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4-Nov-14
Larry Reynolds
University Distinguished Professor
Office: 209B Morrill Hall
Phone: (701) 231-7646 or (701) 205-4105
Email: [email protected] (preferred), or
[email protected] (secondary)
Brief Biography
For more than 35 years, the goal of Dr. Reynolds’ program has been to
improve both fertility (the ability to conceive and to maintain pregnancy) and
pregnancy outcomes (i.e., birth weights and postnatal health) in livestock,
both of which have major scientific, health, and socioeconomic implications
for humans as well.
Dr. Reynolds and collaborators in the U.S., Australia, Europe, and South
America have impacted the field in several ways. They helped establish that placental (uterine and umbilical) blood
flows are key to normal placental function (i.e., transport capacity) throughout gestation. Subsequently, they were the
first to show that the placenta produces angiogenic factors, which drive the dramatic vascular development of the
placenta. Recognizing that placental growth also is critical, they were among the first to develop methods to evaluate
the rate of cell turnover (cell proliferation and apoptosis) in tissues in vivo. More recently, Dr. Reynolds and coworkers showed that the placenta, and especially its vascular development and function, are key mediators by which
maternal stressors such as malnutrition affect pre- and postnatal well-being, and were among the first to recognize
and investigate the potential impact of ‘developmental programming’ in livestock production. They also have shown
profound effects of assisted reproductive technologies on placental vascular development very early in pregnancy.
They currently are investigating therapeutic and management strategies to improve fertility and pregnancy outcomes,
and in addition are investigating the role of fetal and maternal steroids in the processes of fetal organ maturation and
birth.
Dr. Reynolds has been PI or Co-PI on 35 federal grants from NIH, NSF, and USDA, totaling more than $10
million. He has published more than 200 book chapters and journal articles including 26 invited reviews
(http://www.ncbi.nlm.nih.gov/pubmed?term=reynolds%20lp). His publications have been cited more than 8,100 times.
As a result of his research efforts he has received the American Society of Animal Science’s Animal Growth and
Development Award, the American Society of Animal Science’s Animal Physiology and Endocrinology Award, the
st
Eugene R. Dahl Excellence in Research Award at NDSU, and the 51 NDSU Faculty Lectureship.
Dr. Reynolds has taught more than 20 different undergraduate and graduate courses in cell biology,
endocrinology, growth biology, and reproductive biology, and mentored more than 35 undergraduate research
interns, 13 graduate students, and 30 postdoctoral fellows, visiting scientists and junior faculty. He also is Co-Director
of the Frontiers in Reproduction summer course at the Marine Biological Lab in Woods Hole, MA
(http://courses.mbl.edu/FIR/Home.html).
Dr. Reynolds has co-organized or spoken at 45 national/international symposia and held 15 Visiting
Professorships and Keynote Speakerships throughout the world. Since 1986, he has served on or chaired more than
50 federal grant-review panels for NIH and USDA. He also is involved with a national effort promoting farm animals
as dual-use models for agricultural and biomedical research (http://www.adsbm.msu.edu). From 2005 to 2008, Dr.
Reynolds served as Editor-in-Chief of the Journal of Animal Science, the world’s top-ranked Animal Science journal.
He was named ‘University Distinguished Professor of Animal Sciences’ at NDSU in 2008.
Center for Nutrition and Pregnancy (CNP)
Dr. Reynolds is a founding Director of the Center for Nutrition and Pregnancy (http://www.ag.ndsu.edu/cnp/aboutcnp), which has extensive research and educational efforts that address issues critical to long-term health, well-being,
and productivity of both livestock and humans.
Selected Recent and Key Publications (from more than 200 refereed articles and book chapters) – these
include top-cited articles in each of three major journals – Biol Reprod, J Anim Sci, and Reproduction) – for
all pubs, see: http://www.ncbi.nlm.nih.gov/pubmed?term=reynolds%20lp
Shukla P, Ghatta S, Dubey N, Lemley CO, Johnson ML, Modgil A, Vonnahme K, Caton JS, Reynolds LP, Sun C,
O’Rourke ST. Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing
factor-like pathway in sheep fetal coronary arteries. Amer J Physiol: Heart Circ; (In press; accepted 08 May 2014).
