7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE Scientific Program 15 October 2014, Wednesday 05:30 - 6:00 pm Welcome Ceremony Kok Onn Lee John Kopchick Terry Wood Venue 16 October 2014, Thursday Venue Summit 2 PL Plenary Lecture Chair: Pinchas Cohen Los Angeles, United States Summit 2 06:00 - 07:00 pm OL1 The William H Daughaday Lecture Chair: Adrian Herington Brisbane, Australia Intervening in Ageing to Prevent Ageing-related Disease Linda Partridge London, United Kingdom 07:00 - 08:00 pm Welcome Reception Room 334 08:00 - 08:30 am PL1.1 08:30 - 09:00 am PL1.2 09:00 - 09:30 am IGF-like Signaling of Drosophila Marc Tatar Rhode Island, United States Effects of Growth Hormone Releasing Hormone on Visceral Fat, Metabolic and Cardiovascular Indices in Human Studies Steve Grinspoon Massachusetts, United States Break Room 334 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 16 October 2014, Thursday Venue 16 October 2014, Thursday 09:30 - 11:15 am OR1 GH Clinical: Orals 1 Actions and Applications Chair: Jens Otto Jørgensen Aarhus, Denmark Summit 2 09:30 - 11:15 am OR2 IGF Basic: Orals 1 IGFBP Chair: Briony Forbes Adelaide, Australia Christian Strasburger Berlin, Germany Venue Room 331 Youngman Oh Virginia, United States 09:30 am OR1-1 GH Treatment Modulates Mortality in Adult onset GH Deficiency and Discordant Socio-Economic Status is Apparent Kirstine Stochholm Aarhus University Hospital Aarhus, Denmark 09:30 am OR2-1 Impaired mTORC1 Activity Up-Regulates IGFBP-1 Synthesis During Dietary Protein Restriction Asako Takenaka Meiji University Kanagaw, Japan 09:45 am OR1-2 Impairment of Anaerobic Capacity in Adults with GH Deficiency Ken Ho Princess Alexandra Hospital Brisbane, Australia 10:00 am OR1-3 The Molecular Mechanism of Dominantly Inherited Short Stature Caused by GH Polymers Zida Wu Charité, Universitätsmedizin Berlin Berlin, Germany 09:45 am OR2-2 The Mitochondrial Peptide Humanin has Fasting Mimetic Activity Leading to Suppression of Circulating IGF-I and Increases in IGFBP-1 Levels Jialin Xiao University of Southern California Los Angeles, United States 10:15 am OR1-4 Successful GH Treatment for Severe Growth Failure in Pediatric Patients with Anorexia Nervosa Juliane Leger Robert Debre Hospital Paris, France 10:00 am OR2-3 The Cardin-Weintraub Motif Present in IGFBP-2 is Required for Growth and Function of the Mouse Brain Nancy Schindler Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Germany 10:30 am OR1-5 Short Term Low Dose GH Therapy Improves Insulin Sensitivity But Does Not Affect Cortisol Metabolism and Ectopic Fat Accumulation in GH Deficient Adults Kevin Yuen Oregon Health & Science Univeristy Portland, United States 10:15 am OR2-4 Exogenous Administration of Protease-Resistant, Non Matrix-Binding IGFBP-2 Inhibits Tumour Growth in a Murine Model of Breast Cancer Cher-Lynn Soh University of Adelaide Adelaide, Australia 10:30 am OR2-5 Linkage of Reproductive Development, Fat Metabolism and Life-Span by the RGD-Motif of IGFBP-2 in Female Transgenic Mice Andreas Hoeflich Leibniz Institute for Farm Animal Biology (FBN) Dummerstorf, Germany 10:45 am OR1-6 Combination Medical Therapy for Acromegaly: The ACROSTUDY Experience Beverly MK Biller Massachusetts General Hospital Boston, United States 10:45 am OR2-6 Cyclic Glycine-Proline is a Regulator that Dynamically Controls IGF-1 Homeostasis through Altering IGF-1 Binding to IGFBP3 Jian Guan University of Auckland Auckland, New Zealand 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 16 October 2014, Thursday 15-18 October 2014 • SINGAPORE Venue Guided Poster Tour & Lunch 11:15 am - 12:45 pm GP1 GH Basic Chairs:John Kopchick Athens, United States Venue Room 334 Pinchas Cohen Los Angeles, United States GP1-1 