2015 Winter Meeting on Translational Heart Failure Research Organized by the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the ESC Les Diablerets, Switzerland, January 21 – 24, 2015 1 Day 1 Thursday, 22.01.2015 08:00 – 08:10 Gerasimos Filippatos Welcome from the President of the HFA Session 1 Chairs: Genome Biology in Myocardial Research Johannes Backs (DE), Emilio Hirsch (IT) 08:10 – 08:35 Josef Penninger Genome wide functional genetics in haploid cells Eileen Furlong Coordinated regulation of cardiac transcription factors Vincent Christoffels High-resolution model of the 3D structure of cardiac genomic loci Timothy McKinsey Chromatin-based therapeutics for heart failure 08:35 – 09:00 09:00 – 09:25 09:25 – 09:50 09:50 – 10:20 Coffee Break Session 2 Chairs: Hypertrophic cardiomyopathy Nazha Hamdani (DE/NL), Zoltán Papp (HU) 10:20 – 10:40 Burkert Pieske The clinical problem Björn Knollmann Focal energy deprivation as a new mechanism for arrhythmias Jolanda van der Velden Tension cost in HCM Thomas Eschenhagen How Ca2+ sensitivity affects mitochondrial redox Lucie Carrier Gene therapy 10:40 – 11:05 11:05 – 11:30 11:30 – 11:55 11:55 – 12:20 12:30 Lunch 17:00 – 19:45 Poster Session Poster Judges Denise Hilfiker-Kleiner (Chair) Rodolphe Fischmeister Mauro Giacca Adelino Leite-Moreira Frank Heinzel Lars S. Maier 20:00 Dinner (GR) (AT) (DE) (NL) (US) (AT) (US) (NL) (DE) (DE) (DE) (FR) (IT) (PT) (AT) (DE) 2 Day 2 Friday, 23.01.2015 Session 3 Chairs: Ageing: Hallmarks and Principles Ajay Shah (UK), Eva van Rooij (NL) 08:00 – 08:25 Maria Blasco Hallmarks of Ageing Nilesh Samani Shortening of telomeres during cardiac ageing Giovanni Camici Age-related endothelial dysfunction Stefanie Dimmeler Therapeutic approaches of cardiac ageing 08:25 – 08:50 08:50 – 09:15 09:15 – 09:40 (ES) (UK) (CH) (DE) 09:40– 10:10 Coffee Break Session 4 Chairs: Mitochondria: Dynamics, autophagy and redox control Christoph Maack (DE), Barbara Casadei (UK) 10:10 – 10:35 Luca Scorrano Linking mitochondrial fusion to cardiomyocyte differentiation Gerald Dorn Novel functions of mitofusin-2 for mitophagy Michael Ristow The concept of mitohormesis in aging Anthony Schapira Therapeutic lessons from neurodegenerative diseases 10:35 – 11:00 11:00 – 11:25 11:25 – 11:50 11:55 – 12:30 Chairs: (IT) (US) (CH) (UK) Brutsaert Lecture Dirk Brutsaert (BE), Gerd Hasenfuß (DE) Introduction: Gerd Hasenfuß (DE) Walter Paulus Heart Failure with preserved ejection fraction 12:30 Group Photograph 12:45 Lunch 16:30 – 17:15 Poster viewing with coffee (NL) 3 Session 5 Chairs: Vascular aspects of cardiac disease Jean-Luc Balligand (BE), Frank Ruschitzka (CH) 17:00 – 17:25 Christian Weber (DE) Chemokine ligand/receptor axis in endothelial dysfunction and cardiovascular disease Andreas Papapetropoulos (GR) The role of gasotransmitters NO, CO, H2S in cardiovascular diseases David Attwell (UK) Role of pericytes in regulation of coronary flow Dirk J. Duncker (NL) Microvascular dysfunction underlying cardiovascular diseases: lessons from large animal models 17:25 – 17:50 17:50 – 18:15 18:15 – 18:40 Debate Session: Stem Cells in Heart Failure trials Do they have a future? 18:45 – 19:05 19:05 – 19:25 No! Yes! 19:25 – 20:00 General debate Moderators: Alexander Lyon (UK), Gerasimos Filippatos (GR) Discussion panel: Andreas Zeiher Karin Sipido Wolfram H. Zimmermann from 20:15 Dinner and announcement of poster prize winners Loren Field Stefan Janssens (US) (BE) (DE) (BE) (DE) 4 Day 3 Saturday, 24.01.2015 Session 6 Chairs: Long non-coding RNAs Manuel Mayr (UK), Thomas Thum (DE) 08:30 – 08:55 Thierry Pedrazzini Enhancer derived lncRNAs Daniel Teupser Trans-regulation of Gene networks by lncRNAs Yvan Devaux lncRNS as biomarkers Ching-Pin Chang Protective lncRNAS in hypertrophy 08:55 – 09:20 09:20 – 09:45 09:45 – 10:05 10:05 – 10:25 Coffee Break Session 7 Chairs: Fibrosis: Biology and clinical impact Stephane Heymans (NL), Guido Tarone (IT) 10:25 – 10:45 Johann Bauersachs Fibrosis as a clinical target Sylvia M. Evans Origin of cardiac fibroblasts Hans J. de Haas Molecular imaging of the cardiac extracellular matrix Liliane Schaefer Proteoglycans mediated Toll-like receptor signalling in fibrosis. Rudolf A. de Boer Revival of galectin-3: Biomarker and therapeutic target! 10:45 – 11:10 11:10 – 11:35 11:35 – 12:00 12:00 – 12:25 12:25 – 12:30 Concluding remarks (Christoph Maack) 12:45 Lunch 13:15 Departure of bus to Geneva (CH) (DE) (LU) (US) (DE) (US) (NL) (DE) (NL) 5