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Curriculum Vitae and Bibliography
Tamas Ordog, MD
PERSONAL INFORMATION
Citizenship:
United States
Work Address:
Mayo Clinic
200 First Street SW
Rochester, MN 55905
507-538-3906
Email Address:
[email protected]
PRESENT ACADEMIC RANK AND POSITION
Full Faculty Privileges in Biomedical Engineering - Mayo Graduate
School, Mayo Clinic College of Medicine
07/12/2006 - Present
Associate Professor of Physiology - Mayo Clinic College of Medicine
12/01/2006 - Present
Consultant - Department of Physiology & Biomedical Engineering,
Mayo Clinic, Rochester, Minnesota
07/04/2012 - Present
Consultant (Joint Appointment) - Division of Gastroenterology and
Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester,
Minnesota
07/04/2012 - Present
EDUCATION
University of Pécs Medical School, Pecs, Hungary
MD, Research Thesis: Interactions between membrane-bound and
intracellular hormone receptors in estrogen target tissues. Mentor:
Marietta Vertes, M.D., Ph.D., D.Sc.
1988
Department of Physiology, University of Pécs Medical School
Postdoctoral Research Fellowship, Research: Regulation of cell
proliferation by opioid peptides in the rat uterus. Mentor: Marietta Vertes,
M.D., Ph.D., D.Sc.
1989 - 1991
Laboratory for Neuroendocrinology, University of Texas Medical School
at Houston
Postdoctoral Research Fellowship, Research: Neuroendocrine
regulation of reproduction; electrophysiological analysis of
gonadotropin-releasing hormone pulse generator activity. Mentor: Ernst
Knobil, Ph.D.
1992 - 1995
Laboratory for Neuroendocrinology, University of Texas Medical School
at Houston
Senior Postdoctoral Research Fellow, Research: Neuroendocrine
regulation of reproduction; electrophysiological analysis of
gonadotropin-releasing hormone pulse generator activity. Mentor: Ernst
Knobil, Ph.D.
1995 - 1997
Tamas Ordog, MD
Page 2 of 34
Additional Education
Exchange Medical Student in Internal Medicine
Department of Internal Medicine, Dijkzigt Hospital, Erasmus University
School of Medicine
Rotterdam, Netherlands
06/1986
Exchange Medical Student in Pediatrics
Department of Pediatrics, St. Mary’s Hospital, University of Lisbon
Faculty of Medicine
Lisbon, Portugal
06/1987
BrainWave Training Class
BrainWave Inc.
Northglenn, Colorado
05/1993
Introduction to Molecular and Cellular Research
The Endocrine Society
San Diego, California
02/1997
Quantitative Fluorescent Microscopy
Mount Desert Island Biological Laboratory
Salisbury Cove, Maine
06/1999
HONORS/AWARDS
Scholarship for Outstanding Academic Achievement - University of
Pécs Medical School
01/1983 - 01/1984
Scholarship for Outstanding Academic Achievement - Republic of
Hungary
01/1984 - 01/1988
Summa Cum Laude (Highest Honors) - University of Pécs Medical
School
01/1988
Travel Award - The Endocrine Society, Bethesda, MD
01/1997
Young Investigator Award - American Motility Society
01/2000
Young Investigator Award - American Motility Society
01/2002
Alvarez Award - International Electrogastrographic Society
01/2005
Samsung Award - International Society of Neurogastroenterology and
Motility
09/2007
Masters Award in Gastroenterology - Award for Basic or Clinical
Research in Digestive Sciences - American Gastroenterological
Association
05/2008
Honorary Membership - Hungarian Gastroenterological Association,
Budapest, Hungary
2010 - Present
Géza Hetényi Medal - Hungarian Gastroenterological Association,
Budapest, Hungary
2010
MILITARY SERVICE
Lieutenant; Staff Physician Officer - Department of Neurology, 3rd
Hospital, Hungarian Army, Hungary, Pecs, Hungary
10/01/1988 - 09/01/1989
Tamas Ordog, MD
Page 3 of 34
PREVIOUS PROFESSIONAL POSITIONS AND MAJOR APPOINTMENTS
Research and Teaching Assistant - Department of Physiology,
Neurophysiology Research Group, Hungarian Academy of Sciences,
University of Pécs Medical School, Pecs, Hungary
Research: Interactions between membrane-bound and intracellular
hormone receptors in estrogen target tissues
1984 - 1988
Junior Scientist - Department of Physiology, Neurophysiology
Research Group, Hungarian Academy of Sciences, University of Pécs
Medical School, Pecs, Hungary
Research: Regulation of cell proliferation by opioid peptides in the rat
uterus
Participation in medical education: Group discussions, lab: Medical
Physiology,
Neurophysiology, Hematology
1991 - 1992
Research Assistant Professor - Department of Physiology and Cell
Biology, University of Nevada School of Medicine, Reno, Nevada
1997 - 2003
Assistant Professor - Department of Physiology and Cell Biology,
University of Nevada School of Medicine, Reno, Nevada
2003 - 2006
Teaching/Examining Privileges in Biomedical Engineering - Mayo
Graduate School, Mayo Clinic College of Medicine
06/14/2006 - 07/11/2006
Senior Associate Consultant II-Research - Department of Physiology
& Biomedical Engineering, Mayo Clinic, Rochester, Minnesota
08/14/2006 - 07/03/2012
Senior Associate Consultant II-Research (Joint Appointment) Division of Gastroenterology and Hepatology, Department of Internal
Medicine, Mayo Clinic, Rochester, Minnesota
11/30/2007 - 07/03/2012
PROFESSIONAL & COMMUNITY MEMBERSHIPS, SOCIETIES AND SERVICES
Professional Memberships & Services
American Association for Cancer Research
Member, Philadelphia, Pennsylvania
2012 - Present
American Association for the Advancement of Science
Member
01/1998 - Present
American Diabetes Association
Grant Reviewer
01/2006
American Gastroenterological Association
Member
Abstract Reviewer
Abstract Platform Presentation Moderator
Review Team Member
Reviewed Chapter 2: Functional Gastrointestinal Disorders and
Motility Disorders of Opportunities and Challenges in Digestive
Diseases Research: Recommendations of the National
Commission on Digestive Diseases. NIH Publication No.
08-6514, U.S. Department of Health and Human Services,
National Institutes of Health, Bethesda, MD, 2009
01/2004 - Present
12/2005 - Present
05/2006 - Present
02/2008
Tamas Ordog, MD
Symposium Organizer/Chair
Councilor
Neurogastroenterology and Motility Section
Page 4 of 34
06/2009
05/05/2010 - 05/19/2012
American Neurogastroenterology and Motility Society
Member
Abstract Reviewer
Abstract Platform Presentation Moderator
01/2004 - Present
08/2008 - 09/2012
08/2010 - Present
American Physiological Society
Member, Bethesda, Maryland
2010 - Present
Endocrine Society, Bethesda, MD
Member
01/1997 - Present
European Commission, Research Directorate-General
Expert Panel Member, Brussels, Belgium
12/2004
International Gastrointestinal Electrophysiology Society
Member
Formerly: International Electrogastrographic Society
Council Member
Formerly: International Electrogastrographic Society
Abstract Reviewer
Formerly: International Electrogastrographic Society
Treasurer
Formerly: International Electrogastrographic Society
Meeting Organizer
Formerly: International Electrogastrographic Society
Mayo Clinic Center for Individualized Medicine
Conference Organizer, Rochester, Minnesota
Epigenetics to Practice Workshop
Conference Organizer, Rochester, Minnesota
Epigenomics to Practice Workshop
Society for Neuroscience
Member
05/2005 - Present
05/2007 - 05/2011
01/2008 - 05/2009
11/2008 - 05/2011
08/2009
10/02/2013
10/08/2014
01/1997 - Present
Study Sections
National Institutes of Health
Center for Scientific Review
ZRG1 DKUS-D
Member, Study Section, Bethesda, Maryland
ZRG1 DKUS-D (80) Special: Pilot and Feasibility Clinical
Research Studies in Digestive Diseases and Nutrition
ZRG1 DKUS-E
Member, Study Section, Bethesda, Maryland
ZRG1 DKUS-E (10) Small Business: Digestive Sciences
National Institute of Diabetes and Digestive and Kidney Diseases
Ad Hoc Member, Bethesda, Maryland
03/2012
03/2012
10/2010
Tamas Ordog, MD
DDK-C; Digestive Diseases and Nutrition Subcommittee C
Ad Hoc Member, Bethesda, Maryland
DDK-C; Digestive Diseases and Nutrition Subcommittee C
Temporary Member, Bethesda, Maryland
National Institute of Diabetes and Digestive and Kidney
Diseases Initial Review Group, DDK-C Subcommittee
Page 5 of 34
10/2012
10/2013
JOURNAL RESPONSIBILITIES
Journal Editorial Responsibilities
American Journal of Physiology: Gastrointestinal and Liver Physiology
Editorial Board Member
07/01/2011 - 06/30/2012
Frontiers in Autonomic Neuroscience
Review Editor
05/2011 - Present
Frontiers in Enteric Neuroscience
Review Editor
Journal merged with Frontiers in Autonomic Neuroscience in May
2011
Neurogastroenterology and Motility
Editorial Board Member
Journal Other Responsibilities
American Journal of Gastroenterology
Ad Hoc Reviewer
(invited)
American Journal of Physiology: Cell Physiology
Ad Hoc Reviewer
(invited)
American Journal of Physiology: Endocrinology and Metabolism
Ad Hoc Reviewer
American Journal of Physiology: Gastrointestinal and Liver Physiology
Ad Hoc Reviewer
American Journal of Physiology: Regulatory, Integrative and
Comparative Physiology
Ad Hoc Reviewer
Autonomic Neuroscience: Basic & Clinical
Ad Hoc Reviewer
(invited)
Bioelectromagnetics
Ad Hoc Reviewer
02/2009 - 05/2011
08/01/2010 - Present
Tamas Ordog, MD
BioMed Central
Biomed Central Gastroenterology
Ad Hoc Reviewer
BioMed Central
BioMed Central Medical Genomics
Ad Hoc Reviewer
(invited)
Brain Research
Ad Hoc Reviewer
(invited)
British Journal of Cancer
Ad Hoc Reviewer, London, United Kingdom
(invited)
British Journal of Pharmacology
Ad Hoc Reviewer
Cancer Research
Ad Hoc Reviewer
(invited)
Clinical and Experimental Pharmacology and Physiology
Ad Hoc Reviewer
(invited)
Clinical Genetics
Ad Hoc Reviewer
(invited)
Digestive Diseases and Sciences
Ad Hoc Reviewer
European Journal of Histochemistry
Ad Hoc Reviewer
Experimental Gerontology
Ad Hoc Reviewer
(invited)
Expert Opinion on Pharmacotherapy
Ad Hoc Reviewer
FASEB Journal
Ad Hoc Reviewer
(invited)
Frontiers in Neurology
Ad Hoc Reviewer
Page 6 of 34
Tamas Ordog, MD
(invited)
Future Medicinal Chemistry
Ad Hoc Reviewer
(invited)
Gastroenterology
Ad Hoc Reviewer
Gut
Ad Hoc Reviewer
Histology and Histopathology
Ad Hoc Reviewer
International Journal of Molecular Sciences
(invited)
Ad Hoc Reviewer
Investigational New Drugs
Ad Hoc Reviewer
Journal of Cancer Research and Clinical Oncology
Adjunct Reviewer
(invited)
Ad Hoc Reviewer
(invited)
Journal of Cellular and Molecular Medicine
Ad Hoc Reviewer
Journal of Digestive Diseases
Ad Hoc Reviewer
(invited)
Journal of Gastrointestinal Cancer
Ad Hoc Reviewer
Journal of Physiology, London
Ad Hoc Reviewer
Journal of the American Society of Nephrology
Ad Hoc Reviewer
Life Sciences
Ad Hoc Reviewer
Microcirculation
Ad Hoc Reviewer
(invited)
Page 7 of 34
Tamas Ordog, MD
Page 8 of 34
Molecular Cancer
Ad Hoc Reviewer
(invited)
Neurogastroenterology and Motility
Ad Hoc Reviewer
News in Physiological Sciences
Ad Hoc Reviewer
Physiological Genomics
Ad Hoc Reviewer
PLoS ONE
Ad Hoc Reviewer
(invited)
Proceedings of the National Academy of Sciences of the United States
of America
Ad Hoc Reviewer
Regulatory Peptides
Ad Hoc Reviewer
(invited)
Stem Cells
Ad Hoc Reviewer
Tumor Biology
Ad Hoc Reviewer
Virchows Archiv
Ad Hoc Reviewer
World Journal of Gastroenterology
Ad Hoc Reviewer
(invited)
EDUCATIONAL ACTIVITIES
Curriculum/Course Development
Endocrine Physiology
Part of PCB611/711 Systems Physiology
University of Nevada School of Medicine and University of Nevada,
Reno Graduate School
Reno, Nevada
2000 - 2004
Systems Physiology III (BME 8872)
Mayo Graduate School
2006 - Present
Epigenetics & Epigenomics (CTSC 5140)
Center for Translational Science Activities
2012 - Present
Tamas Ordog, MD
Page 9 of 34
Teaching
Systems Physiology, Neurophysiology and Hematology
Seminars and lab to medical students
University of Pecs Medical School
Pecs, Hungary
1989 - 1992
Endocrine Physiology
Part of PCB611/711 Systems Physiology; Lectures to medical and Ph.D.