Growth hormone targets expression of specific lipolytic genes to promote lipolysis of white adipose tissue Yi Ying Law Perdana University Graduate School of Medicine Serdang, Malaysia GP1-2 Autocrine human Growth Hormone suppression of E-CADHERIN via p44/42 MAPK promotes Epithelial-to-Mesenchymal Transition (EMT) of Colorectal Carcinoma cells Jingjing Wang National University of Singapore, Department of Pharmacology Singapore GP1-3 Role of growth hormone (GH) signaling pathways in the development of atherosclerosis Mayumi Ishikawa Nippon Medical School Kawasaki, Japan GP1-4 Mortality in patients with non-functioning pituitary adenoma with and Late Breaking without growth hormone replacement therapy. Acase-controlled study in more than 400 patients Daniel Olsson Sahlgrenska University Hospital Gothenburg, Sweden 16 October 2014, Thursday 11:15 am - 12:45 pm GP2 IGF Basic Chair: Jeff Holly Bristol, United Kingdom Room 334 GP2-1 IGF-I Ameliorates Hepatic Fibrosis in Mouse Models of Non-Alcoholic Steatohepatitis and Cirrhosis via Inhibiting the Activity or Hepatic Stellate Cells Hitoshi Nishizawa Kobe University Graduate School of Medicine Kobe, Japan GP2-2 The Deubiquitinating Enzyme, USP9X Positively Regulates Insulin-like Growth Factor (IGF)-Dependent Cell Growth by Inhibition of Degradation of IGF-I Receptor (IGF-IR) and Insulin Receptor Substrate (IRS)-2 in Prostate Cancer Cells Haruka Furuta The University of Tokyo Tokyo, Japan GP2-3 The Role of the Insulin Receptor in Breast Cancer Progression Derek LeRoith Rambam Health Care Campus Haifa, Israel GP2-4 Insulin-like Growth Factor Binding Protein (IGFBP)-1 and its RGD Domain: Favorable in Vivo Actions in Glucose Regulation Natalie Haywood University of Leeds Leeds, United Kingdom GP2-5 Hyperglycaemia Induces Chemo-Resistance of Breast Cancer Cells via Regulating IGFBP-2/Oestrogen Receptor (ERα) Interactions: Role of ERa Phosphorylation Li Zeng University of Bristol Bristol, United Kingdom GP2-6 Differential effects of IGFBP-6 on migration of two ovarian cancer cell lines Leon Bach Monash University Melbourne, Australia GP2-7 The IGF/IGFR pathway regulates axial patterning during early... The IGF/IGFR Late Breaking pathway regulates axial patterning during early neural development in mammal Nozomu Takata RIKEN, Center for Developmental Biology Kobe, Japan 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 16 October 2014, Thursday Venue PL Plenary Lecture Chair: Shin Takahashi Tokyo, Japan Summit 2 12:45 - 01:15 pm PL1.3 01:15 - 01:45 pm PL1.4 Data on Efficacy of Long-acting Growth Hormone Luo Xiaoping Wuhan, China Taking the Stress Out of Breast Cancer: Role of the IGFBPs Claire Perks Bristol, United Kingdom 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 16 October 2014, Thursday 02:00 - 05:00 pm SY1 Growth Hormone Symposium Supported by an unrestricted educational grant from Novo Nordisk Session 1 Chairs:Pinchas Cohen Los Angeles, United States 15-18 October 2014 • SINGAPORE Venue SY2 IGFs, Isulin and IGFBPs in Cancer Chair: Rob Baxter Sydney, Australia 02:00 pm SY2-1 Insulin-like Growth Factor 2 mRNA Binding Proteins (IMP/IGF2BP) as mRNA Safe Houses in Cancer and Development Finn Nielsen Copenhagen, Denmark 02:30 pm SY2-2 The IRS proteins: Determinants of IGF-1R Signaling and Tumor Metabolism Leslie Shaw Massachusetts, United States 02:50 pm SY1-3 Dosing and Monitoring GH Treatment in Children Born SGA Juliane Leger Paris, France 03:15 pm SY1-4 Dosing and Monitoring GH treatment in Turner’s Syndrome Toshiaka Tanaka Tokyo, Japan Break Session 2 Chairs:Ken Ho Brisbane, Australia Jens S Christiansen Aahus, Denmark 04:00 pm SY1-5 GH Replacement in Adult GHD: Long-term Efficacy and Safety Gudmundur Johansson Gothenburg, Sweden 