124 (15)

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2014 124: e33-2469
124 (15)
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9 OCTOBER 2014 x VOLUME 124, NUMBER 15
CONTENTS
COVER FIGURE
Immunofluorescence microscopy of E12.5 yolk sac of a CD68-GFP transgenic mouse
embryo. Monocytes and macrophages express the GFP reporter gene driven by the
human CD68 promoter. Costaining with PECAM-1 shows close association between
endothelial cells (red) and macrophages (green) in the developing vasculature. Nuclei
are stained blue with the DNA dye DAPI. See the article by Iqbal et al on page e33.
INSIDE BLOOD COMMENTARIES
2315
Renal risk and response in amyloidosis
Angela Dispenzieri
Comment on Palladini et al, page 2325
2316
It takes a village
Naomi Winick
Comment on Bhatia et al, page 2345
2317
Concealed dagger in FLT3/ITD1 AML
Yishai Ofran
Comment on Ostronoff et al, page 2400
2319
Inflammatory Langerhans cell differentiation
Herbert Strobl
Comment on Mart´ınez-Cingolani et al, page 2411
2320
Macrophages shine bright
Oliver Soehnlein
Comment on Iqbal et al, page e33
2322
Self-control of platelets: a new ITIM story
Xiaoping Du
Comment on Fan et al, page 2421
2323
CEA a thrombus CAM: CEACAM2, a twin of CEACAM1?
Andrea Kristina Horst
Comment on Alshahrani et al, page 2431
PLENARY PAPER
2325
A staging system for renal outcome and early markers of renal response to
chemotherapy in AL amyloidosis
Giovanni Palladini, Ute Hegenbart, Paolo Milani, Christoph Kimmich, Andrea Foli,
Anthony D. Ho, Marta Vidus Rosin, Riccardo Albertini, Remigio Moratti, Giampaolo Merlini,
and Stefan Sch¨onland
BLOOD SPOTLIGHT
2333
Molecular and clinical predictors of inhibitor risk and its prevention and treatment in
mild hemophilia A
Giancarlo Castaman and Karin Fijnvandraat
REVIEW ARTICLE
2337
Autoimmune and other cytopenias in primary immunodeficiencies:
pathomechanisms, novel differential diagnoses, and treatment
Markus G. Seidel
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CLINICAL TRIALS AND
OBSERVATIONS
2345
6MP adherence in a multiracial cohort of children with acute lymphoblastic
leukemia: a Children’s Oncology Group study
Smita Bhatia, Wendy Landier, Lindsey Hageman, Heeyoung Kim, Yanjun Chen,
Kristine R. Crews, William E. Evans, Bruce Bostrom, Jacqueline Casillas, David S. Dickens,
Kelly W. Maloney, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey,
F. Lennie Wong, and Mary V. Relling
2354
Impact of induction regimen and stem cell transplantation on outcomes in double-hit
lymphoma: a multicenter retrospective analysis
Adam M. Petrich, Mitul Gandhi, Borko Jovanovic, Jorge J. Castillo, Saurabh Rajguru,
David T. Yang, Khushboo A. Shah, Jeremy D. Whyman, Frederick Lansigan,
Francisco J. Hernandez-Ilizaliturri, Lisa X. Lee, Stefan K. Barta, Shruthi Melinamani,
Reem Karmali, Camille Adeimy, Scott Smith, Neil Dalal, Chadi Nabhan, David Peace, Julie Vose,
Andrew M. Evens, Namrata Shah, Timothy S. Fenske, Andrew D. Zelenetz, Daniel J. Landsburg,
Christina Howlett, Anthony Mato, Michael Jaglal, Julio C. Chavez, Judy P. Tsai, Nishitha Reddy,
Shaoying Li, Caitlin Handler, Christopher R. Flowers, Jonathon B. Cohen, Kristie A. Blum,
Kevin Song, Haowei (Linda) Sun, Oliver Press, Ryan Cassaday, Jesse Jaso, L. Jeffrey Medeiros,
Aliyah R. Sohani, and Jeremy S. Abramson
HEMATOPOIESIS AND
STEM CELLS
2362
UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell
activity
Marie-Eve Bordeleau, Romain Aucagne, Jalila Chagraoui, Simon Girard, Nadine Mayotte,
´ Bonneil, Pierre Thibault, Caroline Pabst, Anne Bergeron, Fr´ed´eric Barab´e, Jos´ee H´ebert,
Eric
Martin Sauvageau, Christel Boutonnet, Sylvain Meloche, and Guy Sauvageau
IMMUNOBIOLOGY
2370
Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance
Dagmar Gotthardt, Eva M. Putz, Elisabeth Straka, Petra Kudweis, Mario Biaggio, Valeria Poli,
Birgit Strobl, Mathias M¨uller, and Veronika Sexl
LYMPHOID NEOPLASIA
2380
Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during
murine leukemogenesis
Esther Rodr´ıguez-D´ıez, Victor Quereda, Florian Bellutti, Michaela Prchal-Murphy, David Partida,
Manuel Eguren, Karoline Kollmann, Marta G´omez de Cedr´on, Pierre Dubus, Marta Cañamero,
Dolores Mart´ınez, Veronika Sexl, and Marcos Malumbres
MYELOID NEOPLASIA
2391
The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells
Philipp B. Staber, Pu Zhang, Min Ye, Robert S. Welner, Elena Levantini, Annalisa Di Ruscio,
Alexander K. Ebralidze, Christian Bach, Hong Zhang, Junyan Zhang, Katrina Vanura,
Ruud Delwel, Henry Yang, Gang Huang, and Daniel G. Tenen
2400
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML
patients and leads to induction failure: a COG and SWOG report
Fabiana Ostronoff, Megan Othus, Robert B. Gerbing, Michael R. Loken, Susana C. Raimondi,
Betsy A. Hirsch, Beverly J. Lange, Stephen Petersdorf, Jerald Radich, Frederick R. Appelbaum,
Alan S. Gamis, Todd A. Alonzo, and Soheil Meshinchi
2408
Brief Report
Impact of early molecular response in children with chronic myeloid leukemia
treated in the French Glivec phase 4 study
Fr´ed´eric Millot, Joelle Guilhot, Andr´e Baruchel, Arnaud Petit, Yves Bertrand,
Françoise Mazingue, Patrick Lutz, Cecile V´erit´e, Christian Berthou, Claire Galambrun,
Nicolas Sirvent, Karima Yakouben, Claudine Schmitt, Virginie Gandemer, Yves Reguerre,
G´erard Couillault, Françoise Mechinaud, and Jean-Michel Cayuela
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PHAGOCYTES,
GRANULOCYTES, AND
MYELOPOIESIS
2411
Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with
thymic stromal lymphopoietin and TGF-b
Carolina Mart´ınez-Cingolani, Maximilien Grandclaudon, Marine Jeanmougin, Mabel Jouve,
Rapha¨el Zollinger, and Vassili Soumelis
e33
e-Blood
Human CD68 promoter GFP transgenic mice allow analysis of monocyte to
macrophage differentiation in vivo
Asif J. Iqbal, Eileen McNeill, Theodore S. Kapellos, Daniel Regan-Komito, Sophie Norman,
Sarah Burd, Nicola Smart, Daniel E. W. Machemer, Elena Stylianou, Helen McShane,
Keith M. Channon, Ajay Chawla, and David R. Greaves
PLATELETS AND
THROMBOPOIESIS
2421
Paired immunoglobulin-like receptor B regulates platelet activation
Xuemei Fan, Panlai Shi, Jing Dai, Yeling Lu, Xue Chen, Xiaoye Liu, Kandi Zhang, Xiaolin Wu,
Yueping Sun, Kemin Wang, Li Zhu, Cheng Cheng Zhang, Junfeng Zhang, Guo-qiang Chen,
Junke Zheng, and Junling Liu
2431
CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways
and thrombus growth in vitro and in vivo
Musaed M. Alshahrani, Eunice Yang, Jana Yip, Simona S. Ghanem, Simon L. Abdallah,
Anthony M. deAngelis, Cindy J. O’Malley, Fatemeh Moheimani, Sonia M. Najjar,
and Denise E. Jackson
THROMBOSIS AND
HEMOSTASIS
2442
Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics
of conformational changes in platelet factor 4
Martin Kreimann, Sven Brandt, Krystin Krauel, Stephan Block, Christiane A. Helm,
Werner Weitschies, Andreas Greinacher, and Mihaela Delcea
2450
The impact of bleeding complications in patients receiving target-specific oral
anticoagulants: a systematic review and meta-analysis
Chatree Chai-Adisaksopha, Mark Crowther, Tetsuya Isayama, and Wendy Lim
TRANSPLANTATION
2459
Brief Report
Impact of acute and chronic graft-versus-host disease on human B-cell generation
and replication
Salom´e Glauzy, Juliette Soret, Isabelle Fournier, Corinne Douay, H´el`ene Moins-Teisserenc,
R´egis Peffault de Latour, Guitta Maki, Marie Robin, G´erard Soci´e, Antoine Toubert,
and Emmanuel Clave
BLOOD WORK
2463
Coexistent BCR-ABL1 and JAK2 V617F: converting CML dwarves to ET staghorns
with imatinib therapy
Craig Soderquist and Adam Bagg
2464
Basophilic blast phase of chronic myelogenous leukemia
Hani M. Babiker and Maria Proytcheva
CORRESPONDENCE
2465
The prognostic advantage of calreticulin mutations in myelofibrosis might be
confined to type 1 or type 1-like CALR variants
Ayalew Tefferi, Terra L. Lasho, Alexander Tischer, Emnet A. Wassie, Christy M. Finke,
Alem A. Belachew, Rhett P. Ketterling, Curtis A. Hanson, and Animesh D. Pardanani
xii
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2467
Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid
malabsorption that responds to treatment
Charlotte Pawlyn, Mohid S. Khan, Ann Muls, Priya Sriskandarajah, Martin F. Kaiser,
Faith E. Davies, Gareth J. Morgan, and H. Jervoise N. Andreyev
ERRATA
2469
Lo SM, Choi M, Liu J, et al. Phenotype diversity in type 1 Gaucher disease:
discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype
by individual genome analysis. Blood. 2012;119(20):4731-4740.
OTHER DEPARTMENTS
xxiii
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