Venue How to get there: By train: take the Augsburg / Munich train to Günzburg station. You can either take a taxi or walk 2.2 km. Schloss Reisensburg Bürgermeister-Johann-Müller-Str. 1 89312 Günzburg / Donau Tel: +49 (0)8221 / 907-0 http://www.uni-ulm.de/reisensburg/ Contact Michèle Zimmerman Sekretariat SFB 1074 Universitätsklinik Ulm Albert-Einstein-Allee 23 89081 Ulm Tel: 0731-500-45523 Fax: 0731-500-45525 Email: [email protected] By car: From Ulm (A8 direction München) - Take the "Günzburg" exit and follow the signs for "Günzburg". - Stay on this road (B16) for about 3.3km. Turn left at the junction "Günzburg Nord/Bahnhof". - After about 250m turn left into "Ludwig-Heilmeyer-Str.", signposted "Reisensburg". - This road takes you into the village of Reisensburg. At the end of that road, turn left and follow the road straight up the hill. - On the top of the hill, you will find free parking in front of the gate of Schloss Reisensburg. Günzburg is approx. 40km from Ulm. Program Dear Ladies and Gentlemen, We cordially invite you, principal investigators and scientific staff, to the second retreat of our SFB 1074. We look forward to an intensive discussion and scientific interchange, as well as an enjoyable day at Schloss Reisensburg! Monday, February 10th, 2014 08:15 Arrival at Schloss Reisensburg 08:45 - 09:00 Welcoming remarks Moderation Thomas Wirth 09:00 - 09:30 A1 Hartmut Geiger Distinct DNA repair pathways in hematopoietic stem cells – contribution to genetic instability and leukemia 09:30 - 10:00 Hartmut Döhner 10:00 - 10:30 A2 Hans Jörg Fehling 15:30 - 16:00 Martina Bach (Hassan Jumaa group) "Role of PI3K signaling in CLL" Z1 Hans Kestler, Christian Buske 16:30 - 17:00 B2 Daniel Mertens, Hartmut Döhner, Coffee Break 11:00 - 11:30 A3 Franz Oswald Notch signaling as a novel target of AML1/ ETO A4 Christian Buske Dissecting Lef1 function in leukemic stem cells A7 Thomas Wirth Role of EZH2 in B-lymphoid and myeloid leukemogenesis 12:30 - 13:30 Lunch Moderation Hartmut Geiger 13:30 - 14:00 A5 Arefeh Rouhi, Florian Kuchenbauer (presenter will be Edith Schneider) 14:00 - 14:30 15:00 - 15:30 B1 Stephan Stilgenbauer Telomere dysfunction in pathogenesis and clinical course of CLL 16:00 - 16:30 Coffee break 10:30 - 11:00 12:00 - 12:30 Role of the hematopoiesis-specific Rho GTPase RhoH in the development of B-cell leukemias Dissecting hematopoietic defects in Mixed-LineageLeukemia-5-deficient mice and cell lines: towards a molecular understanding of Mll5 function Next generation sequencing facility - Parallel algorithms for robust clustering, classification, and visualization 11:30 - 12:00 14:30 - 15:00 A8 Peter Gierschik Moderation Klaus-Michael Debatin Stephan Stilgenbauer Genomic and epigenetic mechanisms in CLL pathogenesis 17:00 - 17:30 B3 Konstanze Döhner, Lars Bullinger Molecular and functional characterization of cooperating events in acute myeloid leukemia with NPM1 mutation 17:30 - 18:00 B4 Verena Gaidzik Functional analysis of recurrent deletions of chromosomal band 3p14.1-p13 in acute myeloid leukemia 18:00 - 18:30 B6 Lüder-H. Meyer, Klaus-M. Debatin The NOD/SCID/huALL xenotransplant model: characterization and prognostic impact of distinct engraftment properties (time to leukemia, TTL) of primary ALL cells Transcriptional and epigenetic regulation of microRNAs through MEIS1 in the pathogenesis of acute myeloid leukemia 18:30 - 19:00 B7 Christian Beltinger Attenuated oncolytic measles virus against ALL of childhood: preclinical proof-of-principle and molecular mechanisms A6 Michaela Feuring-Buske, Vijay Rawat 19:00 - 19:15 Concluding remarks VENTX: a novel regulator in human leukemias 19:15 Dinner