students
University of Nevada School of Medicine and University of Nevada,
Reno Graduate School
Reno, Nevada
2000 - 2006
Identification and Isolation of Specific Cell Types
Part of CMPP 793 Current Topics in Cell Biology; Lectures and
demonstration to Ph.D. students
University of Nevada, Reno Graduate School
Reno, Nevada
2003
Diabetic Complications
Part of CMB 710 Molecular Cell Biology / Current Topics in Cell
Physiology; Lectures to Ph.D. students
University of Nevada, Reno Graduate School
Reno, Nevada
2004
Interstitial Cells of Cajal (ICC) in Murine Diabetic Gastropathy
Mayo Clinic Monday Morning GI Seminar Series
Rochester, Minnesota
10/19/2006
Progenitors of Interstitial Cells of Cajal (ICC) in the Postnatal Murine
Stomach: Stem Cell-Like Characteristics and Role in Diabetic
Gastroparesis
Mayo Clinic Gastroenterology Research Unit Seminar Series
Rochester, Minnesota
10/27/2006
Gastric Physiology Including Acid-Peptic Disease (CTSC 5271)
Part of CRTP Gastrointestinal Cellular and Molecular Physiology
Mayo School of Graduate Medical Education
07/2007 - Present
KitlowCD44+CD34+ Cells of the Murine Gastric Tunica Muscularis: ICC
Precursors with Stem Cell-Like Characteristics
Mayo Clinic Gastroenterology Research Unit Seminar Series
Rochester, Minnesota
09/21/2007
Natural History of Interstitial Cells of Cajal - A View from the
Transcriptome
Mayo School of Graduate Medical Education Enteric NeuroScience
Seminar Series
Rochester, Minnesota
02/01/2008
Systems Physiology III (BME 8872)
Role: Course Director and Instructor
Mayo Graduate School
04/2008 - Present
Integrative Physiology of GI Motility: From Animals to Molecules and
Back
Mayo Graduate School, Physiology and Biomedical Engineering
Seminar Series
Rochester, Minnesota
08/01/2008
Tamas Ordog, MD
Page 10 of 34
New Insights into the Function and Turnover of Interstitial Cells of Cajal
Mayo School of Graduate Medical Education Clinical Enteric
Neuroscience Translational and Epidemiological Research
(C.E.N.T.E.R.) Group
Rochester, Minnesota
10/14/2008
Metabolic Control of Interstitial Cells of Cajal (ICC) and Their Turnover:
An Adaptation to Abundant Caloric Intake?
Mayo Clinic Division of Gastroenterology and Hepatology Monday
Research Conference
Rochester, Minnesota
12/15/2008
Differentiation of Adult Stem/Progenitor Cells from the Murine Gastric
Tunica Muscularis: Do Polycombs Control the Switch?
Mayo Clinic Gastroenterology Research Unit Transcription, Chromatin,
and Epigenetics of Cancer Conference
Rochester, Minnesota
12/18/2008
Kit-low Stem Cells for Interstitial Cells of Cajal (ICC) Cause Resistance
to Kit/Pdgfra Inhibitors in Gastrointestinal Stromal Tumors (GIST)
Mayo Clinic Cancer Center GI Program Lecture Series
Rochester, Minnesota
03/2010
Longevity and gastrointestinal health – Is there a conflict?
Mayo School of Graduate Medical Education Clinical Enteric
Neuroscience Translational and Epidemiological Research
(C.E.N.T.E.R.) Group
Rochester, Minnesota
08/03/2010
Transcriptional and Epigenetic Regulation of Stem Cells (BMB 8660
Transcription, Chromatin and Epigenetics)
Mayo Graduate School
Rochester, Minnesota
12/07/2010
Epigenetic Control of Cell-Autonomous and Smooth Muscle-Derived
Factors Regulating Postnatal Maintenance of Interstitial Cells of Cajal
Mayo Graduate School, Physiology and Biomedical Engineering
Seminar Series
Rochester, Minnesota
07/29/2011
Transcriptional Control of Cell Differentiation in the Mesenchymal
Compartment of the Postnatal Gut: Cell-Autonomous and
Microenvironmental Mechanisms
Transcription, Chromatin, and Epigenetics Interest Group
Rochester, Minnesota
11/17/2011
Epigenetic Control of Cell Differentiation in the Mesenchymal
Compartment of the Postnatal Gut: Cell-Autonomous and
Microenvironmental Mechanisms
Mayo Clinic Division of Gastroenterology and Hepatology Monday
Research Conference
Rochester, Minnesota
03/12/2012
Ordog Lab Research Program
Mayo Clinic Cancer Center GI Program
Rochester, Minnesota
05/08/2012
Epigenetic Syndromes (CTSC 5140)
Part of CTSC 5140 Epigenetics and Epigenomics
Mayo Graduate School
03/01/2013 - Present
Tamas Ordog, MD
Page 11 of 34
Epigenetics of Complex Diseases (CTSC 5140)
Part of CTSC 5140 Epigenetics and Epigenomics
Mayo Graduate School
03/15/2013 - Present
Paradoxical Convergence of Aging and Caloric Restriction in the
Gastrointestinal Neuromuscular Apparatus
Mayo Clinic Division of Gastroenterology and Hepatology Monday
Research Conference
Rochester, Minnesota
04/18/2013
Mentorship
Cheung, Wai Kwok T (Undergraduate Student)
Outcomes: Peer-reviewed paper: 1
Published abstract: 1
1998 - 1999
Irwin, Nigel, PhD (Undergraduate Student)
Current Status: Lecturer in Pharmacology, School of Biomedical
Sciences, University of Ulster, Coleraine, Northern Ireland
Outcomes: Published abstract: 1
1999 - 2000
Baldo, Marjolaine, PhD (Ph.D. Student)
Current Status: Senior Sales Director- Global at GATC Biotech,
London, United Kingdom
Outcomes: Peer-reviewed paper: 1
Published abstract: 1
2000 - 2001
Yanagida, Hiroe, MD, PhD (Postdoctoral Fellow)
Current Status: Visiting Fellow; Div. Neuroscience,
John Curtin School of Medical Research, Canberra, Australia (last
known)
Outcomes: Published abstract: 1
2000 - 2002
Vittal, Harsha, MD (Resident)
Current Status: South Bay Gastroenterology, San Jose, CA
Outcomes: Peer-reviewed papers: 2
Published abstracts: 3
2001 - 2003
Danko, Reka P, BSc (Undergraduate Student)
Current Status: Medical Student, University of Nevada School of
Medicine, Reno, Nevada
Outcomes: Accepted into medical school
2001 - 2004
Chen, Hui, MD, PhD (Ph.D. Student)
Current Status: Resident, Memorial Sloan-Kettering Cancer
Center, New York
Outcomes: Peer-reviewed papers: 4
Published abstracts: 5
International presentation: 1
2002 - 2006
Horvath, Viktor J, MD, PhD (Postdoctoral Fellow)
Current Status: Assistant Professor, 1st Dept. of Internal Medicine,
Semmelweis University, Budapest, Hungary
Outcomes: Peer-reviewed papers: 6
Published abstracts: 12
International presentations: 2
2003 - 2005
Tamas Ordog, MD
Page 12 of 34
Lorincz, Andrea, MD (Postdoctoral Fellow)
Current Status: Professor, Dept. of Biological Science, Florida
State College, Jacksonville, FL
Outcomes: Peer-reviewed papers: 7
Published abstracts: 22
International presentations: 2
2003 - 2009
Young, David L (Undergraduate Student)
Current Status: MD/PhD Student, University of Washington,
Seattle, WA
Outcomes: Peer-reviewed paper: 1
Published abstract: 1
Accepted into Mayo SURF Program, 2008
2004 - 2006
Anderson, Leigh R, MD (Resident)
Current Status: Assistant Professor, Dept. of Internal Medicine,
University of Nevada School of Medicine, Reno, Nevada
Outcomes: Published abstracts: 2
International presentation: 1
2004 - 2006
Bardsley, Michael R, MSc (MSc Student)
Current Status: Senior Research Technologist I, Dept. of
Physiology and Biomedical Engineering, College of Medicine, Mayo
Clinic Rochester, MN
2004 - 2005
Danko, Reka P, BSc (Medical Student)
Current Status: Medical Student, University of Nevada School of
Medicine, Reno, Nevada
Outcomes: Peer-reviewed paper: 1
Published abstracts: 2
International presentation: 1
2004 - 2006
Baker-Deadmond, Kimberly J (Ph.D. Student)
Current Status: Postdoctoral Research Fellow, University of Texas
Health Science Center at Tyler
2004 - 2005
Bardsley, Michael R, MSc (Research Technician)
Current Status: Senior Research Technologist I, Dept. of
Physiology and Biomedical Engineering, College of Medicine, Mayo
Clinic Rochester, MN
Outcomes: Peer-reviewed papers: 2
Published abstracts: 3
2005 - 2006
Bardsley, Michael R, MSc (Senior Research Technologist)
Outcomes: Peer-reviewed papers: 10
Book chapter: 1
Published abstracts: 33
International presentations: 2
2006 - 2012
Young, David L (SURF Student)
Current Status: MD/PhD Student, University of Washington,
Seattle, WA
Outcomes: Published abstracts: 1
2007
Popko, Laura N (Summer Undergraduate Student)
Current Status: Medical Student, University of Nevada School of
Medicine, Reno, NV
2007
Tamas Ordog, MD
Page 13 of 34
Izbeki, Ferenc, MD, PhD, Prof. habil (Postdoctoral Fellow)
Current Status: Chair, Dept. of Internal Medicine, St. George
Hospital of County Fejer, Szekesfehervar, Hungary; Private
Professor, University of Szeged School of Medicine, Szeged,
Hungary
Outcomes: Peer-reviewed papers: 2
Published abstracts: 8
2007 - 2008
Popko, Laura N (Research Technician)
Current Status: Medical Student, University of Nevada School of
Medicine, Reno, NV
Outcomes: Accepted into medical school
Peer-reviewed papers: 3
Book chapter: 1
Published abstracts: 12
2008 - 2009
Young, David L (Research Technician)
Current Status: MD/PhD Student, University of Washington,
Seattle, WA
Outcomes: Accepted into Mayo MD/PhD Program; accepted into
University of Washington MD/PhD Program
Peer-reviewed papers: 4
Book chapter: 1
Published abstracts: 12
International presentation: 1
2008 - 2009
Aarsvold, Kirsten H (Summer Undergraduate Student)
Outcomes: Accepted into Mayo SURF Program, 2009
2008
Mok, Huram (SURF Student)
Current Status: Medical Student, University of Texas Southwestern Medical School, Dallas, TX
Outcomes: Recipient of the Clinical Anatomy Course Award,
University of Texas - M.D. Anderson Cancer Center, Houston, TX;
May-August 2009
Published abstract: 1
2008
Asuzu, David T (Ph.D. Student)
Description: Lab rotations, thesis, F31 NIH grant
Current Status: Medical Student, Yale School of Medicine, New
Haven, CT
Outcomes: PhD defended on 11/17/2011
Funded grant: 1 F31 DK089974-01; Title: Epigenetic regulation of
stem cell senescence in aging; 7/1/2010 - 12/31/2012; $36,120 per
year
Peer-reviewed papers: 5
Published abstracts: 14
Other presentation: 1
2008 - 2011
Hayashi, Yujiro, PhD (Postdoctoral Fellow)
Outcomes: Peer-reviewed papers: 5
Published abstracts: 23
2008 - 2013
Aarsvold, Kirsten H (SURF Student)
Current Status: Master of Engineering Student, University of
California, San Diego, CA
Outcomes: Peer-reviewed paper: 1
Published abstracts: 2
2009
Tamas Ordog, MD
Page 14 of 34
Zhang, Xin (Summer Undergraduate Student)
Current Status: Medical Student, University of Minnesota Medical
School
2009
Zins, Kimberly A (SURF Student)
Current Status: Medical Student, Edward Via Virginia College of
Osteopathic Medicine, Blacksburg, VA
Outcomes: Published abstracts: 2
2009
McGehee, Cordelia D (SURF Student)
Current Status: MD/PhD Student, Mayo Medical School/Mayo
Graduate School, Rochester, MN
Outcomes: Published abstract: 2
Other presentation: 1
Accepted into Mayo MSTP
2010
Toyomasu, Yoshitaka, MD, PhD (Postdoctoral Fellow)
Outcomes: Published abstracts: 7
Other presentation: 1
2011 - Present
Watson, Emma (SURF Student)
Current Status: Undergraduate Student, University of Kansas,
Lawrence, KS
Outcomes: Published abstracts: 2
2011
Nagy, Rea A, MD (Postdoctoral Fellow)
Outcomes: Rosztoczy Foundation (Avondale, AZ, USA) Fellowship
Published abstracts: 3
2011 - Present
Syed, Sabriya A (Ph.D. Student)
