgical, anesthetic,
perfusion, and critical care techniques –
and the strong collaboration between
anesthesiology and cardiac surgery –
those same patients have a 70-80
percent survival into adulthood. That’s
why we’ve been able to shift our focus to
the quality of their survival.
In pediatric cardiac anesthesia, we’ve
long been concerned about the effect
on the developing brain of early exposure
to potent inhalational or IV anesthetics.
In order to examine outcomes, we’ve
needed to develop databases and use
the tools of evidence-based medicine –
especially randomized clinical trials and
comparative effectiveness trials – to
critically examine what types of clinician
behaviors (i.e. surgical, anesthetic,
perfusion, and intensive care) positively
affect outcome. This has been a big part
of my career.
And though it took an act of Congress
to get people to spend money on
pediatric clinical trials, we are making
progress, especially with thoughtful,
collaborative networks, like the Pediatric
Heart Network. Similarly, the Congenital
Cardiac Anesthesia Society – in partnership with cardiothoracic surgeons – is
developing a database that includes
best practices in the operating room for
patients with congenital heart disease.
At UCSF, we are fostering
collaborations among basic scientists
and clinical-translational thinkers in
pediatric neurology, cardiology, surgery
and anesthesia to do programmatic,
outcome-based investigations. That
work is enhanced by UCSF Benioff
Children’s Hospital San Francisco
moving to Mission Bay, where clinical
scientists can work ever more closely
with basic scientists.
The current thinking is that
repeated exposure to anesthesia at
key developmental points – as well
as to cardiopulmonary bypass – can
trigger cellular events that lead to
bad neurologic outcomes. But we’re
also learning that a lot of babies with
congenital heart disease are born with
brain abnormalities that, in some cases,
predate the exposure to anesthesia
or bypass. Unlacing these issues is
essential if we’re to minimize the risk and
maximize the benefit of new therapies
and surgical techniques that can mitigate
the harmful effects of anesthesia.
At UCSF, we are among those testing
the efficacy of an alpha 2 adrenergic
agonist – dexmedetomidine – which
many academic centers are starting to
use before, during and/or after pediatric
open-heart surgery. Early studies
indicate it can have several salutory
effects on the heart and brain, because
it stabilizes the heart rhythm against
supra ventricular tachycardia and may
have neuroprotective effects because
of its mechanism of action in the brain.
In my clinical experience with
dexmedetomidine one can give a
fraction of the amount of opiates
typically required with other anesthetics.
One caution: it can slow heart rate,
so it’s important to mitigate that
untoward effect with drugs or devices
that mitigate the undesired cardiac
rhythm consequence.
A lot of the seminal work on
dexmedetomidine was done by
investigators at UCSF, but there are still
gaps in our knowledge so our group has
been collaborating with the NIH and
UCSF Department of Anesthesia and Perioperative Care |
pharmaceutical companies to do the
work that will create proper protocols
and pediatric labeling for this and other
drugs, including those in the pipeline that
have a pharmaceutical sponsor. That’s
the challenge now: how to properly apply
new therapeutics in the clinical setting.
We are also looking at new, inhaled
agents like xenon, which is another
interesting possibility for countering the
effects of anesthesia on young children.
It was originally used to measure blood
flow to the brain, but now we are
investigating its potential to protect the
developing brain from anesthesia and
cardiopulmonary bypass.
Finally, as noted above, thanks to
these types of advances there are now
more adults living with congenital heart
disease than children living with the
condition. Many of these adults come to
the operating room for a variety of
non-cardiac surgical procedures, but
because of their palliated congenital
heart disease, they often require the
expertise of pediatric cardiac
anesthesiologists to manage their
medically complex preoperative issues.
This is an essential evolving role for us
as pediatric cardiac anesthesiologists:
we care for these patients throughout
their life, not just for cardiac surgery, but
for non-cardiac surgery as well.
Anesthesia News | 2015 | 4
In Pursuit of Excellence
Creating the Ronald D. Miller
Distinguished Professorship of
Anesthesia and Perioperative Care
F
or more than half a century, the UCSF Department of Anesthesia and
Perioperative Care has been making groundbreaking clinical discoveries and
training generations of leaders in both academic anesthesia (24 chairpersons
to date) and private practice.
Much of our department’s success has grown from the vision of our first
three chairs: Stuart C. Cullen, William K. Hamilton and Ronald D. Miller. All three
believed that anesthesia was in a unique position to conduct important clinical
research – and that doing so would draw the best and brightest to our specialty.
And they were right.
Yet at a time of intense healthcare change and reduced availability of
research support, maintaining this tradition and the department’s international
leadership requires carving out a position where someone can dedicate themselves
fully to these pursuits. Thus we are redoubling our efforts to raise $2,500,000 to
establish the Ronald D. Miller Distinguished Professorship of Anesthesia and
Perioperative Care.
The pursuit of excellence – the title of Dr. Miller’s 2009 Rovenstine Lecture to
the ASA – has been the lodestar of Dr. Miller’s career, a highlight of which was his
election to the Institute of Medicine at the National Academy of Sciences in 1998.
His research contribution began with the historic clinical research he initiated
in a combat hospital during the Vietnam Conflict in 1968-69 – work that changed
the way hospitals treat coagulopathies associated with massive blood transfusion.
It continued with his seminal work on the safe use of neuromuscular blockade,
and his serving on several NIH study sections, including being chairperson of
the NIH Surgery, Anesthesia, and Trauma Study Section. Dr. Miller’s many
contributions to medicine and patient safety honor a history that begins with the
research discoveries of John Severinghaus, Ted Eger and Dr. Miller’s classmate,
George Gregory.
When he assumed department leadership in 1983, Dr. Miller was determined
that others have similar opportunities to make their mark and that the department
and specialty expand its leadership role in all aspects of perioperative medicine.
During his 26 years of leadership, the department created a nationally recognized
multidisciplinary outpatient pain clinic and an inpatient pain service, both of which
helped establish UCSF as a leader in pain treatment and anesthesia as the go-to
specialty for pain. He continued to expand anesthesia’s leadership in intensive care
at UCSF – a role pioneered by his two predecessors as chair. Dr. Miller’s authorship
of the most widely used textbook for anesthesia in the world (Miller’s Anesthesia)
has highlighted UCSF faculty and dramatically enhanced our department’s
international reputation. And he established a translational research fellowship
while recruiting leading investigators to our faculty to ensure we grew a research
portfolio that reached across specialties and around the world.
Now the pressures of modern healthcare pose a challenge to the department’s
and Dr. Miller’s legacies. But as Dr. Miller said recently, “It’s still of prime
importance to think big and dream.” We should honor his service and his vision.
The holder of the Ronald D. Miller Distinguished Professor of Anesthesia and
Perioperative Care will further Dr. Miller’s deep commitment to clinical research in
anesthesia and to excellence in the training and mentoring of young physicians.
UCSF Department of Anesthesia and Perioperative Care |
For more information or to
make a gift, please contact
Tommy Williams at (415)
476-5825 or send an email to
[email protected].
Anesthesia News | 2015 | 5
From top:
Ronald D. Miller
William K. Hamilton
and Stuart C. Cullen
Education
Giving
Residents
a Place to
Call Home
D
oximity and US News and
World Report recently named
the residency program at
UC San Francisco’s Department of
Anesthesia and Perioperative Care the
number one residency in the country
for anesthesiology.
No surprise there; the program has
been a national leader for years.
But the department knows it cannot
rest on its laurels. At a time when
residency programs are judged not just
by the rigor of their training but also by
the support and life-work balance they
offer, maintaining leadership means
finding creative ways to help new
physicians adapt to the intense demands
of residency.
This can be tricky in a large
department like UCSF’s, with its 90
residents rotating to a new location every
two months. The size creates unique
learning opportunities, but it can also be
confusing for entering residents seeking
support and guidance. That’s why the
department decided to create virtual
“houses” – named for each of the
department’s long-serving department
chairs: Stuart Cullen, William Hamilton
and Ronald Miller – where groups of
residents can find the support and
guidance they need.
Making People Feel At Home
in a Large Institution
“We wanted to create the type of
camaraderie you see in smaller
institutions,” says Kristina Sullivan, MD,
who directs the anesthesia internship
for the department and was recently
elected to the UCSF Academy of
Medical Educators.
“We figured why not have a family
to go to, rather than just one faculty
advisor?” says Kevin Thornton, MD,
who serves as chair of the departmental
residency well-being committee and
program director for UCSF’s Adult
Cardiothoracic Anesthesiology
“We figured
why not have a
family to go to,
rather than
just one faculty
advisor?”
— Kevin Thornton, MD
Fellowship program. “The houses create
a structure for vertical mentoring.”
Vertical mentoring – where each
resident receives mentoring from
peers the next level up – helps avert
residents’ sense of being on their own,
while clarifying the expectations that
go along with being in a top notch
residency program.
“It offers support for those who
may be having a difficult time and,
sometimes, it means asking people to
dig deeper if they don’t understand
what’s expected,” says Chief Resident
Wendy Smith.
Creating Common Ground
At a kickoff event in June 2014, every
resident, fellow and faculty member was
assigned to a house. Veteran faculty
spoke of the values each of the historic
chairmen brought to the department
and the impact they had on residents’
lives and careers.
“A lot of the residents were very
moved and talked about how much they
liked understanding the history of the
department better,” says Smith.
Over the summer, the houses began
to bond through a series of facultyhosted barbecues and additional
meetings, out of which emerged selfgoverning resident leadership councils.
The councils, with the help of a faculty
mentor, coordinate individual and
all-house activities, which include social,
career-focused and academic events. As
of the writing of this article, those events
have included group birthday parties,
a panel on fellowship opportunities
and an organized discussion about
professionalism in medicine.