04:25 pm SY1-6 Growth Hormone and Sarcopenia - Future Aspects Michael Thorner Charlottesville, United States 04:50 pm SY1-7 Abuse of Growth Hormone Christian Strasburger Berlin, Germany 05:15 pm Room 331 Anne-Marie Kappelgaard Copenhagen, Denmark 02:25 pm SY1-2 Dosing and Monitoring GH Treatment in GH Deficient Children Pinchas Cohen Los Angeles, United States Venue Summit 2 02:00 pm SY1-1 Metabolic Actions of GH Throughout Life-span Jens Otto Jørgensen Aarhus, Denmark 03:40 pm 16 October 2014, Thursday Question & Answer Room 334 03:00 pm SY2-3 Obesity, Diabetes and Cancer Risk: Identifying Causal Factors Emily Gallagher Newark, United States 03:30 pm Break Room 334 04:00 pm SY2-4 IGFBP-2 in Cancer: From The Matrix to The Inside Job Vince Russo Melbourne, Australia Room 331 Summit 2 04:30 pm SY2-5 The G protein Estrogen Receptor (GPER) is involved in IGF-I/Insulin Signaling in Cancer Cells Marcello Maggiolini Cosenza, Italy 05:00 pm Question & Answer 05:15 - 06:15 pm IGF General Meeting Room 331 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 17 October 2014, Friday Venue PL Plenary Lecture Chair: Leon Bach Melbourne, Australia Summit 2 08:00 - 08:30 am PL2.1 Not So Simple: Splicing News on Somatostatin and Ghrelin Justo P Castaño Córdoba, Spain 08:30 - 09:00 am PL2.2 IGF-II and IGF2R in Cancer, Structure and Function Bass Hassan Oxford, United Kingdom 09:00 - 09:30 am PL2.3 Nuclear IGF Receptors - A New Layer of Signalling Control Haim Werner Tel Aviv, Israel 09:30 - 10:00 am Break Room 334 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 17 October 2014, Friday Venue 17 October 2014, Friday 10:00 - 11:30 am OR3 GH Basic: Orals 1 Secretion and Actions Chair: Ken Ho Brisbane, Australia Summit 2 10:00 - 11:30 am OR4 IGF Clinical: Orals Chair: Naomi Hizuka Tokyo, Japan Jorgen Isgaard Gothenburg, Sweden 10:00 am OR3-1 Spatial Learning, Memory and Signalling Crosstalk: Genomic and Behavioural Analysis of Wild Type versus GH Modified (BGH and GHA) Mice Amrita Basu Ohio University Athens, United States 10:15 am OR3-2 GH Enhances Spine Density in Amygdalar Neurons Barbara Gisabella Massachusetts Instutite of Technology Cambridge, United States 10:30 am OR3-3 Liver-specific (LiGHRKO) and fat-specific (FaGHRKO) growth hormone receptor gene disrupted mice demonstrate paradoxical longevity and provide evidence for GH stimulated liver/adipose tissue-crosstalk Edward List Ohio University Athens, United States 10:45 am OR3-4 GH activated STAT5 is required for Induction of Beige Fat in Inguinal White Adipose Tissue Caroline Nelson Univeristy of Queensland Brisbane, Australia 11:00 am OR3-5 NPY Neurons as a Critical Hypothalamic Node for the Control of GH Release Relative to Food Intake Frederik Steyn Univeristy of Queensland Brisbane, Australia 11:15 am OR3-6 Loss of Acyl-Ghrelin Signalling in Male Ghrelin-O-Acyltransferase Knock-out Mice Results in Reduced Pulsatile GH Secretion and a Derangement in GH Pulse Pattern Teresa Xie Univeristy of Queensland Brisbane, Australia Derek LeRoith Haifa, Israel 10:00 am OR4-1 Randomised Controlled Clinical Trial Contrasting Current GH Doses with Dose based on IGF-I titration in Children Born Small for Gestational Age (NESGAS) Rikke B Jensen Univeristy of Cambridge Cambridge, United Kingdom 10:15 am OR4-2 Growth Hormone is a More Potent Growth Stimulating Hormone than IGF-I; Clinical Perspective Zvi Laron Schneider Children’s Medical Center Petah Tikva, Israel 10:30 am OR4-3 Safety and Effectiveness of Increlex® Therapy in Children Enrolled in the Increlex Growth Forum Database (IGFD) in Europe: 4-year Interim Results Peter Bang Linköping University Linköping, Sweden 10:45 am OR4-4 The Causal Role of IGFs and IGFBPs in Prostate Cancer: a Mendelian