Outcomes: Peer-reviewed paper: 1
Published abstracts: 3
Other presentation: 2
2011 - Present
Bedekovicsne Gajdos, Gabriella (Senior Research Technologist)
Outcomes: Peer-reviewed papers: 1
Published abstracts: 2
2012 - Present
Modak, Mallika (SURF Student)
Current Status: Undergraduate Student, University of Illinois
Urbana-Champagne, Urbana, IL
Outcomes: Published abstract: 1
Other presentation: 1
2012
Lee, Jeong Heon (Senior Research Technologist)
Description: Job title: Principal Research Technologist
Outcomes: Published abstract: 1
Other presentations: 3
2012 - Present
Tice, Joshua D (Postdoctoral Fellow)
Outcomes: Published abstract: 1
2012
Milosavljevic, Srdjan (Research Technologist)
Outcomes: Published abstracts: 2
2012 - 2014
Mandelkern, Talya (SURF Student)
Current Status: University of Connecticut
2013
Oreskovic, Amy (SURF Student)
Current Status: University of Illinois at Urbana Champaign College
of Engineering, Bioengineering Class of 2015
Outcomes: Other presentation: 1
2013
Tamas Ordog, MD
Page 15 of 34
Hayashi, Yujiro, PhD (Research Associate)
Outcomes: Peer-reviewed papers: 1
Published abstracts: 2
Other presentations: 2
2013 - Present
Kvasha, Sergiy M, PhD (Postdoctoral Fellow)
2013 - Present
Academic Career Development
Endocrine Physiology
University of Texas - Houston Health Science Center
Houston, Texas
1996 - 1997
INSTITUTIONAL/DEPARTMENTAL ADMINISTRATIVE RESPONSIBILITIES,
COMMITTEE MEMBERSHIPS AND OTHER ACTIVITIES
Mayo Clinic
Gastrointestinal Cancer Program
Member, Rochester, Minnesota
11/2010 - Present
Mayo Clinic - Sanford Burnham Medical Research Institute Alliance
Steering Committee
Member
2013
Mayo Clinic - University of Illinois Urbana-Champaign Alliance Steering
Committee
Member
2011 - Present
Mayo Clinic Center for Cell Signaling in Gastroenterology
Full Member, Rochester, Minnesota
Grant Reviewer, Rochester, Minnesota
09/2009 - Present
09/2009 - Present
Mayo Clinic Center for Individualized Medicine
Program Director
2011 - Present
Mayo Clinic Committees
Mayo Clinic Research Committee
Research Core Subcommittee
Member
01/01/2012 - Present
Mayo Clinic in Rochester
Department of Internal Medicine
Division of Gastroenterology and Hepatology
Gastroenterology Research Unit
Director, Rochester, Minnesota
2011 - Present
Activities at Other Institutions
University of Nevada, Reno
Animal Facilities Subcommittee
Member, Reno, Nevada
2005 - 2006
Tamas Ordog, MD
Animal Users' Committtee
Member, Reno, Nevada
Appeals Committee
Member, Reno, Nevada
Biosecurity Subcommittee
Member, Reno, Nevada
Page 16 of 34
2005 - 2006
2002 - 2004
2005 - 2006
PRESENTATIONS
International
Role of Local Progenitors in the Maintenance of Networks of Interstitial
Cells of Cajal in the Postnatal Murine Stomach
Lorincz A, Redelman D, Horvath VJ, Bardsley MR, Ordog T
AGA Institute / British Society of Gastroenterology Symposium on Stem
Cells in Gastrointestinal Development, Regeneration and Neoplasia
Tyson's Corner, Virginia
09/08/2006 - 09/09/2006
Stem Cell-Like Characteristics of KitlowCD44+CD34+ Progenitors of
Interstitial Cells of Cajal (ICC) Isolated from the Postnatal Murine Gastric
Tunica Muscularis
Lorincz A, Horvath VJ, Anderson LR, Young DL, Danko R, Bardsley MR,
Chen H, von Bartheld CS, Redelman D, Ordog T
AGA Institute / British Society of Gastroenterology Symposium on Stem
Cells in Gastrointestinal Development, Regeneration and Neoplasia
Tyson's Corner, Virginia
09/08/2006 - 09/09/2006
Epigenetic control of gastrointestinal pacemaker cell phenotype and
function
Epigenomics to Practice Workshop; Individualizing Medicine 2013
Rochester, Minnesota
10/2013
Genome-wide analysis of histone H3K27me3 and H3K4me3 marks in
gastrointestinal pacemaker stem cells
Epigenomics to Practice Workshop; Individualizing Medicine 2013
Rochester, Minnesota
10/2013
Epigenetic regulation of KIT expression in murine KITlow interstitial cell
of Cajal stem cells (ICC-SC) and KITlow gastrointestinal stromal tumor
(GIST) cells by polycomb group (PcG) repressive complexes (PRC)
Epigenomics to Practice Workshop; Individualizing Medicine 2013
Rochester, Minnesota
10/2013
Whole-genome DNA methylation analysis in HSAN1E patients with
DNMT1 mutation
Epigenomics to Practice Workshop; Individualizing Medicine 2013
Rochester, Minnesota
10/2013
Epigenetic control of gastrointestinal mesenchymal cell
transdifferentiation
Sabriya Syed, Yujiro Hayashi, Jeong Heon Lee, Peter Strege, Huihuang
Yan, Zhiguo Zhang, Gianrico Farrugia, Tamas Ordog
Keystone Symposia: Transcriptional Regulation
Santa Fe, New Mexico
02/04/2014 - 02/09/2014
Tamas Ordog, MD
A promoter for human Ano1 upstream of a newly described exon is
regulated by IL4 through STAT6
Amelia Mazzone, Simon J. Gibbons, Cheryl E. Bernard, Somaira
Nowsheen, Luciana L. Almada, Tamas Ordog, Martin E.
Fernandez-Zapico, Gianrico Farrugia
Keystone Symposia: Transcriptional Regulation
Santa Fe, New Mexico
Page 17 of 34
02/04/2014 - 02/09/2014
INVITED PRESENTATIONS AND VISITING PROFESSORSHIPS
Invited Presentations
The GnRH Pulse Generator
University of Minnesota Institute for Mathematics and Its Applications
Workshop on Endocrinology: Mechanism of Hormone Secretion and
Control
Minneapolis, Minnesota
02/1999
Pathomechanism of ICC Depletion in Diabetic Gastroenteropathy
2nd International ICC Meeting
Singapore, Singapore
12/11/2003
Effects of ICC Loss on Gastric Electrophysiology: Animal Models of
Gastroparesis
American Motility Society CME Workshop in Gastric Dysrhythmias:
From Bench to Bedside
Nashville, Tennessee
01/29/2004
Loss of Interstitial Cells of Cajal in Gastrointestinal Dysmotility: Role of
Growth Factors and Impaired Regeneration
Section of Gastroenterology Grand Rounds, Wake Forest University
Baptist Medical Center
Winston-Salem, North Carolina
11/15/2004
Loss of Pacemaker Cells in Gastrointestinal Dysmotility: Role of Growth
Factors and Impaired Regeneration
European Commission Research Directorate General Workshop on
Organ-Specific Ageing
Brussels, Belgium
12/13/2004
Loss of Interstitial Cells of Cajal in Diabetic Gastropathy: Role of Growth
Factors and Impaired Regeneration
Division of Gastroenterology and Hepatology Monday Research
Conference
Rochester, Minnesota
08/29/2005
Turnover of Interstitial Cells of Cajal in the Murine Stomach:
Regeneration from Local Progenitors and Limited Survival after Loss of
Electrical Pacemaker Activity and Kit Expression
4th International ICC Meeting
Waikoloa, Hawaii
12/09/2005
Multipotent Progenitors in the Postnatal Murine Gastric Tunica
Muscularis and Their Role in the Maintenance of Interstitial Cells of Cajal
Division of Gastroenterology and Hepatology Monday Research
Conference
Rochester, Minnesota
01/23/2006
Tamas Ordog, MD
Page 18 of 34
Resident Progenitors in the Postnatal Murine Gastric Tunica Muscularis
and their Role in Diabetic Gastropathy
Section of Gastroenterology Grand Rounds, Wake Forest University
Baptist Medical Center
Winston-Salem, North Carolina
02/21/2006
ICC, Smooth Muscle and Heraclitus' Flux Doctrine: Paracrine Signals
and Cell Turnover in Murine Diabetic Gastropathy
State-of-the-Art Lecture
14th International Workshop on Electrogastrography
Los Angeles, California
05/24/2006
Diabetes and the Interstitial Cells of Cajal
American Motility Society 2007 Scientific Meeting: Diabetes and the Gut
Freeport, Bahamas
03/03/2007
Differentiation Potential of Putative ICC Progenitors of the Murine
Stomach
5th International ICC Meeting
Carrickmacross, Ireland
08/22/2007
Stem Cell-Like Characteristics of Putative ICC Progenitors of the Murine
Stomach
Gastrointestinal Diseases Research Unit Scientific Conference, Queen's
University
Kingston, Ontario, Canada
09/26/2007
Differential Gene Expression in Functional Classes of Interstitial Cells of
Cajal (ICC) in the Murine Small Intestine
1st Japan-US Collaboration Conference in Gastroenterology
Tokyo, Japan
11/16/2007
Integrative and Translational Biology of Interstitial Cells of Cajal (ICC)
Division of Gastroenterology and Hepatology Special Seminar, Osaka
University
Osaka, Japan
11/19/2007
Differential Gene Expression in Functional Classes of Interstitial Cells of
Cajal (ICC) in the Murine Small Intestine: Making Use of Genomics Data
to Understand Cell Physiology
1st Japan-US Collaboration Conference in Gastroenterology; San Diego
Session
San Diego, California
05/18/2008
Electrical Control of Gut Motility
16th International Symposium on Electrogastrography
San Diego, California
05/22/2008
Neurobiology of the 'Little Brain' - Interstitial Cells of Cajal
2nd Joint International Meeting on Neurogastroenterology and Motility
Lucerne, Switzerland
11/07/2008
Stem Cells As a Therapeutic Option
AGA Institute/ANMS Course on Gastroparesis and Functional
Dyspepsia
Orlando, Florida
01/16/2009 - 01/17/2009
Plasticity of Adult ICC Progenitors: Role in Turnover, Regeneration and
Neoplasia of the Gastrointestinal Musculature
NIDDK Workshop on Organ Smooth Muscle: Development, Physiology
and Pathology
Bethesda, Maryland
03/24/2009 - 03/25/2009
Tamas Ordog, MD
Page 19 of 34
Turnover, Regeneration and Neoplastic Transformation of Interstitial
Cells of Cajal from Local Progenitors
13th Taishotoyama International Symposium on Gastroenterology
Shimoda, Japan
04/17/2009 - 04/18/2009
ICC Turnover from Tissue Progenitors
2009 Digestive Disease Week Translational Symposium on the
Development, Regeneration and Neoplasia of Interstitial Cells of Cajal
Chicago, Illinois
06/02/2009
Regeneration of ICC from stem cells
FASEB Summer Research Conference: Smooth Muscle
Lucca, Italy
08/02/2009 - 08/07/2009
Fate of ICC in Diabetes and Restoration of ICC from Stem Cells
3rd Joint International Meeting on Neurogastroenterology and Motility
Chicago, Illinois
08/26/2009 - 08/30/2009
Effect of Age and Food Excess or Deprivation on ICC
2010 Digestive Disease Week 2010; Research Symposium: New
Concepts on the Aging Gut
New Orleans, Louisiana
05/2010
Epigenetic Control of Cell-Autonomous and Smooth Muscle-Derived
Factors Regulating Postnatal Maintenance of Interstitial Cells of Cajal
Digestive Disease Week 2011; Research Symposium: Development of
Smooth Muscle and Smooth Muscle Differentiation and Regeneration
Chicago, Illinois
05/2011
Epigenetic Control of Cell-Autonomous and Smooth Muscle-Derived
Factors Regulating Postnatal Maintenance of Interstitial Cells of Cajal
53rd Annual Meeting of the Hungarian Society of Gastroenterology
Tihany, Hungary
06/2011
Biologic Relationships between ICC and GIST
Second International Conference on Sarcoma Biology
Chicago, Illinois
10/2011
Epigenetics and Epigenomics: Concepts, Approaches and Implications
for Neurogastroenterology
Digestive Disease Week 2012; Focused Research Roundtable
San Diego, California
05/2012
ICC Stem Cells
Digestive Disease Week 2012; Translational Symposium: Rebuilding the
Enteric Nervous System
San Diego, California
05/2012
Healthy Aging and Gastrointestinal Health – Is There a Conflict?