“In residency, you don’t always have
a sense of what your peers are doing,
so [during the professionalism evening],
residents who have recently been in the
UCSF Department of Anesthesia and Perioperative Care |
same shoes as new residents made clear
our common goals and responsibilities,”
says Chief Resident Ashley Quan.
“It took away the mystery about
what’s expected for everything from
asking for days off to not leaving the
hospital without seeing if colleagues
need breaks,” says Smith.
“What made the professionalism
event work was that it was led by senior
residents, not faculty, and it accelerated
what you need to learn to thrive in a
large, complex system,” says Thornton.
Continually Refining the Effort
To help keep residents engaged, the
department has created a playful
competition among the houses. Each
house receives points for attendance
at events, presentations, planning
and citizenship actions, such as
helping a colleague. At the end of the
year, the winning house decides on its
preferred prize.
Meanwhile, the leadership teams
are refining what they’re doing. Based
on feedback from their houses, the
leadership teams are considering a
number of future events:
■■ A
team-based scavenger hunt through
San Francisco
■■ A
jeopardy style knowledge bowl to
prepare for the in-training exam and
catalyze group studying
■■ A
faculty-hosted and/or resident-run
journal club to encourage peer learning
■■ Events
where families and significant
others can meet, from a chili cook-off
and Panini party to a whiskey tasting.
“We try to figure out what worked and
hasn’t worked so we can better meet
the needs of all the residents,” says
Thornton. “I think people looking at
the program now are excited by what
we’re doing.”
Anesthesia News | 2015 | 6
Research Profile
Exploring Promising Approaches for
Acute Respiratory Distress Syndrome
A
cute respiratory distress syndrome
(ARDS) is a significant public
health concern in the US,
afflicting about 200,000 people each
year, with a mortality rate of as much as
40 percent, depending on the etiology.
Nearly all therapy is supportive: low tidal
volume ventilation, fluid conservative
strategy and prone positioning.
UCSF anesthesiologist Jae-Woo Lee,
MD, is among those working hard to
discover therapies that can actually
repair the damaged lungs.
Healing with Stem Cells
For a number of years, Lee worked with
critical care specialist Michael Matthay,
MD, in a lab focused on using adult
mesenchymal stem cells to normalize
alveolar epithelial permeability and fluid
transport in damaged lungs.
Working with donor human lungs
declined for transplantation, the
research team injured the lungs in the
lab using bacterial pneumonia, and then
administered mesenchymal stem cells,
which homed in on the inflammatory site
and began secreting anti-inflammatory
cytokines.
“We were able to demonstrate these
stem cells have therapeutic effects;
At right: Jae-Woo Lee, MD;
below: chest X-ray of patient with ARDS
they stopped the inflammation and
repaired the damage,” says Lee.
The group then advanced to a series
of pre-clinical studies in collaboration
with University of Texas, Galveston
and Production Assistance for Cellular
Therapies, a NIH-sponsored group
that provides clinical grade cells for
clinical trials. Using a sheep model of
sepsis, the researchers found a very
similar therapeutic effect to what they
originally found in the human lung and
in preclinical small animal models.
“Based on these results, Dr. Matthay
is now conducting a Phase I and II
clinical trial on the therapeutic use of
bone marrow-derived human mesenchymal stem cells for ARDS,” says Lee.
Moving to Microvesicles
To build on that work, Lee’s lab has
begun studying whether microvesicles
can achieve a similar therapeutic
effect to the mesenchymal stem
cells. Microvesicles are membrane
fragments released from the endosomal
compartment of cells as exosomes or
shed from surface membranes. The
microvesicles retain the phenotype of
the cells from which they originate,
due to the presence of mRNA, microRNA
and proteins such as keratinocyte growth
factor, a known epithelial growth factor
with therapeutic properties.
Microvesicles are of interest to medical
researchers because they offer a couple
of potential advantages over live stem
cells. First, because they are anuclear,
they pose minimal risk of spontaneous
tumor formation. Second, the
microvesicles do not require a bone
marrow transplant facility for storage and
so may be less expensive and more
accessible for use as therapeutic agents.
“Our theory is that they will behave
as smart drugs,” says Lee. “Get to the
target site through surface receptors, stop
the inflammation and repair the damage
to the lung.”
To date, Lee’s group has been able
to demonstrate in both bacteria- and
endotoxin-induced ARDS that the microvesicles do retain most of the therapeutic
properties of the live stem cells.
“In pre-clinical models, the effect has
been pretty remarkable,” says Lee.
In addition, his team has been able to
change the phenotype of the microvesicles, depending on how you treat the
cells. “If you stress the cells with TLR3
agonists, you can create a more robust
anti-microbial phenotype,” says Lee.
While Lee’s lab is still engaged in
the pre-clinical work, he believes the
initial findings make microvesicles
very promising for an eventual
translational study to treat ARDS.
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 7
Staff Profile
“
Nurturing a
Department’s
Most Valuable
ASSETs
W
hen a 2014 survey on staff
engagement revealed that, at
times, being spread across
multiple locations can make it difficult for
staff members in the UCSF Department
of Anesthesia and Perioperative Care
to feel like part of a cohesive team,
something clicked for Kien Truong.
Truong – billing coordinator for the
department’s Mount Zion operation –
approached Lorenzo Woo, formerly
the department’s assistant director
for education and Carroll Schreibman,
who at that time was the SFGH
Division Manager and who is currently
the department’s Associate Chair
of Administration and Finance, with
an idea.
“I thought: ‘Why not plan a series of
small functions throughout the year to
bring staff together from the different
work sites?’” says Truong.
Eventually, Truong engaged
colleagues from each site to do just that.
The Anesthesia Staff Support
Engagement Team or ASSET began
functioning in the fall of 2014, and its
members are enthusiastic that they can
enhance the staff’s sense of unity.
“Kien’s personality – he had already
cultivated relationships with many
people – was critical in getting us out
of the starting gate,” says Vanessa
Cheng, another ASSET member.
A Staff-Driven, Staff-Led Effort
Most academic departments understand
how important it is that non-academic
staff members use their professional
skills and institutional knowledge to
support the department’s mission;
the value is evident in a multitude of
interactions that occur every day.
To galvanize and inspire staff
members to continually do their best
“Our main mission is to create a more cohesive work
environment within the department where people are
comfortable approaching each other.” — Kien Truong
Left to right: Phillip Evans, Marie Hollero, Vanessa Cheng, Kien Truong
work, the ASSET team – Truong, Cheng
and Phillip Evans – worked with Martie
Santos (a senior human resources
analyst) to create a staff mixer where
staff members could openly discuss the
survey results and offer specific
feedback about what activities they
would like to see. Marie Hollero joined
ASSET in October of 2014 and brings
valuable team building skills.
“This is very much a staff-driven,
staff-led effort; there is no management
involved, except for Martie [at first]
who was more of an advisor,” says
Truong. “Our main mission is to create
a more cohesive work environment
within the department where people are
comfortable approaching each other.
We want to create events where people
can chat with their co-workers and walk
away saying, ‘That was fun.’”
The Anesthesia Staff Support
Engagement Team (ASSET)
Kien Truong has been with the
department for seven years and is
currently the billing coordinator for the
department’s Mount Zion operation.
He moved to the US from Vietnam when
he was four-years-old and lived in
Rochester, New York and Chicago before
moving to San Francisco. He graduated
in 1993 from the School of the Arts in
SF and then attended college for a year,
before going into retail management.
UCSF Department of Anesthesia and Perioperative Care |
Once an avid figure skater, today he
loves to bowl, sings karaoke, and enjoys
“vegging out at home with a good movie
and awesome snacks.”
Vanessa Cheng has been with the
department for more than two years;
her primary responsibilities are to help
on-board and off-board staff and faculty
and serve as assistant to the vice-chair
of academic affairs. Born in Hong Kong,
she and her family moved to the US
when she was five. After graduating from
Lowell High School and earning her
undergraduate degree in international
relations from UC Davis, she previously
worked at the Asian Week Foundation. In
her spare time, she enjoys volunteering
in her community and quiet hikes. “The
quieter, the better,” she says.
Phillip Evans has been with the
department for more than five years. His
primary responsibilities are managing the
extramural funds for the Center for
Cerebrovascular Research, as well as its
day-today operations. Raised in Oregon,
he has been in the Bay Area for more
than 25 years. Before joining UCSF, he
worked in the hospitality and escrow
industries. In his spare time, he enjoys
weekend getaways and volunteering for
his community to raise much-needed
funds for a variety of charities.
Anesthesia News | 2015 | 8
Farewell
Chuck Hajek and Lorenzo Woo
The Department of Anesthesia and
Perioperative Care would like to
extend its heartfelt gratitude and a
fond farewell to two outstanding
administrative leaders.
C
huck Hajek began his career in the
Anesthesia Department in
February of 2005, as our Budget
and Finance Officer. In this role he
managed all department funds, and
implemented fiscal policies, reporting
systems and controls for all funds under
management. Prior to coming to the
Department, Chuck spent over ten years
in financial management roles in private
industry, and credits Marge O’Halloran
and Dr. Ronald Miller for taking “a chance
on someone with no experience in the
financial management of academic
medicine.” Marge and Dr. Miller’s
“gamble” has certainly paid off.
After successfully stewarding the
Department through the 2009 – 2010
state furlough, Chuck became the
Department’s Associate Chair for
Finance in November of 2010. This
expanded role included strategic planning
and oversight of clinical enterprise and
research program operations. Chuck
developed and implemented mission
based financial statements, which
allowed the Chair to make informed
decisions regarding resource allocation
by Department mission. In addition,
he played a significant role in the
development and implementation of the
Department research bridge funding
program, as well as a strategic plan to
achieve the Morton Society median
compensation for anesthesia faculty.