Randomization Study Jeff Holly University of Bristol Bristol, United Kingdom 11:00 am OR4-5 IGF Bioactivity in Sera and Pleural Effusions from Patients Suspected of Lung Cancer Jan Frystyk Aarhus University Aarhus, Denmark 11:15 am OR4-6 The Expression of Insulin-Like Growth Factor Type 1 Receptor (IGF1R) is Increased in Obese Children Carlos Martinelli Ribeirão Preto Medical School-USP Ribeirão Preto, Brazil Venue Room 331 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 17 October 2014, Friday 15-18 October 2014 • SINGAPORE Venue Guided Poster Tour & Lunch 11:30 am - 01:15 pm GP3 GH Clinical Poster Tour Chairs:Frederik Steyn Brisbane, Australia 17 October 2014, Friday Venue Rom 334 Gudmundur Johannsson Gothenburg, Germany GP3-1 Growth hormone (GH) replacement has a beneficial effect on glycosylated haemoglobin (HbA1c) levels in adult patients with GH deficiency (GHD) enrolled in the NordiNet® International Outcome Study (IOS) Effie Pournara Novo Nordisk Health Care AG Zurich, Switzerland GP3-2 Rosiglitazone treatment : Acromegaly Patients do not differ from normal Type 2 Diabetics in their IGFBP-1 and Insulin dynamics with euglycemic glucose clamp Mya Thway Tint National University of Singapore Singapore GP3-3 The Diagnostic Accuracy of Pegvisomant-Primed Glucagon Stimulation Test (PV-GST) Compared To Insulin Tolerance (ITT) And Glucagon Stimulation (GST) Tests In Evaluating Adult Growth Hormone (GH) Reserve Kevin Yuen Oregon Health & Science Univeristy Portland, United States GP3-4 Discordance Of Post-Surgical Nadir GH During OGTT And Serum IGF-I Levels In Patients With Acromegaly Izumi Fukuda Tokyo Women’s Medical University Tokyo, Japan 11:30 am - 01:15 pm GP4 IGF Clinical Poster Tour Chair: Peter Bang Linköping, Sweden Room 334 GP4-1 Loss of PI 3-Kinase-Binding Protein PI3KAP/XB130 Suppresses Thyroid Function and Induces Enlargement of Thyroid Glands in Mice. Daisuke Yamanaka Nippon Medical School Kawasaki, Japan GP4-2 Effects of Heparin Administration on the Generation of IGFBP-4 Fragments During PCI Treatment of ST-Elevation Myocardial Infarction Patients Rikke Hjortebjerg Aarhus University Aarhus, Denmark Epigenetic Analyses of the Insulin-like Growth Factor Binding Protein 1 Gene in Diabetes and Diabetic Nephropathy Harvest Gu Karolinska Institutet Stockholm, Sweden GP4-3 GP4-4 SGA Short Stature Bearing with a Novel Nonsense Mutation (p.W1219X) in the IGF1R gene Masanobu Fujimoto Tottori University Yonago, Japan GP4-5 Circulating Levels of Insulin-like Growth Factor-1(IGF-I)/Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in Obese Patients: the State of Type 2 Diabetes Min Sun Kim Chonbuk National University Medical School Jeonju-si, Korea GP4-6 Effects of GH/IGF-I Axis on Retinal Vascular Morphology: Retinal Vascular Morphology in Laron Syndrome Z. Alev Ozon Hacettepe University, Faculty of Medicine Ankara, Turkey GP4-7 Late Breaking ProIGF-II not matureIGF-II promotes estrogen independent breast cancer growth and metastasis in a SCID and Nude mouse model: Differential signallng mechanisms thru IGF and Insulin receptors and phosphorylation/ activation of estrogen and progesterone receptors. Daisy De Leon Loma Linda University United States 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 17 October 2014, Friday Venue PL Plenary Lecture Chair: Michael J Waters Brisbane, Australia Summit 2 01:15 - 01:45 pm PL2.4 01:45 - 02:15 pm PL2.5 02:15 - 02:45 pm PL2.6 Prolactin, STAT5 and Prostate Cancer Marja Tuili Nevulainen Philadelphia, United States 02:45 - 03:15 pm Break Growth Hormone in Prader-Willi Syndrome Cheri Deal Montreal, Canada mTOR Regulation and the Control of Cell and Organismal Growth Joseph Avruch Massachusetts, United States Room 334 