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2014 124: 2617-2754
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23 OCTOBER 2014 x VOLUME 124, NUMBER 17
CONTENTS
COVER FIGURE
Prior to the appearance of polyploid megakaryocytes, the early embryo generates
platelets from a population of diploid cells. This image shows proplatelets being
generated in vitro after the culture of E10.5 yolk sac cells. See the article by
Potts et al on page 2725.
INSIDE BLOOD COMMENTARIES
2617
The fat and the skinny on acute lung injury
James C. Zimring
Comment on Ortiz-Muñoz et al, page 2625
2618
A novel treatment of anemia of inflammation
Andrea U. Steinbicker
Comment on van Eijk et al, page 2643
2619
MDS-related mutations in aplastic anemia
Seishi Ogawa
Comment on Kulasekararaj et al, page 2698
2620
Diploid, not polyploid: new platelet producers
Eriko Nitta and Atsushi Iwama
Comment on Potts et al, page 2725
2622
Stress-enhanced translation of g-globin mRNA
Jane-Jane Chen
Comment on Hahn and Lowrey, page 2730
2623
KIR B or not to be?...that is the question for ALL
Michael R. Verneris and Jeffrey S. Miller
Comment on Oevermann et al, page 2744
PLENARY PAPER
2625
Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and
attenuates acute lung injury in mice
Guadalupe Ortiz-Muñoz, Beñat Mallavia, Adriaan Bins, Mark Headley, Matthew F. Krummel,
and Mark R. Looney
HOW I TREAT
2635
How I treat myelofibrosis
Francisco Cervantes
CLINICAL TRIALS AND
OBSERVATIONS
2643
Brief Report
Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease
in serum iron in humans
Lucas T. van Eijk, Aaron S. E. John, Frank Schwoebel, Luciana Summo, St´ephanie Vaul´eon,
Stefan Z¨ollner, Coby M. Laarakkers, Matthijs Kox, Johannes G. van der Hoeven,
Dorine W. Swinkels, Kai Riecke, and Peter Pickkers
vii
BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17
CONTINUED ON viii
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HEMATOPOIESIS AND
STEM CELLS
2647
Epigenetic control of dendritic cell development and fate determination of common
myeloid progenitor by Mysm1
Haejung Won, Vijayalakshmi Nandakumar, Peter Yates, Suzi Sanchez, Lindsey Jones,
Xue F. Huang, and Si-Yi Chen
IMMUNOBIOLOGY
2657
Fine-mapping of HLA associations with chronic lymphocytic leukemia in
US populations
Loren Gragert, Stephanie Fingerson, Mark Albrecht, Martin Maiers, Matt Kalaycio,
and Brian T. Hill
2666
Human T-follicular helper and T-follicular regulatory cell maintenance is
independent of germinal centers
Elizabeth F. Wallin, Elaine C. Jolly, Ondˇrej Such´anek, J. Andrew Bradley, Marion Esp´eli,
David R. W. Jayne, Michelle A. Linterman, and Kenneth G. C. Smith
LYMPHOID NEOPLASIA
2675
Pyk2 promotes tumor progression in multiple myeloma
Yu Zhang, Michele Moschetta, Daisy Huynh, Yu-Tzu Tai, Yong Zhang, Wenjing Zhang,
Yuji Mishima, Jennifer E. Ring, Winnie F. Tam, Qunli Xu, Patricia Maiso, Michaela Reagan,
Ilyas Sahin, Antonio Sacco, Salomon Manier, Yosra Aljawai, Siobhan Glavey, Nikhil C. Munshi,
Kenneth C. Anderson, Jonathan Pachter, Aldo M. Roccaro, and Irene M. Ghobrial
2687
A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma
through a novel link between autophagy and apoptosis
Shuang Chen, Yu Zhang, Liang Zhou, Yun Leng, Hui Lin, Maciej Kmieciak, Xin-Yan Pei,