The following year, Chuck became
the Department’s Associate Chair for
Finance and Administration, taking on
oversight responsibility for all Department
functional areas. As Associate Chair for
Finance and Administration, Chuck
continued to make improvements to the
Department’s financial and administrative
management processes to improve
efficiency, customer service, and
accountability. In addition, he led the
Chuck Hajek
Department’s effort to analyze and
negotiate the new UCSF Health Funds
Flow model.
However, Chuck’s biggest challenge
in this role was addressing the
Department’s recent forecasted financial
deficit for FY13-14. In the spring of 2013,
Anesthesia was forecasting a significant
financial loss for FY12-13 and, given the
state of finances at the time, our initial
budget for FY13-14 indicated an even
deeper loss. While the Department had
(and continues to have) appropriate
reserve levels, it was clear that our
anticipated financial performance path
was not sustainable.
The drivers for the poor financial
performance were twofold; (1) lower than
expected clinical revenues due to the
implementation of the APeX electronic
medical record system and (2) expense
growth rate that outpaced Department
professional fee growth.
In order to address the financial
performance issue, Chuck collaborated
with the Department’s Finance
Committee to develop cost reduction
measures with the following goals:
1. Identify areas of cost savings that did
not inhibit the ability of the Department
to achieve its core mission of improving
patient lives through excellence,
innovation, and leadership in patient
care, scientific discovery, and education.
2. Distribute the burden of cost saving
measures across Department missions
(clinical, research, education, academic
affairs, and central expense).
3. Assess the near term (FY13-14 &
FY14-15) impact.
UCSF Department of Anesthesia and Perioperative Care |
Lorenzo Woo
A thoughtful, clear cost reduction
package was developed, presented to
and unanimously approved by the
Department’s Chair Advisory Group
(CAG). A communication approach
specifically targeting each impacted
employee group was developed.
A Department-wide communication
followed. While most cost reduction
decisions were not popular, the
Department at large appreciated the
transparency and fairness in the
decision making process.
As a result of these cost reduction
measures and better than expected
professional fee revenue, the
Department’s financial performance is
back on track.
While managing these financial and
administrative challenges, Chuck has
always maintained a focus on staff
development, and names participating
in the success of those around him as
his biggest reward. Chuck’s belief is that
our overall contributions are measured
by our impact on others around us –
and he has certainly lived this out during
his time in the Anesthesia Department.
We wish him the best of luck in his
next endeavors.
I
n March of 2010, when the
Anesthesia Department’s beloved
Residency Program Coordinator and
den mother, Jeanie Murakawa, passed
away after a sudden and unexpected
illness, she left a gaping hole in the
Department on both a professional and
personal level.
continued on next page
Anesthesia News | 2015 | 9
Farewell
continued from previous page
While no one could take Jeanie’s place,
we were extremely lucky to hire Lorenzo Woo
to take on the responsibility of a newly formed
and expanded position: Assistant Director for
Anesthesia Education. In addition to operational
duties, the position was now responsible for
strategic planning for the Department’s
Education Domain.
Lorenzo came to the Department with over
20 years of graduate medical education (GME)
experience, previously directing the UCSF
Office of GME. This experience allowed
Lorenzo to quickly and realistically assess the
Anesthesia Education Domain’s established
goals, objectives and operations and suggest
improvements to streamline the workflow.
From the start, Lorenzo embraced a
teamwork-based approach, which extended
even beyond the Education Domain. In fact,
perhaps his most outstanding legacy will be
his efforts to engage the entire Anesthesia
staff group following less than optimal results
on a 2013 UCSF-wide Gallop poll about
staff engagement. In April of that year, the
Department launched a grass roots campaign
with the initial goal of hearing from the staff
about how to work collaboratively to create a
“great place to work.” This led to Lorenzo (in
collaboration with Carroll Schreibman, who at
that time was the SFGH Division Manager and
who is now the Department’s MSO) hosting
small staff working groups to stimulate the
engagement discussion and garner feedback
and ideas from the staff members themselves.
While Lorenzo would say that he was
“just a bean counter” during this process, his
leadership and positivity created an open
atmosphere and a safe environment for staff to
voice both their concerns and their suggestions
for improvement. This work led to the
establishment of quarterly staff meetings, a
stronger focus on staff development, and most
importantly, the formation of the staff ASSET
(Anesthesia Staff Support Engagement Group)
group. ASSET now has a funded mandate to
engage the staff through a UCSF Chatter
group and various staff events. Recently, they
conducted a morale poll that showed
improvement in staff morale and engagement
since the commencement of their efforts.
Lorenzo’s leadership was instrumental in
making these improvements.
Although we will miss Lorenzo greatly,
at least we know we can still stop by the
Millberry Union Fitness and Recreation Center
to participate in his BodyPump class! We
wish him all the best as he focuses on his
most important role: being a super-dad.
New Faculty
Career Faculty
RESIDENCY
Anesthesiology: Stanford
FELLOWSHIPS
Angela Lipshutz,
MD
Assistant Professor
in Residence
Joined Faculty
September 2014
ADVANCED DEGREE
MPH: Johns Hopkins Bloomberg
School of Public Health
MEDICAL SCHOOL
UCSF
INTERNSHIP
Internal Medicine: Stanford
University School of Medicine
Post-Doctoral Fellowship, Biomedical
Engineering and Neuroscience:
The Johns Hopkins University
School of Medicine
Pain Management: UCSF
PREVIOUS EMPLOYMENT
Volunteer Associate Professor,
UCSF Department of Anesthesia
and Perioperative Care
Private Practice Attending,
Pain Clinic of Monterey Bay
Visiting Faculty
RESIDENCY
Erik Litonius, MD,
PhD
FELLOWSHIP
Visiting Assistant
Professor
Joined Faculty
November 2014
Anesthesiology: Massachusetts
General Hospital & UCSF
Critical Care Medicine: UCSF
PREVIOUS EMPLOYMENT
Per Diem Anesthesiology Faculty:
UCSF
Erin McKay, MD
Health Sciences
Assistant Clinical
Professor
Joined Faculty
July 2014
MEDICAL SCHOOL
Boston University School of
Medicine
INTERNSHIP
ADVANCED DEGREE
PhD: University of Helsinki, Finland
MEDICAL SCHOOL
University of Helsinki, Finland
RESIDENCY
Anesthesiology: Helsinki University
Hospital (HUCH)
PREVIOUS EMPLOYMENT
Family Physician: Inga and Sibbo
Healthcare Centers, Finland
Attending Physician
Helsinki University Central Hospital
(HUCH)
Anesthesiology: UCSF
Romain Pirracchio,
MD, PhD
RESIDENCY
Anesthesiology: UCSF
Visiting Associate
Professor
Joined Faculty
February 2015
FELLOWSHIP
Critical Care Medicine: UCSF
Lawrence Poree,
MD, PhD, MPH
ADVANCED DEGREE
Health Sciences
Clinical Professor
Joined Faculty
February 2015
MEDICAL SCHOOL
ADVANCED DEGREES
MPH, PhD
Toxicology and Environmental Health
Sciences: UC Berkeley
MEDICAL SCHOOL
Stanford University School of
Medicine
INTERNSHIP
Transitional: Santa Clara Valley
Medical Center
UCSF Department of Anesthesia and Perioperative Care |
PhD, Epidemiology and Biostatistics:
Paris Diderot University
Lariboisiere Medical School,
Paris Diderot University
FELLOWSHIP
Critical Care: Hôpital Lariboisiere
PREVIOUS EMPLOYMENT
Head of the Surgical and Trauma
Critical Care Team,
Hôpital Européen Georges
Pompidou, Paris Descartes
University
Anesthesia News | 2015 | 10
Resident Profiles
Gregory Chinn and Marisa Hernandez-Morgan
G
regory Chinn was born in San
Francisco and grew up in Southern
California. He completed his
undergraduate and MD/PhD degrees at
UC Irvine. Greg’s research involved
transcription factors and their role on
cortical development in mice. Last year,
he returned to San Francisco to complete
his intern year at UCSF as part of the
categorical anesthesia residency. Currently
he is in the first year of anesthesia training
as a CA-1.
Greg reflected on the selection process
he went though: “I ranked UCSF at the
top of my list after doing an away sub-I in
Anesthesia here and seeing firsthand the
program’s many strengths. Immediately, I
appreciated the diversity of patients and
types of cases that the different sites offer,
from the veterans at the VA, to the trauma
and underserved at SFGH, to the complex
‘zebras’ at Moffitt. Additionally, both the
faculty and the residents were phenomenal
teachers and I knew I wanted to be at that
level one day. I also ranked the research
tract highly given my interest in research
and desire for a career in academics.
UCSF Anesthesia is incredibly generous
with support for research interests in any
topic, and there are countless opportunities
for projects.”
When Greg is not at the hospital, he
enjoys spending time with his wife and
daughter as they take advantage of all the
Bay Area has to offer. They love the giraffes
at the SF Zoo, the aquarium at the California
Academy of Sciences, and the carousel in
Golden Gate Park. There are so many
outdoor activities to enjoy: hiking in the
Marin headlands with breathtaking views of
the Golden Gate Bridge and SF, biking
through Sausalito, and day trips to Napa.
When asked about his current
experience, Greg said, “Now that I’m a
CA-1 and get to practice anesthesia daily,
I couldn’t be happier or feel more fulfilled.
I love my co-residents; it feels like we’re
family. We all are there to support each
other, which makes the steep learning
curve bearable. I feel so lucky be at this
incredible institution with faculty, mentors,
and co-residents that I truly admire
and respect.”
M
arisa Hernandez-Morgan was born and raised in a small town in
Southern California, but she later moved to the big city of Los Angeles.
