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1971 37: 367-376
ABSTRACTS
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ABSTRACTS
Mario
Klaus
M.D.,
Betke,
Arthur
Bloom,
Thomas
Munich,
H. Bothwell,
M.D.,
Jacques
Jyoti
M.D.,
NI. Bridges,
Caen,
Kope,
Johannesburg,
Guido
Lucarelli,
B. Chatterjea,
Northern
Paris,
M.D.,
M.D.,
Pavia,
Ludvik
Donner,
M.D.,
Prague,
Patricia
Fames,
M.D.,
Providence,
M.D.,
Tokyo,
Frederick
\V.
M.D.,
Sydney,
S. Jacob,
Harry
Michel
M.D.,
Jamra,
Hans-Jurg
Kassirsky,
Sven-Age
Minneapolis,
M.D.,
Minnesota
Ralph
Denmark
ERYTHROCYTES
J.
normal
erythrocytes
IN
OF
MACROPLANIA
DISEASES
TRACT
OF
WITH
C.
SPECIAL
Verloop
ment
of Internal
pital,
Arnhem,
State
University
partment
sity,
AND
J.
Diseases,
Utrecht,
The
measure
of
jected
donor
LEP-
positive
MCD
Hos-
Utrecht,
and
State
Netherlands.
De-
a
UniverBrit.
and
J.
1970.
correlation
of
biliary
is a study
disease
of 20
and
patients
macroplania,
with
normal
hepatowhich
is
defined
as an increased
erythrocyte
surface
area
seen
in a blood
smear.
The macroplania
in these patients
was associated
with
leptocytosis
but
without
target
cells.
Osmotic
fragility
of erythrocytes
labeled
with
Na251CrO4
was
determined
by
measuring
the
radioactivity
BLooD,
VOL.
of
37,
No.
the
supernatant.
3 (MARCH),
Labeled
1971
culation
of
similar
of
to
the
MCD
Suzuki,
mean
of
fragility
into the
leptocytosis
MEASUREMENT
IN
OF
USING
VARIOUS
M.
ito
of
cir-
became
fragility
C.
V.
ERYTHROCYTE
PROPIONAL
THIO-
Shibata,
S. Shibazaki.
The
DIsr.sEs.
and
amount
erythrocyte
The osmotic
introduced
CHOLINESTERASE
CHOLINE
and
and
a positive
(diminished)
osmotic
own
erythrocytes.-M.
patients’
a
in-
MCD
was
m.
with
the
The
following
There
was a
changes
in
(2) There
was
There
sq.
a
as
of
between
patients
the
AUTOMATIC
C.
(1)
between
area.
(4)
erythrocytes
surface
This
Thereafter
bilirubin.
per
into
determined
made:
between
Calif.
hepatobiliary
fragility
(3)
cholesterol
Francisco,
introduced
was
correlation
fragility.
Netherlands
N.Y.
erythrocytes.
negative
osmotic
Tile
with
osmotic
correlation
serum
RI.
illinois
San
York,
patients
were
N.Y.
Georgia
leptocytosis.
the
York,
Utrecht,
M.D.,
Argentina
Pawtucket,
Savannah,
curve”
observations
of Hematology,
Clinic,
19:223-235,
TO
Municipal
Biochemistry,
and
“radioactivity
New
were
of
BILIARY
P. W. Helleman,
de Gier.
Depart-
Department
of
Haemat.
and
diseases
ERYTHROCYTES
REFERENCE
J. M. Werre,
TOCYTOSIS.
M.
OF
Livicn
THE
circulation
Aires,
Chicago,
New
Weiss,
Sweden
Yugoslavia
Ph.D.,
M.D.,
0. \Vallerstein,
Harvey
the
CAUSES
M.D.,
C. Verloop,
Martin
U.S.S.R.
Copenhagen,
M.D.,
M.D.,
Israel
Stockholm,
Buenos
M.D.,
E. Ultmann,
John Vaughn,
Switzerland
Moscow,
M.D.,
John
Steiner,
Mass.
Belgrade,
B. Schorr,
Australia
Hashomer,
M.D.,
M.D.,
France
Boston,
Tel
Rico
Italy
Adeistide,
M.D.,
S. Sack, M.D.,
Manfred
Brazil
Berne,
M.D.,
Killmann,
Rolovk,
Juhian
Australia
M.D.,
C. Reizenstein,
Edgardo
Japan
Pesaro,
M.D.,
Puerto
Poland
Villejuif,
F. Necheles,
Zoran
Hungary
S#{227}oPaulo,
M.D.,
Huser,
Joseph
Budapest,
Holl#{225}n, M.D.,
A. Morley,
R.l.
Fukutake,
R.
Alexander
Peter
Czechoslovakia
M.D.,
Ramot,
San Juan,
Warsaw,
Math#{233},M.D.,
Bracha
Italy
Katsuhiro
Susan
India
M.D.,
M.D.,
Georges
Thomas
Calcutta,
deNicola,
Gunz,
Ireland
France
Pietro
A. Klipstein,
Maria
Belfast,
M.D.,
Editor
Wales
S. Africa
John
M.D.,
Frederick
Germany
Cardiff,
M.D.,
Baldini,
H.
367
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
368
ABSTRACTS
Second
Tokyo
Chin. Hemat.
National
Hospital.
Jap.
11(4)
:490-494,
1970.
J.
was
acetyl
thiochohine
od,
a
using
was
good
and
both
revealed
terase
is
correlation
between
the
phenol
erythrocytes
that
the
decreased
and
erythrocyte
in
the
red
meth-
serum.
It
cholines-
leukemia
and
premature
rocyte
Activity
of cholinesterase
in erythrocytes
was measured
routinely
by automation,
using
propionyl
thiocholine.
It was
found
that
there
and
above
or
ency
among
ity.
duration
deficiency
POLYMORPHISM
PYRUVATE
OF
KINASE
Blume,
D.
Arnold
and
EFFECT
DEFICIENCY.
K.
R.
Busch,
G.
W.
Hoffbauer,
Freiburg
Humangenetik
i.
9:257-259,
lasting
as
infant.
The
authors
B.
ROLE
in
vitro
and
lactate
production,
lytic intermediates
in
vivo.
An
Cer-
content
rose,
increase
in
reticulocyte
J.
Rim
OF
M.
Whaun
Hospital
and
CELL
GLUTATHI-
NEONATAL
JAUNDICE.
F.
of the University
Philadelphia,
555-560,
BLOOD
TO
Pennsylvania.
A.
Oski.
From
the
of Pennsylvania,
J. Pediat.
76:
1970.
Red
cell glutathione
peroxidase
is significantly
lower
in newborns
healthy adults.
