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Ablation Technologies Worldwide Market, 2009-2019:
Products, Technologies, Markets, Companies and
Opportunities
Phone:
+44 20 8123 2220
Fax:
+44 207 900 3970
[email protected]
http://marketpublishers.com
Phone: +44 20 8123 2220
http://marketpublishers.com
Ablation Technologies Worldwide Market, 2009-2019: Products,
Technologies, Markets, Companies and Opportunities
MedMarket Diligence, LLC
Date: Jun, 2010
Pages: 488
Price: US$ 3,750.00
ID: A20D720626DEN
This report is a detailed market and technology assessment and forecast of the applications, products,
technologies and opportunities in the global ablation market for treatment of soft tissues via energy-based
modalities, including electrosurgery, radiosurgery, gamma knife, brachytherapy, cryosurgery, fluidjet
therapy (hydrotherapy), microwave ablation, radiofrequency ablation, laser, thermal ablation, and ultrasonic
ablation.
The report describes alternative energy-based technologies and the nature of their effect on soft tissue, the
underlying basis of the technology, the requisite systems for their use (including capital equipment, devices
and disposables), and their strengths and weaknesses for specific clinical applications. The report details
current and anticipated target applications and assesses the current and forecast caseload for each
energy-based therapeutic considering competition from any and all alternative energy-based or other
therapeutics, with current and worldwide market forecasts (2009-2019) segmented by technology type and
specific clinical segment. The report provides segmentation of the worldwide ablation market by both
ablation technology and region/country: Americas (USA, Canada, Mexico, Brazil), Europe (Germany,
United Kingdom, France, Italy, Spain, BeNeLux), Asia/Pacific (Japan, China, India, Australia) and Rest of
World. The report details the current and emerging products, technologies and markets for each
energy-based therapy. The report profiles 76 key companies in this industry detailing their current products,
current market position and products under development.
Table of Content
EXECUTIVE SUMMARY
SECTION 1: DISEASE STATES TREATED WITH ENERGY-BASED ABLATIVE TECHNOLOGY
1.1 Overview of Ablation Technologies for the Treatment of Disease
1.1.1 Electrical
1.1.1.1 Enhancing Ablation Using Argon Gas
1.1.1.2 Irreversible Electroporation
1.1.2 Radiation
1.1.2.1 Image-guided radiotherapy (IGRT)
1.1.2.2 Image-modulated Radiotherapy (IMRT)
1.1.2.3 Tomotherapy
1.1.2.4 Increased Use of Hypofractionation, IGRT and IMRT
1.1.2.5 Hyperfractionation May Have its Benefits
1.1.2.6 Radiation and Concurrent Use of Chemotherapy
1.1.2.7 Brachytherapy
1.1.2.8 Stereotactic Radiosurgery and SBRT
1.1.2.9 FDA Tightening Approval Process for Radiation-emitting Devices
1.1.2.10 Nano-radiation Therapy
1.1.3 Light
1.1.3.1 Lasers and Their Effects on Tissue
1.1.4 Radiofrequency
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1.1.4.1 Temperature Controlled
1.1.4.2 Fluid Cooled
1.1.4.3 Catheter Manipulation Systems
1.1.5 Ultrasound
1.1.6 Cryotherapy
1.1.7 Thermal
1.1.8 Microwave
1.1.9 Hydromechanical
1.1.10 Technologies Under Development
1.1.10.1 Induction Heating Cancer Therapy (IHCT) Using Magnetic Nanoparticles
1.1.11 Audiosurgery for Tumors
1.2 Disease States and Applicable Ablation Technologies
1.2.1 Cancer
1.2.1.1 Breast
1.2.1.1.1 Current and Emerging Treatment Trends
1.2.1.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.1.2 Liver
1.2.1.2.1 Current and Emerging Treatment Trends
1.2.1.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.1.3 Lung
1.2.1.3.1 Current and Emerging Treatment Trends
1.2.1.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.1.4 Prostate Cancer
1.2.1.4.1 Gleason Grades and Scores
1.2.1.4.2 Prostate Cancer Staging
1.2.1.4.3 Current and Emerging Treatment Trends