She completed undergraduate studies, medical school and a Master’s
degree in Public Policy at UCLA. Marisa reflected on the fourth year of medical
school: “when it came time to choose a residency program I knew what I was
looking for, and I knew I would find it all at UCSF. I wanted a program that
would give me the chance to work at several different training sites, one that
emphasized compassionate care and provided the opportunity to work with a
diverse patient population.”
When asked about her current experience as a resident, she replied,
“not only has the program provided the vigorous clinical training that I was
looking for, but it has also given me the chance to work with leaders in the field
who are patient, enthusiastic teachers. Everyday I work with faculty who are
dedicated to resident education; it is a real strength of the program.”
Marisa enjoys being in one of the most unique cities in the world. In her
free time she’s usually out enjoying the San Francisco food scene, hiking or
exploring the city via scooter. There are so many street festivals, concerts
and outdoor events it is impossible to be bored!
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 11
Peer Reviewed Publications
Abla AA, Rutledge WC, Seymour ZA, Guo D, Kim H,
Gupta N, Sneed PK, Barani IJ, Larson D, McDermott
MW, Lawton MT. A treatment paradigm for
high-grade brain arteriovenous malformations:
volume-staged radiosurgical downgrading followed
by microsurgical resection. Journal of neurosurgery.
2015;122(2):419-432.
Asmussen S, Ito H, Traber DL, Lee JW, Cox RA,
Hawkins HK, McAuley DF, McKenna DH, Traber LD,
Zhou H, Wilson J, Herndon DN, Prough DS, Liu KD,
Matthay MA, Enkhbaatar P. Human mesenchymal
stem cells reduce the severity of acute lung injury
in a sheep model of bacterial pneumonia. Thorax.
2014 Sep;69(9):819-25.
Bendjilali N, Nelson J, Weinsheimer S, Sidney S,
Zaroff JG, Hetts SW, Segal M, Pawlikowska L,
McCulloch CE, Young WL, Kim H. Common variants
on 9p21.3 are associated with brain arteriovenous
malformations with accompanying arterial
aneurysms. J Neurol Neurosurg Psychiatry.
2014 Apr 28.
Bokoch MP, Gelb AW. From the journal archives:
cyclopropane: induction and recovery with a bang!
Canadian journal of anaesthesia = Journal canadien
d’anesthesie. 2014;61(8):763-766.
Braun S, Plitzko G, Bicknell L, Van Caster P, Schulz
J, Barthuber C, Preckel B, Pannen B, Bauer I.
Pretreatment with helium does not attenuate liver
injury after warm ischemia reperfusion. Shock.
2014 May;41(5):413-9.
Cakmakkaya OS, Kolodzie K, Apfel CC, Pace NL.
Anaesthetic techniques for risk of malignant tumour
recurrence. The Cochrane database of systematic
reviews. 2014;11:Cd008877.
Calfee CS, Delucchi K, Parsons PE, Thompson BT,
Ware LB, Matthay MA. Subphenotypes in acute
respiratory distress syndrome: latent class analysis
of data from two randomised controlled trials.
The Lancet. Respiratory medicine. 2014;2(8):611-620.
Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris
KN, Matthay MA, Ware LB; the NIH NHLBI ARDS
Network. Distinct Molecular Phenotypes of Direct
Versus Indirect ARDS in Single and Multi-Center
Studies. Chest. 2014.
Chen W, Choi EJ, McDougall CM, Su H. Brain
arteriovenous malformation modeling, pathogenesis,
and novel therapeutic targets. Transl Stroke Res.
2014 Jun;5(3):316-29.
Chen W, Sun Z, Han Z, Jun K, Camus M, Wankhede
M, Mao L, Arnold T, Young WL, Su H. De novo
cerebrovascular malformation in the adult mouse
after endothelial Alk1 deletion and angiogenic
stimulation. Stroke. 2014 Mar;45(3):900-2.
Choi EJ, Chen W, Jun K, Arthur HM, Young WL, Su
H. Novel brain arteriovenous malformation mouse
models for type 1 hereditary hemorrhagic
telangiectasia. PLoS One. 2014 Feb 10;9(2):e88511.
Choquet H, Nelson J, Pawlikowska L, McCulloch
CE, Akers A, Baca B, Khan Y, Hart B, Morrison L,
Kim H. Association of cardiovascular risk factors with
disease severity in cerebral cavernous malformation
type 1 subjects with the common Hispanic mutation.
Cerebrovasc Dis. 2014 37(1):57-63.
Choquet H, Pawlikowska L, Nelson J, McCulloch
CE, Akers A, Baca B, Khan Y, Hart B, Morrison L,
Kim H. Polymorphisms in inflammatory and immune
response genes associated with cerebral cavernous
malformation type 1 severity. Cerebrovascular
diseases (Basel, Switzerland). 2014;38(6):433-440.
Cohen JM, Kolodzie K, Shah S, Aleshi P.
Preoperative Sciatic and Femoral Nerve Blocks
for Anterior Cruciate Ligament Reconstruction:
A Retrospective Analysis. J Anesth Clin Res.
2014(5):452.
Cohen NH, Patterson AJ, Coursin DB. Time to break
down silos: alternative approaches to staffing ICUs.
Crit Care Med 2014 Jul;42(7):e535-6.
Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S,
Liu X, Cohen NH, Crosby G. Academic productivity of
directors of ACGME-accredited residency programs
in surgery and anesthesiology. Anesth Analg.
2014 Jan;118(1):200-5.
Dickerson DM, Naidu RK. Preparing for the
physician payment sunshine act. Reg Anesth Pain
Med. 2014 May-Jun;39(3):185-8.
Dong TT, Gelb AW. Perioperative Stroke Remains an
Underappreciated Cause of Morbidity and Mortality.
J Anesth Perioper Med. 2014;1(1):57-59.
Eger EI, 2nd. From the Journal archives: A harbinger
of modern anesthesia. Canadian journal of
anaesthesia = Journal canadien d’anesthesie.
2014;61(1):76-79.
Eger EI, 2nd. Three memorable years. Anesthesia
and analgesia. 2014;119(6):1232-1234.
Elobu AE, Kintu A, Galukande M, Kaggwa S,
Mijjumbi C, Tindimwebwa J, Roche A, Dubowitz G,
Ozgediz D, Lipnick M. Evaluating international
global health collaborations: perspectives from
surgery and anesthesia trainees in Uganda.
Surgery. 2014;155(4):585-592.
Fidler R, Hirsch J, Stechert M, Johnson M.
Three modes of cardiac compressions in a single
patient: a comparison of usual manual compressions,
automated compressions, and open cardiac
massage. Resuscitation. 2014;85(5):e75-76.
Flexman AM, Wong H, Riggs KW, Shih T,
Garcia PA, Vacas S, Talke PO. Enzyme-inducing
Anticonvulsants Increase Plasma Clearance of
Dexmedetomidine: A Pharmacokinetic and
Pharmacodynamic Study. Anesthesiology.
2014 May;120(5):1118-25.
Gelb AW. Lifelong lessons I learned from my
resident research project. Canadian journal of
anaesthesia = Journal canadien d’anesthesie.
2014;61(12):1130-1131.
Golden MJ, Morrison LA, Kim H, Hart BL. Increased
Number of White Matter Lesions in Patients with
Familial Cerebral Cavernous Malformations. AJNR.
American journal of neuroradiology. 2015.
UCSF Department of Anesthesia and Perioperative Care |
Gotts JE, Abbott J, Matthay MA. Influenza causes
prolonged disruption of the alveolar-capillary barrier
in mice unresponsive to mesenchymal stem cell
therapy. American journal of physiology. Lung cellular
and molecular physiology. 2014;307(5):L395-406.
Guo Y, Tihan T, Kim H, Hess C, Lawton MT, Young
WL, Zhao Y, Su H. Distinctive distribution of
lymphocytes in unruptured and previously untreated
brain arteriovenous malformation. Neuroimmunology
and neuroinflammation. 2014;1(3):147-152.
Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C,
Song YK, Wei JS, Pawlikowska L, Bao Y,
Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli
SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T,
Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA.
Expression quantitative trait loci and receptor
pharmacology implicate Arg1 and the GABA-A
receptor as therapeutic targets in neuroblastoma.
Cell reports. 2014;9(3):1034-1046.
Han SJ, Englot DJ, Kim H, Lawton MT. Brainstem
arteriovenous malformations: anatomical subtypes,
assessment of “occlusion in situ” technique, and
microsurgical results. Journal of neurosurgery.
2015;122(1):107-117.
Han Z, Li L, Wang L, Degos V, Maze M, Su H.
Alpha-7 nicotinic acetylcholine receptor agonist
treatment reduces neuroinflammation, oxidative
stress, and brain injury in mice with ischemic stroke
and bone fracture. Journal of neurochemistry.
2014;131(4):498-508.
Han Z, Shen F, He Y, Degos V, Camus M, Maze M,
Young WL, Su H. Activation of alpha-7 nicotinic
acetylcholine receptor reduces ischemic stroke injury
through reduction of pro-inflammatory macrophages
and oxidative stress. PloS one. 2014;9(8):e105711.
Hetts SW, Cooke DL, Nelson J, Gupta N, Fullerton H,
Amans MR, Narvid JA, Moftakhar P, McSwain H,
Dowd CF, Higashida RT, Halbach VV, Lawton MT,
Kim H. Influence of Patient Age on Angioarchitecture
of Brain Arteriovenous Malformations. AJNR Am J
Neuroradiol. Jul;35(7):1376-80.
Hirsch J. Hemodynamic Control and Delirium.
Current Anesthesiology Reports. 2015(January).
