Knowledge Synthesis in KT: Choosing among Literature Review Options

Knowledge Synthesis in KT:
Choosing among Literature
Review Options
Kitty Corbett, PhD, MPH and Aislin Ryan (MPH2B)
Knowledge into Action Student-led Conference
Simon Fraser University
Saturday, January 25, 2014
THANKS to Aislin Ryan for background work, brainstorming assistance, & some excellent graphics.
• Conflict of interest: None for this presentation
• SPECIAL THANKS to Dr. Charlie Goldsmith and students in SFU’s
HSCI 891 Special Topics: Knowledge Translation, fall 2013
• This is a work in progress. If you have suggestions, please let us
know. [email protected]
• If you draw from our scheme for a presentation or paper, please
cite us. SLIDES will be available through the conference link or a
link at https://communication4health.wordpress.com/
The art & science of using the literature
“My copy doesn’t have the
references, Professor.
Would you please provide
them?”
“I did that for many years. I no longer
do. I mention some people in the
paper, but frankly I’ve drawn from so
many over my whole career, I can’t
cite everybody. You can look up
relevant sources if you want to.”
http://bradoilpainting.com/male/oil-painting-professor/
Workshop objectives
By the end of the workshop, participants will
• Be able to differentiate among 4 types of literature reviews
• Be able to construct questions suitable for each of these
types of reviews
• Have an enhanced understanding of types of literature
reviews and the synthesis of literature in KT
Road map
• Literature synthesis in the KT cycle
• So many labels!
• Kinds of questions that reviews seek
to answer
• Four key types & their characteristics
1.
2.
3.
4.
Plus activities
The gold standard for rigour & effectiveness assessment:
Systematic review
A sometimes formal approach addressing breadth of what’s
been done: Scoping review
An approach that asks about the black box (e.g., who, how,
theory) of policy & other interventions : Realistic review
A generic type that requires your clarification: Narrative review
• Recommendations
Image Source: http://theinkroad.blogspot.ca/2009/11/biker-in-road.html
Monitor
Knowledge
Use
Select, Tailor,
Implement
Interventions
Assess
Barriers/Facilitators to
Knowledge Use
KNOWLEDGE CREATION
Knowledge
Inquiry
Synthesis
Adapt
Knowledge
to Local Context
Evaluate
Outcomes
Products/
Tools
Sustain
Knowledge
Use
Identify Problem
Identify, Review,
Select Knowledge
http://www.cihr-irsc.gc.ca/e/41953.html
Knowledge Synthesis (KS)
• Why do it? To determine
• What is already known
• Where there is a strong evidence base
• When and how we might move that evidence
into action
• The formal use of K Synthesis in KT is mostly
• Systematic reviews
• Meta-analysis
7
“BRANDS” of reviews of studies, evidence,
intervention strategies, etc.
Rapid review
Qualitative review
Synthesis review
Grounded theory review
Scoping review
Thematic synthesis
Realist review
Critical interpretive synthesis
Meta-ethnography
Framework synthesis
Review of reviews
Narrative review
Systematic review
Meta-analytic review / meta-analysis
Narrative systematic review
Rapid realist review
Meta-synthesis
Systematic narrative review
Conceptual review
“Critical review”
“Synthesis review” …
• “When I use a word,” Humpty
Dumpty said, in rather a scornful
tone, “it means just what I choose
it to mean — neither more nor
less.”
• “The question is,” said Alice,
“whether you can make words
mean so many different things.”
(Lewis Carroll, Through the Looking
Glass)
Image Source: http://www.aliceinwonderlandshop.co.uk/toys.html
BRANDS OVERLAP; definitions
overlap
Systematic review
Meta-analytic review / meta-analysis
Qualitative review
Systematic narrative review
Realist review
Rapid realist review
Scoping review
Qualitative
review
Meta-ethnography
Narrative review
Synthesis review
Grounded theory review
For our purposes today: 4
types
Systematic review
Realist review
Scoping review
Narrative review
It all begins with a question.
• What works / what is effective?