Although
serum
levels were the same in 3-day-old
IN
FERROCHELATASE
and
Pol.
A.
s-1.
of Radiobiology
Institute
of
Nu-
Poland.
11:1-10,
Acta
1970.
activity
in
was
rat
found
liver
mito-
be
stimu-
to
by crude
lipid extracts
from chromatoof Rhodopseudomonas
spheroides,
by
neutral
lipids,
phosphatidylethanolamine
and
acidic
phospholipids.
The
inhibitory
effect of albumin
on ferrochelatase
could be
partially
overcome
by lipids
or long-chain
fatty
acids.
Peroxide
not
stimulate
the
preparations
tion
activity
than
in
bilirubin
full term
of
containing
activity
low
to inactivation
OF
LIVER
TREATED
MIT0-
3,5
WITH
- 1,4 - DIHYDRO
- 2,4,6, (DDTP).
B. Panfll
TRIMETHYL-PIRIDINE
M.
led
K.
IN
RATS
DIETHOXYCARBONYL
A.
Oxida-
to peroxides
enzyme.-M.
CHANGES
CHONDRIA
did
activity.
lipids
of the
BIOCHEMICAL
lipids
of ferrochelatase
specific
of mitochondrial
1970.
V.
PEROXIDASE
of
lated
M.
ONE
an increased
degrees
Warsaw,
extracts
and
RELATION
have
severe
Protection,
Ferrochelatase
count and serum
bilirubin
level dropped.
On
the
contrary,
a type
A deficient
patient
(type
A = 0-40%
enzyme
activity)
did not
show a significant
hematological
response.C.
not
with
phores
1970.
ATP/ADP
hemoglobin
may
Research,
chondria
ratio,
glyco(including
FDP)
were
found
both
in vivo and in vitro.
Trying
to
prolong
the life span of pyruvate
kinase
deficient
red blood
cells,
an infusion
therapy
with inosine
and adenine
was applied.
This
therapy
succeeded
in case of a type
B deficient
patient
(type
B = 50-70%
enzyme
activity). The t#{189}
of the red cells increased,
the
does
infants
LIPIDS
Health
one
although
deficiency
A. Mazanawska
Department
Dancewicz.
in
that
S.
OF
ACTIVITY.
prema-
10 months
developing
jaundice.-J.
and
peroxidase
conclude
activity
of
Biochim.
The authors
studied
the metabolic
properties of red cells metabolizing
adenine
and
inosine
as
high
activ-
in
hyperbilirubinemia,
enzyme
THE
with
prolonged
long
a tend-
enzyme
glutathione
peroxidase
in
chance
H.
Br.,
of
were
was
infants
lower
more
tures
low
there
have
eryth-
G.
L#{246}hr. Medizinische
W.
IJniversit#{228}tsklinik,
many.
NUCLEOSIDE
to
was
result
their
levels
mean,
full-term
levels
clear
IN
the
bilirubin
The
whether
peroxidase
below
glutathione
mye-
loma,
while
in polycythemia
vera
and
iron
deficiency
anemia
it shows
high
values.
In
various
cancers
the activity
of erythrocyte
cholinesterase
was
almost
normal.
Because
of the good
correlation
between
cholinesterase
and severity
in leukemia,
its measurement
seems
to be useful
in diagnosis
and
treatment
of this disease-K.
F.
THE
infants
glutathione
Dancewicz.
Department
of
Radiobiology
and Health
Protection,
Institute
of
Nuclear
Research,
Warsaw,
Poland.
Acta
Biochim.
Pol. 17:143-150,
DDTP
used
to
is one
induce
porphyria
bolic
in
changes
of
the
the agents
experimental
animals.
The
were
from
enhancement
of
tase,
of catalase
activity.
remained
The
following
demonstrated
rnitochondria
decrease
commonly
hepatic
rats
metain
treated
with
S-aminolevulinate
activity
unchanged.
chondrial
respiration
ever,
when
glutamate
and
of
synthe-
ferrochelatase
cytochrome
No
were
(but
liver
DDTP:
changes
oxidase
in
mito-
observed,
hownot succinate)
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
369
ABSTRACTS
was
used
as
substrate;
partial
uncoupling
of
HESIOLYTIC-UREMIC
oxidative
phosphorylation
was found
to occur. In vitro DDTP
showed
the same effect
On the
oxidative
phosphorylation
but
did
not affect the activity
of the examined
mitochondrial
enzymes.-M.
IRON
ING
LEVEL
AND
M.
School
of
M.
iron
43
and
with
clinical
picture.
involvement
not
level
tively
of
the
Institute
Poland.
of
Reuma-
TIBC
with
treatment
the
No
Hyperfibrinolysis,
the
in
subgroup
of
dominating
the
cases
without
Fe
normal
of
the
and
joint
TIBC
values
previous
the
majority
serum
iron
did
This
the
be
One
with
case,
detectable
of
The
of
level
cases
re-
and
minor
prognosis
nates
by
over
the
stitute
Poland,
IN
SHIPYARD
A
WELDERS.
of Occupational
coagulant
therapy
the
ture
of
renal
of sideroform
of
not
see
any
cases
of
Uselis.
InCdai’isk,
1970.
Poland.
shipyard
welders
with
examined
and compared
with
a control
group
of 14 healthy
men of
similar
age,
having
no occupational
exposure
to inhalation
of iron compounds.
The
mean
level of serum
iron was found
to he
increased
in shipyard
welders,
the content
of transferrin
in serum
was diminished
and
the
degree
of transferrin
saturation
was
change
markedly
pared
K.
as
the
OF
not
well
predomi-
pointed
out
syndrome.
Anti-
clinical
overpassed
SMALL
clinical
are
recovery.
the
to
DOSES
hemolytic
present
The
case in the
A. J.
studied.-M.
course.
the
cases
stages
fatal
patients
a pic-
author
series
OF
did
of ten
X-IIAY5
ON
M. Szoter,
A. Albinowska,
T.
Skatuiska-Surmacka
and
W.
Leyko.
Blood-Bank
and
Department
of
Biophysics,
University
of L#{243}di, L#{243}d,
30
was
increased.-M.
Since
insufficiency.
EFFECT
presented
benign
ones
on
hemorrhagic
BLOOD.
Pol.
34:437-434,
A group
pneumoconiosis
a
the
walls.