Hirsch J, Chalkley RJ, Bentley T, Burlingame AL,
Frank JA. Double impact of cigarette smoke and
mechanical ventilation on the alveolar epithelial type
II cell. Critical care (London, England). 2014;18(2):R50.
Hirsch J, DePalma G, Tsai TT, Sands LP, Leung JM.
Impact of intraoperative hypotension and blood
pressure fluctuations on early postoperative delirium
after non-cardiac surgerydagger. British journal of
anaesthesia. 2015.
Jian M, Li X, Wang A, Zhang L, Han R, Gelb AW.
Flurbiprofen and hypertension but not hydroxyethyl
starch are associated with post-craniotomy
intracranial haematoma requiring surgery. British
journal of anaesthesia. 2014;113(5):832-839.
continued on next page
Anesthesia News | 2015 | 12
Peer Reviewed Publications
continued from previous page
Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV.
Identifying blood-brain-barrier selective single-chain
antibody fragments. Biotechnology journal.
2014;9(5):664-674.
Kim H, Abla AA, Nelson J, McCulloch CE, Bervini D,
Morgan MK, Stapleton C, Walcott BP, Ogilvy CS,
Spetzler RF, Lawton MT. Validation of the
supplemented Spetzler-Martin grading system for
brain arteriovenous malformations in a multicenter
cohort of 1009 surgical patients. Neurosurgery.
2015;76(1):25-31; discussion 31-22; quiz 32-23.
Kim H, Al-Shahi Salman R, McCulloch CE, Stapf C,
Young WL, for the MARS Coinvestigators. Untreated
brain arteriovenous malformation: patient level
meta-analysis of hemorrhage predictors. Neurology.
2014 Aug 12;83(7):590-7.
Kremer PH, Koeleman BP, Pawlikowska L,
Weinsheimer S, Bendjilali N, Sidney S, Zaroff JG,
Rinkel GJ, van den Berg LH, Ruigrok YM, de Kort GA,
Veldink JH, Kim H, Klijn CJ. Evaluation of genetic
risk loci for intracranial aneurysms in sporadic
arteriovenous malformations of the brain. Journal
of neurology, neurosurgery, and psychiatry. 2014.
Kropski JA, Pritchett JM, Zoz DF, Crossno PF,
Markin C, Garnett ET, Degryse AL, Mitchell DB,
Polosukhin VV, Rickman OB, Choi L, Cheng DS,
McConaha ME, Jones BR, Gleaves LA, McMahon FB,
Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP,
Zaynagetdinov R, White ES, Kurtis JD, Johnson JE,
Groshong SD, Lancaster LH, Young LR, Steele MP,
Phillips Iii JA, Cogan JD, Loyd JE, Lawson WE,
Blackwell TS. Extensive Phenotyping of Individuals
At-risk for Familial Interstitial Pneumonia Reveals
Clues to the Pathogenesis of Interstitial Lung
Disease. American journal of respiratory and critical
care medicine. 2014.
Lee BH, Chan JT, Hazarika O, Vutskits L, Sall JW.
Early exposure to volatile anesthetics impairs longterm associative learning and recognition memory.
PloS one. 2014;9(8):e105340.
Lee BH, Chan JT, Kraeva E, Peterson K, Sall JW.
Isoflurane exposure in newborn rats induces
long-term cognitive dysfunction in males but not
females. Neuropharmacology. 2014;83:9-17.
Lee BH, Hazarika OD, Quitoriano GR, Lin N, Leong J,
Brosnan H, Chan JT, May LD, Yu D, Alkhamisi A,
Stratmann G, Sall JW. Effect of combining
anesthetics in neonates on long-term cognitive
function. International journal of developmental
neuroscience : the official journal of the International
Society for Developmental Neuroscience.
2014;37:87-93.
Lee CZ, Gelb AW. Anesthesia management for
endovascular treatment. Current opinion in
anaesthesiology. 2014;27(5):484-488.
Lee JW, Rocco PR, Pelosi P. Mesenchymal stem cell
therapy for acute respiratory distress syndrome: a
light at the end of the tunnel? Anesthesiology.
2015;122(2):238-240.
Lewin MR, Bickler P, Heier T, Feiner J, Montauk L,
Mensh B. Reversal of experimental paralysis in a
human by intranasal neostigmine aerosol suggests a
novel approach to the early treatment of neurotoxic
envenomation. Clinical case reports. 2013;1(1):7-15.
Lewin M, Samuel S, Wexler D, Bickler PE, Mensh B.
Early treatment with intranasal neostigmine reduces
mortality in a mouse model of Naja naja (Indian
cobra) envenomation J. Tropical Medicine.
2014:131835.
Li K, Tavare R, Zettlitz KA, Mumenthaler SM, Mallick
P, Zhou Y, Marks JD, Wu AM. Anti-MET immunoPET
for non-small cell lung cancer using novel fully
human antibody fragments. Molecular cancer
therapeutics. 2014;13(11):2607-2617.
Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan
ML, Fang X, Cosgrove K, Calfee CS, Lee JW,
Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE,
Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna
DH, Thompson BT, Matthay MA. Design and
implementation of the START (STem cells for ARDS
Treatment) trial, a phase 1/2 trial of human
mesenchymal stem/stromal cells for the treatment of
moderate-severe acute respiratory distress
syndrome. Annals of intensive care. 2014;4:22.
Long LS, Wolpaw JT, Leung JM. Sensitivity and
specificity of the animal fluency test for predicting
postoperative delirium. Canadian journal of
anaesthesia = Journal canadien d’anesthesie. 2014.
Mar JS, Nagalingam NA, Song Y, Onizawa M, Lee
JW, Lynch SV. Amelioration of DSS-induced murine
colitis by VSL#3 supplementation is primarily
associated with changes in ileal microbiota
composition. Gut microbes. 2014;5(4):494-503.
Mashour GA, Moore LE, Lele AV, Robicsek SA, Gelb
AW. Perioperative care of patients at high risk for
stroke during or after non-cardiac, non-neurologic
surgery: consensus statement from the Society for
Neuroscience in Anesthesiology and Critical Care*.
Journal of neurosurgical anesthesiology.
2014;26(4):273-285.
McAuley DF, Curley GF, Hamid UI, Laffey JG, Abbott
J, McKenna DH, Fang X, Matthay MA, Lee JW.
Clinical grade allogeneic human mesenchymal stem
cells restore alveolar fluid clearance in human lungs
rejected for transplantation. Am J Physiol Lung Cell
Mol Physiol. 2014 May;306(9):L809-15.
Mehta NN, Miyasaki SH, Hirsch J, Fidler RL.
Easy-to-implement oral cavity modification to expand
simulation-based training in airway management.
Simulation in healthcare : journal of the Society for
Simulation in Healthcare. 2014;9(4):260-263.
Meng L, Gelb AW. Regulation of cerebral
autoregulation by carbon dioxide. Anesthesiology.
2015;122(1):196-205.
Miller RD, Ward TA, McCulloch CE, Cohen NH.
A comparison of lidocaine and bupivacaine digital
nerve blocks on noninvasive continuous hemoglobin
monitoring in a randomized trial in volunteers.
Anesth Analg. 2014 Apr;118(4):766-71.
UCSF Department of Anesthesia and Perioperative Care |
Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS,
Overbey JR, Al-Shahi Salman R, Vicaut E, Young WL,
Houdart E, Cordonnier C, Stefani MA, Hartmann A,
von Kummer R, Biondi A, Berkefeld J, Klijn CJ,
Harkness K, Libman R, Barreau X, Moskowitz AJ;
international ARUBA investigators. Medical
management with or without interventional therapy
for unruptured brain arteriovenous malformations
(ARUBA): a multicentre, non-blinded, randomised
trial. Lancet. 2014 Feb 15;383(9917):614-21.
Monsel A, Zhu YG, Gennai S, Hao Q, Liu J, Lee JW.
Cell-based therapy for acute organ injury: preclinical
evidence and ongoing clinical trials using
mesenchymal stem cells. Anesthesiology.
2014;121(5):1099-1121.
Mudumbai SC, Takemoto S, Cason BA, Au S,
Upadhyay A, Wallace AW. Thirty-day mortality risk
associated with the postoperative nonresumption of
angiotensin-converting enzyme inhibitors: a
retrospective study of the Veterans Affairs Healthcare
System. Journal of hospital medicine : an official
publication of the Society of Hospital Medicine.
2014;9(5):289-296.
Mudumbai SC, Wagner T, Mahajan S, King R,
Heidenreich PA, Hlatky M, Wallace AW, Mariano ER.
Effectiveness of preoperative beta-blockade on intraoperative heart rate in vascular surgery cases
conducted under regional or local anesthesia.
SpringerPlus. 2014;3:227.
Potts MB, Jahangiri A, Jen M, Sneed PK, McDermott
MW, Gupta N, Hetts SW, Young WL, Lawton MT,
UCSF Brain AVM Study Project. Deep Arteriovenous
Malformations in the Basal Ganglia, Thalamus, and
Insula: Multimodality Management, Patient Selection,
and Results. World Neurosurg. 2014 Mar 19.
Rollins MD, Feiner JR, Lee JM, Shah S, Larson M.
Pupillary Effects of High-dose Opioid Quantified with
Infrared Pupillometry. Anesthesiology. 2014.
Rutledge WC, Ko NU, Lawton MT, Kim H.
Hemorrhage rates and risk factors in the natural
history course of brain arteriovenous malformations.
Transl Stroke Res. 2014 Oct;5(5):538-42.
Schartel SA, Kuhn C, Culley DJ, Wood M, Cohen N.
Development of the anesthesiology educational
milestones. J Grad Med Educ. 2014 Mar;6
(1 Suppl 1):12-4.
Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD.
Body temperature and mortality in patients with
acute respiratory distress syndrome. American
journal of critical care : an official publication,
American Association of Critical-Care Nurses.