British Society for Research on Ageing Annual Scientific Meeting, 2012
Birmingham, United Kingdom
07/03/2012
ICC Stem Cells: Interaction Between Nutrient-Sensing and
Morphogenetic Pathways to Control Self-Renewal and Senescence
7th International Symposium on Interstitial Cells of Cajal
Florence, Italy
09/2012
Development and Plasticity of ICC
Joint International Neurogastroenterology and Motility Meeting, 2012
Bologna, Italy
09/2012
Tamas Ordog, MD
Page 20 of 34
Review of the 7th International Symposium on Interstitial Cells of Cajal
Joint International Neurogastroenterology and Motility Meeting, 2012
Bologna, Italy
09/2012
Epigenetic control of ICC turnover in health, motility disorders and
cancer
Department of Physiology and Biophysics Seminar
Virginia Commonwealth University School of Medicine, Medical College
of Virginia Campus
Richmond, Virginia
02/21/2013
Visiting Professorships
Visiting Faculty
Workshop on Endocrinology: Mechanism of Hormone Secretion and
Control
Institute for Mathematics and Its Applications, University of Minnesota
Minneapolis, Minnesota
02/15/1999 - 02/19/1999
Visiting Faculty
Section of Gastroenterology, Wake Forest University Baptist Medical
Center
Winston-Salem, North Carolina
11/15/2004 - 11/16/2004
Visiting Faculty
Division of Gastroenterology and Hepatology, Mayo Clinic
Rochester, Minnesota
08/28/2005 - 08/30/2005
Visiting Faculty
Section of Gastroenterology, Wake Forest University Baptist Medical
Center
Winston-Salem, North Carolina
02/20/2006 - 02/22/2006
Visiting Professor
Division of Gastroenterology and Hepatology, Department of Internal
Medicine, Osaka University
Osaka, Japan
11/17/2007 - 11/20/2007
Visiting Faculty
Department of Physiology and Biophysics, Virginia Commonwealth
University School of Medicine, Medical College of Virginia Campus
Richmond, Virginia
02/20/2013 - 02/22/2013
RESEARCH INTERESTS
Gastrointestinal pacemaking, interstitial cells of Cajal, diabetic gastroenteropathy, eating disorders,
protein-energy malnutrition, aging, gastrointestinal stromal tumors, receptor tyrosine kinases,
tissue-specific progenitors, adult stem cells, conditionally immortalized cell lines, cell-based therapy,
transcriptome analysis, epigenetics, epigenomics, genomics, individualized medicine
RESEARCH GRANTS AWARDED
Active Grants
Federal
Program
Director /
Principal
Investigator
Project 2: Mechanisms of Gastric Dysfunction in
Chronic Caloric Restriction in: Pathobiology of the
Enteric System. Funded by National Institute of
Diabetes and Digestive and Kidney Diseases. (P01
DK 68055)
08/2010 - 06/2015
Tamas Ordog, MD
Page 21 of 34
Program
Director /
Principal
Investigator
Interstitial cells of Cajal in diabetic gastropathy.
Funded by National Institute of Diabetes and
Digestive and Kidney Diseases. (R01 DK 58185)
09/2011 - 07/2016
Co-Investigator
Calcium Dynamics in Interstitial Cells of Cajal.
Funded by National Institute of Diabetes and
Digestive and Kidney Diseases. (R01 DK 57061)
07/2010 - 06/2014
Principal
Investigator
Interstitial Cells of Cajal in Diabetic Gastropathy.
Funded by National Institute of Diabetes and
Digestive and Kidney Diseases. (1 R01 DK058185)
09/2002 - 08/2006
Program
Director /
Principal
Investigator
Interstitial cells of Cajal in diabetic gastropathy.
Funded by National Institute of Diabetes and
Digestive and Kidney Diseases. (R01 DK 58185)
11/2006 - 08/2011
Program
Director
Core B: Tissue, cell and tissue culture core. Funded
by National Institute of Diabetes and Digestive and
Kidney Diseases. (P01 DK041315)
05/2004 - 08/2006
Co-Investigator
Project 1: Mechanism of electrical activity in ICC.
Funded by National Institute of Diabetes and
Digestive and Kidney Diseases. (P01 DK041315)
05/2004 - 08/2006
Co-Investigator
Electrical control of gastric motility. Funded by
National Institute of Diabetes and Digestive and
Kidney Diseases. (2 R37 DK040569)
05/2004 - 08/2006
Principal
Investigator
Development of an in Vitro Model to Study
Gastrointestinal Pacemaker Cell Transplantation in
Diabetic
Gastroparesis. Funded by Seed grant from the UNR
Sanford Center for Aging.
07/2000 - 06/2001
Principal
Investigator
Tissue Engineering Approaches to Replacement of
Interstitial Cells of Cajal in Aging and Aging-Related
Diseases. Funded by Multidisciplinary Pilot Grant
from the UNR Sanford Center for Aging.
07/2003 - 06/2004
Program
Director /
Principal
Investigator
Life Raft in: Transcriptome and Methylome of Human
ICC. Funded by The Life Raft Group. (Life Raft)
04/2011 - 12/2011
Consultant
Exploring Molecular and Cellular Approaches to
Rejuvenate the Aging Testis. Funded by
Collaborative Pilot Grant from the UNR Sanford
Center for Aging.
07/2006 - 12/2007
A Model to Study Entrainment of Gastric
Pacemakers. Funded by American Motility Society /
Janssen Pharmaceutica Research Grant Award.
03/2002 - 06/2003
Completed Grants
Federal
Foundation
Industry
Principal
Investigator
Tamas Ordog, MD
Page 22 of 34
BIBLIOGRAPHY
Peer-reviewed Articles
1. Ordog T, Vertes Z, Vertes M. Inhibition of oestradiol-induced DNA synthesis by opioid peptides in
the rat uterus. Life Sci. 1992; 51(15):1187-96. PMID:1528088.
2. Ordog T, Vertes Z, Vertes M. Role of endogenous opioids in progesterone antagonism on
oestradiol-induced DNA synthesis in the rat uterus. J Steroid Biochem Mol Biol. 1993 May;
45(5):455-7. PMID:8499351.
3. Cardenas H, Ordog T, O'Byrne KT, Knobil E. Single unit components of the hypothalamic multiunit
electrical activity associated with the central signal generator that directs the pulsatile secretion of
gonadotropic hormones. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9630-4. PMID:8415752.
PMCID:47623.
4. Vertes Z, Ordog T, Vertes M, Kovacs S. Changes of [3H]naloxone binding in oestrogen stimulated
rat uterus. J Steroid Biochem Mol Biol. 1993 Dec; 46(6):819-25. PMID:8274417.
5. Ordog T, Knobil E. Estradiol and the inhibition of hypothalamic gonadotropin-releasing hormone
pulse generator activity in the rhesus monkey. Proc Natl Acad Sci U S A. 1995 Jun 20;
92(13):5813-6. PMID:7597033. PMCID:41591.
6. Chen MD, Ordog T, O'Byrne KT, Goldsmith JR, Connaughton MA, Knobil E. The insulin
hypoglycemia-induced inhibition of gonadotropin-releasing hormone pulse generator activity in the
rhesus monkey: roles of vasopressin and corticotropin-releasing factor. Endocrinology. 1996 May;
137(5):2012-21. PMID:8612542.
7. Ordog T, Chen MD, Nishihara M, Connaughton MA, Goldsmith JR, Knobil E. On the role of
gonadotropin-releasing hormone (GnRH) in the operation of the GnRH pulse generator in the
rhesus monkey. Neuroendocrinology. 1997 May; 65(5):307-13. PMID:9158062.
8. Chen M-D, Ordog T. Leptin mitigates the inhibitory effect of morphine on hypothalamic
gonadotropin-releasing hormone pulse generator in the rhesus monkey. Chin J Endocrinol Metab.
1998; 14:163-7.
9. Ordog T, Chen MD, O'Byrne KT, Goldsmith JR, Connaughton MA, Hotchkiss J, Knobil E. On the
mechanism of lactational anovulation in the rhesus monkey. Am J Physiol. 1998 Apr; 274(4 Pt
1):E665-76. PMID:9575828.
10. Chen MD, Ordog T, Knobil E. Mitigation of the somnolence of insulin-induced hypoglycemia by a
vasopressin V1 receptor antagonist in the rhesus monkey. Psychoneuroendocrinology. 1998 Jul;
23(5):497-503. PMID:9802124.
11. Ordog T, Goldsmith JR, Chen MD, Connaughton MA, Hotchkiss J, Knobil E. On the mechanism of
the positive feedback action of estradiol on luteinizing hormone secretion in the rhesus monkey. J
Clin Endocrinol Metab. 1998 Nov; 83(11):4047-53. PMID:9814490.
12. Ordog T, Ward SM, Sanders KM. Interstitial cells of cajal generate electrical slow waves in the
murine stomach. J Physiol. 1999 Jul 1; 518(Pt 1):257-69. PMID:10373707. PMCID:2269418.
