mily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao,
heo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron
cLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian
ead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice,
osie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David
owells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian
arshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells,
anne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren
gan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina
yriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice
utton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph
antzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner,
auralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart
an der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis
anagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter
andercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet
Macleod
ahor, Jing Liao, Theo Hirst, Kim Wever, HugoMalcolm
Pedder, Katerina
Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios
erghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah
Professor of Neurology and Translational Neurosciences
aCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle,
ndrew Rice, Rosie Moreland, Nathalie Percie
du Sert, Paul
Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay
University
of Edinburgh
homson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae,
uart Allan, Ian Marshall, Xenios Mildonis, Konstantinos and
Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor,
avid Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna
Consultant
Neurologist,
NHSJing
Forth
esterinen, Kieren Egan, Honorary
Nicki Sherratt,
Cristina Fonseca,
Zsannet Bahor,
Liao,Valley
Theo Hirst, Kim Wever, Hugo
edder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey
oodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam
alman, Joseph Frantzias,
Robin Grant, Paul
Brennan,to
IanMeta-Analysis
Whittle, Andrew Rice,
Moreland,
Collaborative
Approach
andRosie
Review
of Nathalie Percie du
ert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins,
Animal Data from Experimental Studies
i Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos
ilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan,
eter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca,
sannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru,
CAMARADES:
evidence
translational
medicine
elios Serghiou, Aaron McLean, Catherine
Dick, Tracey Bringing
Woodruff, Patrice
Sutton, to
Andrew
Thomson, Aparna
Polturu,
Rigour Mortis
How bad research is killing science
Purposes of an inaugural lecture
• To try to explain to family and friends what it is
that you actually do
• To try to convince colleagues that what you do is
actually useful
• To try to encourage the next generation of
researchers and teachers to improve on what
you do
CAMARADES: Bringing evidence to translational medicine
What is translational
neuroscience?
My Definition: using information from one research domain
to guide research in a different research domain
I am not in the
office at the
moment. Send
any work to be
translated.
CAMARADES: Bringing evidence to translational medicine
Winner of the 2012 Ignoble Prize for Neuroscience
CAMARADES: Bringing evidence to translational medicine
What is a stroke?
• Interruption of the blood supply to part of the brain
• Stops that bit of the brain from working
• The consequences depend on which part of the brain is
affected
• In a warning stroke the blockage is temporary
• If the blockage is permanent that part of the brain dies
• When this happens, other bits of brain can sometimes
learn to take over some of the functions which have
been lost
CAMARADES: Bringing evidence to translational medicine
A couple of important
things about the brain …
CAMARADES: Bringing evidence to translational medicine
CAMARADES: Bringing evidence to translational medicine
The burden of stroke
• 5.5m people die worldwide each year –
one every 6 seconds
• ~150,000 per year in the UK
• 40% of patients die
• 30% become disabled as a result of their
stroke
CAMARADES: Bringing evidence to translational medicine
Developing treatments for stroke
1026
Developed in in vitro and in vivo experiments
O’Collins et al, 2006
CAMARADES: Bringing evidence to translational medicine
Developing treatments for stroke
1026 603
Tested in focal ischaemia
O’Collins et al, 2006
CAMARADES: Bringing evidence to translational medicine
Developing treatments for stroke
1026 883374
Effective in focal ischaemia
O’Collins et al, 2006
CAMARADES: Bringing evidence to translational medicine
Developing treatments for stroke
1026 883 550
Tested in clinical trial
97
18
O’Collins et al, 2006
CAMARADES: Bringing evidence to translational medicine
Developing treatments for stroke
1026 883550
Effective in clinical trial
1
3
O’Collins et al, 2006
CAMARADES: Bringing evidence to translational medicine
300
Infarct Volume
250
200
150
100
50
0
Control
half
dose
10-120
M
-60 M
full
10dose
CAMARADES: Bringing evidence to translational medicine