2015;24(1):15-23.
Schumacher M, Pasvankas G. Topical capsaicin
formulations in the management of neuropathic pain.
Progress in drug research. Fortschritte der
Arzneimittelforschung. Progres des recherches
pharmaceutiques. 2014;68:105-128.
continued on next page
Anesthesia News | 2015 | 13
Peer Reviewed Publications
continued from previous page
Shen F, Degos V, Chu PL, Han Z, Westbroek EM,
Choi EJ, Marchuk D, Kim H, Lawton MT, Maze M,
Young WL, Su H. Endoglin Deficiency Impairs Stroke
Recovery. Stroke. 2014 Jul;45(7):2101-6.
Sheth SA, Potts MB, Sneed PK, Young WL, Cooke
DL, Gupta N, Hetts SW. Angiographic features help
predict outcome after stereotactic radiosurgery for
the treatment of pediatric arteriovenous
malformations. Childs Nerv Syst. 2014
Feb;30(2):241-7.
Sinha AC, Singh PM, Grewal N, Aman M, Dubowitz
G. Comparison between continuous non-invasive
estimated cardiac output by pulse wave transit time
and thermodilution method. Annals of cardiac
anaesthesia. 2014;17(4):273-277.
Stechert MM, London MJ. Facilitating
transesophageal echocardiography probe placement
by esophageal bougie in an anesthetized patient. A &
A case reports. 2014;3(8):100-103.
Steffner KR, McQueen KA, Gelb AW. Patient safety
challenges in low-income and middle-income
countries. Current opinion in anaesthesiology.
2014;27(6):623-629.
Stratmann G, Lee J, Sall JW, Lee BH, Alvi RS,
Shih J, Rowe AM, Ramage TM, Chang FL,
Alexander TG, Lempert DK, Lin N, Siu KH, Elphick
SA, Wong A, Schnair CI, Vu AF, Chan JT, Zai H,
Wong MK, Anthony AM, Barbour KC, Ben-Tzur D,
Kazarian NE, Lee JY, Shen JR, Liu E, Behniwal
GS, Lammers CR, Quinones Z, Aggarwal A, Cedars
E, Yonelinas AP, Ghetti S. Effect of general anesthesia
in infancy on long-term recognition memory in
humans and rats. Neuropsychopharmacology : official
publication of the American College of
Neuropsychopharmacology. 2014;39(10):2275-2287.
Sun Z, Su H, Long B, Sinclair E, Hetts SW, Higashida
RT, Dowd CF, Halbach VV, Cooke DL. Endothelial cell
high-enrichment from endovascular biopsy sample by
laser capture microdissection and fluorescence
activated cell sorting. Journal of biotechnology.
2014;192pa:34-39.
Tada Y, Makino H, Furukawa H, Shimada K, Wada
K, Liang EI, Murakami S, Kudo M, Kung DK, Hasan
DM, Kitazato KT, Nagahiro S, Lawton MT, Hashimoto
T. Roles of estrogen in the formation of intracranial
aneurysms in ovariectomized female mice.
Neurosurgery. 2014;75(6):690-695; discussion 695.
Tada Y, Wada K, Shimada K, Makino H, Liang EI,
Murakami S, Kudo M, Kitazato KT, Nagahiro S,
Hashimoto T. Roles of hypertension in the rupture of
intracranial aneurysms. Stroke. 2014
Feb;45(2):579-86.
Tada Y, Wada K, Shimada K, Makino H, Liang EI,
Murakami S, Kudo M, Shikata F, Pena Silva RA,
Kitazato KT, Hasan DM, Kanematsu Y, Nagahiro S,
Hashimoto T. Estrogen protects against intracranial
aneurysm rupture in ovariectomized mice.
Hypertension. 2014 Jun;63(6):1339-44.
Takayanagi T, Crawford KJ, Kobayashi T, Obama T,
Tsuji T, Elliott KJ, Hashimoto T, Rizzo V, Eguchi S.
Caveolin 1 is critical for abdominal aortic aneurysm
formation induced by angiotensin II and inhibition of
lysyl oxidase. Clin Sci (Lond). 2014
Jun;126(11):785-94.
Talke PO, Sharma D, Heyer EJ, Bergese SD,
Blackham KA, Stevens RD. Society for Neuroscience
in Anesthesiology and Critical Care Expert consensus
statement: anesthetic management of endovascular
treatment for acute ischemic stroke*: endorsed by
the Society of NeuroInterventional Surgery and the
Neurocritical Care Society. J Neurosurg Anesthesiol.
2014 Apr;26(2):95-108.
Talke PO, Sharma D, Heyer EJ, Bergese SD,
Blackham KA, Stevens RD. Republished: Society for
Neuroscience in Anesthesiology and Critical Care
expert consensus statement: Anesthetic
management of endovascular treatment for acute
ischemic stroke. Stroke; a journal of cerebral
circulation. 2014;45(8):e138-150.
Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL,
Winters JL, Gropper MA, Hubmayr RD, Matthay
MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV,
Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair
DC, Sanchez Rosen R, Looney MR.. Recipient clinical
risk factors predominate in possible transfusionrelated acute lung injury. Transfusion. 2014.
Valone F III, Lieberman J, Burch S. Postoperative
Blindness Due to Posterior Reversible Encephalopathy
Syndrome Following Spine Surgery. A Case Report
and Review of the Literature. JBJS Case Connect.
2014(4:e30.).
Valone F 3rd, Lyon R, Lieberman J, Burch S. Efficacy
of transcranial motor evoked potentials, mechanically
elicited electromyography, and evoked
electromyography to assess nerve root function
during sustained compression in a porcine model.
Spine. 2014;39(17):E989-993.
Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield
DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR,
Matthay MA, Rock JR, Chapman HA. Lineagenegative progenitors mobilize to regenerate lung
epithelium after major injury. Nature.
2015;517(7536):621-625.
Wada K, Makino H, Shimada K, Shikata F,
Kuwabara A, Hashimoto T. Translational research
using a mouse model of intracranial aneurysm. Transl
Stroke Res. 2014 Apr;5(2):248-51.
Ware LB, Landeck M, Koyama T, Zhao Z, Singer J,
Kern R, Neidlinger N, Nguyen J, Johnson E, Janz DR,
Bernard GR, Lee JW, Matthay MA; California
Transplant Donor Network. A randomized trial of the
effects of nebulized albuterol on pulmonary edema in
brain-dead organ donors. Am J Transplant. 2014
Mar;14(3):621-8.
Ware LB, Lee JW, Wickersham N, Nguyen J,
Matthay MA, Calfee CS. Donor smoking is
associated with pulmonary edema, inflammation and
epithelial dysfunction in ex vivo human donor lungs.
American journal of transplantation : official journal of
the American Society of Transplantation and the
American Society of Transplant Surgeons.
2014;14(10):2295-2302.
Whitlock EL, Torres BA, Lin N, Helsten DL, Nadelson
MR, Mashour GA, Avidan MS. Postoperative delirium
in a substudy of cardiothoracic surgical patients in
the BAG-RECALL clinical trial. Anesth Analg. 2014
Apr;118(4):809-17.
Wilhelmsen K, Khakpour S, Tran A, Sheehan K,
Schumacher M, Xu F, Hellman J. The
Endocannabinoid/Endovanilloid N-Arachidonoyl
Dopamine (NADA) and Synthetic Cannabinoid
WIN55,212-2 Abate the Inflammatory Activation of
Human Endothelial Cells. J Biol Chem. 2014 May
9;289(19):13079-100.
Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M,
Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW,
Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK,
Leavitt A, McKenna D, Thompson BT, Matthay MA.
Mesenchymal stem (stromal) cells for treatment of
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medicine. 2015;3(1):24-32.
Yeh DD, Tang JF, Chang Y. The use of furosemide in
critically ill trauma patients: A retrospective review. J
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Youngblom E, DePalma G, Sands L, Leung J. The
temporal relationship between early postoperative
delirium and postoperative cognitive dysfunction in
older patients: a prospective cohort study. Canadian
journal of anaesthesia = Journal canadien
d’anesthesie. 2014;61(12):1084-1092.
Zavala K, Lee J, Chong J, Sharma M, Eilers H,
Schumacher MA. The anticancer antibiotic
mithramycin-A inhibits TRPV1 expression in dorsal
root ganglion neurons. Neuroscience letters.
2014;578:211-216.
Walter J, Ware LB, Matthay MA. Mesenchymal stem
cells: mechanisms of potential therapeutic benefit in
ARDS and sepsis. The Lancet. Respiratory medicine.
2014;2(12):1016-1026.
Zhao L, Qu L, Zhou J, Sun Z, Zou H, Chen YY,
Marks JD, Zhou Y. High throughput identification of
monoclonal antibodies to membrane bound and
secreted proteins using yeast and phage display. PloS
one. 2014;9(10):e111339.
Wang L, Wang X, Su H, et al. Recombinant Human
Erythropoietin Improves the Neurofunctional
Recovery of Rats Following Traumatic Brain Injury via
an Increase in Circulating Endothelial Progenitor
Cells. Translational stroke research. 2015;6(1):50-59.
Zhu YG, Feng XM, Abbott J, Fang XH, Hao Q,
Monsel A, Qu JM, Matthay MA, Lee JW. Human
mesenchymal stem cell microvesicles for treatment
of Escherichia coli endotoxin-induced acute lung
injury in mice. Stem Cells. 2014 Jan;32(1):116-25.