1.2.1.4.4 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.1.5 Kidney
1.2.1.5.1 Current and Emerging Treatment Trends
1.2.1.5.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2 Cardiovascular Disease
1.2.2.1 Angina Pectoris
1.2.2.1.1 Current and Emerging Treatment Trends
1.2.2.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.2 Atrial Fibrillation and Atrial Flutter
1.2.2.2.1 Current and Emerging Treatment Trends
1.2.2.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.3 Ventricular Arrhythmias
1.2.2.3.1 Current and Emerging Treatment Trends
1.2.2.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.4 Wolf-Parkinson-White Disease
1.2.2.4.1 Current and Emerging Treatment Trends
1.2.2.4.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.5 AVNRT (Atrioventricular nodal reentry tachycardia)
1.2.2.5.1 Current and Emerging Treatment Trends
1.2.2.5.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.6 Critical Limb Ischemia
1.2.2.6.1 Current and Emerging Treatment Trends
1.2.2.6.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.7 Critical Ischemic Stroke
1.2.2.7.1 Current and Emerging Treatment Trends
1.2.2.7.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.2.8 Hypertension
1.2.2.8.1 Current and Emerging Treatment Trends
1.2.2.8.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
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1.2.2.9 Varicose Veins
1.2.2.9.1 Current and Emerging Treatment Trends
1.2.2.9.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.3 Ophthalmology
1.2.3.1 Cataracts
1.2.3.1.1 Current and Emerging Treatment Trends
1.2.3.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.3.2 Disorders of the Retina
1.2.3.2.1 Current and Emerging Treatment Trends
1.2.3.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.3.3 Vision Correction
1.2.3.3.1 Current and Emerging Treatment Trends
1.2.3.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.3.4 Central Retinal Vein Occlusion
1.2.3.4.1 Current and Emerging Treatment Trends
1.2.4 General Surgery
1.2.4.1 Barrett’s Esophagus
1.2.4.1.1 Current and Emerging Treatment Trends
1.2.4.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.4.2 Fecal Incontinence
1.2.4.2.1 Current and Emerging Treatment Trends
1.2.4.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.4.3 Gastroesophageal Reflux Disease (GERD)
1.2.4.3.1 Current and Emerging Treatment Trends
1.2.4.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.4.4 Tonsillectomy
1.2.4.4.1 Current and Emerging Treatment Trends
1.2.4.4.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.5 Gynecology
1.2.5.1 Menorrhagia
1.2.5.1.1 Current and Emerging Treatment Trends
1.2.5.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.5.2 Fibroids
1.2.5.2.1 Current and Emerging Treatment Trends
1.2.5.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.5.3 Cervical Dysplasia and Cancer
1.2.5.3.1 Current and Emerging Treatment Trends
1.2.5.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.6 Pain Management
1.2.6.1 Current and Emerging Treatment Trends
1.2.6.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.7 Urology
1.2.7.1 Kidney Stones
1.2.7.1.1 Current and Emerging Treatment Trends
1.2.7.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.7.2 Benign Prostatic Hypertrophy (BPH)
1.2.7.2.1 Current and Emerging Treatment Trends
1.2.7.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.8 Orthopedics
1.2.8.1 Joint Instability (Conducting Capsular Shrinkage)
1.2.8.1.1 Current and Emerging Treatment Trends
1.2.8.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.8.2 Chondroplasty
1.2.8.2.1 Current and Emerging Treatment Trends
1.2.8.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
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1.2.8.3 Discogenic Back Pain
1.2.8.3.1 Current and Emerging Treatment Trends
1.2.8.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9 Aesthetic Treatments