Some
favors
even
PRESERVED
SELECTED
Diseases,
of Maritime
Medicine,
Pol. Tyg. Lek. 25:755-757,
benign
and
would
avoid
evolution,
of fatal
studies
patients
and
J.
to
capillary
features
the
first
Some
between
fibrinogen
the
with
the
Minas
of uremia.
on
number
in
of
of fibrin,
is severe.
the
presented
mechanism
pathophysiological
known,
constitute
nervous
that
of
products
lesions,
plate-
found
hyperfibrinolysis.
is
mechanism
and
due
the
State
benign
me-
flow,
are
was
fibrin
with
observed
removal
of
attacks
cases
were
Horizonte,
a protection
have
irrespec-
Ten
degradation
deposition
a
blood
and
of hemolysis
of
syn-
indicating
the
correlation
degree
THE
OF
main
hemorrhage,
The
central
They
Belo
of
CAPACITY
Department
the
involvement
cells”
with
picture.
of
of
suggested
to be a probable
cause
penia
observed
in the
articular
rheumatic
fever.-M.
K.
GROUP
Biol.
anemia
coagulation;
involved.
decrease
slight
serum
In
is
lowering
arthritis.
BINDING
Med.
on
renal
to
discussed.
Gerais.
fever
( prednisone
turned
to normal
values
after
treatment.
Moderate
anemia
was
also
much
more
frequent
in the children
with polyarthritis.
Accumulation
of iron in inflammatory
synovial
changes
has
been
recently
described
in
IRON
Horizonte,
hemolytic
of “Burr
to intravascular
let deficiency
the
clinical
region
exam-
The
resistance
Significant
only
number
chanical
and
).
the
were
rheumatic
polyarthritis
rheumatic
fever.
with
hyposideremia,
rheumatoid
de
hemolytic-uremic
the
presence
and
during
In
uremia;
system
children
from
Wr#{243}blewska-
and
and
both
differ
Belo
focusing
points.
with
the
the
of
is presented
diagnostic
WITH
1970.
followed
by aspirin
the serum
iron
level
TIBC
were
found
children
BIND-
and K. Kuof Pediatrics,
Warsaw,
Serum
in
M.
review
drome
Lewenfu-Wojna-
Medicine
8:107-114,
med
T.
Mikolajew
Department
Rheumatology,
tologia.
IRON
) IN CHILDREN
Kope5,
Kalukwska,
bicka.
Second
before
TOTAL
( TIBC
FEVER.
rowska,
Rocho.
I.
Hematologia,
K.
CAPACITY
RHEUMATIC
FelIcio
de
Brazil.
Rev. Bras. de Pesquisas
3(3-4):5-11,
1970.
A
SERUM
Departmento
Hospital
R.
SYNDROME.
Carvalbo.
The
effect
changes
taken
Acid
ADP,
DPG,
the
Przegl.
Radiol.
Med.
Nuki.
1970.
of a dose
occurring
of 40 R of X rays
during
storage
of
on
blood
with
ACD
solution
were
examined.
soluble
phosphate
compounds
(AMP,
ATP,
CMP,
CTP,
NAD,
NADP,
3,3Pi) GSSG
and potassium
contents
in
whole
blood
and in plasma
did not
during
with
21
control
days
of
unirradiated
storage
as
blood.
comThe
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
ABSTRACTS
370
only
change
observed
hemolysis
in the
was
some
irradiated
increase
in
blood.-M.
GRANiJLOCYTE
POTENTIAL
ard,
F.
IN
OF
R.
K. Shadduck,
Jr. From
Hospital,
thology
2:297,
Cultures
of
mouse
were
made
with
those
of mouse
numbers
colonies
produced.
onies
or
grew
in
cell
many
explanted
same
to
spleen
colonies
of
It was
4
6-8
recipients.-F.
W.
gray
per
cells
irradiated
METABOLIC
riety
ON
STUDIES
The
in
eclips
be
to
which
virus
of
within
particles
megagaryocytes
in
C-particles.-K.
ACTIVITIES
and
as
the
F.
hibit
of
syn-
leukocytes
reduction,
and
maternal
in
PROTECTION
LEUKEMIA
VIRUS
VACCINE.
T. Nagao,
K.
Y. Suga,
T. Sezaki,
K. Kitajima
and
K. Hiraki.
Okayama
University
Medical
School,
Okayama,
Japan.
Acta
Haemat.
Jap. 33:219-225,
1970.
of
newborn
to
pooled
THE
ZINC
shunt
whereas
show
mere-
leukocytes
granulomatous
such
responses.
also
The
demonstrated
capacity
human
and
normal
chronic
staphylocidal
of
exNBT
newborn
granulocytes
ence
infants
showed
with
Va-
consumption,
activities,
failed
B.
the
monophosphate
cells
these
normal
WITH
From
phagocytosis
patients
OF
Park,
Hospital,
Minneapolis,
76:237-241,
1970.
hexose
white
from
H.
Good.
oxygen
During
ments
A.
Heart
increased
LEUKOCYTES
B.
J. Pediat.
activity.
were
R.
Club
Resting
cent
IN
INFANTS.
Minnesota.
the
G.
RAUSCHER
of
NEWBORN
newborn
AGAINST
in
immature
disease
EXPERIMENTAL
By electron
observed
considered
cells
bodies
of
con-
numbers
lethally
is
mice.
/3-
of the
formed
were
megakaryocytes
in
the
initial
stage
of leukemia,
but
leukemic
cells
in
the advanced
stage
of leukemia.
Virus
particles
which
were
challenged
in vaccinated
mice
were
neutralized
by circulating
antibody.
Nonneutralized
particles
were held
Holmes,
times
marrow
comparable
in
virus
liver
fetus
only
fetal
leukemic
The
showed
and
were
col-
“committed”
even though
However,
produce
and
of
numbers
cultured.
as
of
spleen
form
colonies
numbers
showed
cells.
liver
needed
geneic
cells
16#{189}-day mouse
counts
fetal
of
the
in
liver
but
relationship
a considerable
cell compartment,
granulocytic
The
growth
were
suspencompared
cells.
Similar
the
cell
and
a linear
of
the
liver
contains
myeloid
stem
liver
agar
the
cells
that
initial
soft
with
when
marrow
eluded
Pa-
marrow
cells,
between
Boston,
fraction
of y-globulin
due to a reaction
Rauscher
leukemia.
virus particles
were
7 days.
and
St.
Mass.
abnormal
host toward
microscopy
Rauscher
Rick-
D. E. Howard
Research
Dept.,
fetal
in
caused
myeloid
of
A.
1970.
sions
suspensions
GROWTH
K.
LIVER.
Stohiman,
Elizabeth’s
VITRO
FOETAL
no such
marked
increase
globulin,
probably
LEUKOCYTES
THE
vealed
a
K.
in
the
serum-f.
pres-
B.
S.
