From www.bloodjournal.org by guest on November 14, 2014. For personal use only. 2014 124: 2895-3034 124 (19) Updated information and services can be found at: http://www.bloodjournal.org/content/124/19.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on November 14, 2014. For personal use only. 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19 CONTENTS COVER FIGURE Hyaluronan is detected on the endothelial surface, in subendothelial tissues, and in germinal centers of B-cell follicles of a reactive lymph node. For comparison with Hodgkin lymphoma, see the article by Fhu et al on page 2973. INSIDE BLOOD COMMENTARIES 2895 Heparan sulfate: a stem cell therapy target? Timothy S. Olson Comment on Saez et al, page 2937 2897 Lymphotoxin-a keeps the gate open for T-cell inﬁltration in cHL Uta E. H¨opken Comment on Fhu et al, page 2973 2898 Hit the spleen, JAK! Steven W. Lane and Ann Mullally Comment on Wang et al, page 2987 2900 Leukemia cells make ruthless competitors Ravi Bhatia Comment on Kagoya et al, page 2996 2901 Identifying mutant pathways in the histiocytoses H. Miles Prince Comment on Chakraborty et al, page 3007, and on Emile et al, page 3016 PLENARY PAPER 2905 Dominant unit CD341 cell dose predicts engraftment after double-unit cord blood transplantation and is inﬂuenced by bank practice Duncan Purtill, Katherine Smith, Sean Devlin, Richard Meagher, Joann Tonon, Marissa Lubin, Doris M. Ponce, Sergio Giralt, Nancy A. Kernan, Andromachi Scaradavou, Cladd E. Stevens, and Juliet N. Barker HOW I TREAT 2913 How I treat Burkitt lymphoma in adults Caron Jacobson and Ann LaCasce CLINICAL TRIALS AND OBSERVATIONS 2921 A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients Edward A. Stadtmauer, Keith M. Sullivan, Francisco M. Marty, Sanjeet S. Dadwal, Genovefa A. Papanicolaou, Thomas C. Shea, Sherif B. Mossad, Charalambos Andreadis, Jo-Anne H. Young, Francis K. Buadi, Mohamed El Idrissi, Thomas C. Heineman, and Elchonon M. Berkowitz 2930 Clinical heterogeneity and predictors of outcome in primary autoimmune hemolytic anemia: a GIMEMA study of 308 patients Wilma Barcellini, Bruno Fattizzo, Anna Zaninoni, Tommaso Radice, Ilaria Nichele, Eros Di Bona, Monia Lunghi, Cristina Tassinari, Fiorella Alﬁnito, Antonella Ferrari, Anna Paola Leporace, Pasquale Niscola, Monica Carpenedo, Carla Boschetti, Nicoletta Revelli, Maria Antonietta Villa, Dario Consonni, Laura Scaramucci, Paolo De Fabritiis, Giuseppe Tagariello, Gianluca Gaidano, Francesco Rodeghiero, Agostino Cortelezzi, and Alberto Zanella v BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19 CONTINUED ON vi From www.bloodjournal.org by guest on November 14, 2014. For personal use only. HEMATOPOIESIS AND STEM CELLS 2937 Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning Borja Saez, Francesca Ferraro, Rushdia Z. Yusuf, Colleen M. Cook, Vionnie W. C. Yu, Ana Pardo-Saganta, Stephen M. Sykes, Rahul Palchaudhuri, Amir Schajnovitz, Sutada Lotinun, Stefania Lymperi, Simon Mendez-Ferrer, Raquel del Toro, Robyn Day, Radovan Vasic, Sanket S. Acharya, Roland Baron, Charles P. Lin, Yu Yamaguchi, Amy J. Wagers, and David T. Scadden 2948 Brief Report OVOL2 is a critical regulator of ER71/ETV2 in generating FLK11, hematopoietic, and endothelial cells from embryonic stem cells Ju Young Kim, Ra Ham Lee, Tae Min Kim, Dong-Wook Kim, Young-Joo Jeon, Sung-Ho Huh, Se-Yeong Oh, Michael Kyba, Hiroshi Kataoka, Kyunghee Choi, David M. Ornitz, Jung-Il Chae, and Changwon Park IMMUNOBIOLOGY 2953 An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment John D. Gibbins, Lindsay R. Ancelet, Robert Weinkove, Benjamin J. Compton, Gavin F. Painter, Troels R. Petersen, and Ian F. Hermans 2964 Autosomal-dominant B-cell deﬁciency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100 Cindy Eunhee Lee, David A. Fulcher, Belinda Whittle, Rochna Chand, Nicole Fewings, Matthew Field, Daniel Andrews, Christopher C. Goodnow, and Matthew C. Cook LYMPHOID NEOPLASIA 2973 Reed-Sternberg cell–derived lymphotoxin-a activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma Chee Wai Fhu, Anne M. Graham, Celestial T. Yap, Suhail Al-Salam, Antonio Castella, Siew Meng Chong, and Yaw-Chyn Lim 2983 Brief Report Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation with mRNA levels C´eline Bossard, Maria Pamela Dobay, Marie Parrens, Laurence