Analyst and Investor Day September 12, 2011 [1] Safe Harbor Summary This presentation includes forward-looking statements that are subject to many risks and uncertainties. These forward-looking statements, such as statements about Amyris’s short-term and long-term growth strategies, total addressable market expectations, and efforts to develop and commercialize products, can sometimes be identified by use of terms such as “intend,” “expect,” “plan,” “estimate,” “future,” “strive,” and similar words. These statements involve many risks and uncertainties that may cause actual results to differ from what may be expressed or implied in these statements. These risks are discussed in Amyris’s Securities and Exchange Commission filings and reports, including the risks identified under the section captioned “Risk Factors” in its annual report on Form 10-K filed on March 14, 2011 and its quarterly reports on Form 10-Q filed May 11 and August 11, 2011. Amyris disclaims any obligation to update information contained in these forward-looking statements whether as a result of new information, future events, or otherwise. [2] Your Speakers Today JOHN MELO JERI HILLEMAN CEO CFO NEIL RENNINGER PAULO DINIZ Co-Founder & CTO President, Brasil MARIO PORTELA JOEL VELASCO COO SVP, External Relations JIM RICHARDSON President, Lubricants [3] Agenda 9-9:30 Technology and Near-Term Products (Neil) 9:30-10 Production: Operations and Expansion (Mario) Showcase: Brasil Feedstock (Joel) 10-10:30 Q&A 10:30-10:45 Break 10:45-12 Markets and Customers (John) Showcase: Amyris Lubricants (Jim) Outlook (Jeri) 12-1 Q&A [4] Overview Transformational year since IPO : Delivered on Milestones and More Achieved target yield for Commercialization of Farnesene 3 Production Facilities in Place; 2 in Construction Expanded Demand: 10 Customer Agreements added since IPO Launched Squalane, Lubricants on track for Q4 Outlook for Year Ahead: Escalating Value Creation Continue to Advance Efficiency and Expand Molecules and Products Maximize CMO Production and Paraíso and SMA on-line Execute on Product Roll-out and Deliver on Customer Agreements Achieve Positive Cash Flow from Operations [5] Synthetic Biology: The Technology of this Century Amyris Modifies Microorganisms to Enable Production of 1,000s of Target Molecules YEAST CELL ANTI-MALARIAL DRUG ISOPRENOID PATHWAY FARNESENE (C15) SUGAR SOURCE ISOPRENE (C5) C10 [6] VIDEO: Industrializing Synthetic Biology through Automation THIS SLIDE CONTAINS A VIDEO [7] Industrializing Synthetic Biology through Microfluidics [8] Producing High-Value Products Through Low-Cost Fermentation PLANT SUGARS FERMENTATION PROPRIETARY BUILDING BLOCK FINISHED PRODUCTS IN 6 VERTICALS Fuels Lubricants Polymers & Plastic Additives Farnesene (C15) Home & Personal Care C10 Isoprene (C5) Flavors & Fragrances Cosmetics [9] Value Creation through Diversified Product Slate Products Fuels Lubricants Polymers & Plastic Additives Home & Personal Care Customers & Partners Diesel Jet Base Oils Industrial Lubricants Passenger Car Motor Oil Oxygen Scavengers Farnesene-Based Polymers Surfactants Other Ingredients Flavors & Fragrances Ingredient #1 Ingredient #2 Cosmetics Squalane [ 10 ] Value Creation through Diversified Product Slate Products Diesel Jet Fuels Lubricants Polymers & Plastic Additives Home & Personal Care Customers & Partners Base Oils Industrial Lubricants Passenger Car Motor Oil Oxygen Scavengers Farnesene-Based Polymers Surfactants Other Ingredients Flavors & Fragrances Ingredient #1 Ingredient #2 Cosmetics Squalane = Farnesene = Farnesene-derived molecule [ 11 ] Finishing Farnesene Diesel Base Oil Hydrogenation Squalane FARNESENE Surfactants Polymers P&G Application F&F Molecule [ 12 ] No Compromise® Products Amyris Renewable Diesel Amyris Renewable Chemicals [ 13 ] Common Routes to Diesel from Biological Sources Fermentable Sugars Amyris Renewable Diesel Farnesene Renewable Diesel Triglycerides (Vegetable oil) Oil Crops Biodiesel Fatty Acid Methyl Ester (FAME) Each product