RAUSCHER
Saito,
Three
kinds
were
emulsified
used
for
Rauscher
with
virus
Freund’s
vaccination.
completely
inoculation
of infected
virulent
of
These
vaccines
kill
protect
all
the
against
control
animals,
challenge
prepared.
AND
and
Oncologic
OF
CERVICAL
M. Kalasiewicz,
S. ZurawskaI. W#{243}jcik-Janiszek.
District
Hospital,
Lublin,
Tyg.
Lek.
25:921-922,
Zinc
content
was
Poland.
Pol.
1970.
almost
protected
mice against
challenge
of 1 per cent supernatant
fluids
spleen
homogenates
sufficiently
to
not
GRANULOCYTES
BREAST
CARCINOMA.
and
but
of 10%
supernatant
fluids similarly
Twenty
days
after
virus
inoculation,
an
abnormal
fraction
which
was considered
to be specific
in Rauscher
leukemia,
not found
in normal
mice, was detected
between
a2-globulin
and
f-globulin
fractions
and markedly
increased
with the progression
of leukemia.
Electrophoretic
studies
in mice
which
were
protected
against
leukemia
with vaccination
redid
IN
WITH
Poleszak
vaccines
adjuvant
CONTENT
PATIENTS
determined
by
a
score
technique
in 30 patients
with breast cancer,
in 30 patients
with cervical
carcinoma
and
in 30 control
healthy
women.
In both groups
of
patients,
zinc
lower
by
The
differences
recommend
-M.
content
23-24
per
were
the
test
of
cent
not
for
was
granulocytes
than
distinct
diagnostic
in
controls.
enough
to
purposes.
K.
NEW
ASPECTS
TION
Medical
sanne,
OF
THE
OF
ENZYMATIC
THE
Department,
Cantonal
REGULA-
A. Vanotti.
From
University
of LauHospital,
Switzerland.
LEUKOCYTE.
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
371
ABSTRACTS
Pol.
Arch.
Med.
Wevnet.
blast
44:355-358,
Some
new
the
leukocytes
of
aspects
of
were
that
glycogen
content,
and
lactate
formation
granulocytes
from
exudate
These
with
(luring
locyte.
cultures
the
ties
not
cells
necessary
of
to
the
formed
for
porphyrin
STUDIES
OF
IN
CHRONIC
S.
Ballard
the
York,
crisis,
durK.
MYELOGENOUS
and
Veterans
New
with
bone
normal
A.
I.
Mar-
Administration
N.Y.
New
J.
Eng.
1970.
this
activi-
complication
leukemia.
pain,
or
the
of
chronic
appearance
or
symptoms
termination
in
The
gastrointestinal
nervous-system
lym-
enzymatic
disease.-J.
282:663-665,
myelogenous
vitro
demonstrated
while
the
the
of
York
Hospital,
adults
in
long
Only 1 1 cases of hypercalcemia
associated
with
leukemia
have
been
described
previously.
The
present
paper
describes
two
be
en-
granu-
in
New
Med.
experiments,
were
show
in
for
of
series
porphirins,
did
cui.
granulo-
demands
lymphocytes
to synthesize
phocyte
considered
functions
second
blast
of
normal
are
before
phase
H.
LEUKEMIA.
increased
with
occurs
chronic
HYPERCALCEMIA
inflammatory
increased
pyroninophilic
M.
were
the
found
consumption
pentoneal
defense
In
activity
It was
glucose
changes
connected
enzymatic
studied.
as compared
cytes.
ergy
crisis
ing
1970.
should
serum
of
central-
prompt
calcium
de-
level.-
J. E. U.
synthesis.-
K.
CHRorIosoIE
CYTOGENETJC
IN
CHRONIC
MYELOID
Fleishman,
M.
graduated
Institute,
Probl.
The
CELL
A.
Cemat.
authors
Central
Moscow,
15:
No.
18 of them
that
in
most
and
these
two
during
the disease.
In
cells
containing
Philadelphia
ond
one
chronic
chromosomes
the
cells
usually
In two
phase
conclusion
that
nant
constituting
48
of
D
to draw
formation
these
and
each,
contained
(extrachromosomes
Thus,
it is possible
cells
the
the first patient,
47 chromosomes
in
substrate
MYE-
S. Kawasaki
Kyoto
University,
Haemat.
Jap.
33:54-
studies
types
with
of
primary
strated
by
chromosomes
as
Dq +
dence
cell
that
Bq
the
and one
demoncell
lines
such
-
marker
aberrant-C,
,
Eviabnormal
respectively.
that
these
generate
new
to
patients,
of
MG-like,
further
possess
and
with
abnormal
presence
presented
lines
marrow
patients
multiple
myeloma
macroglobulinemia
chromosomes,
was
addition
bone
in eight
independent
characterized
and
of
cells
new
marker
original
in
In
of
ones.
associations
of
subclones
chromosomes
two
a series
marker
chro-
such as Dq+
with MG-like,
Dq+
with aberrant-C,
and Bq - with aberrant-C
were the examples.
One of the most important findings
was that many
of such marker
chromosomes
were
noted
in a patient
with
myeloma
of the “no-anomaly”
type.
These
results
suggest
that
production
of paraimmunoglobulin
and
chromosomal
aberration
are not closely
related
as to the cause
and
effect of the disease,
but further
studies
are
mosomes
required
to
clarify
such
relationship-K.
F.
two
the
sec-
THE
MECHANISM
PERIODIC
H.
Misima,
of maligfor
a
67-78,
ALTERATIONS
MSPC-1.
T. Imai.
National
Japan.
1970.
SIGNIFICANCE
AND
PLOIDY
MYELOMA,
G groups).
preliminary
of clones
the
of
were
chromosomes
and
the
Hoshino,
Sic-
ITS
MULTIPLE
Acta
blood
various
pa-
patients,
the
development
of blast
transformation
could
be observed
in the bone
marrow
with proliferation
of aneuploid
cells
that had been seen 24 and 8 months
before,
respectively,
Japan.
cultured
nonblastic
were
hyperdiploid
cells,
Philadelphia
chromosomes.
S. Itani,
T.
Nakayama.
Cytogenetic
with
The
exacerbation
of
the leukemia,
one
or
more
( up to three)
aneuploid
cell clones
could
be found
along
with
a clone
of cells
characterized
by a
pseudodiploid
complement
of chromosomes
and
containing
the
Philadelphia
chromosome.
Nevertheless,
the presence
of these
“additional”
clones
in periods
of exacerbalion was extremely
small (2-12%)
and only
in a small
number
of patients
it reached
25-80
per cent. The karyotype
of the cells
in the “additional”
clones was different
in
the different
patients.
