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Translational Medicine – What, Why and How:
An International Perspective
Translational Research in Biomedicine
Vol. 3
Series Editor
Samuel H.H. Chan
Kaohsiung
Associate Editor
Julie Y.H. Chan
Kaohsiung
Translational Medicine –
What, Why and How:
An International
Perspective
Volume Editors
Barbara Alving Bethesda, Md.
Kerong Dai Shanghai
Samuel H.H. Chan Kaohsiung
14 figures, 7 in color, and 14 tables, 2013
Basel · Freiburg · Paris · London · New York · New Delhi · Bangkok ·
Beijing · Tokyo · Kuala Lumpur · Singapore · Sydney
Barbara Alving, MD
Kerong Dai, MD
Uniformed Services
University of the Health Sciences
7118 Glenbrook Road
Bethesda, MD 20814 (USA)
Clinical Translational Center of Stem Cell and
Regenerative Medicine
Ninth People's Hospital
Shanghai Jiao Tong University
School of Medicine
Shanghai (China)
Samuel H.H. Chan, PhD
Center for Translational Research in Biomedical
Sciences
Kaohsiung Chang Gung Memorial Hospital
123, Taipei Road
Kaohsiung 83801(Taiwan)
The Chang Gung Medical Foundation is the patron of this book series.
Library of Congress Cataloging-in-Publication Data
Translational medicine : what, why, and how : an international perspective /
volume editors, Barbara Alving, Kerong Dai, Samuel H.H. Chan.
p. ; cm. -- (Translational research in biomedicine, ISSN 1662-405X ;
v. 3)
Includes bibliographical references and indexes.
ISBN 978-3-318-02284-1 (hard cover : alk. paper) -- ISBN 978-3-318-02285-8
(electronic version)
I. Alving, Barbara M. II. Dai, Kerong. III. Chan, Samuel H. H. IV. Series:
Translational research in biomedicine ; v. 3. 1662-405X
[DNLM: 1. Translational Medical Research. 2. Academic Medical
Centers--trends. W 20.55.T7]
610.72--dc23
2012041085
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and
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retrieval system, without permission in writing from the publisher.
© Copyright 2013 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISSN 1662–405X
e-ISSN 1662–4068
ISBN 978–3–318–02284–1
e-ISBN 978–3–318–02285–8
Section Title
Contents
VII
VIII
1
6
18
29
36
47
56
63
74
82
Foreword
Chan, S.H.H. (Kaohsiung)
Preface
Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung)
The What and Why of Translational Medicine
Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung)
Partnership Model for Academic Health Science Systems to Address the
Continuum from Discovery to Care, at Scale
Fish, D.; Chantler, C.; Kakkar, A.K.; Trembath, R.; Tooke, J. (London); on behalf of
UCLPartners
The US Initiative: Clinical and Translational Science Awards – The UC Davis
Perspective
Tarantal, A.F.; Rainwater, J.; Wun, T.; Berglund, L. (Sacramento, Calif.)
National Agenda and Strategies for the Development and Implementation of
Translational Medicine
Zhao, Y. (Beijing)
Developing a Translational Research Workforce in the USA
Pearson, T.A. (Rochester, N.Y.); Kapoor, W.N. (Pittsburgh, Pa.); Holloway, R.G.
(Rochester, N.Y.)
Training Translational Investigators in China
Shi, T.Z. (Catonsville, Md.); Dai, K. (Shanghai)
Translational Medicine in Taiwan: The Role of Private Foundation Funding
Chan, S.H.H. (Kaohsiung)
Utilizing Pilot Funding and Other Incentives to Stimulate Interdisciplinary
Research
Denne, S.C.; Sajdyk, T. (Indianapolis, Ind.); Sorkness, C.A.; Drezner, M.K. (Madison, Wisc.);
Shekhar, A. (Indianapolis, Ind.)
Building Expertise in Translational Processes through Partnerships with
Schools of Business
Cheng, S.K.; Dilts, D.M. (Portland, Oreg.)
Creating Ethical, High-Value Industry-Academic Partnerships
Steele, S. (Rochester, N.Y.); Holroyd, K.J. (Nashville, Tenn.); Fadem, T.J. (Philadelphia, Pa.)
V
Alving B, Dai K, Chan SHH (eds): Translational Medicine – What, Why and How: An International Perspective.