1.2.9.1 Body Contouring
1.2.9.1.1 Current and Emerging Treatment Trends
1.2.9.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9.2 Laser Hair Removal
1.2.9.2.1 Current and Emerging Treatment Trends
1.2.9.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9.3 Laser Tattoo Removal
1.2.9.3.1 Current and Emerging Treatment Trends
1.2.9.3.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9.4 Port-wine Stains
1.2.9.4.1 Current and Emerging Treatment Trends
1.2.9.4.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9.5 Psoriasis
1.2.9.5.1 Current and Emerging Treatment Trends
1.2.9.5.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.9.6 Scar Reduction and Removal
1.2.9.6.1 Current and Emerging Treatment Trends
1.2.9.6.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.10 Other Treatments
1.2.10.1 Severe Asthma
1.2.10.1.1 Current and Emerging Treatment Trends
1.2.10.1.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
1.2.10.2 Unresectable Liver Tumors
1.2.10.2.1 Current and Emerging Treatment Trends
1.2.10.2.2 Applicable Ablation Technologies: Rationale for Use and Effect on Tissues
SECTION 2: PRODUCTS AND TECHNOLOGIES
Comprehensive product listing and selected recent developments discussed
2.1 Electrical
2.2 Radiation
2.2.1 Brachytherapy
2.2.2 High-Dose-Rate (HDR) Brachytherapy
2.2.3 Pulsed-Dose-Rate (PDR) Brachytherapy
2.2.4 Permanent Seed Prostate Brachytherapy (LDR)
2.2.5 Stereotactic Radiosurgery (SRS) and Stereotactic Radiotherapy (SRT)
2.2.6 Stereotactic Body Radiation Therapy (SBRT)
2.2.7 Proton Beam Therapy
2.3 Light/Laser
2.4 Radiofrequency
2.4.1 RF Ablation for Atrial Fibrillation
2.4.2 RF Electrosurgical Devices
2.5 Ultrasound
2.6 Cryotherapy
2.7 Thermal
2.8 Microwave
2.9 Hydromechanical
SECTION 3: MARKET ASSESSMENT
3.1 World Market Overview
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3.2 Market Segmentation by Product Type
3.2.1 Electrical
3.2.2 Radiation
3.2.3 Light
3.2.4 Radiofrequency
3.2.5 Ultrasound
3.2.6 Cryotherapy
3.2.7 Thermal
3.2.8 Microwave
3.2.9 Hydromechanical
3.3 Market Trends
3.3.1 Market Drivers
3.3.1.1 Aging populations
3.3.1.2 Cardiac Arrhythmias
3.3.1.3 Cancer
3.3.1.4 Healthcare Economics
3.3.2 Market Restraints
3.3.2.1 Recession
3.3.2.2 US Healthcare Reforms
3.3.2.3 Procedure Time
3.3.2.4 Cost of Capital Expenditure
3.4 Leading Companies in Global Market
3.5 Major National Markets
3.5.1 Americas
3.5.1.1 U.S.A.
3.5.1.2 Canada
3.5.1.3 Mexico
3.5.1.4 Brazil
3.5.2 European Union
3.5.2.1 United Kingdom
3.5.2.2 Germany
3.5.2.3 France
3.5.2.4 Spain
3.5.2.5 Italy
3.5.2.6 BeNeLux
3.5.3 Asia/Pacific
3.5.3.1 Japan
3.5.3.2 China
3.5.3.3 India
3.5.3.4 Australia
3.5.4 Rest of World
SECTION 4: COMPANY PROFILES
(Select companies profiled; note that not all companies covered in the report are profiled.)
4.1 Accuray
4.1.1 CyberKnife Robotic Radiosurgery System
4.1.2 CyberKnife VSI System
4.1.3 CyberKnife for Unresectable Renal Tumors
4.1.4 International Randomized Study to Compare CyberKnife Stereotactic Radiotherapy With Surgical
Resection In Stage I Non-small Cell Lung Cancer (STARS)
4.1.5 CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR
Brachytherapy Dosimetry
4.1.6 CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Cancer
4.2 Alcon Laboratories
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4.2.1 Infiniti Vision System
4.2.2 Constellation Vision System
4.2.3 Purepoint Laser
4.2.4 Allegretto Wave Eye-Q Excimer Laser System
4.2.5 Bid from Novartis to Acquire Alcon
4.3 American Medical Systems
4.3.1 TherMatrx Office Thermo Therapy
4.3.2 GreenLight Laser Therapy
4.4 AngioDynamics
4.4.1 StarBurst XL RFA device
4.4.2 The Habib 4X bipolar resection device
4.4.3 NanoKnife IRE System
4.4.4 VenaCure EVLT
4.4.5 A Prospective, Multi-Center, Clinical Trial Using Irreversible Electroporation (IRE) for the Treatment
of Early-Stage Hepatocellular Carcinoma (HCC)