In all cases,
except
one,
with
AND
HUMAN
66, 1970.
(29
cases
S.
Kyoto.
1970.
40 patients
repeatedly.
IN
LOMA.
V.
PostU.S.S.R.
1, 33-36,
investigated
chronic
myelosis,
studies
proved
tients ) , during
E.
LEUKEMIA.
Volkova.
ABNORMALITY
NLFICANCE
DYNAMICS
K.
Morowaki
Institute
Acta.
OF
MOUSE
IN
Haemat.
of
and
Genetics,
Jap.
33:
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
372
ABSTRACTS
Mouse
plasma
cell
hibited
periodic
ploid
to tetraploid
serial
tumor,
ploidy
of
from
di-
and
vice versa during
for two years.
Pre-
transplantation
treatment
ex-
MSPC-1,
alterations
the
host
animal
by
activity
of alkaline
phosphatase
was markedly
increased.
This
aug-
mented
significantly
in the
dialysing
after 24 hours of peritoneal
dialysis.-M.
fluid
ray
caused
apparently
rapid
apof the
transplanted
tumor,
but
could not give any significant
effect
on the
ploidy
change.
Using
marker
chromosomes
and
autoradiography
of incorporated
Hthymidine
it was found
that the diploid
cells
became
tetraploid
cells through
the beinucleate
stage
that
resulted
from
failure
of
sarcoma
cytokinesis.
is
tetraploid
cells
could
not
NODULAR
SCLEROTIC
FURTHER
Bennett,
A.
Brit.
A
M.
233
When
with
lympholymph
nodes
microscopical
examinain the
treatment
THE
change
ETIOLOGY,
LAXIS
PATHOGENESIS
OF
LEUKEMIAS
THE
AND
IN
ANIMALS
IN
STUDIES.
I.
Aleksandrowicz.
partment
of
Internal
Medicine,
11:1-14,
Krakow,
1970.
A theory
of the
for
leukemias
of
was discussed.-K.
two
personal
OF
EPIDEMIOLocIc
The
on
first
is
a
genetic
enrichment
of
the
soil
with
is proposed
as a possible
kemia
prophylaxis.-M.
K.
THE
OF
ACTIVITY
OF
LEUKOCYTES
FAILURE
to
Poland.
615,
BY
Wewnet.
44:609-
OF
and
M.
alkaline
cytes
was
examined
acute
renal
failure,
ney insufficiency,
nephritis
without
healthy
persons.
non-inflammatory
phosphatase
in
25
of
patients
leukowith
of chronic
kid15 patients
with
chronic
renal
failure
and
in 12
In uremia,
particularly
in
16
cases
renal
failure,
the
M.
Seven
treated
with
and
with
but a
continue
clinical
evidence
of
to 19 years-f.
E. U.
INVOLVEMENT
surrounding
disease
was
Tist
LEUKEMIAS:
L.
N.
cardiac
leukemias
radiotherapy
who
in
Terry,
Jr.
University
of North
Hill,
NC.
Cancer
25:
Chapel
1970.
patients
similar
type
MYOCARDIAL
Kligerman.
patients
was
last
AND
lymphomas
when
have less eflocalized
dis-
lymphosarcoma
RADIOTHERAPY.
Carolina,
1003-1008,
had
involvement
who
were
are
presented.
pericardial
mediastinal
otherwise
invasion
nodes
and
confined
to the
lymphatic
system
were
treated
radically.
They
are alive without
evidence
of disease
at 2 years
and
1 year,
respectively.
The
remaining
five
were
treated
palliatively.
Of
these five, three patients
had excellent
responses.
of
AND
This
patients
disease,
to
the
up
LYMPHOMAS
Rou
in
With
rate
from
periods
PERICARDIAL
better
lymphosarcoma,
of
free
for
whose
RENAL
J. Kuska.
Medicine,
Katowice,
DIALYsIs.
Med.
leu-
1970.
Activity
acute
WITH
of Internal
of Medicine,
Pol. Arch.
for
marked
diffuse
sclerotic
survive,
was
generalized
percentage
disease,
from
PHOSPHATASE
PATIENTS
BY
Department
School
nodular
the
sclerotic
groups.
be expected
lymphoma,
greater
Two
from
ALKALINE
IN
TREATED
Third
Silesian
method
with
can
follicular
pre-
magnesium
more
within
nodular
of
feet upon the outcome.
ease, the 5-year
survival
disposition
indicated
by
the
results
of
anthropometric
and dactyloscopic
investigations. The second
is a harmful
ecologic
factor demonstrated
by epidemiological
studies.
The
was
presenting
banding
typical
improvement
and
mechanisms
importance
the basis
of
The
discussed
studies.
AND
Third
DeMedicine,
School
of
Poland,
Acta Med. Pol.
proposed.
is
PROPHY-
HUMANS
pathogenetic
is
factors
LIGHT
F.
fibrous
nodes,
W.
1969.
periodic
lymph
Farrer-
London,
lymphosarcoma,
the
prognosis
than in the other histological
showed
G.
H.
patients
primarily
reported.
tion
M.
and
23:683-692,
of
arising
Millett,
Hospital,
J. Cancer
study
L.
Jelliffe,
Middlesex
Brown.
A
LYMPHOSARCOMA.
Y.
REvww.
longer
than
a few transplant
generations.
The diploid
cells proliferating
actively
in the next diploid
stage derived
from
a
minor
diploid
cell
population,
which
emerged
from the previous
diploid
stage
as
a variant.
Immunological
significance
of this
survive
ploidy
K.
200-R
gamma
pearance
The
in leukocytes
activity
Although
significant
palliation
was
not achieved
in the other
two patients
cause
of the
widespread
nature
of
disease,
their pericardial
effusions
were
trolhed by the radiotherapy.
It is felt
radiotherapy
ical
with
and
can
palliative
cardiac
leukemias.-J.
prove
valuable
management
involvement
E. U.
betheir
conthat
in
the
of
patients
by lymphomas
rad-
and
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
373
ABSTRACTS
THE
ASSOCIATION
RITIS
OF
WITH
CYTIC
CELL
NEOPLASMS.
Paraskevas
of
and
L.
Manitoba,
ada.
Previous
of
cell
stressed
as
found
cases
‘4C
the
the
asso-
the
and
neoplasms
was
is
rheumatoid
1 12 cases
sug-
arthritis
of
plasma
neoplasms.-J.
E.
of
cell
tion
of
PLATELET
PROTEIN
FREE
SYNTHESIS
STUDIED
IN
A
sity,
M.
SYSTEM.
tate
and
CO9
ing,
however,
was
which
cose-6-14C
was
Providence,
RI.
