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From www.bloodjournal.org by guest on February 2, 2015. For personal use only.
29 JANUARY 2015 x VOLUME 125, NUMBER 5
CONTENTS
COVER FIGURE
Cytoskeleton disorganization caused by the R46W mutation of a-actinin 1. ACTN1
is a gene recently identified as responsible for a new, autosomal-dominant form
of inherited thrombocytopenia, ACTN1-related thrombocytopenia. Expression of the
mutant R46W form of a-actinin 1 (green) in human fibroblasts causes complete
disorganization of the cytoskeleton with actin (red) no longer organized in filaments,
which are instead observed in surrounding untransfected cells. See the article by
Bottega et al on page 869.
INSIDE BLOOD COMMENTARIES
741
There’s no such fool like an immunosenescent fool
Markus G. Seidel
Comment on Stepensky et al, page 753
742
Dissecting complement blockade for clinic use
Antonio M. Risitano
Comment on Peffault de Latour et al, page 775
744
The off-target effects of nonspecific NK cells
Dean A. Lee
Comment on Shah et al, page 784
745
Blind men and an elephant
Shaji Kumar
Comment on Pawlyn et al, page 831
747
Proplatelets slip slidin’ away
Alexandra Mazharian and Yotis A. Senis
Comment on Bender et al, page 860
748
Inherited thrombocytopenias: the beat goes on
A. Koneti Rao and Natthapol Songdej
Comment on Bottega et al, page 869
750
PI3Kb inhibition: all that glitters is not gold
Mauro Torti
Comment on Laurent et al, page 881
PLENARY PAPER
753
Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence
associated with tripeptidyl-peptidase II deficiency
Polina Stepensky, Anne Rensing-Ehl, Ruth Gather, Shoshana Revel-Vilk, Ute Fischer,
Schafiq Nabhani, Fabian Beier, Tim H. Br¨ummendorf, Sebastian Fuchs, Simon Zenke, Elke Firat,
Vered Molho Pessach, Arndt Borkhardt, Mirzokhid Rakhmanov, B¨arbel Keller, Klaus Warnatz,
Hermann Eibel, Gabriele Niedermann, Orly Elpeleg, and Stephan Ehl
BLOOD SPOTLIGHT
762
Fcg-receptor–mediated trogocytosis impacts mAb-based therapies: historical
precedence and recent developments
Ronald P. Taylor and Margaret A. Lindorfer
v
BLOOD, 29 JANUARY 2015 x VOLUME 125, NUMBER 5
CONTINUED ON vi
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HOW I TREAT
767
How I treat the older patient with acute myeloid leukemia
Gert Ossenkoppele and Bob L¨owenberg
CLINICAL TRIALS AND
OBSERVATIONS
775
Assessing complement blockade in patients with paroxysmal nocturnal
hemoglobinuria receiving eculizumab
R´egis Peffault de Latour, V´eronique Fremeaux-Bacchi, Rapha¨el Porcher, Ali´enor Xhaard,
J´er´emie Rosain, Diana Cadena Castaneda, Paula Vieira-Martins, St´ephane Roncelin,
Paula Rodriguez-Otero, Aur´elie Plessier, Flore Sicre de Fontbrune, Sarah Abbes, Marie Robin,
and G´erard Soci´e
784
Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following
T-cell–depleted stem cell transplantation
Nirali N. Shah, Kristin Baird, Cynthia P. Delbrook, Thomas A. Fleisher, Mark E. Kohler,
Shakuntala Rampertaap, Kimberly Lemberg, Carolyn K. Hurley, David E. Kleiner,
Melinda S. Merchant, Stefania Pittaluga, Marianna Sabatino, David F. Stroncek,
Alan S. Wayne, Hua Zhang, Terry J. Fry, and Crystal L. Mackall
HEMATOPOIESIS AND
STEM CELLS
793
Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and
telomere biology disorders
Arun Balakumaran, Prasun J. Mishra, Edyta Pawelczyk, Sayuri Yoshizawa, Brian J. Sworder,
Natasha Cherman, Sergei A. Kuznetsov, Paolo Bianco, Neelam Giri, Sharon A. Savage,
Glenn Merlino, Bogdan Dumitriu, Cynthia E. Dunbar, Neal S. Young, Blanche P. Alter,
and Pamela G. Robey
IMMUNOBIOLOGY
803
A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis
Jacob T. Jackson, Chayanica Nasa, Wei Shi, Nicholas D. Huntington, Clifford W. Bogue,
Warren S. Alexander, and Matthew P. McCormack
815
Brief Report
Histone deacetylase inhibition regulates inflammation and enhances Tregs after
allogeneic hematopoietic cell transplantation in humans
Sung Won Choi, Erin Gatza, Guoqing Hou, Yaping Sun, Joel Whitfield, Yeohan Song,
Katherine Oravecz-Wilson, Isao Tawara, Charles A. Dinarello, and Pavan Reddy
LYMPHOID NEOPLASIA
820
Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic
leukemia (ALL) in the central nervous system (CNS)
Sarah Krause, Christian Pfeiffer, Susanne Strube, Ameera Alsadeq, Henning Fedders,