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 17 October 2014, Friday Venue 17 October 2014, Friday 03:15 - 04:45 pm OR5 GH Basic Orals 2: Prolactin, Signalling & Cancer Chair: Peter Lobie Singapore Summit 2 03:15 - 04:45 pm OR6 IGF Basic: Orals Physiology Chair: Rosemary O’Connor Cork, Ireland Jan Frustuk Aarhus, Denmark 03:30 pm OR5-2 Rabbits are a Suitable Animal Model for the Pre-Clinical Development of Growth Hormone Agonists and Antagonists Max Bielohuby Medizinische Klinik und Poliklinik IV München, Germany Terresa Wood Newark, United States 03:30 pm OR6-2 IRS-1 Promotes Embryonic Growth of Zebrafish through IGF-IR Signal- Dependent and Independent Mechanisms in Response to Developmental Stages and Environmental Oxygen Availability Hirayasu Kamei The University of Tokyo Tokyo, Japan 03:45 pm OR5-3 A GH Antagonist Fusion with GH Binding Protein is Biologically Active, Shows Delayed Clearance and Inhibits Growth in a Rabbit Model Ian Wilkinson University of Sheffield Sheffield, United Kingdom 03:45 pm OR6-3 Early Postnatal Nutritional Programming of Growth Involves GHRH Neurons Axon Growth Stimulation by Leptin & IGF-I Laurent Kappeler Inserm Paris, France 04:00 pm OR5-4 The Choice of hGH Receptor Signalling Pathway Determines Longevity Yash Chhabra Institute for Molecular Bioscience, University of Queensland Brisbane, Australia 04:15 pm OR5-5 Autocrine hGH Stimulated miRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer Weijie Zhang University of Science and Technology of China/Hefei National Laboratory for Physical Sciences at Microscale Hefei, China 04:00 pm OR6-4 Sustained IGF-II Production is Necessary for Adult Neurogenesis Steven W. Levison Rutgers University Newark, United States 04:15 pm OR6-5 Sexual Dimorphism of Insulin like Growth Factor I in Exercise V.A. Munive Herrera Cajal Institute Madrid, Spain 04:30 pm OR6-6 Dermal Fibroblast Secreted IGF-I Protects Skin Keratinocytes Against Ultraviolet B Radiation Induced Damage D.R. Van Lonkhuyzen Institute for Health and Biomedical Innovation Kelvin Grove, Australia 04:30 pm OR5-6 Amplified Stem/Progenitor Cells in a Mouse Model of Prostate Tumorigenesis Induced by Autocrine Prolactin L Sackmann Sala Inserm Paris, France GRS General Assembly Room 331 03:15 pm OR6-1 Dicarba Modification of Insulin Peptides Results in Lower Mitogenic Activity Signaled via IGF-1R and IR than Insulin Shee Chee Ong Flinders University Adelaide, Australia 03:15 pm OR5-1 Mechanism of Activation of JAK2 by Growth Hormone Michael J Waters University of Queensland Brisbane, Australia 04:45 - 05:45 pm Venue Summit 2 07:00 - 10:00 pm Congress Dinner 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 18 October 2014, Saturday Venue PL Plenary Lecture Chair: Beverly MK Biller Boston, United States Summit 2 08:00 - 08:30 am PL3.1 08:30 - 09:00 am PL3.2 The Louis E Underwood Lecture: Two Years in Growth Hormone Christian Strasburger Berlin, Germany 09:00 - 09:30 am Break The Francesco Minuto Lecture: Two Years in IGF / IGFBPs Rob Baxter Sydney, Australia Room 334 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 18 October 2014, Saturday Venue 09:30 - 11:30 am OR7 GH Clinical: Orals 2 Long Acting GH Chair: Martin Bidlingmaier Munich, Germany Summit 2 18 October 2014, Saturday Venue Jens Christiansen Aarhus, Denmark 09:30 am OR7-1 A Reversible Albumin-binding GH Derivative Possesses a Promising Once-weekly Treatment Profile and is Well Tolerated in Adult Subjects with GH Deficiency Michael Rasmussen Novo Nordisk Global Development Søborg, Denmark 10:45 am OR7-6 Late Breaking Safety and Efficacy of ARX201: Six Month Dose-Ranging Study of a Novel Long-acting Pegylated Growth Hormone in Young Adults with Growth Hormone Deficiency Douglas Axelrod DW