• What is the range of [policy/program] interventions for [XYZ]?
• What kinds of theory-based intervention strategies have been
tried for [XYZ]?
• What kinds of audiences have been addressed?
• What looks interesting / promising about…?
ONE clear
question
4 key types of reviews.
For each, we’ll introduce:
• Definition
• Methodology
• Types of questions that are appropriate
• Examples
• How To guidelines are at end of presentation
slides
Four key types of reviews & their
characteristics
1. The gold standard for rigour &
assessment of intervention/treatment
effectiveness: Systematic review
2. A sometimes formal approach addressing breadth of what’s
been done: Scoping review
3. An approach that asks about the black box (e.g., who, how,
theory) of policy & other interventions : Realistic review
4. A generic type that requires your clarification: Narrative
review
Does “X” work?
Systematic Reviews
“Rigourous & reproducible”
Image Source: http://ecoopportunity.net/2013/11/great-example-of-canadian-ledcollaboration-towards-a-gold-standard-benchmark-for-sustainable-business/
Definition
Systematic Reviews
• “a review of the evidence on a clearly
formulated question that uses systematic and
explicit methods to identify, select and
critically appraise relevant primary research,
and to extract and analyse data from the
studies that are included in the review.” [1]
Systematic Reviews
Methodology, in general
Systematic reviews are usually characterized by
•
•
•
Their application to many important questions of
effects of medical treatment, & other determinants,
on health outcomes  clarity & precision of question
A formal algorithm for the whole process; great
elaboration of detail about how the review is done 
enhancement of reliability
Great attention to the research design &
methodological rigour of the included studies; risk of
bias  quality assurance
Methodology: steps
Systematic Reviews
1. Define the review question
2. Develop criteria for including studies (inclusion & exclusion
criteria)
3. Decide on sources of studies, e.g., literature databases
4. Select studies (using #2)
5. Collect data
6. Assess risk of bias in included studies
7. Analyse data (undertake meta-analysis, if applicable)
8. Address reporting biases
9. Present results and ‘Summary of findings’ tables
10. Interpret results and draw conclusions
Use of databases & selection of references 
need their own workshop
•
•
•
•
•
•
•
•
•
•
•
Academic Search Premier
MEDLINE with Full Text
Web of Science
CINAHL
Global Health
PsycINFO
Communication & Mass Media Complete
Communication Abstracts
Business Source Complete
Social Sciences Abstracts (H. W. Wilson)
Sociological Abstracts
PRISMA
flow diagram
showing selection of
studies, inclusion &
exclusion criteria
A diagram such as
this is typically
expected for all
systematic reviews &
most others.
Systematic Reviews
Typical types of questions
Effectiveness-related questions
• Does ‘X’ work; is it effective?
• What are the benefits and harms of treatment ‘X’ in humans?
• What is the accuracy of diagnostic test ‘X’?
• Is approach ‘A’ better than approach ‘B’?
E.g.,
• Does exercise + stress management training improve QoL
compared to exercise alone, over the short term, in university
students?
Phrasing the question for a
systematic review. Good questions
for systematic reviews are
represented by the mnemonic
“PICO” – or PICO[TS]
P = participants
I = intervention
C = comparison (if
appropriate)
O = outcome
T = time
S = setting
Systematic Reviews
PICO[TS]
PICOS de Alberta
Example
Systematic Reviews
Forbes, D., Thiessen, E.J., Blake, C.M., Forbes, S.C., Forbes, S.
(2013). Exercise Programs for people with dementia (Updated).