Experientia
26:786,
Microsomes
times
were
of
freshly
gradient
analysis
somes
treated
veahed
the
cients
these
an(l
proved
form.
pure
myosin
they
chemical
isolation
until
constant
these
were
to
of
myosin-
and
in
by
0.088
tion
of
TOSIS.
Baldini.
The
Brown
chim.
BASIS
OF
Division
Memorial
of
a
cytosis
Acta
Providence,
201:471-478,
the
of
latter
pend
cycle.
Particles
s
not
did
acid
this
exproduce
cycle.
The
to
phago-
different
mainly
shunt
in
the
their
from
While
hexosemono-
metabolic
phagocytosis,
upon
stud-
stimula-
leukocytes.
utilize
accompanying
highest
quite
the
phosphate
smaller
size
platelets
therefore
a
a
production
The
( smallest
citric
no
of the
platelets
over
rate.
1.5
gluwas
showed
14C02
acid
of polymorphonuclear
burst
platelets
a mitochondrial
de-
electron
phenomenon.-.\f.
STUDIES
reached.
that
transfer
S.
LIPID
M.
Research,
and
R.I. Bio1970.
Lab.
Chin.
simple
say
in
platelets
use
of
an
solutions
Med.
for
described
Freshly
by
the
produced
clear
measure-
platelets
in the
collection
as-
peroxide
photometric
collected
effect
1970.
which,
lant
content.
Providence,
lipid
of lipid peroxides.
significant
M.
Re( Paw-
75:283,
detergent,
for
OF
and
Hematologic
quantities
used
Steiner
Hospital
is
ionic
EFFECT
University,
method
suitable
ments.
M.
of
Brown
PLATELETS.
AND
Memorial
) an(l
J.
IN
ASSAY
Division
The
tucket
RI.
PEROXIDES
OF
At. Okuma,
search,
perOxi(le
PHACOCY-
and
ON
METHOD
A
were
(Pawtucket)
was
There
activity
While
the
that
of the
mole-
Steiner
the
of
of
na-
RNA
Hematologic
Hospital
University,
Biophys.
M.
size
Baldini.
proteins
PLATELET
Kuramoto,
A.
citric
the
14C02
production
produced
the
in
when
particles
particles
response
no
METABOLIC
4a)
lacstrik-
only
parabolic
metabolic
adding
indicated
actin-like
a
stis-
both
increase
noted
period,
STORAGE.
proteins
monocistronic
lactate
stimulation
I.
G. B.
cules.-M.
ied
repeated
was
size
latex
of
at
of
substrate.
in the
shunt.
with
the size of the
purifi-
by
products
activity
and
Ofl
time
increased
myosin
respective
polysomal
3-hour
polypeptides
the
the
specific
synthesized
as
followed
of the
prod-
synthesized
actin
rate
for
14C
incorporate
achieved
the
the
platelet
The
polypeptide
Isolation
was
or
synthesis
estimated
synthesized
This
cell-free
Analysis
to
proteins.
that
tive
coeffi-
characterized
the
of heavy
were
into
were
of
re-
respectively.
able
acids
actin-like
cation
micro-
classes
3405,
were
which
ucts
platelet
polysomes
amino
vol-
Sucrose
sedimentation
and
polysomes
large
deoxycholate
of two
The
6505
labeled
such
sodium
existence
of
he
from
platelets.
of
with
polyribosomes.
to
isolated
collected
Glucose-
Particularly
was
increase
linear
the
increase
production.
production
ceeding
1970.
par-
added.
to
an
hexosemonophosphate
Steiner.
Division
of Hematologic
Research,
The Memorial
Hospital
( Pawtucket)
and Brown UniverCELL
were
particles
produced
incubated
HEMOSTASIS
platelet
polystyrene-latex
size
latex
pension
concomitant
U.
aerobic
in human
which
varying
phago-
determining
labeled
at various
carbons
was used as
substrate
and
14CO,
and
14C-lactate
the end products
assayed.
The addi-
were
and
incidence
of
among
lymphocytic
1969.
arthritis
increased
four
tides
to
platelet
of
studied
anaerobic
Can-
Here
lymphocytic
An
and
basis
by
glycolysis
was
suspensions
disturbances
rheumatoid
or
investigated.
and
12:569-579,
have
of
F.
University
Manitoba,
metabolic
cytosis
Goldenberg,
neoplasms.
coexistence
gested,
Israels.
autoimmune
lymphoproliferative
plasma
J.
G.
Rheum.
reports
ciation
G.
The
ARTHLYMPHO-
AND
Winnipeg,
Arthritis
were
RHEUMATOID
PLASMA
The
had
small
anticoagu-
of platelets
on
their
Storage
of
had
subsequent
platelets
at
4#{176}C
or
20#{176}Cresulted
in rapid
and
progressive
accumulation
of lipid
peroxides.
Platelet
concentrates
collected
from
ACD
blood and stored
at 20#{176}C
had a significantly
higher
peroxide
accumulation
than
those
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
374
ABSTRACTS
collected
in EDTA
blood
and stored
at 4#{176}C. 14C-lactate
than
did
those
from
normals
when
incubated
with glucose-6-14C.
By reLipid peroxide
formation
could be prevented
ferring
metabolic
values
to the protein
conby the addition
of tocopherol,
Tween
80 or
tent
rather
than
to the
platelet
number,
increasing
the
H +
concentration
in
the
platelet
preparation.
Freezing
of
platelets
however,
only
a small
difference
was noted
with
glycerol
promoted
lipid peroxide
acin the citric
acid cycle
activity
and lactate
cumulation
them
in
dimethylsulfoxide
live
agents
per
peroxide
se
formation.
which
can
influence
peroxides
in
practical
are
while
did
had
platelets
freezing
importance
because
lipid
to be able
to interfere
known
function
and
with
not. The cryoprotecno influence
on lipid
The
study
of factors
the formation
of lipid
was
thought
to be of
peroxides
with cell
between
controls
and
to the
platelets
produced
Rou
OF
BLOOD
HEMORRHAGIC
THE
PLATELETS
IN
OF
SCURVY
DIATHESIS
A.
GUINEA-PIG.
Popiawska.
Faculty
THE
IN
PopIawski
and
of
Physiological
T.
Chemistry
and Department
of Hygiene,
School
of Medicine,
Bialystok,
Poland.
Acta Physiol.
Pol. 21 :363-369,
1970.
guinea
in
platelet
behavior
acid
citric
tients
scurvy
in
the
of aggregation
of plateADP was markedly
prolonged
as
with
control
animals.
