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TTST 2014
The XII Thrombolysis Symposium
Thrombolysis, Thrombectomy and Acute Stroke Treatment
Oct 18-20, 2014, Mannheim/Heidelberg
Alte Aula, University of Heidelberg and Mannheim Congress Center (m:con)
Program
Saturday, October 18, 2014
Opening and Reception, Aula and Bel Etage University of Heidelberg
17.00
Transportation from Mannheim to Heidelberg Alte Aula
18.00 – 19.45 Opening Ceremony
18.00
Welcome: Werner Hacke
Greetings: Steve Davis (AUS) President WSO
Kennedy Lees (UK) President ESO
18.20
Lecture 1: Hermann Zeumer (GER)
Transvascular treatment strategies in ischemic stroke: How it all
begun
Lecture 2: Tony Furlan (USA)
The development of clinical trials for transvascular therapies
Lecture 3: Etsuro Mori (JAP)
Developing and establishing a new treatment
Lecture 4: Greg del Zoppo (USA)
Systemic or intraarterial acute recanalization
18.40
19.00
19.20
19.45-21.00
Reception
21.00
Return to Mannheim
Sunday, Oct 19, 2014
Scientific Sessions
Location:
m:con Congress Center Mannheim, all sessions at Albert Schönberg Auditorium
(except e-poster s and e-poster session at Alban Berg Room
8.00 – 9.30 Session 1: Smoke On The Water
Clinical trial update: Thrombolysis and Imaging-guided Selection
Chairpersons: Laszlo Csiba (HUN) and Gudrun Boysen (DEN)
Speakers and Topics:
Götz Thomalla (GER): Wake Up
Hemasse Amiri (GER): ECASS 4
Geoff Donnan (AUS): EXTEND
Mark Parsons (AUS): TASTE
Andrej Alexandrov (USA): CLOTBUSTER
Keith Muir (UK) ATTEST
Stephen Meairs (GER): TRUMBI and the future of sonothrombolysis
9.30 – 10.00 Break
10.00 – 11.30 Session 2: Stairway To Heaven-Highway To Hell
Critical Care of Severe Ischemic and Hemorrhagic Stroke
Chairpersons: Martin Grond (GER) and Larry Wechsler (USA)
Speakers and Topics:
Eric Juettler (GER): Decompressive surgery
Jürgen Beck (SUI): Decompression for intracranial bleeds
Stefan Schwab (GER): Hypothermia
Tom Tomsick (USA): Risks and complications of thrombectomy
Dan Hanley (USA): Intraventricular Bleeds
Phil Bath (UK): Ongoing primary ICH trials
Thorsten Steiner (GER): ATACH 2
11.30 – 12.30 Session 3: I Should Have Known Better
PRO-CON Discussion
Chairpersons: Markku Kaste (FIN) and Etsuro Mori (JAP) (tbc)
Speakers and Topics:
Topic 1: Basilar Artery Occlusion: Thrombectomy or Systemic Therapy?
Pro systemic: Wouter Schoneville (NED)
Pro thrombectomy: Gerhard Schroth (SUI)
Topic 2: M2 occlusions: Thrombectomy or Systemic Therapy?