4.5 Ardian, Inc.
4.5.1 Symplicity I Trial
4.5.2 Symplicity HTN-2 Trial
4.6 ArthroCare Corporation
4.6.1 Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep
Apnea (OSA) in Children
4.7 Asthmatx, Inc.
4.7.1 Asthma Intervention Research 2 (AIR2) Trial
4.8 AtriCure
4.8.1 The AtriCure Synergy Bipolar System
4.8.2 Bipolar Radiofrequency Ablation of Permanent Atrial Fibrillation (ABLATE)
4.8.3 RESTORE SR IIB
4.9 ATS Medical
4.9.1 ATS CryoMaze
4.10 Bard Electrophysiology
4.10.1 MAGELLAN
4.11 Barrx Medical
4.11.1 Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of
Follow-up to 5 Years (AIM)
4.11.2 Endoscopic RF Ablation for Barrett’s Esophagus: Five-Year Durability Outcomes from a
Prospective Multi-Center Trial
4.12 Bausch + Lomb
4.12.1 Stellaris Vision Enhancement System
4.12.2 Millennium Microsurgical System
4.13 Baylis Medical
4.13.1 TransDiscal System
4.14 Biosense Webster
4.14.1 Irrigated Tip Catheter product lines
4.14.2 NaviStar ThermoCool Catheter for the Treatment of AF—TX Clinical Trial
4.14.3 CLARITY Clinical Study
4.14.4 Study of a New Catheter Using Force Sensing Capabilities for the Treatment of AF and Ventricular
Tachycardia (EZCF-125)
4.14.5 NaviStar ThermoCool Catheter for the Radiofrequency Ablation of Drug Refractory Recurrent
Symptomatic Paroxysmal AF Clinical Trial
4.15 Biotronik
4.15.1 AlCath Flux/AlCath Flux Gold Ablation Catheters
4.16 Boston Scientific
4.16.1 VersaPulse PowerSuite 100 Watt Holmium laser
4.16.2 Prolieve Thermodilatation System
4.16.3 Blazer II X Temperature Ablation Catheter
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4.16.4 RF 3000 Radiofrequency Ablation System
4.16.5 iLab Ultrasound Imaging System with Ultra ICE Catheter
4.16.6 Prolieve Post-Marketing Study Treatment of Benign Prostatic Hyperplasia (BPH)
4.16.7 A Prospective Randomized Study Comparing Radiofrequency Energy With Cryoenergy
(CRYO-RF)
4.17 Bovie Medical
4.17.1 The Aaron line of electrosurgical products
4.17.2 The Bovie line of electrosurgery generators
4.17.3 MEG Endoscopic Instruments
4.18 BSD Medical
4.18.1 Phase III Clinical Trial of the BSD-2000 Hyperthermia System
4.18.2 Phase II MicroThermX® Microwave Ablation System (MTX-180)
4.18.3 BSD 500 Hyperthermia System
4.18.4 BSD-2000
4.19 Cardima
4.19.1 Cardima Surgical Ablation System
4.19.2 Cardima EP Ablation System
4.19.3 Cardima Revelation T-Flex Ablation device
4.20 CardioFocus
4.20.1 Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CFEAS- AC)