13. Ward SM, Ordog T, Bayguinov JR, Horowitz B, Epperson A, Shen L, Westphal H, Sanders KM.
Development of interstitial cells of Cajal and pacemaking in mice lacking enteric nerves.
Gastroenterology. 1999 Sep; 117(3):584-94. PMID:10464134.
Tamas Ordog, MD
Page 23 of 34
14. Sanders KM, Ordog T, Koh SD, Torihashi S, Ward SM. Development and plasticity of interstitial
cells of Cajal. Neurogastroenterol Motil. 1999 Oct; 11(5):311-38. PMID:10520164.
15. Ward SM, Ordog T, Koh SD, Baker SA, Jun JY, Amberg G, Monaghan K, Sanders KM.
Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum
and mitochondria. J Physiol. 2000 Jun 1; 525(Pt 2):355-61. PMID:10835039. PMCID:2269944.
16. Ordog T, Takayama I, Cheung WK, Ward SM, Sanders KM. Remodeling of networks of interstitial
cells of Cajal in a murine model of diabetic gastroparesis. Diabetes. 2000 Oct; 49(10):1731-9.
PMID:11016458.
17. Sanders KM, Ordog T, Koh SD, Ward SM. A novel pacemaker mechanism drives gastrointestinal
rhythmicity. News Physiol Sci. 2000 Dec; 15:291-8. PMID:11390929.
18. Kim TW, Beckett EA, Hanna R, Koh SD, Ordog T, Ward SM, Sanders KM. Regulation of
pacemaker frequency in the murine gastric antrum. J Physiol. 2002 Jan 1; 538(Pt 1):145-57.
PMID:11773323. PMCID:2290029.
19. Sanders KM, Ordog T, Ward SM. Physiology and pathophysiology of the interstitial cells of Cajal:
from bench to bedside. IV. Genetic and animal models of GI motility disorders caused by loss of
interstitial cells of Cajal. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G747-56.
PMID:11960771.
20. Ordog T, Baldo M, Danko R, Sanders KM. Plasticity of electrical pacemaking by interstitial cells of
Cajal and gastric dysrhythmias in W/Wv mutant mice. Gastroenterology. 2002 Dec;
123(6):2028-40. PMID:12454859.
21. Kim TW, Koh SD, Ordog T, Ward SM, Sanders KM. Muscarinic regulation of pacemaker frequency
in murine gastric interstitial cells of Cajal. J Physiol. 2003 Jan 15; 546(Pt 2):415-25. PMID:12527728.
PMCID:2342515.
22. Koh SD, Ward SM, Ordog T, Sanders KM, Horowitz B. Conductances responsible for slow wave
generation and propagation in interstitial cells of Cajal. Curr Opin Pharmacol. 2003 Dec;
3(6):579-82. PMID:14644007.
23. Ordog T, Redelman D, Miller LJ, Horvath VJ, Zhong Q, Almeida-Porada G, Zanjani ED, Horowitz
B, Sanders KM. Purification of interstitial cells of Cajal by fluorescence-activated cell sorting. Am J
Physiol Cell Physiol. 2004 Feb; 286(2):C448-56. PMID:14534083.
24. Ordog T, Redelman D, Horowitz NN, Sanders KM. Immunomagnetic enrichment of interstitial cells
of Cajal. Am J Physiol Gastrointest Liver Physiol. 2004 Feb; 286(2):G351-60. PMID:14563669.
25. Sanders KM, Koh SD, Ordog T, Ward SM. Ionic conductances involved in generation and
propagation of electrical slow waves in phasic gastrointestinal muscles. Neurogastroenterol Motil.
2004 Apr; 16(Suppl 1):100-5. PMID:15066013.
26. Ordog T, Redelman D, Horvath VJ, Miller LJ, Horowitz B, Sanders KM. Quantitative analysis by
flow cytometry of interstitial cells of Cajal, pacemakers, and mediators of neurotransmission in the
gastrointestinal tract. Cytometry A. 2004 Dec; 62(2):139-49. PMID:15536638.
27. Ro S, Hwang SJ, Ordog T, Sanders KM. Adenovirus-based short hairpin RNA vectors containing
an EGFP marker and mouse U6, human H1, or human U6 promoter. Biotechniques. 2005 Apr;
38(4):625-7. PMID:15884680.
Tamas Ordog, MD
Page 24 of 34
28. *Horvath VJ, Vittal H, Ordog T. Reduced insulin and IGF-I signaling, not hyperglycemia, underlies
the diabetes-associated depletion of interstitial cells of Cajal in the murine stomach. Diabetes.
2005 May; 54(5):1528-33. PMID:15855342.
29. *Forrest AS, Ordog T, Sanders KM. Neural regulation of slow-wave frequency in the murine gastric
antrum. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G486-95. Epub 2005 Sep 15.
PMID:16166340. DOI:10.1152/ajpgi.00349.2005.
30. *Horvath VJ, Vittal H, Lorincz A, Chen H, Almeida-Porada G, Redelman D, Ordog T. Reduced
stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic
gastroparesis. Gastroenterology. 2006 Mar; 130(3):759-70. PMID:16530517.
DOI:10.1053/j.gastro.2005.12.027.
31. Ro S, Kang SH, Farrelly AM, Ordog T, Partain R, Fleming N, Sanders KM, Kenyon JL, Keef KD.
Template switching within exons 3 and 4 of KV11.1 (HERG) gives rise to a 5' truncated cDNA.
Biochem Biophys Res Commun. 2006 Jul 14; 345(4):1342-9. Epub 2006 May 15. PMID:16723117.
DOI:10.1016/j.bbrc.2006.05.032.
32. *Chen H, Redelman D, Ro S, Ward SM, Ordog T, Sanders KM. Selective labeling and isolation of
functional classes of interstitial cells of Cajal of human and murine small intestine. Am J Physiol
Cell Physiol. 2007 Jan; 292(1):C497-507. Epub 2006 Aug 30. PMID:16943245.
DOI:10.1152/ajpcell.00147.2006.
33. *Chen H, Ordog T, Chen J, Young DL, Bardsley MR, Redelman D, Ward SM, Sanders KM.
Differential gene expression in functional classes of interstitial cells of Cajal in murine small
intestine. Physiol Genomics. 2007 Nov 14; 31(3):492-509. Epub 2007 Sep 25. PMID:17895395.
DOI:10.1152/physiolgenomics.00113.2007.
34. Ordog T. Interstitial cells of Cajal in diabetic gastroenteropathy. Neurogastroenterol Motil. 2008
Jan; 20(1):8-18. PMID:18173559. DOI:10.1111/j.1365-2982.2007.01056.x.
35. *Lorincz A, Redelman D, Horvath VJ, Bardsley MR, Chen H, Ordog T. Progenitors of interstitial
cells of cajal in the postnatal murine stomach. Gastroenterology. 2008 Apr; 134(4):1083-93. Epub
2008 Jan 18. PMID:18395089. PMCID:2435491. DOI:10.1053/j.gastro.2008.01.036.
36. Choi KM, Gibbons SJ, Nguyen TV, Stoltz GJ, Lurken MS, Ordog T, Szurszewski JH, Farrugia G.
Heme oxygenase-1 protects interstitial cells of Cajal from oxidative stress and reverses diabetic
gastroparesis. Gastroenterology. 2008 Dec; 135(6):2055-64, 2064.e1-2. Epub 2008 Sep 11.
PMID:18926825. PMCID:2796242. DOI:10.1053/j.gastro.2008.09.003.
37. Gomez-Pinilla PJ, Gibbons SJ, Bardsley MR, Lorincz A, Pozo MJ, Pasricha PJ, Van de Rijn M,
West RB, Sarr MG, Kendrick ML, Cima RR, Dozois EJ, Larson DW, Ordog T, Farrugia G. Ano1 is
a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J
Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1370-81. Epub 2009 Apr 16. PMID:19372102.
PMCID:2697941. DOI:10.1152/ajpgi.00074.2009.
38. Wouters MM, Roeder JL, Tharayil VS, Stanich JE, Strege PR, Lei S, Bardsley MR, Ordog T,
Gibbons SJ, Farrugia G. Protein kinase Cgamma mediates regulation of proliferation by the
serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009 Aug 7; 284(32):21177-84. Epub
2009 Jun 16. PMID:19531484. PMCID:2755840. DOI:10.1074/jbc.M109.015859.
39. Ordog T, Hayashi Y, Gibbons SJ. Cellular pathogenesis of diabetic gastroenteropathy. Minerva
Gastroenterol Dietol. 2009 Sep; 55(3):315-43. PMID:19829287. PMCID:2854169.
Tamas Ordog, MD
Page 25 of 34
40. Soffer E, Abell T, Lin Z, Lorincz A, McCallum R, Parkman H, Policker S, Ordog T. Review article:
gastric electrical stimulation for gastroparesis--physiological foundations, technical aspects and
clinical implications. Aliment Pharmacol Ther. 2009 Oct; 30(7):681-94. Epub 2009 Jul 02.
PMID:19573170. DOI:10.1111/j.1365-2036.2009.04082.x.
41. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R,
Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR,
Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F.
Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting.
Neurogastroenterol Motil. 2010 Feb; 22(2):113-33. Epub 2009 Dec 09. PMID:20003077.
PMCID:2892213. DOI:10.1111/j.1365-2982.2009.01434.x.
42. Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR,
Szurszewski JH, Gibbons SJ, Farrugia G. CD206-positive M2 macrophages that express heme
oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology. 2010 Jun;
138(7):2399-409, 2409.e1. Epub 2010 Feb 20. PMID:20178793. PMCID:2883675.
DOI:10.1053/j.gastro.2010.02.014.
43. *Izbeki F, Asuzu DT, Lorincz A, Bardsley MR, Popko LN, Choi KM, Young DL, Hayashi Y, Linden
DR, Kuro-o M, Farrugia G, Ordog T. Loss of Kitlow progenitors, reduced stem cell factor and high
oxidative stress underlie gastric dysfunction in progeric mice. J Physiol. 2010 Aug 15; 588(Pt
16):3101-17. Epub 2010 Jun 25. PMID:20581042. PMCID:2956948. DOI:10.1113/jphysiol.2010.191023.
44. *Bardsley MR, Horvath VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL,
Lomberk GA, Urrutia RA, Farrugia G, Rubin BP, Ordog T. Kitlow stem cells cause resistance to
Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors.
Gastroenterology. 2010 Sep; 139(3):942-52. Epub 2010 Jun 04. PMID:20621681. PMCID:2933938.
DOI:10.1053/j.gastro.2010.05.083.
45. Gomez-Pinilla PJ, Gibbons SJ, Sarr MG, Kendrick ML, Shen KR, Cima RR, Dozois EJ, Larson DW,
Ordog T, Pozo MJ, Farrugia G. Changes in interstitial cells of cajal with age in the human stomach
and colon. Neurogastroenterol Motil. 2011 Jan; 23(1):36-44. Epub 2010 Aug 19. PMID:20723073.
PMCID:2999641. DOI:10.1111/j.1365-2982.2010.01590.x.
46. Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han
JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R. A functional family-wide screening of SP/KLF
proteins identifies a subset of suppressors of KRAS-mediated cell growth. Biochem J. 2011 Apr
15; 435(2):529-37. PMID:21171965. PMCID:3130109. DOI:10.1042/BJ20100773.
47. Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Rae JL, Parkman HP,
Linden DR, Szurszewski JH, Ordog T, Gibbons SJ, Farrugia G. Altered expression of Ano1
variants in human diabetic gastroparesis. J Biol Chem. 2011 Apr 15; 286(15):13393-403. Epub
2011 Feb 24. PMID:21349842. PMCID:3075685. DOI:10.1074/jbc.M110.196089.
48. Grzenda A, Ordog T, Urrutia R. Polycomb and the emerging epigenetics of pancreatic cancer. J
Gastrointest Cancer. 2011 Jun; 42(2):100-11. PMID:21336826. PMCID:3678558.
DOI:10.1007/s12029-011-9262-4.