Pro systemic: Andrew Demchuk (CDN)
Pro thrombectomy: Mirko Pham (GER)
12.30 – 13.00 Break
13.00 – 14.00 Symposium:
Part 1: Recent Trial Results: It´s Now Or Never
Chairpersons: Wade Smith (USA) and Christophe Cognard (FRA)
Diederick Dippel (NL): MR CLEAN: Design, Epidemiology and Safety
Rüdiger von Kummer (GER): DIAS 3: Design, Rationale and Safety
Osama Zaidat (USA): New technical developments
Part 2: Round Table: We´re Not Gonna Take It
Communicating the scientific integrity of the i.v. -thrombolysis trials
Participants and writing group: Timothy Ingall (USA) Chair)
Peter Sandercock (UK), Pat Lyden (USA), Stephen Davis (AUS), Ken
Lees (UK) John Marler (USA), Werner Hacke (GER), Ed Jauch (USA)
14.00 – 15.45 Session 4: The Final Countdown
Clinical Trial Update: Interventional
A Joint Session with ESMINT, supported by an unrestricted educational
grant by Covidien
Chairpersons: Istvan Szikora (HUN) and Juan Arenillas (ESP)
Speakers and Topics:
Jeff Saver (USA): SWIFT PRIME 4 min each
Pooja Kathri (USA): THERAPY
Martin Bendszus (GER): THRILL
Tudor Jovin (USA): DAWN, ESCAPE, REVASCAT
Serge Bracard (FRA): THRACE
Jaap Kapelle (NED): BASICS
Sheila Martins (BRA): RESILIENT
Keith Muir (UK): PISTE
Tiago Moreira (SWE): SITS-Open
15.45-16.00 Break
16.00 – 17.00 Session 5: With A Little Help From My Friends
Peri-interventional Therapy
(supported by an unrestricted educational grant by Stryker)
Chairpersons: Michael Söderman (SWE) and Gene Sung (USA)
Speakers and Topics:
Laurent Pierot (FRA): Conscious sedation
Julian Bösel (GER): Anesthesia: For whom and how?
Patrick Lyden (USA): Neuroprotection by thrombin-inhibitors
Michael Hill (CDN): Improving collateral flow
17.00 – 19.30 Poster Session
Chairpersons: Takenori Yamaguchi (JAP) and Phil Teal (CDN)
18.30 – 19.30 Session 6: Imagine (Imaging)
Consensus document: How much Imaging is needed for thrombectomy?
(Partially in parallel with e-poster session)
A Joint Session with STIR-VISTA:
Chairpersons: Steven Warach (USA) and Heinrich Mattle (SUI)
Writing group:
Marie Luby (USA), Max Wintermark (USA) (Co-Chairs)
Joanna Wardlaw (UK), Greg Albers (USA), Marten Lansberg (USA),
Geoff Donnan (AUS), Peter Schellinger (GER), Steven Warach (USA),
David Liebeskind (USA), Jochen Fiebach (GER), Antoni Davalos ESP),
Jens Fiehler (GER), Catherine Oppenheim (FRA), Christophe
Cognard (FRA)
Monday Oct 20, 2014
Location:
m:con Congress Center Mannheim, all sessions at Albert Schönberg Auditorium
8.00 – 9.30 Session 7: Nothing Else Matters
Improving treatment delivery
A joint session with the WSO
Chairpersons: Steve Davis (AUS) and Valeria Caso (ITA)
Speakers and Topics:
Edward Jauch (USA): Improving Emergency room standards
Turgut Tatlisumak (FIN): Telemedicine
Heinrich Audebert (GER): Preclinical thrombolysis: The Berlin model
Jim Grotta (USA): Prehospital selection and lysis in Texas
Christopher Levi (AUS): Improving thrombolysis uptake: The
Australian experience
Peter Ringleb (GER): Populationwide implementation of
thrombolysis
Lee Schwamm (USA): Thrombolysis in USA and Canada: Get with the
guidelines
Jeyaraj Pandian (IND): Challenges and obsticles for thrombolysis in
India
Ayrton Massaro (BRA): Challenges and obsticles for thrombolysis in
South- America
9.30 – 10.00 Break
10.00 – 11.30 Session 8: Message In A Bottle
Advanced Imaging Selection
Chairpersons: Mark Fisher (USA) and Jean Claude-Baron (FRA)
Speakers and Topics:
Catherine Oppenheim (FRA): Penumbral selection for thrombolysis
and thrombectomy
Olav Jansen (GER): Clot Imaging
David Liebeskind (USA): Assessing collateral flow
Ashfaq Shuaib (CDN): Thrombectomy or thrombolysis without
collaterals
Keith Muir (UK): Multimodal CT for Imaging selection
Matthias Endres (GER): Recanalization or reperfusion - what
correlates better with outcome
11.30 – 12.30 Session 9: Help!