for the Treatment of Symptomatic Atrial Fibrillation
4.21 CardioGenesis
4.22 Celon AG
4.22.1 Surgery/Radiology
4.22.2 Phlebology
4.23 Chongqing Haifu (HIFU) Technology Co. Ltd.
4.24 Cook Group
4.24.1 LMA StoneBreaker Pneumatic Lithotripter
4.24.2 Odyssey 30 Holmium Laser System
4.24.3 The StoneBreaker Trial
4.25 ConMed
4.25.1 Beamer System CE600
4.26 Covidien
4.26.1 Electrosurgery
4.26.2 VNUS Medical Technologies
4.26.2.1 ClosureFAST System
4.26.2.2 LigaSure RF Ablation device
4.27 CryoMedix
4.28 CSA Medical
4.28.1 Study of CryoSpray Ablation to Determine Treatment Effect, Depth of Injury, and Side Effects in the
Esophagus. (CSA Depth 3)
4.29 Cynosure
4.30 Dornier MedTech
4.30.1 Compact Delta II and Delta II UIMS
4.30.2 Dornier Lithotripter S II
4.30.3 Dornier Medilas D MultiBeam
4.30.4 Dornier Medilas H
4.31 EDAP TMS S.A.
4.31.1 Ablatherm HIFU
4.31.2 Sonolith i-move
4.31.3 ENLIGHT Clinical Trial
4.32 Elekta
4.32.1 Elekta Axesse
4.32.2 Elekta Infinity
4.32.3 Elekta Synergy S
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4.32.4 Leksell Gamma Knife® Perfexion Stereotactic radiosurgery system
4.33 EndoPhotoniX
4.33.1 Solar & Atrilaze Atrial Fibrillation Trial (SAAF-T)
4.34 Endosense
4.34.1 TOCCATA Clinical Trial
4.34.2 EFFICAS I
4.35 Erbe Elektromedizin GmbH
4.36 Ethicon Endo-Surgery
4.37 Galil Medical
4.38 Gynesonics
4.39 Halt Medical
4.39.1 Laparoscopic Radiofrequency Ablation of Symptomatic Uterine Fibroids (Halt Lap RFA)
4.40 Hansen Medical
4.41 HealthTronics, Inc.
4.42 Hologic, Inc.
4.42.1 NovaSure Endometrial Ablation system
4.42.2 Digital mammography and breast biopsy
4.43 IBt-Bebig, SA
4.44 InSightec
4.44.1 ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Metastatic
Bone Tumors for the Palliation of Pain
4.44.2 Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused
Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and
Multiple Myeloma
4.45 Integra LifeSciences
4.46 Medtronic
4.46.1 Cardiac Rhythm Disease Management (CRDM)
4.46.2 Spinal and Biologics
4.46.3 CardioVascular
4.46.4 Neuromodulation
4.46.5 Diabetes
4.46.6 Surgical Technologies
4.46.7 AF Solutions Franchise
4.46.8 Arctic Front Cardiac CryoAblation Catheter
4.46.9 Cardiac CryoAblation System
4.46.10 The STOP AF Clinical Trial
4.46.11 The TTOP AF Clinical Trial
4.46.12 The CURE-AF/Perst Clinical Trial
4.47 Mederi Therapeutics
4.47.1 Secca Procedure for fecal incontinence
4.47.2 Stretta Procedure for GERD
4.48 MedWaves
4.49 Mirabilis Medica
4.50 Misonix
4.50.1 Sonablate
4.50.2 SonaStar Ultrasonic Surgical Aspirator
4.50.3 Bone Scalpel Ultrasonic Bone Cutter
4.51 nContact Surgical
4.51.1 Numeris Coagulation System with VisiTrax
4.51.2 Numeris-AF Tethered Coagulation System for Treatment of Longstanding Persistent Atrial
Fibrillation (AF)
4.51.3 Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding Persistent
Atrial Fibrillation (CAPstopsLSPAF)
4.51.4 Safety and Efficacy Study of the Combined Ablation Procedure to Treat Paroxysmal Atrial
Fibrillation (CAP STOPS AF)
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4.52 NeuWave Medical
4.52.1 Certus
4.53 Novian Health
4.53.1 Novilase
4.53.2 American Breast Laser Ablation Therapy Evaluation (ABLATE)
4.54 NuVue Therapeutics
4.55 Olympus Medical
4.55.1 UES-40 SurgMaster Electrosurgical Unit
4.55.2 SonoSurg Ultrasonic Surgical System
4.56 PhotoMedex
4.57 PhotoThera
4.58 RFA Medical
4.58.1 InCircle RF Ablation
4.59 Sanarus Technologies LLC
4.59.1 Cassi II Core Biopsy Device
4.59.2 ImarC Tissue Marker System
4.59.3 Visica 2 Treatment System
4.59.4 Z1072 Clinical Trial
4.60 SenoRx
4.60.1 Contura Multi-Lumen Balloon (MLB)
4.60.2 Multi-Site, Prospective, Non-Randomized Study of the Contura Multi-Lumen Balloon (MLB)