49. *Asuzu DT, Hayashi Y, Izbeki F, Popko LN, Young DL, Bardsley MR, Lorincz A, Kuro-O M, Linden
DR, Farrugia G, Ordog T. Generalized neuromuscular hypoplasia, reduced smooth muscle myosin
and altered gut motility in the klotho model of premature aging. Neurogastroenterol Motil. 2011 Jul;
23(7):e309-23. Epub 2011 May 24. PMID:21605285. PMCID:3149585. DOI:10.1111/j.1365-2982.2011.01730.x.
Tamas Ordog, MD
Page 26 of 34
50. Kashyap P, Gomez-Pinilla PJ, Pozo MJ, Cima RR, Dozois EJ, Larson DW, Ordog T, Gibbons SJ,
Farrugia G. Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in
patients with slow transit constipation. Neurogastroenterol Motil. 2011 Aug; 23(8):760-5. Epub
2011 May 17. PMID:21585622. PMCID:3138829. DOI:10.1111/j.1365-2982.2011.01729.x.
51. Stanich JE, Gibbons SJ, Eisenman ST, Bardsley MR, Rock JR, Harfe BD, Ordog T, Farrugia G.
Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011 Dec;
301(6):G1044-51. Epub 2011 Sep 22. PMID:21940901. PMCID:3233782. DOI:10.1152/ajpgi.00196.2011.
52. Grover M, Bernard CE, Pasricha PJ, Parkman HP, Abell TL, Nguyen LA, Snape W, Shen KR, Sarr
M, Swain J, Kendrick M, Gibbons S, Ordog T, Farrugia G. Platelet-derived growth factor receptor
alpha (PDGFRalpha)-expressing "fibroblast-like cells" in diabetic and idiopathic gastroparesis of
humans. Neurogastroenterol Motil. 2012 Sep; 24(9):844-52. Epub 2012 Jun 01. PMID:22650155.
PMCID:3756591. DOI:10.1111/j.1365-2982.2012.01944.x.
53. Mazzone A, Eisenman ST, Strege PR, Yao Z, Ordog T, Gibbons SJ, Farrugia G. Inhibition of cell
proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1. Biochem Biophys
Res Commun. 2012 Oct 19; 427(2):248-53. Epub 2012 Sep 17. PMID:22995309. PMCID:3479349.
DOI:10.1016/j.bbrc.2012.09.022.
54. Ordog T, Syed SA, Hayashi Y, Asuzu DT. Epigenetics and chromatin dynamics: a review and a
paradigm for functional disorders. Neurogastroenterol Motil. 2012 Dec; 24(12):1054-68. Epub
2012 Oct 24. PMID:23095056. PMCID:3607505. DOI:10.1111/nmo.12031.
55. *Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ,
Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog
T. Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated
pathways. PLoS One. 2013; 8(10):e76822. Epub 2013 Oct 07. PMID:24116170. PMCID:3792098.
DOI:10.1371/journal.pone.0076822.
56. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi
Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and
repair in mice. Gastroenterology. 2014 May; 146(5):1339-1350.e1. Epub 2014 Feb 04.
PMID:24503129. PMCID:4001704. DOI:10.1053/j.gastro.2014.01.061.
57. Wang Y, Marino-Enriquez A, Bennett RR, Zhu M, Shen Y, Eilers G, Lee JC, Henze J, Fletcher BS,
Gu Z, Fox EA, Antonescu CR, Fletcher CD, Guo X, Raut CP, Demetri GD, van de Rijn M, Ordog T,
Kunkel LM, Fletcher JA. Dystrophin is a tumor suppressor in human cancers with myogenic
programs. Nat Genet. 2014 May 04. PMID:24793134. DOI:10.1038/ng.2974.
Non-peer-reviewed Articles
1. Ordog T. Cellular origin of GIST from the “good” cells’ perspective. Life Raft Group Newsletter.
2012 Apr 12; 13(2):3-12.
Book Chapters
1. Sanders KM, Ordog T, Koh SD, Ward SM. Properties of electrical rhythmicity in the stomach. In:
Koch KL and Stern RM. Handbook of electrogastrography. New York: Oxford; 2004. p. 13-36.
(Book chapter)
2. Camp J, Simpson K, Bardsley MR, Popko LN, Young DL, Kemp BJ, Lowe V, Ordog T, Robb R. 3D
Registration of Micro-PET-CT for Measurable Correlates of Dyspeptic Symptoms in Mice. In: Hu
XP, Clough AV. Proceedings of SPIE. Medical Imaging 2009: Biomedical Applications in Molecular,
Structural, and Functional Imaging. Vol. 7262. Bellingham, WA: SPIE; 2009. p. 72620Z-1-8. (Book
chapter)
Tamas Ordog, MD
Page 27 of 34
3. Ordog T. Cellular pathogenesis of gastroparesis. In: Parkman HP, McCallum RW. Gastroparesis:
Pathophysiology, Presentation, Diagnosis, and Treatment. New York: Springer; 2012. p. 47-64.
(Clinical Gastroenterology) (Book chapter)
Editorials
1. Ordog T. Do we need to revise the role of interstitial cells of Cajal in gastrointestinal motility? Am J
Physiol Gastrointest Liver Physiol. 2008 Feb; 294(2):G368-71. PMID:18270367.
DOI:10.1152/ajpgi.00530.2007.
Abstracts
1. Ordog T, Vertes M, Flondell M. Opioids and cell proliferation in rat uterus. 20th Meeting of the
Federation of European Biochemical Societies, Budapest, Hungary. 1990:259.
2. Chen M-D, O'Byrne KT, Ordog T, Goldsmith JR, Hotchkiss J, Knobil E. Vasopressin does not, but
CRF may, mediate the action of hypoglycemic stress on GnRH pulse generator frequency in the
rhesus monkey. 76th Annual Meeting of the Endocrine Society, Anaheim, CA (Abstract #713)
1994:379.
3. Ordog T, O'Byrne KT, Chen M-D, Goldsmith JR, Knobil E. The inhibition of gonadotropin-releasing
hormone (GnRH) pulse generator activity by estradiol is not due to desynchronization of its
component units. Soc Neurosci. 1994; 20(Part 1):93.
4. Ordog T, Chen M-D, Nishihara M, Goldsmith JR, Connaughton MA, Knobil E. On the
neuromodulation of GnRH pulse generator activity by GnRH. 77th Annual Meeting of the
Endocrine Society, Washington, DC (Abstract #P3-344) 1995:554.
5. Ordog T, Knobil E. Cross-correlation analysis of interactions between hypothalamic units
associated with the gonadotropin-releasing hormone (GnRH) pulse generator. Soc Neurosci.
1995; 21(Part 3):1896.
6. Chen M-D, Ordog T, Connaughton MA, Knobil E. The contribution of vasopressin to the
somnolence of insulin-induced hypoglycemia in the rhesus monkey. 10th International Congress of
Endocrinology, San Francisco, CA (Abstract #P3-844) 1996; 2:965.
7. Ordog T, Chen M-D, Goldsmith JR, Connaughton MA, O'Byrne KT, Hotchkiss J, Knobil E. Role of
prolactin in the lactational anovulation in the rhesus monkey. Soc Neurosci. 1996; 22(Part 3):1788.
8. Ordog T, Goldsmith JR, Chen M-D, Connaughton MA, Knobil E. The positive feedback action of
estradiol on luteinizing hormone secretion in the rhesus monkey is not due to an escape from its
negative feedback effect. 79th Annual Meeting of the Endocrine Society, Minneapolis, MN (Abstr
#OR16-1) 1997:86.
9. Ordog T. Multiple pacemakers are associated with the gonadotropin-releasing hormone (GnRH)
pulse generator in the rhesus monkey. Soc Neurosci. 1997; 23(Part 2):1796.
10. Ordog T, Knobil E. The GnRH pulse generator. Institute for Mathematics and Its Applications
Workshop on Endocrinology: Mechanism of Hormone Secretion and Control, University of
Minnesota, Minneapolis, MN (http://www.ima.umn.edu/biology/wkshp_abstracts/ordog1.html)
1999.
11. Ordog T, Takayama I, Cheung WKT, Ward SM, Sanders KM. Remodeling of networks of interstitial
cells of Cajal in a murine model of diabetic gastroparesis. Neurogastroenterol Motil. 2000; 12:489.
Tamas Ordog, MD
Page 28 of 34
12. *Vittal H, Sanders KM, Ordog T. Immunohistochemical analysis of insulin receptor (IR), insulinlike
growth factor-I receptor (IGF-IR) and stem cell factor (SCF) expression patterns in murine gastric
tunica muscularis. Am J Gastroenterol. 2001; 96:S78-9.
13. *Baldo M, Sanders KM, Ordog T. Plasticity of electrical pacemaking by interstitial cells of Cajal
underlies gastric dysrhythmia in W/WV mice. Gastroenterology. 2002; 122(4 Suppl 1):A-37.
14. *Yanagida H, Sanders KM, Ordog T. Subcellular origin of electrical pacemaking in interstitial cells
of Cajal. Gastroenterology. 2002; 122(4 Supplement):A-158.
15. Ordog T, Redelman D, Miller LJ, Horowitz NN, Zhang Q, Horowitz B, Sanders KM. Approaches to
purification of interstitial cells of Cajal. Neurogastroenterol Motil. 2002; 14:442-3.
16. Ordog T, Vittal H, Sanders KM. Role of insulin, insulin-like growth factor-I (IGF-I) and glucose in the
long-term maintenance of kit expression by interstitial cells of Cajal. Gastroenterology. 2003; 124(4
Suppl 1):A-63.
17. Ordog T, Baker SA, Sanders KM. Functional uncoupling of corpus-to-antrum slow wave
entrainment in W/WV mice. Neurogastroenterol Motil. 2003; 15:8-9.
18. *Horvath VJ, Vittal H, Redelman D, Almeida-Porada G, Ordog T. Stimulation of stem cell
factor(SCF) expression by insulin or insulin-like growth factor-I (IGF-I) is required for the long-term
maintenance of interstitial cells of Cajal (ICC). Gastroenterology. 2004; 126(4 Suppl 2):A102.
19. Ordog T, Irwin N, Takayama I, Ward SM, Sanders KM. Depletion of interstitial cells of Cajal and
electrical abnormalities in a murine model of diabetic colon dysfunction. Neurogastroenterol Motil.
2004; 16:664.
20. *Horvath VJ, Lorincz A, Redelman D, Ordog T. Conditionally immortal interstitial cells of Cajal(ICC)
generate rhythmic electrical pacemaker activity. Neurogastroenterol Motil. 2004; 16:667.
21. Lee HK, Ordog T, Sanders KM, Jung JY, Kim YH, Kim HW. Single Ca2+ channel currents
recorded from guinea pig colonic in interstitial cells of Cajal (ICCs). Biophys J. 2005; 88(1 Part 2
Suppl. S):447A.
22. Ordog T, Redelman D, Anderson LR, Lorincz A, Young DL, Horvath VJ. Isolation and
characterization of a CD34+ multipotent progenitor cell line from the postnatal murine gastric tunica
muscularis. Gastroenterology. 2005; 128(4 Suppl 2):P-273.
23. *Chen H, Ordog T, Redelman D, Ro S, Ward SM, Sanders KM. Selective labeling and isolation of
functional classes of interstitial cells of Cajal (ICC) of the human and murine small intestine.
Gastroenterology. 2005; 128(4 Suppl 2):P-314.
24. *Horvath VJ, Lorincz A, Ordog T. Role of cell turnover in the maintenance of networks of interstitial
cells of Cajal (ICC). Neurogastroenterol Motil. 2005; 17:33-4.
25. *Lorincz A, Baker SA, Danko R, Sanders KM, Ordog T. Functional uncoupling of corpus-toantrum
slow wave entrainment in a murine model of diabetic gastroparesis. Neurogastroenterol Motil.
2005; 17:478.
26. Redelman D, Lorincz A, Horvath VJ, Bardsley MR, Chen H, Ordog T. Turnover of Interstitial Cells
of Cajal in the murine stomach: Regeneration from local progenitors and limited survival after loss
of electrical pacemaker activity and Kit expression. Gastroenterology. 2006; 130(4 Suppl 2):A-538.