has a different value proposition in the marketplace and associated cost of production [ 14 ] Diesel Fuel Performance Comparison Energy Density Cold Filter Pour Point (°C) Higher value provides increase fuel economy Lower value improves cold weather engine operation Amyris Diesel Amyris Diesel Renewable Diesel Renewable Diesel Biodiesel Biodiesel Petroleum Petroleum Petroleum 110 115 120 125 130 -80 -70 -60 -50 -40 -30 -20 -10 0 Measured in 1000 x BTU/Gal Lubricity (µ) Engine Emission Impact (NOx) Lower value provides decrease engine wear Lower value better for environment and health NOx reduction Amyris Diesel Amyris Diesel Renewable Diesel Renewable Diesel Biodiesel Biodiesel Petroleum Petroleum 300 Sources: NREL, Neste, MWM 350 400 450 500 550 -20 -10 NOx increase Baseline NOx level 0 10 20 [ 15 ] 30 Building the Value Proposition with Diesel de Cana™ Monetizing Beneficial Performance Characteristics of Renewable Diesel Regulatory approval for fuels is required in each geography OEM approval is required to drive demand for the product Policy forces help aid demand through incentives and/or mandates City of Sao Paulo mandates 100% renewable fuel use in city buses by 2018 Biodiesel approved for use only up to 20%, by bus manufacturers 80% of the Sao Paulo bus fleet diesel demand available for Amyris Renewable Diesel (100 MGPY) [ 16 ] Expediting Validation through Industry Partnerships Engine Testing Validating Amyris Diesel through fuel system, engine and vehicle manufacturer tests Brazil Fleet Testing Confirming Amyris Diesel fuel quality and durability through robust road demonstration Brazil Registration & Approvals Achieving market entry by securing government registration and approvals [ 17 ] Diesel de Cana’s Land Use Efficiency vs. Alternatives in Brazil WITH CELLULOSIC TECHNOLOGY IN PLACE FOR CANE... Soybean Biodiesel 468 Liters/year 900 1,000 km Ethanol with Ignition improver 5,100 6,800 km 6,936 9,250km 6.460 Liters/year 8.800 Liters/year Amyris Diesel 4.180 liters/year 5.684 Liters/year Source: UNICAMP, Embrapa, Amyris, SPTRANS, Mercedes-Benz; NOTE: Amyris Diesel figures consider technology at target productivity and yields. 7,600 9,500 km 10,300 12,900km [ 18 ] No Compromise® Products Amyris Renewable Diesel Amyris Renewable Chemicals Disruptive supply and pricing of existing products Superior performance and market pull for novel, renewable molecules [ 19 ] No Compromise® Squalane Innovative Process [ 20 ] No Compromise® Flavors & Fragrances Customer World’s 2nd largest F&F company World’s largest F&F company Application Three fragrance ingredients Farnesene as building block Value Proposition Replace existing plant-derived sources of fragrance molecules with price points of $50/kg and higher Use farnesene as a building block for the synthesis of a key fragrance ingredient with an ASP>$400/kg [ 21 ] No Compromise® Home and Personal Care Ingredients Customer Application Value Proposition Leading AgriChemical Company in Asia World’s largest CPG company Farnesene derived non-ionic surfactants for applications including emulsifiers, laundry detergents, hardsurface cleansers Farnesene as ingredient in one of P&G’s largest product lines Develop renewable replacements for surfactants phased-out by regulatory agencies Achieve performance currently not achievable with traditional petroleum based compounds; hedge oil volatility [ 22 ] No Compromise® Renewable Chemicals Customer Leading chemical company Leading chemical company Application Oxygen Scavengers for use in PET juice and beer bottles Rubber products, adhesives, soft grips Value Proposition Replace non-renewable products (ASP~$10/kg) for customers such as Coca-Cola Replace petroleum derived feedstocks such as isoprene ($4/kg) and butadiene ($3.7/kg) [ 23 ] Technology and Product Summary World’s Experts at Engineering Yeast Broad Platform of Molecules and Applications Delivering No Compromise® fuels and chemicals [ 24 ] Agenda 9-9:30 Technology and Near-Term Products (Neil) 9:30-10 Production: Operations and Expansion (Mario) Showcase: Brasil Feedstock (Joel) 10-10:30 Q&A 10:30-10:45 Break 10:45-12 Markets and Customers (John) Showcase: Amyris Lubricants (Jim) Outlook (Jeri) 12-1 Q&A [ 25 ] Simple Fermentation Process Basis of Design [1] Fermentable Sugars [2] [2] Fermentation [3] [4] [3] Separations [4] Purification Vinasse Disposal Amyris Farnesene Aqueous Hydrocarbon [ 26 ] Integrated Scaled Up U.S. and Brazilian Sites Working in Sync Lab 2 Liters Pilot Plant 300 Liters Lab 2L scale Pilot Plant 300 L Demo Plant 5000 L Production 200 - 600K L [ 27 ] Successful Commercialization Takes Years of Preparation FERMENTOR SIZE Liters Mass and Energy Balances Better Cost Understanding Scaled to 200,000L BC Fermentor First Squalane at Glycotech Multiple Fermentation and Chemical CMO Plant Operations U.S. Brazil Design 1,000,000 Commercial Plant Design 10,000 Semi-Continuous Ferm’tn Alternate Feedstock 4 x 300L Fermentors Integrated Process Dev 1,000 4x Capacity Yield + Syrup 100,000 Detailed Design/ Construction Contract Manufacturing SMA Construction Underway Paraíso Construction Underway Built out Engineering Services Demo Plant Pilot Plant Commercial Production Opnl Excellence – Contamtn Free Deployment – Biomin Start-up 2x 5000L Fermentors Performance Meets/Exceeds Pilot Plant 100 Emeryville Pilot Plant Conversion to Sugar Cane 10 Lab 2007 Lab 2008 2009 2010 Mid-2012 [ 28 ] Production Roadmap Annual Production at Target Efficiency Operating: 50,000,000 liters In Construction: 150,000,000 liters Secured Access: 650,000,000 liters (13M tons crush) 2011 2012 2013 2014 [ 29 ] Biomin Execution of Production in Brazil Biomin • First Commercial Production • Smooth Start Up • Successful Learnings from Transition to Ongoing Operations First Biofene™ production [ 30 ] 1 Additional Plants on Track: 2011 Antibioticos León, Spain Operating Tate and Lyle Decatur, IL Commencing Operations Source: Amyris [ 31 ] VIDEO: Producing Biofene THIS SLIDE CONTAINS A VIDEO [ 32 ] Brazilian Production Paraiso Mill (Brotas, SP) • 1 million tons sugarcane crush • Six 200K liter fermentors • Advantaged economics • Designed for rapid deployment (modified Biomin) 3-D plan • Long lead items being ordered, construction started • Target completion by mid2012 Construction started [ 33 ] Brazilian Production São Martinho (Pradopolis, SP) • Complete foundation work ~November 2011 • Start fermenter installation ~October 2011 • On plan for mid-2012 start-up [ 34 ] Production Roadmap Annual Production at Target Efficiency Operating: 50,000,000 liters In Construction: 150,000,000 liters Secured Access: 650,000,000 liters (13M tons crush) 2011 2012 2013 2014 [ 35 ] Sugarcane in Brazil: Brazil is #1 • Brazil is the world’s largest cane producer, twice #2 India • Brazil's South-Central region accounts for 90% of country’s cane harvest • Brazil’s sugarcane sugar yields have grown at 3% CAGR since late 1970s Source: University of Minnesota Institute on the Environment; Brazilian Sugarcane Industry Association (UNICA), Food and Agricultural Organization (FAO) [ 36 ] Sugarcane in Brazil: Nationwide Output Estimates SUGARCANE 580 Million Tons ⅖ of World Crop RAW SUGAR 37 Million Tons ¼ of World Demand ETHANOL 6 Billion Gallons ½ of U.S. Production ELECTRICITY 1,500 MW ~3% of Brazil Demand Source: UNICA, CONAB. Data is estimate for 2011 crop year. [ 37 ] Sugarcane in Brazil: Location & Share of Agriculture Sugarcane occupies 2.5% of Brazil’s arable land Millions of Hectares (2009) BRAZIL TOTAL AREA 851.2 TOTAL ARABLE LAND 329.9 1. Total Crop Land 59.8 Soybean 21.6 Corn 14.4 Sugarcane 8.1 2. Pastures 158.8 3. Available Area 111.3 1 Hectare = 2.5 acres Sources: UNICA, NIPE-Unicamp, IBGE, CTC, CanaSat, see http://www.dsr.inpe.br/canasat/ [ 38 ] 38 Sugarcane in Brazil: Rule of Thumb 1 hectare yields 85 tons cane ⅓ juice ⅓ bagasse ⅓ straw Source: UNICA; Bagasse is 50% humidity 276 kg/t; Straw is 15% humidity 165 kg/t; Biofene at target yield production 1 ton yields 85 liter of ethanol or 50 liter of