Course leader
Prof. H.J. Noorman
DSM Biotechnology Center and
Delft University of Technology
Delft, the Netherlands
Lecturers
Dr. M.H.M. Eppink
Synthon BV, Nijmegen
and Bioprocess Engineering
Wageningen University
Wageningen, the Netherlands
Board of the course
Prof. G. Eggink
Biobased Products and Bioprocess
Engineering
Wageningen University
Wageningen, the Netherlands
Dr. M.L.A. Jansen
DSM Biotechnology Center
Delft, the Netherlands
Prof. J.J. Heijnen
Cell Systems Engineering,
Delft University of Technology
Department of Biotechnology
Delft, the Netherlands
Dr. R.A. Weusthuis
Biobased Commodity Chemicals
Wageningen University
Wageningen, the Netherlands
Dr. M.G.J. Janssen
Bioprocess Engineering
Wageningen University
Wageningen, the Netherlands
Dr. J. Lievense
Genomatica Inc.
San Diego, CA, USA
Dr. D.E. Martens
Bioprocess Engineering
Wageningen University
Wageningen, the Netherlands
Dr. Y.E. Thomassen
Intravacc
Bilthoven, the Netherlands
Excursion
Bioprocess Pilot Facility
Delft, the Netherlands
Course organisation
Ms. Jenny Boks-Zondervan
Dr. Eline Huisjes
BSDL, Delft University of Technology
Department of Biotechnology
Delft, the Netherlands
Dr. Fre Pepping
Graduate School VLAG
Wageningen University
Wageningen, the Netherlands
The institute Biotechnology Sciences Delft Leiden (BSDL-EDU) constitutes a joint initiative
in biotechnological post-graduate education of Delft University of Technology and Leiden
University and is coordinated from the department of Biotechnology of Delft University
of Technology.
BSDL-EDU was founded in 1987 and has since then very successfully organised various
types of postdoctoral education: the Advanced Course Quality Management in Pharma
and Biotech, the PDEng programmes and the Advanced Courses in biotechnology.
The Advanced Course Quality Management in Pharma and Biotech was developed by
BSDL-EDU and is currently organised by PAO Farmacie. The PDEng programmes are special
two-year postgraduate programmes that are aimed at those who wish to tailor their own
specialisation to the needs of multidisciplinary biotechnological research and design,
and lead to the degree of ‘Professional Doctorate in Engineering’. Originally developed
by BSDL-EDU, these programmes are now hosted by the 3TU School for Technological
Design / Stan Ackermans Institute.
Currently BSDL-EDU offers various Advanced Courses covering the multidisciplinary
spectrum of biotechnology:
ómicrobial
physiology and fermentation technology
óbiocatalysis and protein engineering
ódownstream processing
óenvironmental biotechnology
ógenomics in industrial biotechnology
ómetabolomics for microbial systems biology
Further information
Ms. Jenny Boks-Zondervan
Dr. Eline Huisjes
Course coordination
p +31 15 278 1922 / 8311
f +31 15 278 2355
e [email protected]
w www.biotechnologycourses.nl
Address
Institute Biotechnology Studies Delft Leiden
Department of Biotechnology, Delft University of Technology
Julianalaan 67, 2628 BC Delft, the Netherlands
Design: Leiden in vorm!, Leiden, [email protected], www.leideninvorm.nl
Advanced Course
bioprocess design
20 - 24 April 2015
Aim
Course description
Who should attend?
With recent advances in molecular biology
and a growing biomass availability for use
as industrial feedstock, the bio-based
economy is getting a wider range of inputs.
Scaling up the bio(techno)logy innovations
and implementation in large-scale factories
or biorefineries clearly is a present bottleneck:
industries are struggling to get the
bio-opportunities to the market, as experienced
industrial bioprocess designers and operational
experts are not readily available to meet the
growing needs.
This one-week course is intensive
and has long days. To ensure active
participation by those attending, a
combination of theoretical (lectures)
and practical (exercises, case study)
work is offered.
The course is primarily aimed
at academic and industrial
specialists (MSc, PhD or
equivalent experience)
that seek for refreshing and
broadening their knowhow and
practical insight in Bioprocess
Design, to assist in progress
towards the bio-based economy.
A background in e.g. biochemical
engineering, microbiology
or biochemistry and a basic
working knowledge of the other
disciplines is expected.
Teachers from universities and companies
have joint forces and will present a program
that centers around industrial fermentation
processes, and is flanked by overviews on
upstream and downstream processing, as
well as an economic analysis. The focus of
the course is on design of innovative
microbial fermentations, complemented with
examples of marine and mammalian processes.
A substantial part of the course (ca. 40% of
the time) will be dedicated to a case study,
executed in teams of 4-6 participants, on the
design of a bioprocess for the production
of a chemical (1,4-butanediol), where basic
theory on thermodynamic-based microbial
stoichiometry and kinetics, transport in vessels,
design and scale up/down will be extensively
applied. The team with the best design
performance wins the Genomatica Bioprocess
Design prize. There are several guest lecturers
from leading universities and industries in
the bioprocess field, providing latest insights
in technology innovations, non-conventional
feedstocks and new bio-product categories,
complemented with views from the industrial
practice. The Advanced Course Bioprocess
Design is cooperatively organised by BSDL
and graduate school VLAG.