Tamas Ordog, MD
Page 29 of 34
27. *Lorincz A, Redelman D, Horvath VJ, Bardsley MR, Chen H, Ordog T. Role of local progenitors in
the sustenance of networks of interstitial cells of Cajal (ICC) in the murine stomach.
Neurogastroenterol Motil. 2006; 18(6):484.
28. *Lorincz A, Horvath VJ, Danko R, Anderson LR, Redelman D, Ordog T. In vivo differentiation
potential in a heterologous noninjury transplantation model of KitLowCD44+CD34+ ICC
progenitors isolated from postnatal gastric tunica muscularis. Neurogastroenterol Motil. 2006;
18(8):757.
29. *Lorincz A, Bardsley MR, Redelman D, Chen H, Young DL, Horvath VJ, Ordog T. Isolation of a
KitlowCD44+CD34+ Cell Line with Stem Cell-Like Characteristics from the Gastric Tunica
Muscularis of C57Bl/6 Mice. Gastroenterology. 2007; 132(4 Suppl 2):A-43.
30. *Lorincz A, Horvath VJ, Redelman D, Ordog T. Characterization of conditionally immortalized
interstitial cells of Cajal from the murine stomach. Neurogastroenterol Motil. 2007 Jun; 19(6):526.
31. *Lorincz A, Horvath V, Bardsley M, Redelman D, Ordog T. Survival and differentiation into
interstitial cells of Cajal (ICC) of conditionally immortalized Kit(low)CD44(+)CD34(+) cells with stem
cell-like characteristics following allogeneic transplantation into diabetic NOD mice.
Neurogastroenterol Motil. 2007 Oct; 19(Suppl 3):24.
32. Gomez-Pinilla PJ, Gibbons SJ, Ordog T, Pozo MJ, Sarr MG, Kendrick ML, Cima RR, Dozois EJ,
Larson DW, Farrugia G. DOG-1, a marker for interstitial cells of Cajal in the human gastrointestinal
tract. Neurogastroenterol Motil. 2008; 20(Suppl 1):57-8.
33. *Young DL, Lorincz A, Bardsley MR, Horvath VJ, Chen H, Redelman D, Ordog T. Gene expression
underlying stem cell-like characteristics of putative ICC progenitors isolated from the postnatal
murine stomach. Neurogastroenterol Motil. 2008; 20(Suppl 1):62.
34. *Lorincz A, Bardsley MR, Izbeki F, Popko LN, Gibbons SJ, Shen RK, Sarr MG, Farrugia G, Ordog
T. Gastric dysmotility in eating disorders is associated with depletion of ICC and enteric neurons.
Neurogastroenterol Motil. 2008; 20(Suppl 1):80.
35. *Bardsley MR, Lorincz A, Popko L, Izbeki F, Farrugia G, Ordog T. Gastric emptying in mouse
models of eating disorders. Gastroenterology. 2008 Apr; 134(4 Suppl 1):A-315.
36. *Lorincz A, Bardsley MR, Popko L, Izbeki F, Ordog T. Gastric slow wave dysrhythmias underlying
gastroparesis in mouse models of eating disorders. Gastroenterology. 2008 Apr; 134(4 Suppl
1):A-534.
37. *Lorincz A, Bardsley MR, Izbeki F, Popko LN, Ordog T. Slow wave dysrhythmias and
gastroparesis in mouse models of eating disorders. Neurogastroenterol Motil. 2008 Jun;
20(6):II-III.
38. *Bardsley MR, Popko L, Young DL, Farrugia G, Rubin BP, Ordog T. Accelerated Turnover of
Interstitial Cells of Cajal (ICC) from Local Progenitors in a Mouse Model of Gastrointestinal Stromal
Tumors (GIST). Gastroenterology. 2009; 136(5 Suppl 1):A-51.
39. *Lorincz A, Bardsley MR, Rumessen JJ, Strege PR, Horvath VJ, Redelman D, Farrugia G, Ordog
T. Irreversible Dedifferentiation of Interstitial Cells of Cajal (ICC) in the Absence of Adequate Kit
Signaling. Gastroenterology. 2009; 136(5 Suppl 1):A-52.
40. *Bardsley MR, Lorincz A, Gomez-Pinilla PJ, Gibbons SJ, Farrugia G, Ordog T. Ano1 Is a Selective
Marker for Interstitial Cells of Cajal (ICC) and Their Precursors in the Murine Gastrointestinal Tract.
Gastroenterology. 2009; 136(5 Suppl 1):A-579.
Tamas Ordog, MD
Page 30 of 34
41. *Hayashi Y, Popko L, Young DL, Bardsley MR, Izbeki F, Aarsvold KH, Farrugia G, Gibbons SJ,
Ordog T. Insulin-Like Growth Factor-I (IGF-I) Reverses Delayed Gastric Emptying in Calorically
Restricted Mice and Stimulates Gastric Expression of Stem Cell Factor (SCF). Gastroenterology.
2009; 136(5 Suppl 1):A-62.
42. *Bardsley MR, Camp JJ, Simpson K, Popko LN, Young DL, Kemp BJ, Lowe V, Robb RA, Ordog T.
Effects of chronic caloric restriction and insulin-like growth factor-I (IGF-I) on postprandial cerebral
glucose metabolism in mice. Neurogastroenterol Motil. 2009; 21(Suppl 1):15.
43. *Asuzu DT, Young DL, Mok HM, Lomberk GA, Urrutia RA, Ordog T. Polycomb group (PcG)
transcriptional co-repressors regulate the differentiation of isolated KitlowCD34+CD44+
progenitors of murine gastric interstitial cells of Cajal (ICC). Neurogastroenterol Motil. 2009;
21(Suppl 1):94.
44. Kashyap PC, Gomez-Pinilla PJ, Lurken MS, Cima RP, Dozois EJ, Larson DW, Ordog T, Gibbons
SJ, Farrugia G. Immunoreactivity for ano1 detects depletion of interstitial cells of cajal in patients
with slow transit constipation. Gastroenterology. 2009 May; 136(5):A51.
45. Choi KM, Kashyap PC, Dutta N, Stoltz G, Ordog T, Szurszewski JH, Gibbons SJ, Farrugia G.
Cd206 positive m2 macrophages expressing ho1 protect against the development of delayed ge in
a mouse model of diabetic gastroparesis. Gastroenterology. 2009 May; 136(5):A62.
46. *Asuzu DT, Lomberk GA, Bardsley MR, Hayashi Y, Farrugia G, Urrutia RA, Rubin BP, Ordog T.
KitLow Interstitial Cell of Cajal Stem Cells are a Cell of Origin of Gastrointestinal Stromal Tumors.
Gastroenterology. 2010 May; 138(5 Suppl 1):S1.
47. *Izbeki F, Lorincz A, Asuzu DT, Popko L, Young DL, Bardsley MR, Hayashi Y, Kuro-o M, Farrugia
G, Ordog T. Loss of Gastric Interstitial Cells of Cajal and Impaired Electrical Pacemaking in Klotho
Mice, an Animal Model of Aging. Gastroenterology. 2010 May; 138(5 Suppl 1):S2.
48. Mazzone A, Bernard CE, Galietta LJ, Pasricha PJ, Linden DR, Szurszewski JH, Ordog T, Gibbons
SJ, Farrugia G. Altered Expression of Ano1 Variants in Gastroparesis. Gastroenterology. 2010
May; 138(5 Suppl 1):S21.
49. Choi KM, Dutta N, Stoltz G, Ordog T, Szurszewski JH, Gibbons SJ, Farrugia G. Increased
Expression of M2c Macrophage-Associated Gene Transcripts in Diabetic Mice Resistant to
Delayed Gastric Emptying. Gastroenterology. 2010 May; 138(5 Suppl 1):S22.
50. Stanich JE, Gibbons SJ, Rock JR, Harfe BD, Ordog T, Farrugia G. Ano1 Plays a Role in the
Proliferation of ICC. Gastroenterology. 2010 May; 138(5 Suppl 1):S311.
51. Gomez-Pinilla PJ, Gibbons SJ, Kendrick ML, Sarr MG, Shen KR, Pozo MJ, Ordog T, Farrugia G.
Effects of Aging on Interstitial Cells of Cajal in the Human Stomach. Gastroenterology. 2010 May;
138(5 Suppl 1):S311-2.
52. Gomez-Pinilla PJ, Gibbons SJ, Cima RR, Dozois EJ, Larson DW, Pozo MJ, Ordog T, Farrugia G.
Age-Related Loss of Interstitial Cells of Cajal in the Human Colon. Gastroenterology. 2010 May;
138(5 Suppl 1):S312.
53. *Zins KA, Ordog T, Bardsley MR, Farrugia G, Levitt MD, Slungaard A, Szurszewski JH, Linden DR.
Hydrogen Sulfide Ameliorates Murine Experimental Colitis Through Specific Effects on Diverse
Classes of Infiltrating Immune Cells. Gastroenterology. 2010 May; 138(5 Suppl 1):S621.
Tamas Ordog, MD
Page 31 of 34
54. *Zins KA, Ordog T, Bardsley MR, Farrugia G, Szurszewski JH, Linden DR. Immunophenotypic
Characterization of the Cellular Infiltrate During Murine Experimental Colitis Using Multiparameter
Flow Cytometry. Gastroenterology. 2010 May; 138(5 Suppl 1):S621.
55. *Bardsley MR, Hayashi Y, Asuzu DT, Farrugia G, Rubin BP, Ordog T. KitLow Interstitial Cell of
Cajal Stem Cells are a Cause of Resistance to Imatinib Mesylate in Gastrointestinal Stromal
Tumors. Gastroenterology. 2010 May; 138(5 Suppl 1):S80.
56. *Izbeki F, Popko LN, Asuzu DT, Young DL, Linden DR, Hayashi Y, Bardsley MR, Lorincz A, Kuro-o
M, Farrugia G, Ordog T. Neurodegeneration and loss of interstitial cells of Cajal (ICC) underlie
small intestinal and colonic dysfunction in klotho mice, an animal model of aging.
Neurogastroenterol Motil. 2010 Aug; 22(Suppl s1):6.
57. Mazzone A, Bernard CE, Galietta LJ, Pasricha PJ, Linden DR, Szurszewski JH, Ordog T, Gibbons
SJ, Farrugia G. Altered expression of Ano1 segments in diabetic gastroparesis.
Neurogastroenterol Motil. 2010 Aug; 22(Suppl s1):64.
58. Choi KM, Dutta N, Stoltz GJ, Shea-Donohue T, Bauer AJ, Ordog T, Linden DR, Szurszewski JH,
Gibbons SJ, Farrugia G. Differential activation of M2-macrophage phenotypes during the course of
diabetes and development of diabetic gastroparesis in NOD mice. Neurogastroenterol Motil. 2010
Aug; 22(Supplement s1):11.
59. Choi KM, Kashyap PC, Dutta N, Linden DR, Ordog T, Szurszewski JH, Gibbons SJ, Farrugia G.
CD206 positive M2-macrophages are a marker of diabetic gastroparesis in db/db mice, a model of
type 2 diabetes. Neurogastroenterol Motil. 2010 Aug; 22(Supplement s1):61-2.
60. *Asuzu DT, Hayashi Y, Bardsley MR, Urrutia RA, Farrugia G, Ordog T. Wnt-induced exhaustion of
interstitial cell of Cajal (ICC) stem cells underlying aging-associated ICC loss does not depend on
mTOR signaling and may be mediated by persistent β-catenin activation. Neurogastroenterol
Motil. 2010 Aug; 22(Supplement s1):85.
61. *Lorincz A, Bardsley MR, Choi KM, Asuzu DT, Izbeki F, Young DL, Popko LN, Hayashi Y, Kuro-o
M, Farrugia G, Ordog T. Gastric expression of the anti-aging protein Klotho protects ICC from
oxidative stress. Neurogastroenterol Motil. 2010 Aug; 22(Supplement s1):85-6.
