How to win the Nobel prize… Secret tips from Nobel Laureate Barry J. Marshall AC The 2013 David Maddison lecture will be presented by Nobel Laureate Barry J. Marshall AC, who famously swallowed the highly toxic bacterium, Helicobacter pylori, to prove that it caused peptic ulcers. In recognition of this ground breaking discovery and his innovative approach to medical research he was awarded the Nobel Prize in 2005 with Nobel Laureate J. Robin Warren. Nobel Laureate Marshall is currently Clinical Professor of Medicine and Microbiology at the University of Western Australia, and co-Director of the Marshall Centre for Infectious Diseases Research and Training, UWA. The David Maddison Lecture is a free public lecture open to the community and commemorates the contributions of Professor David Maddison, the Foundation Dean of Medicine at the Newcastle Medical School. This event is proudly supported by the Faculty of Health. WHEN Thursday, 4th April, 2013 5:30pm, for a 5:45pm start WHERE Griffith Duncan Theatre, University of Newcastle, Callaghan Campus RSVP [email protected] Ph: 4985 4292 Campus map: http://newcastle.edu.au/maps/callaghan/ Parking access: http://www.newcastle.edu.au/service/parking/visitors.html Image courtesy of Frances Andrijich SHAPING THE FUTURE OF HEALTH Nobel Laureate Barry J. Marshall AC Clinical Professor, University of Western Australia A medical pioneer whose work transcends all boundaries. In 2005 Barry J. Marshall and J. Robin Warren were awarded the Nobel Prize for Physiology or Medicine in recognition of their 1982 discovery that a bacterium, Helicobacter pylori, which affects 50% of the global population, causes one of the most common diseases of mankind, peptic ulcer disease. Barry Marshall met Robin Warren, a pathologist interested in gastritis, during internal medicine fellowship training at Royal Perth Hospital in 1981. The pair studied the presence of spiral bacteria in association with gastritis. The following year (1982), Helicobacter pylori was cultured for the first time and they developed their hypothesis related to the bacterial cause of peptic ulcer and gastric cancer. In 1984, at Fremantle Hospital, Marshall proved that the germ was harmful in a well-publicised self-administered experiment, in which he drank a culture of H.pylori. Persevering despite widespread skepticism, Marshall also came up with combinations of drugs that killed the bacteria and eliminated ulcers permanently. In 1984 the World Health Organisation recognized H.pylori as the main cause of stomach cancer. Marshall and Warren’s work is acknowledged as the most significant discovery in the history of gastroenterology and is compared to the development of the polio vaccine and the eradication of smallpox. In 1998 Marshall was made a Fellow of the Royal Society. In 2008 he was elected as a Foreign Member of the prestigious US National Academy of Science, an institution that was established in 1863 by President Abraham Lincoln. Dr Marshall founded Ondek Pty Ltd in 2005, to develop and commercialise a novel drug and vaccine delivery platform, based on the use of genetically modified Helicobacter pylori. Dr Marshall and his research team have developed a set of proprietary technologies, referred to as the Helicobacter pylori Platform Technology (HPPT). The HPPT has potential application for oral delivery of immunotherapies, biopharmaceuticals and other drugs, and vaccines. The first product being developed at Ondek is an immunotherapy for the treatment of allergic asthma and food allergies in children. Barry Marshall was born in Kalgoorlie in 1951 and attended Marist Brothers College in Perth from 1960-68. He completed his undergraduate medical degree at The University of Western Australia in 1974. He is married with four children and five grandchildren and lives in Shenton Park, Western Australia. Awarded in conjunction with Dr J. Robin Warren • Nobel Prize for Physiology or Medicine 2005 • Western Australian Citizen of the Year 2006 • Western Australian of the Year 2007 • Companion in the General Division of the Order of Australia (AC) in 2007. • The Paul Ehrlich Prize 1997 • Warren Alpert Prize 1995 Photo courtesy: Adrienne Marshall Current Appointments • Ambassador for Life Sciences for Western Australia • Clinical Professor of Medicine and Microbiology, UWA • co-Director of the Marshall Centre for Infectious Diseases Research & Training, UWA • Consultant Gastroenterologist, Sir Charles Gairdner Hospital • Founder and Director of ONDEK, a biotechnology company • Founder and Director of TRI-MED, a diagnostics company • Western Australian Technology and Industry Advisory Council • Honorary Patron of Scitech, the Ear Science Institute and Fremantle Hospital Medical Research Foundation • Francis R & Helen M. Pentz Visiting Professor of Science at Penn State University, USA • Member of University of Malaya High Impact Research Advisory Council Awards and Fellowships • Elected as a Foreign Member of the Chinese Academy of Engineering • ASMR Medallist for 2011 • Honorary Professor of following Chinese Universities: Shantou, Guangdong; Sichuan, Chengdu; Chinese University of Hong Kong; Third Military Medical University, Chongqing • Honorary Degree of Doctor of Science, honoris causa, University of Oxford, UK • Honorary Doctorate in Medicine at Örebro University, Sweden • Galen Medal, The Worshipful Society of Apothecaries, London • Lennon K. Black Prize for Excellence in Biomedical Research, Jefferson College, USA • The William Beaumont Prize – AGA • Honorary Degree of Doctor of Science, honoris causa, Polish Academy of Medicine • Silver Seal, University of Bologna, Italy • Australian Centenary Medal • The Keio Medical Science Prize • Inaugural Premier’s Prize for Achievement in Science, WA • Prince Mahidol Award for Public Health • Clunies Ross National Science and Technology Award • Inducted as a Fellow of Australian Academy of Science • Benjamin Franklin Medal for Life Science • Buchanan Medal, The British Royal Society of Medicine • The Dr A.H. Heineken Prize for Medicine • The Florey Medal, Australia • Kilby Prize, Dallas Texas • The Gairdner Award, Toronto Canada • The John Scott Award, City of Philadelphia • The Albert Lasker Award