Difficult Decisions in Recanalization:
Supported by an unrestricted educational grant (Bayer Healthcare)
Chairpersons: Antoni Davalos (ESP) and Patrik Michel(SUI)
Speakers and Topics:
Stefan Entgelter (SUI): Dissection and Vasculitis
Domenico Inzitari (ITA): Patients with high risk cardiac disease and
triple therapies
Richard Lindley (AUS): Severe Stroke in over 80 year old patients
Christian Hametner (GER): Progressive stroke, partial occlusion and
low dose lysis
12.30 – 13.00 Break
13.00 – 14.00 Symposium: Won´t Get Fooled Again
Special Aspects in Thrombolysis
Supported by an unrestricted educational grant (Boehringer Ingelheim)
Chairpersons: Raul Nogueira (USA) and Danilo Toni (ITA)
Speakers and Topics:
Roland Veltkamp (UK/GER): The acute ischemic stroke patients
treated with novel anticoagulants
Joe Broderick (USA): The cost of interventions and standard
thrombolysis
Peter Schellinger (GER): Logistics for I.V and I.A. treatment
Opeolu Adeoye (USA): Recanalization and Lysis in patients with
agressive platelet inhibition
14.00 – 15.30 Session 10: Land of Confusion
Improving trial design for acute stroke trials
A joint session with ESO
Chairpersons: Nils Wahlgren (SWE) and John Marler (USA)
Speakers and Topics:
Greg Albers (USA): How clinical equipoise has influenced recent
clinical trials
George Howard (USA): Non-Traditional Clinical Trial Designs – An
Opportunity for Savings?
Joan Montaner (ESP): Biomarkers and prognostic in trial protocols?
Ken Lees (UK): How to measure outcome in recanalization trials?
15.30 – 16.00 Break
16.00 – 16.30 Special Lecture: Paint It, Black
Outcome after severe stroke: What is acceptable? And who decides?
Claude Hemphill (USA)
16.30 – 17.30 Session 11: Brothers In Arms
Pooled Analyses and Registries: New Results
Chairpersons: Peter Sandercock (UK) and Erich Bluhmki (GER)
Speakers and Topics:
Mikael Mazighi (USA): Impact of Onset to Reperfusion Time on
Stroke Mortality, Bleeding, and Treatment Efficacy
John Emberson (UK): New aspects from the pooled analysis
Christoph Gumbinger (GER): Statewide thrombolysis results are
similar to the results of pooled analyses:
Oliver Singer (GER): Outcome Prediction in endovascular stroke
treatment: Data from the ENDOSTROKE registry
Michael Mazya (SWE): News from SITS
17.30 – 18.00 Session 12a: The Dark Side Of The Moon
Recanalization associated Bleeding Complications
Chairpersons: Andreas Unterberg (GER) and Jorge Villacura (CHI)
Speakers and Topics:
Daniel Strbian (FIN): Predicting hemorrhagic risk for thrombolysis
and thromectomy
Kazunori Toyoda (JPN): Bleedings are different in Asia-what are the
consequences?
18.00 - 19.00 Session 12b: Here Comes The Sun
The Heidelberg Bleeding Classification: A classification of bleeding
events for reporting in trials and scientific papers - Consensus proposal
Writing Group:
Rüdiger von Kummer (GER), Joe Broderick (USA) (Co-Chairs)
Nils Wahlgren (SWE), Werner Hacke (GER),
Daniel Strbian (FIN), Will Whiteley (UK), Jeff Saver (USA)
19:00 Summary and Farewell: Werner Hacke (GER)
Hereby we inform the public about the financial support by the industry according to their membership
in the FSA e.V. (Freiwillige Selbstkontrolle für die Arzneimittelindustrie e.V.), im AKG e.V. (Arzneimittel
und Kooperation im Gesundheitswesen).
So far (Aug 20, 2014), we have received the following contributions:
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Bayer AG (Leverkusen, GER) € 10.000
Boehringer Ingelheim (Ingelheim, GER) € 50.000
Penumbra Europe (Berlin GER) € 5.000
Stryker Europe € 15.000
Lundbeck (Copenhagn DEN) € 10.000
Covidien Europe € 10.000