62. *Hayashi Y, Aarsvold KH, Bardsley MR, Gibbons SJ, Ordog T. Inhibition of glycogen synthase
kinase-3 (GSK-3) mimics insulin-like growth factor-I (IGF-I)-induced stem cell factor (SCF)
expression in the murine stomach. Neurogastroenterol Motil. 2010 Aug; 22(Supplement s1):86-7.
63. *Asuzu DT, McGehee CD, Hayashi Y, Bardsley MR, Grzenda AL, Lomberk GA, Farrugia G, Urrutia
RA, Ordog T. Epigenetic control of Kit expression in murine KitLow interstitial cell of Cajal (ICC)
stem cells and gastrointestinal stromal tumors (GIST). Gastroenterology. 2011 May; 140(5 Suppl
1):S-119-20.
64. *Hayashi Y, Asuzu DT, Bardsley MR, Lomberk GA, Farrugia G, Urrutia RA, Ordog T.
Chromatin-remodeling events reveal a novel paradigm for the epigenetic control of stem cell factor
(Kitl) expression in gastrointestinal smooth muscles, mesenchymal cells and stromal tumors.
Gastroenterology. 2011 May; 140(5 Suppl 1):S-120.
65. *Asuzu DT, Hayashi Y, Bardsley MR, Farrugia G, Ordog T. Persistent β-catenin activation
underlies senescence of interstitial cell of Cajal (ICC) stem cells in naturally aging mice.
Gastroenterology. 2011 May; 140(5 Suppl 1):S-139.
Tamas Ordog, MD
Page 32 of 34
66. Mazzone A, Bernard CE, Strege PR, Beyder A, Galietta LJ, Pasricha PJ, Parkman HP, Linden DR,
Szurszewski JH, Ordog T, Gibbons SJ, Farrugia G. Altered expression of Ano1 transcript variants
in diabetes and gastroparesis. Gastroenterology. 2011 May; 140(5 Suppl 1):S-70.
67. Mazzone A, Eisenman ST, Yao Z, Ordog T, Gibbons SJ, Farrugia G. Use of Specific Inhibitor
T16aInh-a Confirms a Key Role for Ano1 in the Regulation of ICC Proliferation. Gastroenterology.
2012; 142(5 Suppl 1):S29.
68. *Asuzu DT, Hayashi Y, Toyomasu Y, Bardsley MR, Farrugia G, Ordog T. Trp53 Mediates Stem
Cell Depletion From Chronically Elevated Canonical Wnt Signaling. Gastroenterology. 2012; 142(5
Suppl 1):S30.
69. *Hayashi Y, Bardsley MR, Toyomasu Y, Choi KM, Taguchi T, Ramachandran A, Gibbons SJ,
Farrugia G, Ordog T. Effects of Crenolanib, a Highly Selective Platelet-Derived Growth Factor
Receptor α/β (PDGFRA/B) Tyrosine Kinase Inhibitor, on the Proliferation of Kit-Mutant
Gastrointestinal Stromal Tumor (GIST) Cells and Interstitial Cell of Cajal (ICC) Precursors.
Gastroenterology. 2012; 142(5 Suppl 1):S30.
70. *Dave M, Hayashi Y, Khanna S, Bardsley MR, Svingen PA, Faubion WA, Ordog T. Adult Stem
Cells for Murine Interstitial Cells of Cajal (ICC) Mediate Immunosuppression In Vitro.
Gastroenterology. 2012; 142(5 Suppl 1):S66.
71. *Hayashi Y, Gibbons SJ, Bardsley MR, Taguchi T, Farrugia G, Rubin BP, Ordog T. Salinomycin
Enhances Imatinib Effects in Murine Interstitial Cell of Cajal (ICC) Stem Cells and Gastrointestinal
Stromal Tumor (GIST) Cells and Inhibits Glycosylation of Kit Protein While Triggering Expression of
Truncated Intracellular Kit. Gastroenterology. 2012; 142(5 Suppl 1):S763.
72. Grover M, Bernard CE, Pasricha PJ, Parkman HP, Abell TL, Nguyen LAB, Snape WJ, Shen KR,
Sarr MG, Swain JM, Kendrick ML, Gibbons SJ, Ordog T, Farrugia G. Platelet-Derived Growth
Factor Receptor α (Pdgfrα)-Expressing “Fibroblast-Like Cells” in Human Diabetic and Idiopathic
Gastroparesis. Gastroenterology. 2012; 142(5 Suppl 1):S836.
73. Yang L, Ordog T, Shah V. The Anti-Aging Protein Klotho Inhibits Hepatic Stellate Cell Activation by
Suppressing the Transforming Growth Factor-β1 (TGF-β1) Signaling Pathway. Gastroenterology.
2012; 142(5 Suppl 1):S974.
74. *Toyomasu Y, Hayashi Y, Lorincz A, Bardsley MR, Popko LN, Young DL, Mason JE, Gibbons SJ,
Linden DR, Szurszewski JH, Farrugia G, Ordog T. Insulin-like growth factor 1 (IGF1) encodes
memory of past food intake by regulating functional capacity of the gastric neuromuscular
apparatus. Endocrine Rev. 2012 Jun; 33(3 Meeting Abstracts):OR32-2.
75. Ordog T, Toyomasu Y, Hayashi Y, Lorincz A, Bardsley M, Popko L, Young D, Gibbons S, Linden
D, Szurszewski J, Farrugia G. Insulin-like growth factor 1 (IGF1) encodes memory of past food
intake via pleiotropic effects on the gastric neuromuscular apparatus. Neurogastroenterol Motil.
2012 Sep; 24:134.
76. Farrugia G, Choi KM, Sha L, Beyder A, Verhulst PJ, Mason J, Bauer A, Ordog T, Linden D,
Szurszewski J, Kashyap P, Gibbons S. Il-10 reverses delayed gastric emptying, slow wave
abnormalities and smooth muscle membrane potential gradient changes in diabetic nod/shiltj mice.
Neurogastroenterol Motil. 2012 Sep; 24:154.
77. Farrugia G, Mazzone A, Eisenman S, Strege P, Yao Z, Ordog T, Gibbons S. Use of a more specific
inhibitor, T16ainh-A, confirms a key role for ano1 in the regulation of ICC proliferation.
Neurogastroenterol Motil. 2012 Sep; 24:189-90.
Tamas Ordog, MD
Page 33 of 34
78. Ordog T, Yujiro H, Bardsley M, Toyomasu Y, Mason J, Linden D, Szurszewski J, Farrugia G.
Hyperplasia of gastric interstitial cells of Cajal (ICC) and ICC stem cells (ICC-SC) in obese diabetic
lepr(db/db) mice without gastroparesis. Neurogastroenterol Motil. 2012 Sep; 24:22.
79. Ordog T. Development and plasticity of ICC. Neurogastroenterol Motil. 2012 Sep 6; 24(Suppl
2):10.
80. Yang L, Popov Y, Schuppan D, Ordog T, Mukhopadhyay D, Shah V. Opposing roles of vegf during
liver fibrosis progression and resolution. Hepatology. 2012 Oct; 56:768A.
81. *Hayashi Y, Bardsley MR, Toyomasu Y, Taguchi T, Rubin BP, Carter M, Ramachandran A, Ordog
T. Crenolanib, a highly selective platelet-derived growth factor receptor alpha/beta (pdgfra/b)
tyrosine kinase inhibitor, destabilizes etv1 protein in kit-mutant gastrointestinal stromal tumor (gist)
cells. Cancer Res. 2013 Apr 15; 73(8).
82. *Hayashi Y, Syed SA, Bardsley MR, Strege PR, Farrugia G, Ordog T. Restoration of Kit
Expression by Pharmacological Inhibition of Polycomb Group (PcG)-Mediated Epigenetic
Repression in Interstitial Cells of Cajal (ICC) Subjected to Chronic Kit Ligand (Kitl) Withdrawal
Gastroenterology. 2013 May; 144(5 Suppl 1):S-27.
83. *Watson E, Hayashi Y, Bardsley MR, Nagy RA, Toyomasu Y, Stanich JE, Taguchi T, Farrugia G,
Rubin BP, Asuzu DT, Ordog T. The Stem Cell-Targeting Drug Salinomycin Inhibits Proliferation of
Normal, Benign Hyperplastic, and Transformed Interstitial Cells of Cajal and Their Stem Cells
(ICC-SC) by Increasing the Expression of Cell Cycle Restriction Checkpoint Regulators.
Gastroenterology. 2013 May; 144(5 Suppl 1):S-3.
84. *Hayashi Y, Toyomasu Y, Bardsley MR, Mason JE, Eisenman ST, Choi KM, Linden DR,
Szurszewski JH, Rubin BP, Farrugia G, Ordog T. Hyperglycemia-Induced Hyperplasia of
Interstitial Cells of Cajal (ICC) and ICC Stem Cells (ICC-SC) Is Associated With Accelerated
Gastric Emptying in Obese Diabetic LeprDb/Db Mice. Gastroenterology. 2013 May; 144(5 Suppl
1):S-38.
85. *Syed SA, Hayashi Y, Modak MV, Tice J, Nagy RA, McGehee CD, Farrugia G, Asuzu DT, Ordog T.
Epigenetic Regulation of Kit Expression in Murine KitLow Interstitial Cell of Cajal Stem Cells
(ICC-SC) and KitLow Gastrointestinal Stromal Tumor (GIST) Cells by Polycomb Group (PcG)
Repressive Complexes (PRC). Gastroenterology. 2013 May; 144(5 Suppl 1):S-52.
86. *Nagy RA, Watson E, Hayashi Y, Bardsley MR, Strege PR, Taguchi T, Gibbons SJ, Farrugia G,
Asuzu DT, Ordog T. Autophagy and Multidrug Resistance Limit the Efficacy of Salinomycin (Sal) in
Gastrointestinal Stromal Tumor (GIST) Cells and Stem Cells (SC) for Interstitial Cells of Cajal
(ICC). Gastroenterology. 2013 May; 144(5 Suppl 1):S-872.
87. Ordog T, Eisenman ST, Bardsley MR, Milosavljevic S, Gajdos GB, Gibbons SJ, Farrugia G.
Selective reduction of kit(low) interstitial cell of cajal stem cells in ano1 knockout mice.
Neurogastroenterol Motil. 2013 Sep; 25:45.
88. *Hayashi Y, Toyomasu Y, Milosavljevic S, Nagy RA, Holtz Heppelmann CJ, Bergen HR, Shen KR,
Linden DR, Szurszewski JH, Farrugia G, Ordog T. Neuronal Nitric Oxide Synthase (Nos1)
Regulates Body Weight Following Chronic Dietary Restriction. Gastroenterology. 2014 May; 146(5
Suppl 1):S-136.
89. Mazzone A, Gibbons SJ, Bernard CE, Nowsheen S, Middha S, Almada LL, Ordog T, Kendrick ML,
Reid Lombardo KM, Shen KR, Galietta LJ, Fernandez-Zapico ME, Farrugia G. IL-4 via STAT6
Regulates a Promoter for the Human Ano1 Gene. Gastroenterology. 2014 May; 146(5 Suppl
1):S-526.
Tamas Ordog, MD
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90. *Dave M, Gajdos BG, Svingen PA, Faubion WA, Ordog T. Adult Stem Cells for Murine Interstitial
Cells of Cajal Suppress Cellular Immunity via PGE2 Secretion. Gastroenterology. 2014 May; 146(5
Suppl 1):S-62.
91. *Syed SA, Lee JH, Yan H, Zhang Z, Hayashi Y, Ordog T. Genome-Wide Epigenetic Determinants
of Interstitial Cell of Cajal (ICC) Dysfunction. Gastroenterology. 2014 May; 146(5 Suppl 1):S-91.
Miscellaneous
1. Ordog T. Interactions between membranebound and intracellular hormone receptors in estrogen
target tissues. M.D. Thesis, (in Hungarian), University of Pecs Medical School, Hungary. 1988.
* Indicates that the primary author was a mentee of this author.