Biofene™ [ 39 ] Sugarcane in Brazil: ATR & Consecana Pricing of Sugarcane in Brazil Sugarcane’s value is in Total Recoverable Sugars (ATR, in Portuguese) Average ton of cane at mill gate will have 135 Kg of ATR this harvest year Payment for cane is a function of market prices of ethanol and sugar Consecana system designed to align incentives between millers & growers ATR PRODUCT CONVERSION ATR in cane ~135 Kg/tonc ~1.05 Kg 1 Kg of Sugar ~1.70 Kg 1 Liter of Ethanol ~3.05 Kg 1 Liter of Biofene® Source: ORPLANA, UNICA [ 40 ] Sugarcane in Brazil: ATR & Consecana Volatility in ATR Pricing Mills have to process cane regardless of returns (not flexible) Amyris seeks to source sugars based lowest of ethanol and sugar Some mills see supplying sugars to Amyris as a hedge in current volatility EXAMPLE WITH TODAY’S COST: 1 Kg of Sugar US$ 0.37 Kg US$ 0.17 per Lb. 1 Liter of Ethanol US$ 0.60 L US$ 2.28 per Gallon ATR for Sugar (VHP) was lowest cost ATR for Ethanol (Hydrous) was lowest cost Source: ORPLANA, UNICA; Biofene at target yield; US$1 equals R$1.60 1 Liter of Biofene US$ 0.73 L US$ 2.75 per Gallon [ 41 ] Partnering with Amyris - payback to mill owners Pre-tax payback for mill owners on incremental CapEx 7.0 6.5 5.7 6.0 Years Payback 5.0 4.1 4.0 3.0 2.0 2.0 1.0 0.0 Sugar/Ethanol Cogeneration Amyris Diesel Amyris Chemicals Note: assumes mill pays 100% of capex and margin is shared 50/50 Partnering with Amyris yields mill owners higher returns on capital while diversifying revenue streams beyond sugar and ethanol [ 42 ] Agenda 9-9:30 Technology and Near-Term Products (Neil) 9:30-10 Production: Operations and Expansion (Mario) Showcase: Brasil Feedstock (Joel) 10-10:30 Q&A 10:30-10:45 Break 10:45-12 Markets and Customers (John) Showcase: Amyris Lubricants (Jim) Outlook (Jeri) 12-1 Q&A [ 43 ] Value Creation through Diversified Product Slate Products Fuels Lubricants Polymers & Plastic Additives Home & Personal Care Customers & Partners Diesel Jet Base Oils Industrial Lubricants Passenger Car Motor Oil Oxygen Scavengers Farnesene-Based Polymers Surfactants Other Ingredients Flavors & Fragrances Ingredient #1 Ingredient #2 Cosmetics Squalane [ 44 ] Chemicals: $40B addressable at today’s yield with positive cash margin $M ASP ($/kg) Future: new pathways in development and applications that reach positive cash margin in future Current: Positive cash margin today Cosmetics Nonionic Anionic personal Cationic personal personal care care surfactant care surfactant 1,700 Specialty surfactant Paraffinic Emollients $2 Emollients Squalane 300 $5 50 $30 1,000 $4-5 700 $4 900 $2 400 $3 150 $1,500 b-carotene F&F 1 42 $30 Polymers & Plastics Additives F&F 3 Linalool 60 $1,500 50 >$100 80 $10 NPE nonionic surfactant 1,000 $3 Geraniol Myrcene 43 $4 120 $10 Menthol 165 $3 250 $3-4 200 $12 Limonene Plasticizer (phthalate) 9,000 Adhesives 600 $12-15 Lycopene Canthaxanthin Pinene F&F 2 Plasticizer O2 scavenger (non phthalate) 80 $3-11 50 $1,000 250 $1,800 Amphoteric surfactant Flavors & Fragrances Consumer Products Astaxanthin 300 $60 12,000 $3 $2 900 $2-4 Cationic surfactants Isoprene & replacement for Adipic Acid natural and synthetic rubber Butadiene 40,000 10,000 $4 $4 Octene 1,300 $3 Hexene 1,500 $3 Anionic surfactant 6,500 5,100 $3-8 $2-3 Lubricants 2,500 $3-5 Industrial lube & base oild Source: Amyris estimates, Nexant 6,000 2,600 $4-6 $7 Lubricant additives Consumer & automotive lube and base oils 825 $2-3 Decene [ 45 ] Terephthalic acid 50,000 $1.3 Model for Success in Application Development and Delivery Prioritize applications Identify first target customer • Strong strategic position • Incentive to move quickly ‘Drop in’ molecule Joint Engagement: • • Rapid identification of target chemistry Develop lowest cost process Accelerate introduction • Shorter time to market • Expanded end market adoption [ 46 ] Product Introduction Plan Starting 2011 SALES PRODUCTION VOLUME [ 47 ] Diesel: Capital and Partner to Scale Fast Emerging agreement with Total for Commercialization of