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From www.bloodjournal.org by guest on November 20, 2014. For personal use only. 2014 124: e45-3176 124 (20) Updated information and services can be found at: http://www.bloodjournal.org/content/124/20.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on November 20, 2014. For personal use only. 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20 CONTENTS COVER FIGURE Confocal fluorescence micrograph of an in vitro–derived CD1031 dendritic cell depicting CD103 antibody staining (yellow), phalloidin for F-actin (magenta), and nucleus counterstain with DAPI (cyan) of a cytospin preparation. The newly described protocol, termed iCD103, efficiently generates CD1031 dendritic cells from murine bone marrow. See the article by Mayer et al on page 3081. INSIDE BLOOD COMMENTARIES 3035 Engraftment’s Holy Grail: is one signal enough? Majlinda Lako and Lyle Armstrong Comment on Ramos-Mej´ıa et al, page 3065 3036 How to generate large numbers of CD1031 dendritic cells Lianne van de Laar and Bart N. Lambrecht Comment on Mayer et al, page 3081 3038 HiJAKing T-ALL Vahid Asnafi Comment on Degryse et al, page 3092 3040 Stress equips CLL cells to survive Rudi W. Hendriks Comment on Krysov et al, page 3101 3041 Cautious enthusiasm about GWAS findings France Gagnon Comment on Ma et al, page 3155 PERSPECTIVES 3043 Curing myeloma at last: defining criteria and providing the evidence Bart Barlogie, Alan Mitchell, Frits van Rhee, Joshua Epstein, Gareth J. Morgan, and John Crowley HOW I TREAT 3052 How I treat patients with massive hemorrhage P¨ar I. Johansson, Jakob Stensballe, Roberto Oliveri, Charles E. Wade, Sisse R. Ostrowski, and John B. Holcomb CLINICAL TRIALS AND OBSERVATIONS 3059 Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab) Constantine S. Tam, Susan O’Brien, William Plunkett, William Wierda, Alessandra Ferrajoli, Xuemei Wang, Kim-Anh Do, Jorge Cortes, Issa Khouri, Hagop Kantarjian, Susan Lerner, and Michael J. Keating HEMATOPOIESIS AND STEM CELLS 3065 HOXA9 promotes hematopoietic commitment of human embryonic stem cells Veronica Ramos-Mej´ıa, Oscar Navarro-Montero, Ver´onica Ayll´on, Clara Bueno, Tamara Romero, Pedro J. Real, and Pablo Menendez 3076 Brief Report Growth hormone receptor signaling is dispensable for HSC function and aging Morag H. Stewart, Paula Gutierrez-Martinez, Isabel Beerman, Brian Garrison, Emily J. Gallagher, Derek LeRoith, and Derrick J. Rossi xi BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20 CONTINUED ON xii From www.bloodjournal.org by guest on November 20, 2014. For personal use only. e45 e-Blood Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice Linping Hu, Hui Cheng, Yingdai Gao, Ming Shi, Yanfeng Liu, Zheng Hu, Jing Xu, Lugui Qiu, Weiping Yuan, Anskar Yu-Hung Leung, Yong-Guang Yang, and Tao Cheng IMMUNOBIOLOGY 3081 Selective and efficient generation of functional Batf3-dependent CD1031 dendritic cells from mouse bone marrow Christian Thomas Mayer, Peyman Ghorbani, Amrita Nandan, Markus Dudek, Catharina Arnold-Schrauf, Christina Hesse, Luciana Berod, Philipp St¨uve, Franz Puttur, Miriam Merad, and Tim Sparwasser LYMPHOID NEOPLASIA 3092 JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model Sandrine Degryse, Charles E. de Bock, Luk Cox, Sofie Demeyer, Olga Gielen, Nicole Mentens, Kris Jacobs, Ellen Geerdens, Valentina Gianfelici, Gert Hulselmans, Mark Fiers, Stein Aerts, Jules P. Meijerink, Thomas Tousseyn, and Jan Cools 3101 Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK Sergey Krysov, Andrew J. Steele, Vania Coelho, Adam Linley, Marina Sanchez Hidalgo, Matthew Carter, Kathleen N. Potter, Benjamin Kennedy, Andrew S. Duncombe, Margaret Ashton-Key, Francesco Forconi, Freda K. Stevenson, and Graham Packham 3110 Differential and limited expression of mutant alleles in multiple myeloma Naim U. Rashid, Adam S. Sperling, Niccolo Bolli, David C. Wedge, Peter Van Loo, Yu-Tzu Tai, Masood A. Shammas, Mariateresa Fulciniti, Mehmet K. Samur, Paul G. Richardson, Florence Magrangeas, Stephane Minvielle, P. Andrew Futreal, Kenneth C. Anderson, Herve Avet-Loiseau, Peter J. Campbell, Giovanni Parmigiani, and Nikhil C. Munshi 3118 FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma Marion J. Vogel, Linka Xie, Hanfeng Guan, Reuben M. Tooze, Thomas Maier, Ulrike Kostezka, Harald J. Maier, Karlheinz Holzmann, Fong Chun Chan, Christian Steidl, Jonathan B. Reichel, Clarissa D. Weitzer, Franziska Gehringer, Anita B. Kick, Ethel Cesarman, Mikhail Roshal, Randy D. Gascoyne, Peter M¨oller, Thomas Wirth, and Alexey Ushmorov MYELOID NEOPLASIA 3130 The TAK1-NF-kB axis as therapeutic target for AML Matthieu Cornelis Johannes Bosman, Hein Schepers, Jennifer Jaques, Annet Zwaantien Brouwers-Vos, Wim Johannes Quax, Jan Jacob Schuringa, and Edo Vellenga PLATELETS AND THROMBOPOIESIS 3141 Interaction of platelet-derived autotaxin with tumor integrin aVb3 controls metastasis of breast cancer cells to bone Raphael Leblanc, Sue-Chin Lee, Marion David, Jean-Claude Bordet, Derek D. Norman, Renukadevi Patil, Duane Miller, Debashish Sahay, Johnny Ribeiro, Philippe Cl´ezardin, Gabor J. Tigyi, and Olivier Peyruchaud RED CELLS, IRON, AND ERYTHROPOIESIS 3151 Brief Report Cell-type–specific transcriptional regulation of PIGM underpins the divergent hematologic phenotype in inherited GPl deficiency Joana R. Costa, Valentina S. Caputo, Kalliopi Makarona, D. Mark Layton, Irene A. G. Roberts, Antonio M. Almeida, and Anastasios Karadimitris xii BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20 CONTINUED ON xiv From www.bloodjournal.org by guest on November 20, 2014. For personal use only. THROMBOSIS AND HEMOSTASIS 3155 Genetic variants in PLG, LPA, and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels Qianyi Ma, Ayse B. Ozel, Shweta Ramdas, Beth McGee, Rami Khoriaty, David Siemieniak, Hong-Dong Li, Yuanfang Guan, Lawrence C. Brody, James L. Mills, Anne M. Molloy, David Ginsburg, Jun Z. Li, and Karl C. Desch 3165 Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda, Takehisa Kitazawa, Tetsuhiro Soeda, Tomoyuki Igawa, Zenjiro Sampei, Taichi Kuramochi, Akihisa Sakamoto, Kenta Haraya, Kenji Adachi, Yoshiki Kawabe, Keiji Nogami, Midori Shima, and Kunihiro Hattori 3172 Brief Report In vitro evidence of a tissue factor-independent mode of action of recombinant factor VIIa in hemophilia Cecilia Augustsson and Egon Persson BLOOD WORK 3175 Small-cell variant of ALK1 anaplastic large-cell lymphoma with a leukemic phase Huifei Liu and Shafinaz Hussein 3176 Granular lymphoid cells are not always part of T-cell lineage: an atypical case of mantle cell lymphoma Emmanuel Benayoun and Orianne Wagner-Ballon OTHER DEPARTMENTS iib Classifieds SUBMISSION INSTRUCTIONS All manuscripts, including figures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Office by phone at 202-776-0548 or via e-mail at [email protected]. xiv BLOOD, 13 NOVEMBER 2014 x VOLUME 124, NUMBER 20
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