The ag-
pig.
lets by
compared
experimental
The
time
induced
by thrombin
was normal.
release
of platelet
factor
4 during
ADP
induced
aggregation
and
prolonged
coagulation
time
were
found.
Fibrinogen
level
and
fibrinolysis
in euglobulins
were
normal.
Addition
of ascorbic
acid
in vitro
did not influence
the parameters
tested.M. K.
from
cycle,
epinephrine
were
normal
patients.
the
affected
children
lesser
degree.
The mother’s
platelets
behaved similarly
to the children’s
platelets
in
regard
to aggregation
by epinephrine,
but
their metabolic
reaction,
particularly
of the
was
and
less
concluded
Disturbances
observed
in
from
the
from
only
very
minimal
stimulation.
production
was also decreased
comto that
in normal
controls
but to a
pared
THE
platelets
those
Whereas
normal
platelets
reacted
with
an
8- to 12-fold
increase
in 14CO2
production
from
glucose-6-14C
when
incubated
with
latex
particles,
the addition
of such
agent
Lactate
S.
viability.-M.
production
to
latex
greater
than
that
that
the
particles
than
that
and
of
of normals.
the
pa-
It was
of
the
due to a
manifestations
Wiskott-Aldrich
syndrome
may be
single
basic
defect
in energy
metabolism
caused
by failure
in regulators
of oxidative
phosphorylation
probably
residing
in
cell
granules.-M.
S.
gregation
Impaired
LACK
OF
TION
PLATELET
IN
THE
A. Kuromoto,
Division
M.
of
Eng.
Steiner
Hematologic
Memorial
Brown
RESPONSE
Hospital
University,
J.
TO
WIsKorr-AU1UcH
Med.
M.
(Pawtucket)
Providence,
282:475-579,
R.I.
striking
the platelets
their mother:
abnormalities
found
OF
M.
PLASMIN
Kotshy.
24:331-289,
The
tivation
IN
Pathology,
Hig. Med.
in
epinephrine;
response
to stimulation
with
polystyrenelatex particles
and with epinephrine.
Platelets from
the
patients
with
the
WiskottAldrich
syndrome
produced
less ‘4C02
and
WrocDosw.
results
of systematic
studies
of fibrinolysis
in the human
of plasminogen,
fibrinolysis
from the patients
and
from
(1) lack of aggregation
with
(2)
decrease
in the metabolic
HU-
of Cen-
1970.
and
New
THE
Faculty
and Experimental
Poland.
Postepy.
is demonstrated
1970.
were
eral
law,
The
Three brothers,
5 to 9 years
of age,
affected
with Wiskott-Aldrich
syndrome
and
one 10 year-old
normal sibling were studied.
Two
BLOOD.
sorption
Baldini.
Research,
ACTIVATION
MAN
blood and in plasma,
as well
fied
system,
are
presented.
STIMULASYNDROME.
and
Tim
activation
as in the
Selective
activators
as the
main
the
of marked
in
on acwhole
puriad-
on fibrin
mechanism
of
clot network
differences
in
as compared
and as the cause
the rate of the fibrin digestion
with
fibrinogen
in blood
and plasma.
It is
shown
that fibrin does not adsorb
plasminogen.-M.
THE
K.
INFLUENCE
zms
kowa,
ON
OF
SOME
SERUM
Bielawiec
PROTEOLYTIC
PRoTEINs.
EN-
B. BogdaniJ. Drozd.
First
arid
of Internal
Medicine,
School
of Medicine,
Bialystok,
Poland.
Pol. Arch.
Med. Wewnet.
44:311-316,
1970.
M.
Department
The
effect
of
fibrinolytic
enzymes
and
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
375
ABSTRACTS
plasminogen
activators
partially
raphy
was
phoretic
of
in
revealed
were
electro-
immunoglobulins
were
technique
proteins
chromatog-
Changes
of
globulin
serum
Sephadex
investigated.
mobility
/3c
on
by
purified
present
lymphocytes,
and
and
K.
demonstrated.-M.
the
in
INVESTIGATIONS
ZYMES
ON
OF
SOME
RABBIT
It
BY
H.
TRANSPLANTATION.
I. Niedworek.
Faculty
Pathology.
perimental
21:393-399,
The
and
acid
examined
blood
and
free
kinins,
of
were
found
cyte
lysosomes
showed
activity
neutral
proteases
was
and
phosphatase
proteases
activities
phosphatase
acid
in
from
peripheral
allogenic
skin
of
The
kininogens
plasma,
neutral
of granulocytes
ing rejection
bits.
and
ExPol.
1970.
authors
of
SiuN
Tch#{243}rzewski
of General
and
Acta
Physiol.
both,
increased.
some
increase
while
that
in
of
THESIS
DURING
CHRONIZED
THE
Kyoto,
CELL
CYCLE
PoPuiTIorss
I.
Namba.
Japan.
Acta
CELLS.
83,
IMMUNOGLOBULIN
IN
OF
the
of
in
the
of
macroglobuhin
that
thymidine.
The
STRUCTURE
OF
HUMAN
AND
CELLS.
T. Shigemafsu,
M.
Kyushu
University,
Hattori.
Kanazawa
Acta
OF
In
University,
the
globulins
light
present
were
Lebanon.
J. Pediat.
Al.
A
fractionated
p-chains
with
vestigation
cells
of
by
were
Freund’s
the
macroglobulin
use
of
the
site
F.
A.
ERYTHEETHOSUC-
Dabbous
the
and
Department
University,
of
Beirut,
76:617-620,
10-year-old
epileptic
with
phenobarbital
and
)
(Zarontin
weakness,
S
The
from
1970.
and
adenopathy
studies
revealed
ESR,
mild
cyhindruria,
macro-
alkylation.
injected
and
The
into
adjuvant.
the
In-
on
loss,
butterfly
with
test,
Following
administration
symptoms
subsided,
fever,
arthralgia,
joint
generalized
rash.
Laboratory
pancytopenia,
proteinuria,
hyperglobulinemia,
previously
diphenyl-
ethosuccimide
presented
antiglobulin
succimide
ia-chains
boy
plus
hepatosplenomegaly,
direct
Japan.
currently
therapy,
weight
swelling,
to
1970.
complete
the
a possible
VITH
From
Idriss.
hydantoin,
Kozuru
and K.
Fukuoka
and
into
and
conditions
Luus
I.
American
and
pathological
by reduction
chains
rabbit
study,
are
THERAPY.
Pediatrics,
MYELOMA
33:37-50,
dissociated
some
SYSTEMIC
SYN-
in
Kanazawa,
Jap.
ergas-
And also, it can
in the cytoplasm
ASSOCIATION
H.