Quinn KE, Ashley AK, Reynolds LP, Grazul-Bilska AT, Ashley RL. Activation of the CXCL12/CXCR4 signaling axis
may drive vascularization of the ovine placenta. Domestic Animal Endocrinol 2014; 47:11-21.
Reynolds LP, Grazul-Bilska AT, Palmieri C, Borowicz PP. 2014. Placental vascular defects in cloned embryos and
other 'compromised' pregnancies. In: Advances in Fetal and Neonatal Physiology (Zhang L and Ducsay C,
eds.), Advances in Experimental Medicine and Biology Series, Springer Science+Business Media, NY. (In press).
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Bio for ANSC web page – Lawrence P. Reynolds, Ph.D. – 4-Nov-14 – Page 2 of 3
Grazul-Bilska AT, Johnson ML, Borowicz PP, Baranko L, Redmer DA, Reynolds LP. Placental development during early
pregnancy in sheep: Effects of embryo origin on fetal and placental growth and global methylation. Theriogenology 2013;
79:94-102.
Meyer, A. M., T. L. Neville, J. J. Reed, J. B. Taylor, L. P. Reynolds, D. A. Redmer, C. J. Hammer, K. A. Vonnahme, and J. S.
Caton. 2013. Maternal nutritional plane and selenium supply during gestation impacts visceral organ mass and intestinal
growth and vascularity of neonatal lamb offspring. J. Anim. Sci. 91:2628-2639.
Neville TL, Meyer AM, Reyaz A, Borowicz PP, Redmer DA, Reynolds LP, Caton JS, Vonnahme KA. Mammary gland growth
and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane
during gestation, J Anim Sci Biotech 2013; 4:6. doi: 10.1186/2049-1891-4-6.
Reynolds LP, Vonnahme KA, Lemley CO, Redmer DA, Grazul-Bilska AT, Borowicz PP, Caton JS. Maternal stress and
placental vascular function and remodeling. Invited review. Current Vascular Pharmacol, Hot Topic Issue ‘Uteroplacental
Circulation and Fetal Vascular Function and Development,” L Zhang (ed.) 2013; 11:564-593.
Vonnahme KA, Neville, TL, Lekatz LA, Reynolds LP, Hammer CJ, Redmer DA, Caton JS. Thyroid hormones and cortisol
concentrations in offspring are influenced by maternal supranutritional selenium and nutritional plane in sheep. Nutrition
and Metabolic Insights 2013; 6:11-21.
Vonnahme KA, Neville, TL, Perry GA, Redmer DA, Reynolds LP, Caton JS. Maternal dietary intake alters organ mass and
endocrine and metabolic profiles in pregnancy ewe lambs. Anim Reprod Sci 2013; 141:131-141.
Yunusova RD, Neville TL, Vonnahme KA, Hammer CJ, Reed JJ, Taylor JB, Redmer, DA, Reynolds LP, Caton JS. Impacts of
maternal selenium supply and nutritional plane on visceral tissues and intestinal biology in 180-day-old offspring in sheep.
J Anim Sci 2013; 91:2229-2242.
Camacho LE, Meyer AM, Neville TL, Hammer C, Redmer DA, Reynolds LP, Caton JS, Vonnahme KA. Neonatal hormone
changes and growth in lambs born to dams receiving differing nutritional intakes and selenium supplementation during
gestation. Reproduction 2012; 144:23-35.
Grazul-Bilska AT, Borowczyk E, Bilski JJ, Reynolds LP, Redmer DA, Caton JS, Vonnahme KA. Overfeeding and underfeeding
have detrimental effects on oocyte quality measured by in vitro fertilization and early embryonic development in sheep.
Domestic Anim Endocrinol 2012; 43:289-298.
Meyer AM, Caton JS, Hess BW, Ford SP, Reynolds LP. 2012. Chapter 14: Epigenetics and effects on the neonate that may
impact feed efficiency. In: Feed Efficiency in the Beef Industry, pp. 199-224 (Hill R ed.), Wiley-Blackwell, Hoboken, NJ
(ISBN 978-0-470-95952-7).