Richard Jones, Robert Z. Orlowski, Yun Dai, and Steven Grant
MYELOID NEOPLASIA
2698
Somatic mutations identify a subgroup of aplastic anemia patients who progress to
myelodysplastic syndrome
Austin G. Kulasekararaj, Jie Jiang, Alexander E. Smith, Azim M. Mohamedali, Syed Mian,
Shreyans Gandhi, Joop Gaken, Barbara Czepulkowski, Judith C. W. Marsh, and Ghulam J. Mufti
2705
TET2 mutations predict response to hypomethylating agents in myelodysplastic
syndrome patients
Rafael Bejar, Allegra Lord, Kristen Stevenson, Michal Bar-Natan, Albert P´erez-Ladaga,
Jacques Zaneveld, Hui Wang, Bennett Caughey, Petar Stojanov, Gad Getz,
Guillermo Garcia-Manero, Hagop Kantarjian, Rui Chen, Richard M. Stone,
Donna Neuberg, David P. Steensma, and Benjamin L. Ebert
PHAGOCYTES,
GRANULOCYTES, AND
MYELOPOIESIS
2713
Monocytic cell differentiation from band-stage neutrophils under inflammatory
conditions via MKK6 activation
Ren´e K¨offel, Anastasia Meshcheryakova, Joanna Warszawska, Annika Hennig, Karin Wagner,
Almut J¨orgl, Daniela Gubi, Doris Moser, Anastasiya Hladik, Ulrike Hoffmann,
Michael B. Fischer, Wim van den Berg, Marije Koenders, Clemens Scheinecker,
Bernhard Gesslbauer, Sylvia Knapp, and Herbert Strobl
PLATELETS AND
THROMBOPOIESIS
2725
Brief Report
A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte
formation in the mouse embryo
Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben,
Emma C. Josefsson, Lachlan W. Whitehead, Kelly L. Rogers, Anna Liakhovitskaia,
Gordon K. Smyth, Benjamin T. Kile, Alexander Medvinsky, Warren S. Alexander,
Douglas J. Hilton, and Samir Taoudi
viii
BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17
CONTINUED ON x
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RED CELLS, IRON, AND
ERYTHROPOIESIS
2730
Brief Report
Induction of fetal hemoglobin through enhanced translation efficiency of g-globin
mRNA
Cynthia K. Hahn and Christopher H. Lowrey
TRANSPLANTATION
2735
T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin
compared with matched sibling HSCT and unrelated HSCT
Yi Luo, Haowen Xiao, Xiaoyu Lai, Jimin Shi, Yamin Tan, Jingsong He, Wanzhuo Xie,
Weiyan Zheng, Yuanyuan Zhu, Xiujin Ye, Xiaohong Yu, Zhen Cai, Maofang Lin,
and He Huang
2744
Brief Report
KIR B haplotype donors confer a reduced risk for relapse after haploidentical
transplantation in children with ALL
Lena Oevermann, Sebastian U. Michaelis, Markus Mezger, Peter Lang, Jacek Toporski,
Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, and Rupert Handgretinger
BLOOD WORK
2748
Digital imaging of peripheral blood identifies atypical chronic lymphocytic
leukemia
Steven Marionneaux and Larry Smith
2749
Caught in transformation
Mina L. Xu and Dennis Cooper
CORRESPONDENCE
2750
Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia
in a Chinese patient
Gang Liu, Shanshan Guo, Gregory J. Anderson, Clara Camaschella, Bing Han,
and Guangjun Nie
2752
Bortezomib is a rapid mobilizer of hematopoietic stem cells in mice via modulation
of the VCAM-1/VLA-4 axis
Armin Ghobadi, Michael P. Rettig, Matthew L. Cooper, Matthew S. Holt, Julie K. Ritchey,
Linda Eissenberg, and John F. DiPersio
OTHER DEPARTMENTS
xxxi
iib
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BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17