Available at: http://summaries.cochrane.org/CD006489/exerciseprograms-for-people-with-dementia
• Background: Exercise has been identified as a lifestyle factor that could
potentially reduce or delay the progression of dementia symptoms
• Methods: Review assessed 16 trials with a total of 937 participants that
evaluated whether exercise improved the following outcomes in people
with dementia: cognition, activities of daily living, behaviour,
depression, and mortality or benefitted their family members
• Results:
• Promising evidence that exercise significantly improve cognition and
performance of daily activities (but with variation between studies)
• No significant effect found of exercise on mood
• Little or no evidence of other outcomes
• Quality of evidence: lack of evidence for behaviour, caregiver burden
& mortality
Example of a “well built
clinical question”* – PICO
Population
Older people with dementia
Intervention
Exercise programs
Systematic Reviews
Comparison Usual care or social contact/activities
(optional)
Dementia outcomes: 1)Cognition 2)Activities of
Outcome
Daily Living 3) Behaviour 4) Depression 5) Mortality
Time
2 year period
Example of a “well built
clinical question”* – PICO
Systematic Reviews
Population
Older people with dementia
Intervention
Exercise programs
Comparison
(optional)
Usual care or social contact/activities
Outcome
Dementia outcomes: 1)Cognition 2)Activities of Daily
Living 3) Behaviour 4) Depression 5) Mortality
Time
2 year period
a.
b.
In _____[P], how does_____[I] compared with ______[C] affect
_____[O] within / over ____[T]?
Are _____[P], who receive _____[I], compared with those without
[C], at higher/lower risk for _____[O] over ____[T]?
Systematic Reviews
ACTIVITY 1: In pairs, generate an example.
Population
Intervention
Comparison
(optional)
Outcome
Time
Setting
1 MINUTE & counting…
Systematic Reviews
Key names
• Cochrane Collaboration :
• Named in honour of Archie Cochrane,
a British medical researcher
• SysRevs focus on effects of health care
• http://www.cochrane.org
Source: Cardiff University Library,
Cochrane Archive, University
Hospital Llandough
• Campbell Collaboration:
• Named in honour of Dr. Donald T. Campbell,
member of National Academy of Sciences, USA
• SysRevs focus on the effects of social interventions
• http://www.campbellcollaboration.org/
Source:
http://www.campbellcollaboration.org/background/index.php
Four key types of reviews & their
characteristics
1. The gold standard for rigour & effectiveness assessment:
Systematic review
2. A sometimes formal approach
addressing breadth of what’s been
done: Scoping review
3. An approach that asks about the black box (e.g., who, how,
theory) of policy & other interventions : Realistic review
4. A generic type that requires your clarification: Narrative
review
Scoping Reviews
“Mapping areas of research”
Definition
Scoping Reviews
• “aim to map rapidly the key concepts underpinning a research
area and the main sources and types of evidence available,
and can be undertaken as stand-alone projects in their own
right, especially where an area is complex or has not been
reviewed comprehensively before” [4]
Arksey and O’Malley’s scheme outlines 4 aims:
1. examine extent, nature, and range of research activity
2. determine value of undertaking a full systematic review
3. summarize and disseminate research findings
4. identify research gaps in the existing literature [4]
Scoping Reviews
Methodology (as per Arksey & O’Malley)
1. Identify research question
• Wide definitions are okay
2. Identify relevant studies
• Can include various study designs (experimental, observational,
qualitative)
• Use different sources of data (e.g., grey lit) & be as comprehensive
as possible
3. Select studies
• Final inclusion & exclusion criteria can be determined post hoc
4. Chart the data
• Synthesize and interpret by sorting into key themes
5. Collate, summarize, and report the results
 Often, no assessment of individual studies for risk of bias as
in systematic revs [4]
Appropriate questions
Scoping Reviews
• Questions that seek to establish what research has already
been published on a given topic [5]
• E.g., What is known from the existing literature about the
effectiveness and cost-effectiveness of services to support carers of
people with mental health problems?
• Questions can be less specific than for systematic reviews and
can apply to various study designs
• Questions can be revised as the review unfolds & researchers
become more comfortable with the literature
• According to Daudt et al. [7] questions that seek to make
comparisons between interventions, programs or approaches
are most suitable [Creeping towards systematicity]
Key names
Scoping Reviews
• Arksey and O’Malley
• Published first methodological framework for conducting scoping
reviews in 2005
• Levac et al.
• In 2010, published “Scoping studies: advancing the methodology”
[6]; aims to clarify and advance Arksey and O’Malley’s
methodology
• Daudt et al.
