Insights 2482 A novel immune regulator links malaria and inflammatory bowel disease Brandon K. Sack and Stefan H. Kappe 2482 2483 Stuart G. Tangye THE JOURNAL OF EXPERIMENTAL MEDICINE Lymphocyte called home: β2-adreneric neurotransmission confines T cells to lymph nodes to suppress inflammation VOLUME 211 NUMBER 13 DECEMBER 15, 2014 www.jem.org T cells require DOCK8 for flexibility and function Kevin Tracey 2484 Sleeping our Alzheimer’s risk away Ryan J. Watts 2485 CCR4 drives ATLL jail break Kevin M. Shannon Brief Definitive Reports 2487 Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease Jee Hoon Roh, Mary Beth Finn, Floy R. Stewart, Thomas E. Mahan, John R. Cirrito, Ashish Heda, B. Joy Snider, Mingjie Li, Masashi Yanagisawa, Luis de Lecea, and David M. Holtzman 2497 Gain-of-function CCR4 mutations in adult T cell leukemia/ lymphoma Masao Nakagawa, Roland Schmitz, Wenming Xiao, Carolyn K. Goldman, Weihong Xu, Yandan Yang, Xin Yu, Thomas A. Waldmann, and Louis M. Staudt 2507 Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell–dendritic cell interactions Federica Moalli, Jovana Cupovic, Flavian Thelen, Pascal Halbherr, Yoshinori Fukui, Shuh Narumiya, Burkhard Ludewig, and Jens V. Stein Articles 2519 CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation James M. Kennedy, Nassima Fodil, Sabrina Torre, Silayuv E. Bongfen, Jean-Frédéric Olivier, Vicki Leung, David Langlais, Charles Meunier, Joanne Berghout, Pinky Langat, Jeremy Schwartzentruber, Jacek Majewski, Mark Lathrop, Silvia M. Vidal, and Philippe Gros 2537 Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K Carrie L. Lucas, Yu Zhang, Anthony Venida, Ying Wang, Jason Hughes, Joshua McElwee, Morgan Butrick, Helen Matthews, Susan Price, Matthew Biancalana, Xiaochuan Wang, Michael Richards, Tamara Pozos, Isil Barlan, Ahmet Ozen, V. Koneti Rao, Helen C. Su, and Michael J. Lenardo ON THE COVER Beck et al. show that immature B cell retention in the bone marrow is an active process, whereas egress is a passive one. B cells are retained in the bone marrow by CXCR4-CXCL12 interactions, which induce ␣4␤1mediated adhesion to VCAM-1. Decreased expression of CXCR4 in B cells approaching sinusoids loosens their grip and allows them to be passively swept out of the marrow. Image shows “rounded up” B cells (blue) in sinusoids in the process of passive exit. Image by New York artist Alta Buden. [email protected]. See page 2567 2549 DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity Qian Zhang, Christopher G. Dove, Jyh Liang Hor, Heardley M. Murdock, Dara M. Strauss-Albee, Jordan A. Garcia, Judith N. Mandl, Rachael A. Grodick, Huie Jing, Devon B. Chandler-Brown, Timothy E. Lenardo, Greg Crawford, Helen F. Matthews, Alexandra F. Freeman, Richard J. Cornall, Ronald N. Germain, Scott N. Mueller, and Helen C. Su 2567 CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow CCDC88B regulates neuroinflammation See page 2519 Thomas C. Beck, Ana Cordeiro Gomes, Jason G. Cyster, and João P. Pereira 2583 Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors Akiko Nakai, Yuki Hayano, Fumika Furuta, Masaki Noda, and Kazuhiro Suzuki 2599 The molecular bases of δ/αβ T cell–mediated antigen recognition Daniel G. Pellicci, Adam P. Uldrich, Jérôme Le Nours, Fiona Ross, Eric Chabrol, Sidonia B.G. Eckle, Renate de Boer, Ricky T. Lim, Kirsty McPherson, Gurdyal Besra, Amy R. Howell, Lorenzo Moretta, James McCluskey, Mirjam H.M. Heemskerk, Stephanie Gras, Jamie Rossjohn, and Dale I. Godfrey 2617 Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress protection in a mouse model of dystrophinopathy Valentina Di Foggia, Xinyu Zhang, Danilo Licastro, Mattia F.M. Gerli, Rahul Phadke, Francesco Muntoni, Philippos Mourikis, Shahragim Tajbakhsh, Matthew Ellis, Laura C. Greaves, Robert W. Taylor, Giulio Cossu, Lesley G. Robson, and Silvia Marino 2635 Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell–mediated allergic response Di Wang, Mingzhu Zheng, Yuanjun Qiu, Chuansheng Guo, Jian Ji, Lei Lei, Xue Zhang, Jingjing Liang, Jun Lou, Wei Huang, Bowen Dong, Songquan Wu, Jianli Wang, Yuehai Ke, Xuetao Cao, Yi Ting Zhou, and Linrong Lu 2651 Dynamic changes in E-protein activity regulate T reg cell development Ping Gao, Xiaojuan Han, Qi Zhang, Zhiqiong Yang, Ivan J. Fuss, Timothy G. Myers, Paul J. Gardina, Fuping Zhang, and Warren Strober 2669 Cytomegalovirus generates long-lived antigen-specific NK cells with diminished bystander activation to heterologous infection Gundula Min-Oo and Lewis L. Lanier Corrections 2681 RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement Agata Cieslak, Sandrine Le Noir, Amélie Trinquand, Ludovic Lhermitte, Don-Marc Franchini, Patrick Villarese, Stéphanie Gon, Jonathan Bond, Mathieu Simonin, Laurent Vanhille, Christian Reimann, Els Verhoeyen, Jerome Larghero, Emmanuelle Six, Salvatore Spicuglia, Isabelle André-Schmutz, Anton Langerak, Bertrand Nadel, Elizabeth Macintyre, Dominique Payet-Bornet, and Vahid Asnafi The molecular bases of δ/αβ T cell– mediated antigen recognition See page 2599 2683 Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation Jian Wang, Fengqi Li, Haiming Wei, Zhe-Xiong Lian, Rui Sun, and Zhigang Tian Bmi1 enhances skeletal muscle regeneration through MT1-mediated oxidative stress. See page 2617