Christian Vokuhl, Sonja Loges, Jonas Waizenegger, Isabel Ben-Batalla, Gunnar Cario,
Anja M¨oricke, Martin Stanulla, Martin Schrappe, and Denis M. Schewe
831
Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse
cytogenetics and may precede IGH translocations
Charlotte Pawlyn, Lorenzo Melchor, Alex Murison, Christopher P. Wardell, Annamaria Brioli,
Eileen M. Boyle, Martin F. Kaiser, Brian A. Walker, Dil B. Begum, Nasrin B. Dahir, Paula Proszek,
Walter M. Gregory, Mark T. Drayson, Graham H. Jackson, Fiona M. Ross, Faith E. Davies,
and Gareth J. Morgan
841
Integrin avb3 acting as membrane receptor for thyroid hormones mediates
angiogenesis in malignant T cells
Florencia Cayrol, Mar´ıa Celeste D´ıaz Flaqu´e, Tharu Fernando, Shao Ning Yang,
Helena Andrea Sterle, Marcela Bolontrade, Mariana Amor´os, Blanca Isse, Ricardo Norberto Far´ıas,
Haelee Ahn, Ye F. Tian, Fabrizio Tabb`o, Ankur Singh, Giorgio Inghirami, Leandro Cerchietti,
and Graciela Alicia Cremaschi
vi
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CONTINUED ON viii
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852
Brief Report
Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
Ryan H. Newton, Yu Lu, Antonella Papa, Greg H. Whitcher, Youn-Jung Kang, Catherine Yan,
Pier Paolo Pandolfi, and Laurence A. Turka
856
Brief Report
Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations
Panagiotis Baliakas, Andreas Agathangelidis, Anastasia Hadzidimitriou, Lesley-Ann Sutton,
Eva Minga, Athina Tsanousa, Lydia Scarf`o, Zadie Davis, Xiao-Jie Yan, Tait Shanafelt,
Karla Plevova, Yorick Sandberg, Fie Juhl Vojdeman, Myriam Boudjogra, Tatiana Tzenou,
Maria Chatzouli, Charles C. Chu, Silvio Veronese, Anne Gardiner, Larry Mansouri,
Karin E. Smedby, Lone Bredo Pedersen, Denis Moreno, Kirsten Van Lom, V´eronique Giudicelli,
Hana Skuhrova Francova, Florence Nguyen-Khac, Panagiotis Panagiotidis, Gunnar Juliusson,
Lefteris Angelis, Achilles Anagnostopoulos, Marie-Paule Lefranc, Monica Facco, Livio Trentin,
Mark Catherwood, Marco Montillo, Christian H. Geisler, Anton W. Langerak, Sarka Pospisilova,
Nicholas Chiorazzi, David Oscier, Diane F. Jelinek, Nikos Darzentas, Chrysoula Belessi,
Frederic Davi, Paolo Ghia, Richard Rosenquist, and Kostas Stamatopoulos
PLATELETS AND
THROMBOPOIESIS
860
Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic
dynein
Markus Bender, Jonathan N. Thon, Allen J. Ehrlicher, Stephen Wu, Linas Mazutis,
Emoke Deschmann, Martha Sola-Visner, Joseph E. Italiano, and John H. Hartwig
869
Brief Report
ACTN1-related thrombocytopenia: identification of novel families for phenotypic
characterization
Roberta Bottega, Caterina Marconi, Michela Faleschini, Gabriele Baj, Claudia Cagioni,
Alessandro Pecci, Tommaso Pippucci, Ugo Ramenghi, Simonetta Pardini, Loretta Ngu,
Carlo Baronci, Shinji Kunishima, Carlo L. Balduini, Marco Seri, Anna Savoia, and Patrizia Noris
RED CELLS, IRON, AND
ERYTHROPOIESIS
873
Hepcidin is suppressed by erythropoiesis in hemoglobin E b-thalassemia and
b-thalassemia trait
Emma Jones, Sant-Rayn Pasricha, Angela Allen, Patricia Evans, Chris A. Fisher, Katherine Wray,
Anuja Premawardhena, Dyananda Bandara, Ashok Perera, Craig Webster, Pamela Sturges,
Nancy F. Olivieri, Timothy St. Pierre, Andrew E. Armitage, John B. Porter, David J. Weatherall,
and Hal Drakesmith
THROMBOSIS AND
HEMOSTASIS
881
Platelet PI3Kb and GSK3 regulate thrombus stability at a high shear rate
Pierre-Alexandre Laurent, Sonia S´everin, B´eatrice Hechler, Bart Vanhaesebroeck,
Bernard Payrastre, and Marie-Pierre Gratacap
BLOOD WORK
889
“Cup-like” blasts in acute myeloid leukemia with FLT3 and NPM1 mutations
Aditi Vidholia and Madhu P. Menon
ERRATA
viii
890
Irving J, Matheson E, Minto L, et al. Ras pathway mutations are prevalent in relapsed
childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition.
Blood. 2014;124(23):3420-3430.
890
Boudreau LH, Duchez A-C, Cloutier N, et al. Platelets release mitochondria serving
as substrate for bactericidal group IIA-secreted phospholipase A2 to promote
inflammation. Blood. 2014;124(14):2173-2183.
BLOOD, 29 JANUARY 2015 x VOLUME 125, NUMBER 5
CONTINUED ON ix
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OTHER DEPARTMENTS
iiib
Classifieds
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