• 2013, paper [7] outlining their experience applying Arksey and
O’Malley’s methodology and proposing clarifications to the
framework, including incorporating an assessment of the quality
of the studies
Scoping Reviews
Examples
Pagliari et al. (2005). What is
eHealth?”: A Scoping Exercise to
Map the Field. Journal of Medical
Internet Research, 7(1): E9.
Available at:
http://dx.doi.org/10.2196/jmir.7.1.e9
Ridde, V. and Morestin, F. (2011). A
scoping review of the literature on the
abolition of user fees in health care
services in Africa. Health Policy and
Planning, 26, 1-11. Available at:
http://dx.doi.org/10.1093/heapol/czq021
Systematic Reviews
ACTIVITY 2: Scoping or systematic? Do this
individually, then discuss in pairs.
What does research say about the information provided by
health care professionals and needed by people with
colorectal cancers across the cancer care continuum?
In Canadian men, does having a vasectomy increase the risk
of getting testicular cancer in the future?
Are children who live within 5 kilometres of a major roadway
more likely than those who live farther away to be diagnosed
with asthma before age five?
Does a multi-faceted physical activity intervention for elders
that includes supportive text messages work better than the
intervention alone?
What has been written about the use of dance as a process
and product in health interventions?
1 MINUTE & counting…
Four key types of reviews & their
characteristics
1. The gold standard for rigour & effectiveness assessment:
Systematic review
2. A sometimes formal approach addressing breadth of what’s
been done: Scoping review
3. An approach that asks about the black
box (e.g., who, how, theory) of policy &
other interventions: Realistic review
4. A generic type that requires your clarification: Narrative
review
Realist reviews
“Explanatory quest”
“Opening the black box”
Image Source: http://www.forbiddenplanet.co.uk/blog/2009/this-will-explaineverything/
Definition
Realist Reviews
• “an explanatory analysis aimed at discerning
what works for whom, in what circumstances,
in what respects and how” [3, p. 32]
• "attempts to provide a transferable theory that
suggests that a certain program is more or less
likely to work in these respects, for these
subjects, in these kinds of situations" [8, p. 2]
• Often about how/why policies & programs work
Methodology
1.
Realist Reviews
Clarify scope
• Research question, purpose of review, key theories to be explored
• Design a theoretically-based evaluation framework
2.
Search for evidence
• Exploratory background literature to see what’s out there
• Progressively focus on relevant program theories and refine inclusion/exclusion
criteria
• Purposive and snowball sampling
3.
4.
Appraise primary studies & extract data
Synthesize evidence & draw conclusions
• Refine program theory – determine what works, for whom, how and when
• Conclusions might be expressed as decision points: If A, then B. If C, then not D
5.
Disseminate, implement, and evaluate
[9, p. 24]
Addition of Snowballing to
track down references
•
•
•
•
•
Realist &
narrative (&
some scoping)
reviews
Pearl growing; “pearling”
Reference harvesting
Hand searching
Pyramiding
Digital snowballing
• Useful for grey literature
• http://hlwiki.slais.ubc.ca/index.php/Snowballing
http://en.wikipedia.org/wiki/Pearl
Realist Reviews
Appropriate questions
• Questions dealing with complex interventions (e.g., multi-faceted;
diverse settings; diverse participants) [9]
• Questions that aim to explain rather than make a judgment
• WHAT is it about this kind of intervention that works, for WHOM, in
what CIRCUMSTANCES, in what RESPECTS and WHY?
Examples
Wong et al. (2011).
Policy guidance on
threats to legislative
interventions in
public health: a
realist synthesis.
BMC Public Health,
11: 222.
Realist Reviews
Greenhalgh, T. et al.
