Epigenomics of Common Diseases 28 – 31 October 2014 Conference programme Tuesday, 28 October 13:00 – 14:00 Registration with buffet lunch 14:00 – 14:10 Welcome and Introductions Stephan Beck 14:10 – 15:10 Keynote Lecture Chair: Stephan Beck Epigenetic modifications: their function and role in cancer Tony Kouzarides Gurdon Institute, UK 15:10 – 16:25 Session 1 - Epigenomics of Common Disease I Chair: Caroline Relton 15:10 Genetics, epigenetics, and the environment Andy Feinberg Johns Hopkins University School of Medicine, USA 15:40 Integrating genetic, genomic and epigenomic data to provide mechanistic insights into Type 2 diabetes pathogenesis. Mark McCarthy University of Oxford, UK 16:10 EpiMatch: harnessing epigenetics for hematopoietic stem cell transplantation Dirk Paul University College London, UK 16:25 – 17:00 Afternoon Tea 17:00 – 18:30 Session 1 – Epigenomics of Common Disease I 17:00 Influence of ancestral environmental perturbations on structure and function in descendant generations Brian Dias Emory University, USA 17:30 Interpreting the results of epigenome-wide association studies John Greally Albert Einstein College of Medicine, USA 18:00 Epigenetic assimilation in the aging human brain Gabriel Oh Centre for Addiction and Mental Health, Canada 18:15 Open discussion 18:30 – 19:45 Drinks reception & poster session 1 (odd numbers) 19:45 – 21:00 19:40 – 23:00 Dinner Bar open (Cash bar) Wednesday, 29 October 09:00 – 10:30 Session 2 – Epigenomics of Common Disease II Chair: Susan Clark 09:00 Epigenome: a manual for genome function and utilization Henk Stunnenberg Radboud University, The Netherlands 09:30 Genetic and environmental impacts on DNA methylation levels in twins Jordana Bell King's College London, UK 10:00 Peeling back the epigenetic layers of the prostate cancer microenvironment Ruth Pidsley The Garvan Institute of Medical Research, Australia 10:15 Open discussion 10:30 – 11.00 Morning Coffee 11:00 – 12:30 Session 2 - Epigenomics of Common Disease II continued 11:00 The methylome of the human frontal cortex within development and schizophrenia Andrew Jaffe Lieber Institute for Brain Development, USA 11.30 The epigenetic language of the circadian clock Paolo Sassone-Corsi University of California, Irvine, USA 12:00 Integrated genetic and epigenetic analysis defines known and novel risk variants in the HLA locus that mediate risk for multiple sclerosis through changes in DNA methylation Maja Jagodic Karolinska Institute, Sweden 12:15 Open discussion 12:30 - 14:00 Lunch 14:00 – 16:10 Session 3 – Epigenetic Inheritance Chair: Andy Feinberg 14:00 Intergenerational epigenetic inheritance in a mouse model of undernutrition Anne Ferguson-Smith University of Cambridge, UK 14:30 The prenatal epigenome and studies into long-term health Bas Heijmans Leiden University Medical Center, The Netherlands 15:00 In utero undernutrition alters patterns of DNA methylation in the second-generation offspring through the paternal lineage Jorg Tost CEA IG C.N.G, France 15:15 Role of DNA methylation in local adaptation, environmental response and transgenerational inheritance Manu Dubin Gregor Mendel Institute, Austria 15:30 Open discussion 15:40 – 16:15 Afternoon Tea 16:15 – 18:15 Session 4 –Transgenerational Epigenomics Debate Panal: George Davey-Smith, Brian Dias, Anne Ferguson-Smith, Bas Heijmans & Marcus Pembrey 16:15 Transgenerational epigenetics - a perspective from: George Davey-Smith, University of Bristol, UK 16:30 Transgenerational epigenetics - a perspective from Marcus Pembrey UCL Institute of Child Health, UK 16:45 Open debate 18:15 – 19:30 Drinks reception & poster session 2 (even numbers) 19:30 – 