Amyris Diesel: • Validation of Amyris technology and diesel economics: expansion after extensive evaluation • Agreement would provide current funding and establishment of JV to fund scale up and commercialize diesel Impact • Expect definitive agreements executed by year end; first dedicated plant operational 2013-2014 [ 48 ] Amyris Lubricants: 3-Pronged Business Base Oils: NovaSpec 1 Amyris-Cosan joint venture Finished Lubricants: EvoShield 2 Direct to Customer 3 Distributorship Network [ 49 ] Base Oil Market Framework Demand & Supply Balance Finished Lubes Sales, kT 40.367 Base Oils demand for Synthetics Products, kT 43.376 40 7.544 4.181 Semi-Syn by Application Flat 20 10 Auto 54% 0 2008 +10 Yrs Source: Kline 2010 Report 5.335 Group IV Group III 14.984 Group II 3.243 40000 12.210 396 Eur 36% Rest 14% Asia 17% 3.921 Group III 2.265 2008 +10 Yrs Top 10 GIII & GIV Capacity, kT/Year 50.569 50000 2.661 Ind'l 46% Base Oil Capacity, kT 45.703 Group IV 741 NA 33% Conventional 30 4.662 2008 Synthetics By Region Synthetic +5 Yrs (only GIII) GIV GIII 878 842 * 1085 30000 517 20000 29.732 29.732 Group I 103 10000 Petro- 0 2009 + 5 Years Canada 216 Ineos 145 93 XOM 284 Petronas 289 Caltex-GS 60 362 241 Neste SK-Pert** S-Oil SK Shell Source: LnG 2010 (confirmed capacities, investments and divestments) * Included total volumes of Bahein and RWAIS Joint Ventures ** Pertamina JV with SK Energy [ 50 ] Traditional Performance Amyris Lubricants: Customer Value Proposition Traditional high performance Base Oils Lubricants Environmentally friendly base oils, poor traditional performance Environmental Performance [ 51 ] Finished Lubricants: EvoShield [ 52 ] Finished Lubricant Product Offering Lead Product Categories Automotive Heavy Duty Engine Oils Automatic Transmission Fluid Heavy Equipment Lubricants 2-cycle Engine Oil Strategy Target markets leveraging differentiated base oil Target niche market with fast time to market and above average margin Build on existing customer or partnership [ 53 ] Product Introduction Plan Starting 2011 SALES PRODUCTION VOLUME [ 54 ] Economics Remain Attractive as Volume Ramps TARGET PRODUCTION VOLUME (ML/yr) 150-200 + + 40-50 6-9 2011 ($/L) 2012 $6-$7 $4-$5 TARGET ASP $3.50-$4.50 2011 TARGET GROSS MARGIN (%) 2012 2013 ~40% ~40% 2012 2013 Profitable 2011 GAAP* and NET CASH OPERATING EXPENSE 2013 ($M) $160-$170 $140-$145 * Excluding ~$25M stock based expense ~$100 $70-$80 GAAP Net Cash 2011 $170-$180 GAAP Net Cash 2012 GAAP Net Cash 2013 [ 55 ] CapEx Outlook 2011 2012 CMO SMA 2011 2012 Paraiso Lab 2013 Expansion $55-$70M Net Project CapEx Spend1 $20-$35M Net Project CapEx Spend2 1. reflects~$20M Biomin project financing and U.S. Equipment lines 2. reflects ~$100M SMA/Paraiso project financing (Sᾶo Martinho contribution expected 2013) [ 56 ] ROY 2011-2012 Cash Outlook Key Assumptions: Cash Outlook dependent on achieving targets for OpEx, CapEx, Debt, Product Margin 2011 2012 Cash Flow From Operations Cash Balance $0 $100M 2H2011 2012 2H2011 2012 [ 57 ] Amyris Near-Term Strengths… Feedstock Access and Production Strong Customer Demand Significantly Expanding Growth Platform • Expect 5 current facilities to produce >200 million liters at target production efficiency • Feedstock for expansion: 13 million tons under LOI/agreement • Expect to be supply constrained • Outlook of $1 billion demand supporting 2013 sales • Diesel step out through Total JV • Adding C5 and C10 molecules along with new customer agreements [ 58 ] …Support Outlook for Scale, Growth and Profitability Feedstock Access and Production Strong Customer Demand • Compelling mill economics support growth and partner investment of capital • Target 10% of Brazilian cane by 2020 • Defined demand and customer agreements of $2.5 billion exceed 2015 production plan • Addressing large markets with No Compromise® products Significantly Expanding Growth Platform Total diesel and jet volumes expands organic growth outlook 2020 [ 59 ] [ 60 ]
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