Lectures
The core lectures are mainly scheduled
in the mornings and will focus on the
following themes:
Ô Rates, thermodynamics and metabolism of micro organisms
Ô Transport processes in bioreactors
Ô Fermentation processes and their scale up features
In the early evenings, invited lectures
are scheduled on e.g. examples of
successful bioprocesses, downstream
processing, novel feedstocks and
economic aspects of bioprocessing.
Exercises and case study
For a better understanding of the
lectures, the theory is applied in
exercises on the Monday and Tuesday
afternoons.
From Wednesday on, the practical work
continues in a case study on a real-life
bioprocess design question where all
theory will be needed.
The course will be given in English.
A pocket calculator is required.
Duration & Location
Accommodation
This Advanced Course will be given on
20 - 24 April 2015
Hotel accommodation can be arranged at your request
addressed to [email protected]. Lunches, the buffet
on Monday and the course dinner on Thursday will be
provided.
The course will be held at the
Department of Biotechnology
Delft University of Technology
Julianalaan 67
2628 BC Delft
The Netherlands
p +31 15 278 1922
f +31 15 278 2355
e [email protected]
w www.biotechnologycourses.nl
Program, 20-24 April 2015
Monday 20 April 2015
Theme: Micro-organisms: Rates, process reaction and metabolism
8:45
Registration
9:00
Introduction and outline
Henk Noorman
09:30 Biochemistry of energy metabolism and product pathways
Ruud Weusthuis
11:00 The process reaction for bioprocess design:
a thermodynamic approach
Sef Heijnen
13:45
Design of bioprocesses based on the process reaction
Sef Heijnen
14:15
Exercises: obtaining the process reaction
15:45
Continuation of the exercises
18:00 Social drink and buffet
Thursday 23 April 2015
Theme: Case study
9:00
Case study:
• Quantification of in- and outputs for the case
• Reporting results
10:45 Microbial synthesis of reduced compounds for the chemical industry
Gerrit Eggink
13:00 Case study:
• Quantification of transport and vessel sizing for
the case
• Strategies for improvements (Genomatica Bioprocess Design Prize)
• Reporting results
17:00 Cost modelling of fermentation processes
Sef Heijnen
19:00 Course dinner
Tuesday 21 April 2015
Theme: Fermentors: transport
9:00
Gas transport
Henk Noorman
9:45
Heat transport
Henk Noorman
10:30 Mixing
Henk Noorman
11:30
Downstream Processing
Michel Eppink
13:30 Exercises: design of transport processes and
fermentor volume
15:15
Continuation of the exercises
17:30 Advances in pretreatment of biomass
Gerrit Eggink
Friday 24 April 2015
Theme: Case study
9:00
Scale-up/scale-down: Introduction to characteristic times
Sef Heijnen
9:45
Case study:
• Full scale conditions and scale-up/scale-down
11:45
Low-pH fermentation to succinic acid, the basis for efficient recovery
Mickel Jansen
15:15
Keynote Lecture
Process design and development: lessons from
the industry
Jeff Lievense
Wednesday 22 April 2015
Theme: Fermentation processes and their scale up features
9:00
Industrial microbial fermentation
Henk Noorman
9:45
Algal processes
Marcel Janssen
10:45 Animal cell cultures
Dirk Martens
11:30
Scale-up/scale-down approach
Henk Noorman
13:30 Excursion to Bioprocess Pilot Facility (BPF)
14:30 Case study:
• Introduction to the case
Henk Noorman
• Lecture “Rate-based design of biosystems”
Sef Heijnen
17:30 Process design in viral vaccine production
Yvonne Thomassen
Fees & Registration
Please register via the website to attend the course. Applicants will
be handled in order of the date of receipt.
The course fee is:
€ 2500 in case of payment received before 6 March 2015 or
€ 2750 in case of payment received after this date.
In the event of cancellation before 6 March, a full refund will be
granted, after this date, a 25% fee charge will be made.
To facilitate enrolment of young PhD-students from universities,
a limited number of fellowships is available. The course fee
with fellowship is € 1250. To apply, please include a copy of your
registration as a PhD-student from your university.
PhD/PDEng students working in the Department of Biotechnology
of TU Delft, or in the research school VLAG may apply for the
special reduced fee of € 625. To apply, please include a proof of
your registration as a PhD student at one of these institutes.
The fee includes course materials, lunches, the buffet on Monday
and the course dinner on Thursday. The fee does not cover other
meals and lodging.
When the number of participants is too low to have a fruitful
course, the Institute BSDL will cancel the event no later than
six weeks before the start of the course. The course fee will be
reimbursed within three weeks after cancellation.
In case a speaker will not be able to present his/her lecture due
to unforeseen circumstances, BSDL will arrange an equivalent
replacement.
Hotel accommodation can be arranged at your request.
The complete set of course books will be supplied at the start
of the course.