MACROGLOBULIN-PRODUCING
Haemat.
the
production-K.
IN
preparations.
FINE
in
ribosomes
SYN-
proved
maximally
CELLS
why
mode.
lymphocyte
MATOSUS
33:79-
Jap.
stage
and minimally
in mitotic
stage.
synthetic
pattern
deviated
considerably
that of total protein
synthesis-K.
F.
THE
as
anti-p
University,
cells
immunoglobuhin
reason
singly
free
large
treated
excess
synthesize
rihosomes,
contained
plasma
1gM
OCCURRENCE
fluctuation
in immunoglobuhin
synduring
the growth
cycle was investiby synchronizing
the myeloma
cells
with
free
acid
1970.
The
thesis
gated
area
with
abundant
free
be expected
that
the
be present
mainly
in
many
a cooperative
be said
MYELOMA
Kyoto
Haemat.
particles
cells did not contain
the ferritin
particles
can
be well explained.
The present
results
revealed
that the macroglobulin
producing
cells do not stem
from
a single
cell line, but from at least two cell
lines:
the large
lymphocyte
with broad
cytoplasm
and abundant
free ribosomes,
and
the plasma
cell from the immature
type
to
the highly
mature
type.
These
cells
may
CIMIDE
IN
FLUCTUATION
Colgi
the
the
of
and
acid
K.
diminished.-M.
Similarly,
or
Granuho-
large
the
in
conjugate
durrab-
kininogens
and
to
with
ferritin
produce
lysozomes
blood
grafts
in
cells
would
cytoplasm
toplasm
DURING
ALLOGENIC
was
particles
chains.
EN-
LEUKOCYTES
IMMUNIZATION
kinins
LYsosoIAL
ferritin
cytoplasm
ribosomes.
the
the
the
plasma
concentrating
ferritin
IMMUNOHEMATOLOGY
that
in both
an
elevated
hematuria
a
and
and
positive
positive
cessation
some
LE
of
etho-
of the
signs
a
week
however
later he developed
pneumonia
with pleurisy.
Following
institution
of prednisone
therapy
there
was
marked
and progressive
improvement.
Within
2 weeks
the abnormal
physical
findings
had
receded.
The
LE
prep
and
positive
Coombs
remained
positive
for 3
months.
Prednisone
was
stopped
after
6
months,
and
1 year
later
he was well.J. B. S.
producing
ferritin
antibody
PRIMARY
LYMPHANGIECTASIA:
PROTEIN
Loss
From www.bloodjournal.org by guest on November 17, 2014. For personal use only.
376
ABSTRACTS
TO
THE
TISSUES
TRACT
AND
PERSPIRATION.
A
Szybi,iski
Department
Medicine,
Med.
Wewnet.
The
authors
year-old
girl
right
a
marked
the
observed.
tissues.
right
Absence
The
hand
tained
of
from
from
According
to
may
left
edematous
the
left
the
authors’
be
due
lymphopenia
was
found
proteinemia
with
10-30
was
hand
after
in
as
reafter
72
days.
this
dif-
distribution
the
upper
blood,
ex-
marked
well
as
The
of
case
taneously
alive
for
nests
demonstrated
of
the
caused
is an
THE
The
the
fetal
spon-
remained
histological
placenta
and
ex-
various
existence
of
fetal
numerous
findings
clearly
transmission
that
alterations
A.
prematurity.-M.
NEOPLASTIC
AND
HEMATOPOIETIC
I.
Clin.
Path.
Five
cases
series
of
unusual
accomdue
of
35
CHAGAS
Middlesex
Ger-
General
N.J.
J.
Amer.
1970.
asbestosis
associated
hematopoietic
cases
of
including
reticulum-cell
a
sarcoma;
macroglobulinemia.
with
system
asbestosis
case
in a
proved
associated
one,
The
by
age
group
Abstractor’s
with
Waldenstr#{246}m’s
incidence
association
is significantly
overall
incidence
of such
corresponding
MISCELLANEOUS
of
OF
M. A.
Brunswick,
53:204-208,
of the
of
DlsosmEns
SYSTEM.
ber.
Laboratories
Hospital,
New
servation
OF
that
leishmania.
These
the transplacental
illness
with
intense
ASBESTOSIS
asbestosis.
TRANSMISSION
the
fetus
pregnant.
she
autopsy are reported. Two
were cases of
multiple myeloma;
two, myeloproliferative
hyper-
classes
variant
of the protein
loss syndrome
panied
by nonspecific
immunotolerance
to lymph
loss.-M.
K.
TRANSPLACENTAL
minutes.
of
showed
of
a
15
disorders,
all
1970.
delivered
tumors
panhypogammaglobulin-
deficiency
immunoglobulins.
only
uneven
cells
peripheral
with
cells
opinion
ArMed.
the
lymphoid
right
to
the
emia
In
was
conloss into
graft
hand
in
con-
hand
Cuyo,
Pesquisas
20 days of being
infected
became
Five
and one half months
later
organs
the
from
de
de
3(3-4):45--49,
amination
technique
skin
immunocompetent
tremities.
of
allogenic
the
6 days,
ference
the
The
from
cent
also
proteins
obtained
Rebuck
per
that
cent.
jected
of
the
70-80
while
per
exudate
by
15-
of
Brasil
The
present
report
is concerned
with
a
female
patient
with acute Chagas
illness
and
ith
demonstrated
parasitemia,
who
after
edema
half
DEMONSTRA-
Nacional
Rev.
Biol.
Significant
right
Universidade
gentina.
in the
the sweat
from
the right
hand
sidered
as the indication
of protein
the
a
was
of
da
A
gastro-
extremity.
on
was
of
losing
cause
upper
hyperperspiration
body
case
Lymphangiectasia
as
the
the
protein
to lymphangiectasias
tract.
demonstrated
of
AND
1970.
describe
HISTOPATHOLOGIC
T. Tano Assini,
G. 0. Otero and C.
Bertona.
Faculdade
de Ci#{234}ncias M#{233}dicas
TION.
HYPER-
VARIANT
44:303-309,
due
digestive
UNILATERAL
NEW
with
enteropathy
DISEASE.
DIGESTIVE
DEFICIENCY,
Z. Hanicki,
M. Hanicka,
and
M. Depowski.
Second
of Internal
Medicine,
School
Krakow,
Poland.
Pol. Arch.
PROBLEM.
z.
of
THE
IMMUNOLOGIC
EOSINOPHILIA
NEW
TO
AND
WITH
of
higher
disorders
of
the
in
patients
comment:
this
than
the
without
This
possibly
ob-
requires
confirmation
with
a larger
number
of patients than reported
here.-J.
E. U.