(2007). Realist
review to understand
the efficacy of
school feeding
programmes. BMJ,
335, 858-861
Key names
Realist Reviews
• Prof. Ray Pawson
Department of Sociology and Social Policy,
University of Leeds
• Developed the Realist Synthesis
approach
Source:
http://www.sagepub.com/books
ProdDesc.nav?prodId=Book22
7875
Source:
http://www.uk.sagepub.com/booksProdDes
c.nav?prodId=Book238842
Systematic Reviews
ACTIVITY 3: Scoping or realist? Do this individually,
then discuss in pairs.
Why do certain engagement in care interventions for persons
with diabetes work well in some contexts and fail in others?
What are the different ways that peer influence strategies
have been used to promote condom use among North
American adolescents?
What is known about the effects of medical tourism in
destination and departure countries?
In what kinds of programs has Photovoice contributed to
policy change? [engaging participants in CBPR through their
own photographs]
1 MINUTE & counting…
Four key types of reviews & their
characteristics
1. The gold standard for rigour & effectiveness assessment:
Systematic review
2. A sometimes formal approach addressing breadth of what’s
been done: Scoping review
3. An approach that asks about the black box (e.g., who, how,
theory) of policy & other interventions : Realistic review
4. A generic type that requires your
clarification: Narrative review
Narrative Reviews
Flexible & eclectic
(“Call it like you see it”)
Source: http://ask2vikramsingh.blogspot.ca/2013/09/5-internet-marketingstrategies-get.html
Definition
Narrative Reviews
• [A more systematic def] “an approach to the systematic review
and synthesis of findings from multiple studies that relies
primarily on the use of words and text to summarise and
explain the findings of the synthesis” …. “at the heart of
narrative synthesis [is telling a trustworthy story]” [13, p. 5]
• “a flexible & eclectic approach that can be used in 3 situations:
1.
2.
3.
before undertaking a statistical meta-analysis
instead of a statistical meta-analysis (because the experimental or quasiexperimental studies included are not sufficiently similar to allow for
this)
where the review questions dictate the inclusion of a wide range of
different research designs […] for which no other specialist approach to
synthesis is appropriate” [14, p. 17]
Methodology
Narrative Reviews
Anything goes?
• Suggested guidelines vary….
• According to Green et al. (2006) [15]:
• There are no strict guidelines for what should and should not be
included in a narrative review.
• Still, they argue narrative reviews should:
1. Follow the structure suggested in manuscript and biomedical
journal guidelines (intro, methods, conclusion, etc.)
2. Be as objective as possible
3. Describe & synthesize available literature and provide a conclusion
4. Describe step by step how study was performed
5. State the database searched, a starting year, and the ending year
and month of the search
6. Briefly describe selection criteria
Narrative Reviews
Methodology (cont’d)
Another brand:
Synthetic
reviews
• Popay et al. [13] lay out slightly more structured criteria
specific to narrative syntheses that look at the effect and
implementation of interventions
• The steps they outline are similar to those of a systematic or
scoping review:
1.
2.
3.
4.
5.
6.
Identifying focus of the review, searching for and mapping
evidence
Specifying the review question
Identifying studies to include in the review
Data extraction and quality appraisal
Synthesis
Reporting results and dissemination
Narrative Reviews
Appropriate questions
• Suitable for the discussion of theory and context – and to
spark scholarly dialogue among readers…. [15]
• In their broadest definition, narrative reviews can answer
theoretical questions that are beyond the scope of any other
review [16]
• Can answer a wide range of questions including those related
to effectiveness or cost effectiveness, issues of efficacy,
appropriateness, feasibility of implementation, or a
combination of these. [13, p. 6]
Narrative Reviews
Examples: Meta-ethnography
Often cited example:
• Pound, P. et al. (2005). Resisting Medicines: A Synthesis of
Qualitative Studies of Medicine Taking. Social Science and Medicine
61, 133–55.
• Campbell, R., et al. (2003). Evaluating Meta-Ethnography: A
Synthesis of Qualitative Research on Lay Experiences of Diabetes
and Diabetes Care. Social Science and Medicine 56, 671–84
Narrative Reviews
Examples: Policy-focused
• Mays, N., Pope, C., Popay, J. Systematically reviewing
qualitative and quantitative evidence to inform management
and policy-making in the health field. Journal of Health
Services Research and Policy. 2005: 10; 6-20.
