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2014 Canada Gairdner Recipients’ Lecture
University of Toronto – Macleod Auditorium
Thursday, October 30, 2014 – 9:00 am – 2:40 pm
Thursday, October 30, 2014
9:00 am – 9:05 am
Opening Session - Welcome Remarks
9:05 am – 9:10 am
Introduction of speakers
Dr. John Dirks
President & Scientific Director, The Gairdner
Foundation
Chair – Dr. Alison Buchan, Vice Dean Research &
International Relations, Faculty of Medicine,
University of Toronto
2014 Canada Gairdner Recipients’ Lecture
9:10 am - 9:40am (30 mins)
How shelterin solves the telomere end
protection problem
9:40 am – 10:10 am (30 mins)
VPF/VEGF: Vascular permeability &
pathological angiogenesis in tumors, wounds &
chronic inflammation
10:10 am -10:30 am (20 mins)
10:30 am -11:00 am (30 mins)
Health Break
The VEGF story: From basic discoveries to
treating cancer & preventing blindness
11:00 am-11:30 am
(30 mins)
The impact of anti-TNF therapy on the
treatment of rheumatoid arthritis and other
chronic inflammatory diseases
Lessons from antiTNF therapy
11:30 am – 12:00 pm
(30 mins)
12:00 pm - 1:00 pm (Lunch by
invitation only)
Dr. Titia de Lange
2014 Canada Gairdner International Laureate,
Rockefeller University, New York, NY, USA
Dr. Harold Dvorak
2014 Canada Gairdner International Laureate,
Beth Israel Deaconess Medical Center, Boston,
MA, USA
Dr. Napoleone Ferrara
2014 Canada Gairdner International Laureate,
University of California, San Diego, La Jolla, CA,
USA
Dr. Ravinder Maini
2014 Canada Gairdner International Laureate,
University of Oxford, Oxford, UK
Sir. Marc Feldmann
2014 Canada Gairdner International Laureate,
University of Oxford, Oxford, UK
Lunch/Networking
2014 Canada Gairdner Recipients’ Lecture
1:00 pm – 1:05 pm (5 mins)
Introduction of speakers
1:05 am -1:35 pm
(30 mins)
Targeting immune checkpoints in cancer
therapy
1:35 pm - 2:05 pm (30 mins)
A gift from the earth: The origins of Ivermectin
2:05 pm - 2:35 pm (30 mins)
Why does cardiovascular disease vary between
populations?
2:35 pm – 2:40 pm (5 mins)
Closing Remarks
Dr. Henry Friesen
1977 Canada Gairdner Laureate, 2001 Canada
Gairdner Wightman Laureate, Distinguished
Professor, University of Manitoba, Manitoba,
Manitoba, CA
Dr. James Allison
2014 Canada Gairdner International Laureate,
University of Texas, Houston, USA
Dr. Satoshi Omura
2014 Canada Gairdner Global Health Laureate,
Kitasato University, Tokyo, Japan
Dr. Salim Yusuf
2014 Canada Gairdner Wightman Laureate,
McMaster University, Hamilton, ON, CA
Dr. John Dirks
President & Scientific Director, The Gairdner
Foundation
2014 Gairdner Symposium
New Advances in Biology and Treatment of Cancer
University of Toronto – Macleod Auditorium
Friday, October 31, 2014 – 8:45 a.m. – 4:00 p.m.
Friday, October 31, 2014
8:45 am – 9:00am
Opening Session - Welcome Remarks
9:00 am – 9:10 am
Introduction of speakers
Dr. Cal Stiller, 2010 Canada Gairdner Wightman
Laureate
Chair Dr. Tom Hudson
President & Scientific Director, Ontario Institute of
Cancer Research
New Advances in Biology and Treatment of Cancer
9:10 am - 9:40am (30 mins) &
10 min. Q&A
The breadth and value of cancer research
9:50 am – 10:20 am (30 mins)
Stem cells in cancer: Do they matter?
10:20 am - 10:50 am
(30 mins)
Epigenetic therapy meets immunology
10:50 am -11:05 am (15 mins)
11:05 am -11:10 am (5 mins)
Health Break
Introduction of speakers
11:10 am-11:40 am
(30 mins)
What cancer is teaching us about cellular
metabolism
11:40 am – 12:10 pm
(30 mins)
Oncolytic Viruses: Replicating Biological
Machines for Cancer Therapy
12:10 pm - 1:00 pm
Lunch/Networking (invitation only)
Dr. Harold Varmus
1984 Gairdner Laureate, Director, National Cancer
Institute, Bethesda, MD, USA
Dr. John Dick
Senior Scientist, Princess Margaret Cancer Centre;
Professor, Department of Molecular Genetics,
University of Toronto; Director, Cancer Stem Cell
Program, OICR, Toronto
Dr. Stephen Baylin
Deputy Director, The Sydney Kimmel
Comprehensive Cancer Center at Johns Hopkins,
Baltimore, MD, USA
10:40 am -10:55 am (15 mins)
Linda Rabeneck, VP, Prevention & Cancer Control,
Cancer Care Ontario, Toronto, CA
Dr. Craig B. Thompson
President, Memorial Sloan-Kettering Cancer
Center, New York, NY, USA
Dr. John Bell,
Senior Scientist, Cancer Therapeutics, Ottawa
Hospital Research Institute
New Advances in Biology and Treatment of Cancer
1:00 pm - 1:05 pm (5 mins)
Introduction of speakers
1:05 am -1:35 pm
(30 mins)
Understanding and overcoming resistance to
anticancer therapy with kinase Inhibitors:
changing the landscape of practice with
lessons from rare tumors
Combination Approaches in Cancer
Immunotherapy
1:35 pm – 2:05 pm (30 mins)
2:05 pm – 2:20 pm (15 mins)
2:20 pm – 2:25 pm (5 mins)
Health Break
Introduction of speakers
2:25 pm – 2:55 pm (30 mins)
PD-1 Pathway blockade: mobilizing the immune
system to treat cancer
2:55 pm -3:25 pm (30 Mins)
CAR therapy and the promise of T cell
engineering
3:25 pm – 4:00 pm
Round Table Discussion
4:00 pm
Closing Remarks
Dr. Michael Julius, Vice President, Research,
Sunnybrook Research Institute, Sunnybrook Health
Sciences Center, Toronto, CA
Dr. George Demetri
Director, Ludwig Center at Harvard, Director, Center
for Sarcoma & Bone Oncology, Harvard Medical
School, Boston, MA, USA
Dr. Jedd Wolchok
Director, Center for Mechanism Based Therapy,
Memorial Sloan-Kettering Cancer Center, NY, NY, USA
Dr. Chris Paige, Vice President of Research, UHN,
Toronto, CA
Dr. Suzanne Topalian
Director, Melanoma Program, Kimmel Cancer
Center, Baltimore, MD, USA
Dr. Michel Sadelain, Director, Center for Cell
Engineering, Memorial Sloan Kettering Cancer
Center, New York, USA
All speakers plus Dr. James Allison and Dr.
Napoleone Ferrara
Dr. John Dirks, President & Scientific Director, The
Gairdner Foundation