Axelrod Consultancy Rancho Santa Fe, United States 09:45 am OR7-2 The MOD-4023 Story: A Long Acting GH From Proof of Concept in Animal Models to GH Deficient Populations in Clinical Studies (Adult and Pediatric) Gili Hart OPKO Biologics Nes Ziona, Israel 11:00 am OR7-7 Late Breaking Pasireotide LAR provides superior efficacy over octreotide LAR and lanreotide ATG in patients with inadequately controlled acromegaly: A phase III, multicenter, randomized study (PAOLA) Maria Fleseriu Oregon Health Science University Portland, United States 11:15 amOR7-8 Late Breaking A Phase II Randomised, Open-Label, ParallelGroup Study of the Safety, Tolerability, Pharmacokinetics and Efficacy of TwoSubcutaneous Dosing Regimens of ATL1103 in Adult Patients with Acromegaly Peter Trainer The Christie NHS Foundation Trust Manchester, United Kingdom 10:00 am OR7-3 Safety and Efficacy Results of a 6 month, Randomized Multi-Center Trial of a Long Acting rhGH (VRS-317) in Naive to Treatment, Pre-Pubertal Children with GH Deficiency George M Bright Versartis, Inc. Redwood City, United States 10:15 am OR7-4 Late Breaking A Phase 2, six-month dose-response study to investigate TransCon hGH, a long-acting hGH, in treatment naïve children with idiopathic Growth Hormone Deficiency (IGHD) Pierre Chatelain Université Claude Bernard Lyon 1 Bron Cedex, France 10:30 am OR7-5 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TV-1106, a New Long-acting Treatment for GH Deficiency Merav Bassan Teva Pharmaceuticals Netanya, Israel 7th INTERNATIONAL CONGRESS OF THE GRS AND IGF SOCIETY 15-18 October 2014 • SINGAPORE 18 October 2014, Saturday 09:30 - 11:30 am OR8 IGF Basic: Orals Cancer Chair: Emily Gallagher Newark, United States Venue 18 October 2014, Saturday Venue Room 331 Daisy De Leon California, United States 09:30 am OR8-1 Insulin Receptor Substrate (IRS)-1 Interacts with Protein Arginine Methyltransferase 5 (PRMT5), Emerging as a Novel Regulator of Alternative Pre-mRNA Splicing Atsufumi Ozoe The University of Tokyo Tokyo, Japan 09:45 am OR8-2 Insulin-like Growth Factor Receptor Inhibition in Mammary Epithelium Enhances Wnt1-Mediated Tumors, Canonical Wnt Signaling and IGF-II/ Insulin-Receptor A Expression Teresa L. Wood NJMS Cancer Center, Rutgers University Newark, United States 10:00 am OR8-3 Role of Deubiquitinase USP7 in Signalling through IGF-1R Claire Worrall Karolinska Institutet Stockholm, Sweden 10:15 am OR8-4 A Novel Antisense Long Noncoding RNA Within the IGF1R Gene Locus is Imprinted in Hematopoietic Malignancies Andrew Hoffman Stanford University and VA Palo Alto Medical Center Palo Alto, United States 10:30 am OR8-5 Novel Mechanisms by which Nedd4-IRS-2 Complexes Enhance IGF-I signals, and their Roles in IGF-I Action in Prostate Cancer Cell Proliferation Tashiaki Fukushima Hiroshima University Hiroshima, Japan 10:45 am OR8-6 The Anti-IGF Signaling Agents Increase the Efficacy of Trabectedin in Ewing Sarcoma Cecilia Garofalo Ortopaedic Rizzoli Institute Bologna, Italy 11:00 am OR8-7 Insulin Like Growth Factor-II (IGF-II) regulates mitochondrial phenotype, Late Breaking metabolism and DNA content to prevent apoptosis and to increase energy production efficiency promoting a more aggressive and chemo resistant breast cancer disease Daisy De Leon LLUSM Loma Linda, United States 11:15 am OR8-8 Serum IGF-I measured longitudinally during pre-school years - relation to Late Breaking gender, body size, and nutrition such as essential fatty acids and vitamin D Jovanna Dahlgren Göteborg Pediatric Growth Research Center Sweden 11:30 - 12:15 pm Award and Closing Ceremony Kok Onn Lee Singapore Summit 2 Haim WernerTel Aviv Israel 12:30 am - 13:30 pm Lunch Room 334
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