• Walt, G., Shiffman, J., Schneider, H., Murray, S.F., Burgha, R.,
Gilson, L. ‘Doing’ health policy analysis: Methodological and
conceptual challenges. Health Policy and Planning. 2008; 23:
303-317.
• Synthesizing evidence for management and policy making
(Supplement). J Health Serv Res Policy. 2005 July;10(Suppl 1).
Some cautions
Narrative Reviews
Some would assert that: “There are no standard methods for
conducting syntheses of qualitative research” (Britten 2002)
Most would agree that: “…many aspects of the steps in the
process remain ill-defined.” (Atkins BMC Medical Research
Methodology 2008, 8:21 )
But perhaps that’s okay?
Key names
• Jennie Popay and collaborators from
a variety of UK universities who
published guidelines on how to
conduct narrative synthesis. She
works with the Campbell
Collaboration Process
Implementation Methods Group
and the Cochrane Collaboration
Qualitative Methods Group.
Narrative Reviews
Jennie Popay
Example
Narrative Reviews
McCreaddie, M. and Wiggins, S. (2008). The
purpose and function of humour in health,
health care and nursing: a narrative review.
Journal of Advanced Nursing, 61(6), 584–
595. Available at:
http://dx.doi.org/10.1111/j.13652648.2007.04548.x
Systematic Reviews
ACTIVITY: Appropriate for a narrative review?
What is important to include in cultural competency training
for students going to do practicum work internationally?
What are the experiences of children living with a sibling with
autism?
How do elderly people living with palliative care perceive
time?
1 MINUTE & counting…
REVIEW:
Four key types of reviews & their
characteristics
1. The gold standard for rigour & effectiveness assessment:
Systematic review
2. A sometimes formal approach addressing breadth of what’s
been done: Scoping review
3. An approach that asks about the black box (e.g., who, how,
theory) of policy & other interventions : Realistic review
4. A generic type that requires your clarification: Narrative
review
Decisions, decisions…
Yes
No
Yes
No
Yes
Yes
No
Yes
No
SYSTEMATIC REVIEW
APPLY FOR MORE
FUNDING
SCOPING REVIEW
BRAINSTORM SOME
MORE ABOUT WHAT
YOU WANT TO GET
OUT OF YOUR REVIEW
REALIST REVIEW
No
Yes
No
NARRATIVE REVIEW
MAYBE YOU NEED A
DIFFERENT TYPE OF
REVIEW
Scoping, realist, or narrative?
Spinning your review label
How can you make your question match criteria?
• SCOPING: emphasize breadth of what’s out there in the lit
• Might be prep for systematic review
• REALIST: emphasize conceptual / theoretical aspects of the
how and why of interventions
• NARRATIVE: you better say what you mean by this.
• E.g., “systematic narrative review”: this is a systematic review
• E.g., selection of cases or ‘stories’ from the literature to illustrate
a particular perspective or point
• E.g., a review involving non-systematic selection of literature, i.e.,
cherry picking “pearls” or exemplars from the literature on a
specific topic [or from cross-disciplinary, cross-topic literature],
for discussing a philosophical, theoretical, political, etc. point
Activity 4: Generate 1 question for
each of the following types of reviews
SYSTEMATIC:
SCOPING:
REALIST:
NARRATIVE:
1 MINUTE & counting…
Recommendation:
Specify what kind of review you’re
doing & provide a reference or example
from the “how to” literature.
• Be specific about which type of review you are conducting
(systematic, scoping, realist) and tell your reader why you
chose that method
• If your following the guidelines laid out in a how-to guide or
reference article, cite it in your methodology section
• This helps guide researchers looking to do future reviews and
helps to standardize different methodologies
Recommendation: Suggested general
competencies to pursue
•
•
•
•
•
Generating & refining questions
Matching questions to search designs
Selecting & using library databases
Conducting key word searches
Using a flow chart to track sample of references in terms of
searches and application of inclusion and exclusion criteria
• Using appraisal systems to assess quality & value of references
for your purposes
• Coding content of references to extract information you need
to (a) answer your question and (b) defend your method
• Interpreting results
Recommendation:
Learn more, find examples, & use
how-to resources
• Seek out how-to articles or guideline documents, to get a better
idea of the methodological criteria specific to particular brands
of review
• If you just go to the Methods sections of papers – regardless of
the brand of review - the methods often sound the same. Go
deeper.