Redmer DA, Milne JS, Aitken RP, Johnson ML, Borowicz PP, Reynolds LP, Caton JS, Wallace JM. Decreasing maternal
nutrient intake during the final third of pregnancy in previously overnourished adolescent sheep: Effects on maternal
nutrient partitioning and feto-placental development. Placenta 2012; 33:114-121.
Reynolds LP, Caton JS. Role of the pre- and post-natal environment in developmental programming of health and productivity.
Invited Review. Molecular and Cellular Endocrinology, Special Issue ‘Environment, Epigenetics and Reproduction,” MK
Skinner (ed.) 2012; 354:54-59.
Reynolds LP, Vonnahme KA, Lemley CO, Redmer DA, Grazul-Bilska AT, Borowicz PP, Caton JS. Maternal stress and
placental vascular function and remodeling. Invited Review. Current Vascular Pharmacol, Hot Topic Issue ‘Uteroplacental
Circulation and Fetal Vascular Function and Development,” L Zhang (ed.) 2012; In press.
Wang H, Zhao J, Huang Y, Yan X, Meyer AM, Du M, Vonnahme KA, Reynolds LP, Caton JS, Zhu MJ. Effects of maternal
plane of nutrition and elevated dietary selenium in first parity ewes on inflammatory response in the ovine neonatal gut. J
Anim Sci 2012; 90:325-333.
Grazul-Bilska AT, Johnson ML, Borowicz PP, Minten MA, Bilski JJ, Wrobleski R, Velimirovich M, Coupe L, Redmer DA,
Reynolds LP. Placental development during early pregnancy in sheep: Cell proliferation, global methylation and
angiogenesis in fetal placenta. Reproduction 2011; 141:529-540.
Lekatz LA, Wu G, Caton JS, Taylor JB, Reynolds LP, Redmer DA, Vonnahme KA. Maternal selenium supplementation and
timing of nutrient restriction in pregnant sheep: Impacts on nutrient availability to the fetus. J Anim Sci. 2011; 89:59-76.
Meyer AM, Reed JJ, Neville TL, Thorson JF, Maddock-Carlin KR, Taylor JB, Reynolds LP, Redmer DA, Luther JS, Hammer
CJ, Vonnahme KA, Caton JS. Nutritional plane and selenium supply during gestation affect
yield and nutrient composition of colostrum and milk in primiparous ewes. J Anim Sci. 2011;
89:1627-39.
Hafez S, Borowicz P, Reynolds L, Redmer D. Maternal and fetal microvasculature in sheep
placenta across several stages of gestation. J Anat 2010; 216:292-300 (A figure from this
paper [right] appeared on the journal cover, March 2010).
Longo LD, Reynolds LP. Historical Perspective on placental developmental biology. Invited
Review. Internat J Develop Biol, Special Issue ‘Placental Developmental Biology,” JS Hunt
and KL Thornburg (eds.) 2010; 54:237-255.
Reynolds LP, Borowicz PP, Caton JS, Vonnahme KA, Luther JS, Hammer CJ, Maddock Carlin
KR, Grazul-Bilska AT, Redmer DA. Developmental programming: The concept, large animal
models, and the key role of utero-placental vascular development. Invited Review. J Anim
Sci 2010; 88 (Suppl. 13):E61-E72.
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Bio for ANSC web page – Lawrence P. Reynolds, Ph.D. – 4-Nov-14 – Page 3 of 3
Reynolds LP, Borowicz PP, Grazul-Bilska AT, Redmer DA. Utero-placental vascular development and placental function: An
update. Invited Review. International J Develop Biol, Special Issue ‘Placental Developmental Biology,” JS Hunt and KL
Thornburg (eds.) 2010; 54:355-366.
Reynolds LP, Ireland JJ, Caton JS, Bauman DE, Davis TA. Commentary on domestic animals in agricultural and biomedical
research: an endangered enterprise. J Nutr. 2009;139(3):427-8.
Roberts, RM, Smith GW, Bazer FW, Cibelli J, Seidel GE Jr, Bauman DE, Reynolds LP, Ireland JJ. Policy Forum: Farm Animal
Research in Crisis. Science 2009; 324:468-469.