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 14
Active Research Grants
Jon Matt Aldrich
Philip Bickler
Jeffrey Ghassemi
Tomoki Hashimoto
Principal Investigator
Principal Investigator
UCOP, Individual Grant,
01/01/2014–12/31/2015
Advanced Resuscitation
Training (ART)
Principal Investigator
Principal Investigator
$113,599
Various Industry Sponsors,
Clinical Trial,
09/01/1986–12/31/2015
Accuracy of Pulse Oximeters
with Profound Hypoxia
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department Seed
Support for Clinical Research
Pedram Aleshi
$19,994
NIH/NINDS, Individual Grant,
03/15/2011–02/29/2016
Intracranial Aneurysm
Pathogenesis-Roles of
Vascular Remodeling and
Inflammation
Principal Investigator
$1,674,637
$300,000
Michael Gropper
Principal Investigator
Irfan Kathiriya
$731,917
Principal Investigator
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
Coviden, Clinical Trial,
01/21/2014–04/04/2015
Controlled Desaturation for
Cerebral Oximetry
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$16,000
Marek Brzezinski
Gordon and Betty Moore
Foundation, Individual Grant,
06/01/2013–03/31/2015
Project EMERGE Planning
Grant at UCSF
Roland Bainton
Principal Investigator
$1,397,844
Alzheimer’s Drug Discovery
Foundation, Individual Grant,
10/01/2011–05/31/2015
Effects of Brain Beta Amyloid
on Postoperative Cognition
Principal Investigator
Principal Investigator
NIH/NINDS, Individual Grant,
09/01/2013–05/31/2018
The Role of Mast Cells in the
Pathophysiology of
Intracranial Aneurysm
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$164,064.02
$300,000
Principal Investigator
$70,800
Principal Investigator
NIH/NIEHS, Individual Grant,
05/25/2012–04/30/2015
A Platform for Rapid
Characterization of Metabolic
Disrupters in Whole Animals
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$70,800
$420,240
Catherine Chen
Principal Investigator
Principal Investigator
NIH/NINDS, Individual Grant,
02/01/2013–01/31/2016
Discovering Fundamental
Metabolic Control Processes
of the Blood Brain Barrier
Foundation for Anesthesia
Education and Research,
Research Career Award,
07/01/2013–06/30/2015
Unnecessary Preoperative
Testing in Medicare Patients
Undergoing Cataract Surgery
$430,002
Matthias Behrends
$75,000
Principal Investigator
Lee-lynn Chen
Anesthesia Department,
Individual Grant,
10/01/2014–9/30/2015
Anesthesia Department Seed
Support for Clinical Research
$16,000
Principal Investigator
Mt. Zion Health Fund, Individual
Grant,
04/01/2014–06/30/2015
Implementation Barriers to the
Colorectal ERAS Pathways at
Mount Zion
Gordon and Betty Moore
Foundation, Individual Grant,
10/01/2014–09/30/2015
Implementation Grant for
EMERGE at University of
California, San Francisco
$100,000
$1,726,306
$4,000,000
Judith Hellman
Principal Investigator
Principal Investigator
Gordon and Betty Moore
Foundation, Individual Grant,
02/01/2015–06/30/2015
UCSF Taskforce Grant
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$37,500
Principal Investigator
Foundation for Anesthesia
Education and Research,
Fellowship Grant,
01/01/2015–12/31/2015
2015 Medical Student
Anesthesia Research
Fellowship Program
$6,200
Zhonghui Guan
Principal Investigator
NIH/NINDS, Research Career
Award,
09/30/2012–08/31/2017
Epigenetic Regulation in
Neuropathic Pain
$947,160
$30,000
Helene Choquet
Principal Investigator
American Heart Association,
Fellowship,
07/01/2014–06/30/2016
Contribution of Cardiovascular
Risk Factors and Inflammation
to Familial CCM1 Disease
Severity
$100,000
Program Director
NIH/NIGMS, Training Grant,
07/01/2012–06/30/2017
Comprehensive Anesthesia
Research Training
$1,094,513
Principal Investigator
UCSF Research Evaluation and
Allocation Committee (REAC),
Individual Grant,
07/01/2013–06/30/2015
Cannabinoid Receptor
Modulation of the Endothelial
Toll-like Receptor-Dependent
Inflammatory Response
$30,000
Principal Investigator
San Francisco Foundation,
Individual Gift,
01/01/2015–12/31/2015
Sepsis Research
$200,000
Jan Hirsch
Richard Fidler
Principal Investigator
VA Office of Academic Affairs,
Fellowship,
07/01/2013–Ongoing
VA Advanced Fellowship
Program in Simulation
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$70,800
Principal Investigator
Foundation for Anesthesia
Education and Research,
Research Career Award,
07/01/2013–06/30/2015
Gene Regulation During
Cardiac Differentiation
$175,000
Helen Kim
Principal Investigator
NIH/NINDS, Individual Grant,
07/01/2013–06/30/2018
Predictors of Spontaneous
Cerebral AVM Hemorrhage
$2,335,649
Project Co-Leader
NIH/NINDS, Multicenter Project
Grant, 09/30/2014–07/31/2019
Project 1: Modifiers of Disease
Severity and Progression in
Cerebral Cavernous
Malformation
$563,366
Sakura Kinjo
Principal Investigator
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
$16,000
Kerstin Kolodzie
Principal Investigator
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
$6,000
$94,000
continued on next page
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 15
Active Research Grants
continued from
previous page
Jae-Woo Lee
Jacqueline Leung
Martin London
Principal Investigator
Principal Investigator
Principal Investigator
Jens Krombach
NIH/NHLBI, Individual Grant,
05/01/2012–04/30/2017
Human Mesenchymal
Stem Cell Microvesicles
for the Treatment of Acute
Lung Injury
NIH/NIA, Individual Grant,
09/15/2009–07/31/2015
Pathophysiology of
Postoperative Delirium in
Older Patients
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$2,067,530
$9,350
Principal Investigator
Jennifer Lucero
Principal Investigator
UCOP Prescription Loss
Prevention Program, Individual
Grant, 07/01/2013–06/30/2015
Development and
Implementation of a
Comprehensive Anesthesia
Checklist App for Routine and
Emergency Procedures
$111,401
Principal Investigator
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
$16,000
Philip Kurien
Principal Investigator
NIH/NINDS, Multicenter Project
Grant, 09/30/2014–07/31/2019
Brain Vascular Malformation
Consortium: Predictors of
Clinical Course
$3,300
$167,000
Co-Principal Investigator
Principal Investigator
$20,520
UCSF Nina Ireland Program for
Lung Health, Individual Grant,
01/01/2015–12/31/2016
Integrin Alpha-v Beta-5 Drives
Pulmonary Vascular Leak
from Ischemia-Reperfusion in
Lung Transplantation
UCSF School of Medicine,
Individual Grant,
08/01/2014–07/31/2015
The Effects of Light vs Deep
Anesthesia on Postoperative
Cognitive Outcomes
James Marks
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
Program Director
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$100,000
Principal Investigator
Michael Lawton
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
UC Office of the President
CHQI/QERM, Individual Grant,
07/01/2013–06/30/2015
Project to Eradicate PostOperative Delirium in HighRisk Patients (PEPOD)
Susan M Lee
$37,400
Chanhung Lee
Principal Investigator
$48,166
Anesthesia Department,
Individual Grant,
07/01/2014–6/30/2015
Anesthesia Department
Research Award
$6,179,248
$1,904,985
$18,569
Principal Investigator
UCSF Helen Diller Family
Comprehensive Cancer Center,
Individual Grant,
02/01/2015–01/30/2016
The END Perioperative
Smoking Pilot Study: A Pilot
Randomized Controlled
Clinical Trial – ”Electronic
Nicotine Delivery Device
(Ecigarette) for Perioperative
Smoking Cessation in
Veterans”
$29,969
$50,000
Bin Liu
Principal Investigator
NIH/NCI, Individual Grant,
03/01/2010–12/31/2015
Identifying Antigens Bound by
Novel scFvs Targeting All
Subtypes of Mesothelioma
$1,249,880
Principal Investigator
NIH/NCI, Individual Grant,
06/08/2011–03/31/2015
Mapping a Clinically
Significant Internalizing Tumor
Epitope Space
$904,004
Principal Investigator
NIH/NCI, Individual Grant,
08/06/2012–07/31/2017
Internalizing Human
Antibody-Targeted Nanosized
siRNA Therapeutics
$1,607,090
Principal Investigator
UCSF Stephen and Nancy
Grand Multiple Myeloma
Translational Initiative,
Individual Grant,
04/15/2013–04/14/2015
Novel Human Antibody
Drug Conjugates Targeting
Multiple Myeloma
$60,000
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
Principal Investigator
UC Irvine, SubcontractResearch,
05/01/2009–04/30/2015
Evolving Diagnostic Antibodies
for Botulinum Neurotoxins
$1,294,897
Principal Investigator
Xoma Corporation,
Subcontract-Research,
12/20/2011–07/31/2015
Development of Therapeutics
for Biodefense
$1,668,357
Principal Investigator
NIH/NIAID, Individual Grant,
02/01/2013–01/31/2018
Generation of Therapeutic
Antibodies for Serotype F
Botulism
$5,448,316
Principal Investigator
CA Dept of Public Health, UCR
(Unfunded Research
Collaboration),
10/15/2012–10/14/2016
Identification of Monoclonal
Antibody Combinations
that Neutralize Variant
Botulinum Neurotoxins
$0
Principal Investigator
NIH/NIAID, Individual Grant,
06/20/2014–05/31/2017
Trispecific Monoclonal
Antibody for Botulinum
Neurotoxin Intoxication