21:00 19.30 – 23.00 Dinner Bar open (Cash bar) Thursday, 30 October 09:00 – 10:30 Session 5 - Population and Environmental Epigenetics Chair: Jon Mill 09:00 Mendelian randomization: Applications and limitations in epigenetic studies Caroline Relton Newcastle University & University of Bristol, UK 09:30 Epigenomics and the environment – can pollutants reprogram our health Andrea Baccarelli Harvard School of Public Health, USA 10:00 Functional genomics implicates novel genes associated with diabetes-related phenotypes Elena Carnero-Montoro Erasmus MC, The Netherlands 10:15 Epigenome-wide association study of Paget's disease of bone Luna De Ferrari University of Edinburgh, UK 10.30 Open discussion 10:40 – 11:10 Morning Coffee 11:10 – 12:50 Session 6 – Epigenomic Technological Advances including Single Cell Epigenomics Chair: Stephan Beck 11:10 Epigenetic reprogramming in mammalian development Wolf Reik Babraham Institute, UK 11:40 Bisulfite sequencing and bioinformatic analysis for single cells and for large cohorts Christoph Bock CeMM Research Institute Vienna, Austria 12:10 Whole genome analysis of methylome and hydroxymethylome in normal and tumor tissues Xin Li Johns Hopkins University, USA 12:25 Global reorganisation of the nuclear landscape in senescent cells Tamir Chandra Wellcome Trust Sanger Institute, UK 12:40 Open discussion 12:50 - 14:15 Lunch 14:15 – 15:55 Session 7 - Informatics & Technology Chair: Bas Heijmans 14:15 Design and analysis of genome-wide CRISPR-Cas9 knockout screens Xiaole Shirley Liu Dana Farber Cancer Institute/Harvard University, USA 14:45 Genome microscopy: targeted sequencing reveals fine details of epigenome and transcriptome Tim Mercer The Garvan Institute of Medical Research, Australia 15:15 eForge: a tool for identifying tissue-specific signal in epigenetic data Charles Breeze University College London, UK 15:30 Ensembl and gene expression regulation Daniel Zerbino EMBL-EBI, UK 15:45 Discussion 15:55 – 16:30 Afternoon Tea 16:30 – 17:30 Keynote Lecture Chair: Caroline Relton Regulatory genomics and epigenomics of complex disease Manolis Kellis Massachusetts Institute of Technology, USA 17:30 – 18.30 Afternoon tea / free time 18:30 18:45 – 19:30 19:30 – 21:30 Coaches depart from Churchill College for Duxford Air Museum Drinks reception Conference dinner at Duxford Air Museum Friday, 31 October 09:00 – 10:40 Session 8 – Epigenomics of Common Disease III Chair: Susan Clark 09:00 Cell composition effects in the analysis of DNA methylation data Andres Houseman Oregon State University, USA 09:30 DNA Methylation in development and disease Alex Meissner Harvard University, USA 10:00 Methylomic trajectories across human fetal brain development. Jonathan Mill University of Exeter, UK 10:15 Conserved immune and neural epigenomic profiles of Alzheimer’s disease in mouse and human Elizabeta Gjoneska Massachusetts Institute of Technology, USA 10:30 Open discussion 10:40 - 11:10 Morning Coffee 11.10 – 12:50 Session 8 - Epigenomics of Common Disease III continued 11:10 The epigenetic clock and biological age Steve Horvath University of California, Los Angeles, USA 11:40 DNA methylation age of blood predicts all-cause mortality in later life Riccardo Marioni University of Edinburgh, UK 11:55 Stochastic epigenetic mutations increase exponentially during aging Davide Gentilini Istituto Auxologico Italiano, Italy 12:10 Genetic-epigenetic interactions in cis- and trans-: immune system and brain Ben Tycko Columbia University, USA 12:40 Open discussion 12:50 – 13:00 Conference summary & announcement of poster prizes 13:00 – 14.00 Lunch 14.00 Coaches depart for Stansted Airport & Heathrow Airport