Lamant, Edoardo Missiaglia, Corinne Haioun, Antoine Martin, Bettina Fabiani, Richard Delarue, Olivier Tournilhac, Mauro Delorenzi, Philippe Gaulard, and Laurence de Leval MYELOID NEOPLASIA 2987 JAK2 inhibitors do not affect stem cells present in the spleens of patients with myeloﬁbrosis Xiaoli Wang, Fei Ye, Joseph Tripodi, Cing Siang Hu, Jiajing Qiu, Vesna Najfeld, Jesse Novak, Yan Li, Raajit Rampal, and Ronald Hoffman 2996 JAK2V617F1 myeloproliferative neoplasm clones evoke paracrine DNA damage to adjacent normal cells through secretion of lipocalin-2 Yuki Kagoya, Akihide Yoshimi, Takako Tsuruta-Kishino, Shunya Arai, Takashi Satoh, Shizuo Akira, and Mineo Kurokawa 3007 Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis Rikhia Chakraborty, Oliver A. Hampton, Xiaoyun Shen, Stephen J. Simko, Albert Shih, Harshal Abhyankar, Karen Phaik Har Lim, Kyle R. Covington, Lisa Trevino, Ninad Dewal, Donna M. Muzny, Harshavardhan Doddapaneni, Jianhong Hu, Linghua Wang, Philip J. Lupo, M. John Hicks, Diana L. Bonilla, Karen C. Dwyer, Marie-Luise Berres, Poulikos I. Poulikakos, Miriam Merad, Kenneth L. McClain, David A. Wheeler, Carl E. Allen, and D. Williams Parsons vi BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19 CONTINUED ON viii From www.bloodjournal.org by guest on November 14, 2014. For personal use only. 3016 Brief Report Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease Jean-François Emile, Eli L. Diamond, Zoﬁa H´elias-Rodzewicz, Fleur Cohen-Aubart, Fr´ed´eric Charlotte, David M. Hyman, Eunhee Kim, Raajit Rampal, Minal Patel, Chezi Ganzel, Shlomzion Aumann, Gladwys Faucher, Catherine Le Gall, Karen Leroy, Magali Colombat, Jean-Emmanuel Kahn, Salim Trad, Philippe Nizard, Jean Donadieu, Val´erie Taly, Zahir Amoura, Omar Abdel-Wahab, and Julien Haroche BLOOD WORK 3020 Histiocytic clearance of neoplastic cells in acute promyelocytic leukemia Kristian T. Schafernak and Seth J. Corey CORRESPONDENCE 3021 In contemporary patients with polycythemia vera, rates of thrombosis and risk factors delineate a new clinical epidemiology Tiziano Barbui, Alessandra Carobbio, Elisa Rumi, Guido Finazzi, Heinz Gisslinger, Francesco Rodeghiero, Maria Luigia Randi, Alessandro Rambaldi, Bettina Gisslinger, Lisa Pieri, Irene Bertozzi, Ilaria Casetti, Animesh Pardanani, Francesco Passamonti, Alessandro M. Vannucchi, and Ayalew Tefferi 3023 Cryptic XPO1-MLLT10 translocation is associated with HOXA locus deregulation in T-ALL Jonathan Bond, Aur´elie Bergon, Amandine Durand, Isabelle Tigaud, Xavier Thomas, Vahid Asnaﬁ, Salvatore Spicuglia, and Elizabeth Macintyre 3025 Two types of amyloid in a single heart Shameem Mahmood, Janet A. Gilbertson, Nigel Rendell, Carol J. Whelan, Helen J. Lachmann, Ashutosh D. Wechalekar, Philip N. Hawkins, and Julian D. Gillmore 3027 A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics Laurens T. van der Meer, Esm´e Waanders, Marloes Levers, Hanka Venselaar, Debbie Roeleveld, Joachim Boos, Claudia Lanvers, Roger J. Br¨uggemann, Roland P. Kuiper, Peter M. Hoogerbrugge, Frank N. van Leeuwen, and D. Maroeska te Loo 3029 Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue produce a 72% 3-year PFS in resistant lymphoma Giuseppe Visani, Pietro Maria Stefani, Saveria Capria, Lara Malerba, Piero Galieni, Francesco Gaudio, Giorgina Specchia, Giovanna Meloni, Filippo Gherlinzoni, Roberta Gonella, Marco Gobbi, Armando Santoro, Felicetto Ferrara, Marco Rocchi, Enrique M. Ocio, Maria Dolores Caballero, Federica Loscocco, and Alessandro Isidori 3031 Blockade of endothelial cell protein C receptor augments factor VIIa hemostatic effect in hemophilia treatment Jagan Sundaram, Usha R. Pendurthi, Charles T. Esmon, and L. Vijaya Mohan Rao ERRATA 3034 viii Young JA, Ting KK, Li J, et al. Regulation of vascular leak and recovery from ischemic injury by general and VE-cadherin–restricted miRNA antagonists of miR-27. Blood. 2012; 122(16):2911-2919. BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19 CONTINUED ON ix From www.bloodjournal.org by guest on November 14, 2014. For personal use only. OTHER DEPARTMENTS xx Author Guide SUBMISSION INSTRUCTIONS All manuscripts, including ﬁgures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Ofﬁce by phone at 202-776-0548 or via e-mail at [email protected]. ix BLOOD, 6 NOVEMBER 2014 x VOLUME 124, NUMBER 19