Borowicz PP, Hafez S, Redmer DA, Reynolds LP. Chapter 10. Methods for evaluating uteroplacental angiogenesis and their
application using animal models. In: Methods in Enzymology, Vol. 445, Angiogenesis, In Vivo, Part B. pp. 229-53. (D
Cheresh, ed.) 2008. Elsevier, NY.
Grazul-Bilska, A.T., D.A. Redmer, J.J. Bilski, A. Jablonka-Shariff, V. Doraiswamy and L.P.
Reynolds. 1998. Gap junctional proteins, connexin 26, 32 and 43 in sheep ovaries throughout
the estrous cycle. Endocrine 8:269-279 (A figure from this paper [right] appeared on the
journal cover, June 1998).
Vonnahme KA, Zhu MJ, Borowicz PP, Geary TW, Hess BW, Reynolds LP, Caton JS, Means WJ,
Ford SP. Effect of early gestational undernutrition on angiogenic factor expression and
vascularity in the bovine placentome. J. Anim Sci. 2007; 85:2464-2472.
Borowicz PP, Arnold DR, Johnson ML, Grazul-Bilska AT, Redmer DA, Reynolds LP. Placental
growth throughout the last two-thirds of pregnancy in sheep: Vascular development and
angiogenic factor expression. Biol Reprod 2007; 76:259-267 (A top-cited article appearing
in the 2007-08 issues of Biology of Reproduction).
Palmieri C, Loi P, Reynolds LP, Ptak G, Della Salda L. Placental abnormalities in ovine somatic
cell clones at term: A light and electron microscopic investigation. Placenta 2007; 28:577-584,
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doi:10.1016/j.placenta.2006.08.003.
Vonnahme KA, Redmer DA, Borowczyk E, Bilski JJ, Johnson ML, Reynolds LP, Grazul-Bilska AT. Vascular composition,
apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F2α-induced regression in
sheep. Over 50 citations since 2006. Reproduction 2006; 131:1115-1126. (A top-50 most-cited article all-time for
Reproduction).
Reynolds, L.P. and D.A. Redmer. 2001. Mini-review: Angiogenesis in the placenta. Invited Review – over 250 citations
since 2001. Biol. Reprod. 64:1033-1040 (A top-50 most-cited and most-read article all-time for Biology of
Reproduction).
Reynolds, L.P., A.T. Grazul-Bilska and D.A. Redmer. 2000. Angiogenesis in the corpus luteum. Invited Review – over 170
citations since 2000. Endocrine 12:1-9.
Reynolds, L.P. and D.A. Redmer. 1995. Utero-placental vascular development and placental function. Invited Review – over
185 citations since 1995. J. Anim. Sci. 73:1839-1851 (The #6 most-cited article all-time for Journal of Animal
Science).
Jin L, Reynolds LP, Redmer DA, Caton JS, Crenshaw JD. Effects of dietary fiber in intestinal growth, cell proliferation, and
morphology in growing pigs. J Anim Sci 1994; 72:2270-2278. Over 150 citations since 1994.
Zheng, J., P.M. Fricke, L.P. Reynolds and D.A. Redmer. 1994. Evaluation of growth, cell
proliferation, and cell death in bovine corpora lutea throughout the estrous cycle. Biol.
Reprod. 51:623-632. Over 110 citations since 1994.
Jablonka-Shariff, A., A.T. Grazul-Bilska, D.A. Redmer and L.P. Reynolds. 1993. Growth and
cellular proliferation of ovine corpora lutea throughout the estrous cycle. Endocrinology
133:1871-1879. Over 130 citations since 1993 (A figure from this paper [right]
appeared on the journal cover, October 1993).
Reynolds, L.P., S.D. Killilea and D.A. Redmer. 1992. Angiogenesis in the female reproductive
system. Invited Review – 350 citations since 2001. FASEB J. 6:886-892.
Magness, R.R., J.M. Huie, G.L. Hoyer, T.P. Huecksteadt, L.P. Reynolds, G.J. Seperich, G.
Whysong and C.W. Weems. 1981. Effect of chronic ipsilateral or contralateral intrauterine
infusion of prostaglandin E2 (PGE2) on luteal function of unilaterally ovariectomized ewes.
Prostaglandins and Medicine 6:389-401. Over 100 citations since 1981.
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