Transl Res Biomed. Basel, Karger, 2013, vol 3, pp I–VI (DOI: 10.1159/000343465)
89
98
110
120
123
124
Increasing the Efficiency and Quality of Clinical Research with Innovative
Services and Informatics Tools
Disis, M.L.; Tarczy-Hornoch, P.; Ramsey, B.W. (Seattle, Wash.)
Engaging the Community in Research with the HealthStreet Model:
National and International Perspectives
Cottler, L.B.; Striley, C.W. (Gainesville, Fla.); O’Leary, C.C. (St. Louis, Mo.); Ruktanonchai, C.W.
(Gainesville, Fla.); Wilhelm, K.A. (Darlinghurst, New South Wales)
Evaluating Translational Research
Kane, C. (Ithaca, N.Y.); Rubio, D. (Pittsburg, Pa.); Trochim, W. (Ithaca, N.Y.)
Envisioning the Future of Translational Medicine: A Snapshot of 2016
Alving, B. (Bethesda, Md.); Dai, K. (Shanghai); Chan, S.H.H. (Kaohsiung)
Author Index
Subject Index
VI
Alving B, Dai K, Chan SHH (eds): Translational Medicine – What, Why and How: An International Perspective.
Transl Res Biomed. Basel, Karger, 2013, vol 3, pp I–VI (DOI: 10.1159/000343465)
Contents
Section Title
Foreword
Welcome to volume 3 of Translational Research in Biomedicine, a monograph series
dedicated to the dissemination of seminal information in contemporary biomedicine
with a translational orientation. This volume marks a new milestone of this series.
Beginning with this volume, Translational Research in Biomedicine will be published
under the generous patronage of Chang Gung Medical Foundation, Taiwan. This
patronage will reduce substantially the increasing financial constraints on scientific
publication, and allow us to concentrate on publishing timely and crucial themes in
translational medicine.
This volume is designed to be a key reference for translational medicine. During
the last decade, translational medicine has become a household word in the arena of
medical research and beyond. Closer scrutiny, however, has revealed that the term
‘translational medicine’ has been interpreted and presented widely, ranging from pure
rhetoric in political orations, golden geese to entrepreneurs or shareholders, to conscientious solutions to health issues. My personal view is that this multiplicity arises
from the lack of a comprehensive overview on the ‘what’, ‘why’, and ‘how’ aspects of
translational medicine. This volume is designed to fill this void based on an international perspective.
I wish to express my deepest appreciation to Drs. Barbara Alving and Kerong Dai,
whose patience and sustaining efforts have made this timely volume, Translational
Medicine – What, Why and How: An International Perspective, a reality. Last but not
least, the publication of Translational Research in Biomedicine would not have been
possible without the foresight, enthusiasm, and whole-hearted support of my dear
friend, Dr. Thomas Karger.
Samuel H.H. Chan, Kaohsiung
Series Editor
VII
Alving B, Dai K, Chan SHH (eds): Translational Medicine – What, Why and How: An International Perspective.
Transl Res Biomed. Basel, Karger, 2013, vol 3, pp VII (DOI: 10.1159/000343465)
Preface
Although translational medicine is now a common term throughout the scientific
world, a comprehensive monograph that addresses the ‘what’, ‘why’, and ‘how’ aspects
of translational medicine, particularly from an international perspective, has not
been forthcoming. This volume will fill this void. Fourteen chapters written by eminent experts with diversified experience will address three general themes: ‘What is
translational medicine?’, ‘Why do governments, research institutions, and other organizations invest in translational medicine?’, and ‘How is translational medicine carried out internationally?’. In so doing, it is our intention to make this volume a key
reference of translational medicine.
Our sincere thanks go to the authors who have kindly consented to contribute their
expert opinion to this volume and to Chang Gung Medical Foundation in Taiwan for
sponsoring the Translational Research in Biomedicine series.
Barbara Alving, Bethesda, Md.
Kerong Dai, Shanghai
Samuel H.H. Chan, Kaohsiung
Volume Editors
VIII
Alving B, Dai K, Chan SHH (eds): Translational Medicine – What, Why and How: An International Perspective.
Transl Res Biomed. Basel, Karger, 2013, vol 3, pp VIII (DOI: 10.1159/000343466)