GLOBAL INDUSTRY INSIGHT:
Antibody Drug Conjugates (ADCs) Therapeutics Market – Pipeline
Analysis, Size, Share, Development, Growth and Demand Forecast to
2023
ADCs Therapeutics Market – Pipeline Analysis, Size, Share,
Development, Growth and Demand Forecast to 2023
The global antibody drug conjugates therapeutics market is expected to witness significant growth
due to current unmet medical need of some chronic diseases such as cancer and immunological
diseases, increasing prevalence of such diseases, advancement in technologies and high demand
for safe and effective medication. The regulatory bodies are supporting the ADCs market by
providing designations and funding for speeding up the drug development process. In April 2015,
ImmunoGen, Inc. drug candidate Mirvetuximab soravtansine got orphan drug designation by
European Medicine Agency for the treatment of ovarian cancer.
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The pipeline of ADCs is rich with more than 200 drugs. The pharmaceutical companies are actively
involved in the research and development of drug for ADCs. Trastuzumab emtansineis, a Phase III
clinical trial drug candidate of Genentech, Inc., utilizes Tumor-Activated Prodrug technology for the
treatment of HER2-positive primary breast cancer. The drug is already marketed under trade name
Kadcyla for the treatment of advanced human epidermal growth factor receptor 2 (HER2)-positive
gastric cancer and early HER2-positive breast cancer.
ADCs are prepared by linking biologically active cytotoxic drugs to monoclonal antibodies. An ADC
comprises of a monoclonal antibody, cytotoxic drug and a linker. ADCs have specific targeting
ability of monoclonal antibody, and hence these are capable of distinguishing healthy and diseased
cells. Moreover, the cancer-killing ability of cytotoxic drugs makes ADCs more effective against the
tumor cells. These characteristics increase the specificity and maximize the efficacy of ADCs. The
antibody component of ADCs recognizes the target antigen and binds with it. After binding with the
antigen, the cytotoxic component is released inside the tumor cell, causing its death or
degeneration. The significant potential of ADCs in cancer treatment has attracted many researchers
and healthcare providers to develop new antibody therapeutics using ADC technology.
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A large number of pharmaceutical companies are focusing towards research and development of
ADCs. However, certain factors such as unknown etiology, complex pathophysiology and high
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ADCs Therapeutics Market – Pipeline Analysis, Size, Share,
Development, Growth and Demand Forecast to 2023
treatment cost of cancer are expected to hamper the growth of the global market during the
forecast period.
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Geographically, North America is expected to be the largest market for ADCs, owing to the large
number of research and development activities, high healthcare expenditure, and high prevalence
of cancer. The U.S. contributed largest revenue to the North American ADCs market and it is
expected to remain the largest market globally, during the forecast period.
Some of the key players operating in the global market are ImmunoGen, Inc., Takeda
Pharmaceutical Company Limited, Seattle Genetics, Inc., F. Hoffmann-La Roche AG, BioAtla LLC,
Philogen S.p.A., Viventia Biotechnologies, Inc., Sutro Biopharma, Inc., Sorrento Therapeutics, Inc.,
and Immunobiochem Corporation.
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ADCs Therapeutics Market – Pipeline Analysis, Size, Share,
Development, Growth and Demand Forecast to 2023
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