• Great SFU resource for Cochrane reviews: Dr. Charlie Goldsmith
• Librarians
References & resources
1.
2.
3.
4.
5.
Cochrane Public Health. Unit 1: Background to Systematic Reviews.
Available at:
http://ph.cochrane.org/sites/ph.cochrane.org/files/uploads/Unit_One.pd
f [ALSO SEE: The Cochrane Collaboration. (2013). Cochrane Reviews.
Available at: http://www.cochrane.org/cochrane-reviews.]
Higgins, J. P.T. and Green, S., eds. (2011). Cochrane Handbook for
Systematic Reviews of Interventions. Version 5.1.0. Available at:
http://handbook.cochrane.org/
Grimshaw, J. (n.d.). A Knowledge Synthesis Chapter. Available at:
http://www.cihrirsc.gc.ca/e/documents/knowledge_synthesis_chapter_e.pdf
Arksey, H. and O'Malley, L. (2005). Scoping studies: towards a
methodological framework. International Journal of Social Research
Methodology, 8(1), 19-32. Available at:
http://dx.doi.org/10.1080/1364557032000119616
HLWIKI International. (2014). Scoping Reviews. Available at:
http://hlwiki.slais.ubc.ca/index.php/Scoping_reviews
References (cont’d)
6. Levac et al. (2010). Scoping studies: advancing the methodology.
Implementation Science, 5:69. Available at:
http://www.implementationscience.com/content/5/1/69
7. Daudt et al. (2013). Enhancing the scoping study methodology: a large,
inter-professional team’s experience with Arksey and O’Malley’s
framework. BMC Medical Research Methodology, 13:48. Available at:
http://www.biomedcentral.com/1471-2288/13/48
8. Saul, J.E. et al. (2013). A time-responsive tool for informing policy making:
rapid realist review. Implementation Science, 8:103. Available at:
http://www.implementationscience.com/content/8/1/103
9. Pawson, R. et al. (2005). Realist review - a new method of systematic
review designed for complex policy interventions. Journal of Health
Services Research & Policy, 10(S1), 21-34. Available at:
http://dx.doi.org/10.1258/1355819054308530
10. Wong et al. (2011). Policy guidance on threats to legislative interventions
in public health: a realist synthesis. BMC Public Health, 11: 222. Available
at: http://www.biomedcentral.com/1471-2458/11/222
References (cont’d)
12. Greenhalgh, T. et al. (2007). Realist review to understand the efficacy of
school feeding programmes. BMJ, 335, 858-861. Available at:
http://dx.doi.org/10.1136/bmj.39359.525174.AD
13. Popay, J., Roberts, H., Sowden, A., Petticrew, M., Arai, L., and Rodgers, M.
(2005). Guidance on the Conduct of Narrative Synthesis in Systematic
Reviews. Version 2. Lancaster, UK: Lancaster University.
14. Popay, J. and Mallinson, S. (2010). Qualitative Research Review and
Synthesis in The Sage Handbook Qualitative Methods Health Research.
London: Sage Publications.
15. Green, B.N. et al. (2006). Writing narrative literature reviews for peerreviewed journals: secrets of the trade. Journal of Chiropractic Medicine,
5(3), 101-117.
16. Baumeister, R.F. and Leary, M.R. (1997). Writing Narrative Literature
Reviews. Review of General Psychology, 1(3), 311-320.
How-to Guidelines
Systematic Reviews
There are many excellent resources and examples for
systematic reviews.
• Higgins, J. P.T. and Green, S., eds. (2011). Cochrane Handbook
for Systematic Reviews of Interventions. Version 5.1.0.