Therapy
$1,336,571
Principal Investigator
Merrimack Pharmaceuticals,
UCR (Unfunded Research
Collaboration),
03/10/2010–02/28/2016
Bispecific Antibodies
Targeting Basal
Breast Cancers
$0
Principal Investigator
DNA 2.0 Inc, UCR (Unfunded
Research Collaboration),
02/05/2013–02/05/2018
Improve the CHO Expression
of a scFv Fragment that
is Moving Towards the
Clinic Optimizing the DNA
Sequence of the scFv and/or
Leader Sequence
$0
Mervyn Maze
Principal Investigator
Masimo Corporation, Clinical
Trial, 06/01/2011–09/30/2015
Providing Good Sleep
for ICU Sedation
$232,987
Principal Investigator
Masimo Corporation, Clinical
Trial, 06/01/2011–09/30/2015
Evaluation of Sleep:
PSG vs. Sedline
$168,500
Principal Investigator
NIH/NIGMS, Individual Grant,
09/01/2013–08/31/2017
Inflammation Resolving
Mechanism Dysregulation
in Postoperative C
ognitive Decline
$1,212,399
Principal Investigator
NIH/NCI, Biomedical
Technology Research Center
Grant,
09/24/2014–08/31/2019
Antibody Technology
Research Center
$5,779,613
continued on next page
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 16
Active Research Grants
continued from
previous page
Jeffrey Sall
Hua Su
Arthur Wallace
Xiaobing Yu
Principal Investigator
Principal Investigator
Principal Investigator
Principal Investigator
Lingzhong Meng
SmartTots, Individual Grant,
08/01/2013–07/31/2015
Recognition Memory
Following Early
Childhood Anesthesia
NIH/NINDS, Individual Grant,
01/01/2014–12/31/2018
Hemodynamics of Cerebral
Arteriovenous Malformations
Northern California Institute for
Research and Education,
Individual Grant,
03/1/2012–03/1/2016
Perioperative Outcomes
Epidemiologic Consortium
Foundation for Anesthesia
Education and Research,
Research Career Award,
07/01/2013–06/30/2015
Treating Neuropathic Pain
with Spinal Cord Transplants
of Genetically Modified Human
Pluripotent Stem Cell–Derived
GABAergic Inhibitory Neurons
Principal Investigator
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
$16,511
Claus Niemann
Principal Investigator
HRSA, Individual Grant,
09/01/2011–08/31/2015
The Effect of Therapeutic
Hypothermia on
Deceased Donor
$200,000
Principal Investigator
UCSF School of Medicine,
Individual Grant,
08/01/2014–07/31/2015
Testosterone’s Role in
Sex-Specific Outcomes
After Early Anesthesia
$97,850
$1,562,940
Principal Investigator
NIH/NINDS, Individual Grant,
04/15/2014–03/31/2016
Soluble VEGF Receptor
Therapy for Brain
Arteriovenous Malformation
$790,313
Principal Investigator
Jonathan Pan
NIH/NIGMS, Individual Grant,
3/1/2015-2/29/2020
Testosterone’s Role in
Sex-Specific Outcomes
After Early Anesthesia
UCSF Research Evaluation and
Allocation Committee (REAC),
Individual Grant,
01/01/2014–12/31/2015
Mouse AVM Models for
Mechanistic Study and
Therapeutic Test
Principal Investigator
$1,524,496
$30,000
Mark Schumacher
Principal Investigator
Principal Investigator
$2,001,108
Foundation for Anesthesia
Education and Research,
Research Career Award,
07/01/2014–06/30/2016
Dexmedetomidine Renders
Neuroprotection via
Modulation of Systemic
and Local Immune
Responses Following
Rodent Spinal Cord Injury
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
NIH/NHLBI, Individual Grant,
01/16/2015–12/31/2018
Cell Type-Specific Influences
on HHT Pathogenesis
$1,582,037
Principal Investigator
Ludmila Pawlikowska
David Shimabukuro
Michael Gropper
The Michael Ryan Zodda
Foundation, Individual Gift,
01/01/2013–Ongoing
Research on Vascular
Malformations of the Brain
Core Co-Leader
Co-Principal Investigators
$20,000
$175,000
NIH/NINDS, Multicenter Project
Grant, 09/30/2014–07/31/2019
Genetic and Statistical
Analysis Core (GSAC)
$130,290
Vanderbilt University,
Subcontract-Research,
08/15/2012–06/30/2017
The MENDS II Study
$417,458
$200,304
Arun Prakash Budde
James Sonner
Principal Investigator
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$63,042
$91,958
Principal Investigator
Principal Investigator
NIH/NIGMS, Research Career
Award,
02/01/2015–01/31/2019
Role of Innate Immune Cells
and Pathways in Ventilated
Lung Ischemia Reperfusion
UCSF Academic Senate,
Individual Grant,
02/01/2015–01/31/2016
Novel Anesthetics
$150,000
Principal Investigator
VA National Anesthesia Office,
Individual Grant,
01/02/2014–01/01/2016
VA Anesthesia Quality
Improvement Program
$100,000
Edward Yap
Principal Investigator
$175,000
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$50,000
Anesthesia Department,
Individual Grant,
10/01/2014–09/30/2015
Anesthesia Department Seed
Support for Clinical Research
$16,000
C. Spencer Yost
Principal Investigator
Mt. Zion Health Fund, Individual
Grant,
04/01/2014–06/30/2015
Improved Fluid Management
in Abdominal Surgery
$23,000
Steven Takemoto
Principal Investigator
Anesthesia Department,
Individual Grant,
07/01/2014–06/30/2015
Anesthesia Department
Research Award
$70,576
Pekka Talke
Principal Investigator
Masimo, Contract-Clinical
Services,
08/14/2013–12/31/2015
Noninvasive Hemoglobin
(SpHb) Measured with Pulse
CO-Oximetry Technology
$42,266
$30,000
$790,880
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 17
Honors & Awards
Events
Faculty Honors, Awards
and Appointments
May 2015
Sue Carlisle, MD, PhD
CAMPUS AWARD
Holly Smith Award for Exceptional Service
to the School of Medicine, 2015
Neal Cohen, MD, MPH, MS
EXTRAMURAL APPOINTMENTS
Chair for the ASA Section on Professional
PracticeOverseeing the Following ASA
Committees:
■■ Committee on Economics
■■ Committee on Academic Affairs
■■ Committee on Governmental Affairs
■■ Committee on Health Policy Research
■■ Committee on Large Group Practice
■■ Committee on Practice Management
■■ Committee on Rural Access to Anesthesia
Member, Practice Expense Subcommittee
of the AMA Relative Value Update Committee
Co-Chair, ABA Critical Care Examination
Committee
Gerald Dubowitz, MB ChB
EXTRAMURAL AWARD
Tomoki Hashimoto, MD
CAMPUS APPOINTMENT
Professor (joint appointment), UCSF
Department of Neurological Surgery
Hung Nguyen, MD
5/8/2015
CAMPUS AWARD
For more information:
[email protected]
Hamilton Award for Excellence in Teaching,
2013 – 2014
James Ramsay, MD
EXTRAMURAL AWARD
Society of Cardiovascular
Anesthesiologists,
Distinguished Service Award, 2015
Muhammad Shaikh, MD, PhD
EXTRAMURAL APPOINTMENT
American Board of Anesthesiology (ABA),
Oral Examiner
Respiratory Therapy Award
Rich Kallet, RT
CAMPUS AWARD
San Francisco Health Commission
Employee Recognition Award
Unrestricted Gift Fund of $50,000 from the
Mulago Foundation for Global Health
Program Support in Uganda
Education Program Awards
EXTRAMURAL HONOR
The UCSF Anesthesiology Residency
Program
Honorary Lecturer, Department of
Anaesthesia, School of Medicine,
College of Health Sciences, Makerere
University, Uganda
Visiting Professor, Stanford University
Visiting Professor, Drexel University
Michael Gropper, MD, PhD
CAMPUS AWARD
UCSF 150th Anniversary Alumni Excellence
Award (Top 150 Campus Alumni)
Pain Summit 2015
RESIDENCY PROGRAM AWARD
Top Anesthesiology Program in the United
States, U.S. News and World Report and
Doximity, 2014
MEDICAL STUDENT PROGRAM AWARD
Anesthesia 110
Highest Rated Core Clerkship, 2013-2014
Top Core Clerkship Program at UCSF for
10 of the Last 12 Years
EXTRAMURAL APPOINTMENT
Anesthesia Residents
Foundation for Anesthesia Education and
Research, Academy of Research Mentors
Highest Rated Clinical Teachers
for the Last 12 Years
Critical Care
Medicine
5/8/2015 to 5/9/2015
UCSF Maintenance
of Certification
in Anesthesia
Simulator Course
5/22/2015 to 5/22/2015
September 2015
The Changing
Practice of
Anesthesia
9/24/2015 to 9/26/2015
UCSF Continuing
Medical Education
Office Registration
https://www.cme.ucsf.edu/
registration.aspx
Welcome —
We are pleased to announce the appointment of Carroll Schreibman as the Department of
Anesthesia and Perioperative Care’s Associate Chair for Finance and Administration. She has served capably in this
role in an interim capacity since Chuck Hajek’s departure to the Dean’s Office in August.
Carroll has been with the Department since 2002, when she started as an analyst supervisor in the Center for
Cerebrovascular Research. In 2006, she became the Director of Administration for the Department’s SFGH Division.
Carroll’s strong financial stewardship of pro-fee collections and the SFGH Affiliation Agreement provided the
Department as a whole with greater stability, supporting projects that have fostered change management and improvement.
Carroll’s collaborative and engaged leadership style is recognized throughout the SFGH and UCSF Communities. She has served in
many campus level leadership roles, as a member of the SOM LDP Selection Committee, as a Campus Skelly Officer, Step One
Grievance Officer, and finally, as a Gallup Engagement Ambassador.
UCSF Department of Anesthesia and Perioperative Care |
Anesthesia News | 2015 | 18