Available at: http://handbook.cochrane.org/
• The Campbell Collaboration. (n.d.). Resource Center. Available
at:
http://www.campbellcollaboration.org/resources/research/th
e_production.php
• How the Aussies are doing it:
http://joannabriggs.org/index.html
How-to Guidelines
Scoping Reviews
• Arksey, H. and O'Malley, L. (2005). Scoping studies: towards a
methodological framework. International Journal of Social
Research Methodology, 8(1), 19-32. Available at:
http://dx.doi.org/10.1080/1364557032000119616
• Levac et al. (2010). Scoping studies: advancing the methodology.
Implementation Science, 5:69. Available at:
http://www.implementationscience.com/content/5/1/69
• Daudt et al. (2013). Enhancing the scoping study methodology: a
large, inter-professional team’s experience with Arksey and
O’Malley’s framework. BMC Medical Research Methodology,
13:48. Available at: http://www.biomedcentral.com/14712288/13/48
How-to Guidelines
Realist Reviews
• Pawson, R. et al. (2005). Realist review - a new method of
systematic review designed for complex policy interventions.
Journal of Health Services Research & Policy, 10(S1), 21-34.
Available at: http://dx.doi.org/10.1258/1355819054308530
How-to do a Rapid Realist Review:
• Saul, J.E. et al. (2013). A time-responsive tool for informing
policy making: rapid realist review. Implementation Science,
8:103. Available at:
http://www.implementationscience.com/content/8/1/103
How-to Guidelines
Narrative Reviews
• Popay, J. and Mallinson, S. (2010). Qualitative Research
Review and Synthesis in The Sage Handbook Qualitative
Methods Health Research. London: Sage Publications.
• Green, B.N. et al. (2006). Writing narrative literature
reviews for peer-reviewed journals: secrets of the trade.
Journal of Chiropractic Medicine, 5(3), 101-117.
• Baumeister, R.F. and Leary, M.R. (1997). Writing narrative
literature reviews. Review of General Psychology, 1(3),
311-320.
More resources
• CIHR. Synthesis Resources: http://www.cihrirsc.gc.ca/e/36331.html
• UBC Library: http://guides.library.ubc.ca/litreviews
• EPPI Centre (policy & professional practice):
http://eppi.ioe.ac.uk/cms/
• http://hlwiki.slais.ubc.ca/index.php/Snowballing
Narrative Reviews
Examples: Meta-ethnography
• Noblit, G. Hare, R. (1988) Meta-Ethnography: Synthesising Qualitative
Studies. Newbury Park, CA: Sage.
• Britten N et al. (2002). , Campbell R, Pope C, Donovan J, Morgan M,
Pill R: Using meta ethnography to synthesise qualitative research: a
worked example. J Health Serv Res Policy, 7, 209-215
PROSPERO
Registration for systematic reviews
• Why?
• to avoid excessive duplication
• Documents compliance with PRISMA Guideline
• Useful one-hour webinar on PROSPERO
http://www.youtube.com/watch?v=6Y-zpftqlUo
If you’re into rigour: check out GRADE
• “GRADE is a systematic and explicit
approach to making judgements about
quality of evidence and strength of
recommendations.
• It was developed by the Grading of
Recommendations, Assessment,
Development and Evaluations (GRADE)
Working Group, and it is now widely seen as
the most effective method of linking
evidence-quality evaluations to clinical
recommendations.”
http://clinicalevidence.bmj.com/x/set/static/eb
m/learn/665072.html
• Quality, methodological
• Consistency of results across different
studies
• Directness - generalisability of
population and outcomes
• Effective size
GRADES = -3 to +4
e.g., Quality score: Systematic review of
RCTs  +4
e.g., Consistency score: Lack of
agreement between studies (e.g.,
statistical heterogeneity between
RCTs, conflicting results)  -1
•“Critically appraising quality and relevance”
http://www.strath.ac.uk/aer/materials/8systematicreview/unit10/appraising/
Constructing a good systematic review
question