Catheter to Deliver Accelerated Partial Breast Irradiation: Analysis of Dosimetry, Local Tumor Control,
Cosmetic Outcome, and Toxicity
4.61 Siemens Healthcare
4.61.1 Siemens to put greater focus on healthcare businesses
4.61.2 Primatom System (IGRT)
4.61.3 Oncor
4.62 Smith & Nephew
4.62.1 Versajet Hydrosurgery System
4.62.2 Dyonics RF System
4.63 Solta Medical
4.63.1 Fraxel re:pair
4.64 Spectrasonics
4.65 St. Jude Medical
4.65.1 Atrial Fibrillation
4.65.2 CABANA Clinical Trial
4.65.3 IRASE AF Clinical Trial
4.65.4 Modified stepwise Ablation Guided by low dose Ibutilide Use in Chronic Atrial Fibrillation Trial
(MAGIC-AF)
4.65.5 AFMAZE-CABG Clinical Trial
4.65.6 Clinical Evaluation of Therapy Cool Path Duo Cardiac Ablation System for the Treatment of
Ischemic Ventricular Tachycardia (VT) (Ablate-VT)
4.66 Starion Instruments
4.67 Stereotaxis
4.67.1 Stereotaxis Magnetic Navigation System
4.68 Theragenics
4.69 TomoTherapy
4.69.1 Hi-Art Treatment System
4.70 Uptake Medical
4.70.1 Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
4.71 Urologix
4.71.1 Targis System
4.72 US HIFU, LLC
4.72.1 Sonablate
4.72.2 Primary Prostate Cancer Clinical Trial
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4.72.3 Recurrent HIFU Clinical Trial
4.73 Varian Medical Systems
4.73.1 Novalis Tx radiosurgery platform
4.73.2 RapidArc
4.73.3 Dynamic Targeting Image-Guided Radiation Therapy (IGRT)
4.73.4 SmartBeam IMRT
4.73.5 Dynamic Adaptive Radiotherapy (DART)
4.73.6 Acuity™ BrachyTherapy Suite™ integrated IGBT solution
4.73.7 Varian Proton Therapy System
4.74 Visualase
4.74.1 Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for
Treatment of Metastatic Brain Tumors
4.75 Xoft
4.75.1 Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of
Early Stage Breast Cancer (EXIBT)
4.75.2 Xoft Electronic Brachytherapy Clinical Protocol for the Primary Treatment of Non-Melanoma Skin
Cancer
4.76 Zeltiq Aesthetics
4.76.1 Non-Invasive Reduction of Abdominal Fat (JUNO)
SECTION 5: KEY CLINICAL TRIALS
5.1 Electrical
5.1.1 AngioDynamics
5.1.1.1 A Prospective, Multi-Center, Clinical Trial Using Irreversible Electroporation (IRE) for the
Treatment of Early-Stage Hepatocellular Carcinoma (HCC)
5.1.2 ArthroCare
5.1.2.1 Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep
Apnea (OSA) in Children
5.2 Radiation
5.2.1 Accuray
5.2.1.1 CyberKnife for Unresectable Renal Tumors
5.2.1.2 CyberKnife for Unresectable Renal Tumors
5.2.1.3 International Randomized Study to Compare CyberKnife Stereotactic Radiotherapy With Surgical
Resection In Stage I Non-small Cell Lung Cancer (STARS)
5.2.1.4 CyberKnife Radiosurgery For Low & Intermediate Risk Prostate Cancer: Emulating HDR
Brachytherapy Dosimetry
5.2.1.5 CyberKnife Radiosurgical Treatment of Inoperable Early Stage Non-Small Cell Cancer
5.2.2 SenoRx
5.2.2.1 Multi-Site, Prospective, Non-Randomized Study of the Contura Multi-Lumen Balloon (MLB)
Catheter to Deliver Accelerated Partial Breast Irradiation: Analysis of Dosimetry, Local Tumor Control,
Cosmetic Outcome, and Toxicity
5.2.3 Xoft
5.2.3.1 Electronic Xoft Intersociety Brachytherapy Trial: Electronic Brachytherapy (EBT) For Treatment of
Early Stage Breast Cancer (EXIBT)
5.2.3.2 Xoft Electronic Brachytherapy Clinical Protocol for the Primary Treatment of Non-Melanoma Skin
Cancer
5.3 Light
5.3.1 CardioFocus
5.3.1.1 Endoscopic Ablation System—Adaptive Contact (EAS-AC) for the Treatment of Symptomatic AF
5.3.2 EndoPhotoniX
5.3.2.1 Solar & Atrilaze Atrial Fibrillation Trial (SAAF-T)
5.3.3 Novian Health
5.3.3.1 American Breast Laser Ablation Therapy Evaluation (ABLATE)
5.3.4 Visualase
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5.3.4.1 Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy
for Treatment of Metastatic Brain Tumors
5.4 Radiofrequency
5.4.1 Ardian, Inc.
5.4.1.1 Symplicity I Trial
5.4.1.2 Symplicity HTN-2 Trial
5.4.2 Asthmatx
5.4.2.1 Asthma Intervention Research 2 (AIR2) Trial
5.4.3 AtriCure
5.4.3.1 Bipolar Radiofrequency Ablation of Permanent Atrial Fibrillation (ABLATE)
5.4.3.2 RESTORE-SR IIB
5.4.4 Bard EP
5.4.4.1 MAGELLAN
5.4.5 Barrx Medical
5.4.5.1 Micro-Layer Ablation of Barrett's Metaplasia- A Two-Phase, Multi-Center Trial - Extension of
Follow-up to 5 Years (AIM)
5.4.5.2 Endoscopic RF Ablation for Barrett’s Esophagus: Five-Year Durability Outcomes from a
Prospective Multi-Center Trial
5.4.6 Biosense Webster
5.4.6.1 NaviStar ThermoCool Catheter for the Treatment of AF—TX Clinical Trial
5.4.6.2 CLARITY
5.4.6.3 Study of a New Catheter Using Force Sensing Capabilities for the Treatment of AF and
Ventricular Tachycardia (EZCF-125)
5.4.6.4 NaviStar ThermoCool Catheter for the Radiofrequency Ablation of Drug Refractory Recurrent
Symptomatic Paroxysmal AF Clinical Trial
5.4.7 BSD Medical
5.4.7.1 BSD-2000 RF Hyperthermia with Chemotherapy for Pancreatic Cancer
5.4.8 Endosense
5.4.8.1 EFFICAS I
5.4.8.2 TOCCATA Clinical Trial
5.4.9 Halt Medical
5.4.9.1 Laparoscopic Radiofrequency Ablation of Symptomatic Uterine Fibroids (Halt Lap RFA)
5.4.10 Medtronic
5.4.10.1 The CURE-AF/Perst Clinical Trial
5.4.10.2 The TTOP AF Clinical Trial
5.4.11 nContact Surgical
5.4.11.1 Numeris-AF Tethered Coagulation System for Treatment of Longstanding Persistent Atrial
Fibrillation (AF)
5.4.11.2 Safety and Efficacy Study of The Combined Ablation Procedure To Treat Longstanding
Persistent Atrial Fibrillation (CAPstopsLSPAF)
5.4.11.3 Safety and Efficacy Study of the Combined Ablation Procedure to Treat Paroxysmal Atrial
Fibrillation (CAP STOPS AF)
5.4.12 St. Jude Medical
5.4.12.1 CABANA Clinical Trial
5.4.12.2 IRASE AF Clinical Trial
5.4.12.3 Modified stepwise Ablation Guided by low dose Ibutilide Use in Chronic Atrial Fibrillation Trial
(MAGIC-AF)
5.4.12.4 Clinical Evaluation of Therapy Cool Path Duo Cardiac Ablation System for the Treatment of
Ischemic Ventricular Tachycardia (VT) (Ablate-VT)
5.5 Ultrasound
5.5.1 EDAP TMS
5.5.1.1 Enlight Clinical Trial
5.5.2 InSightec
5.5.2.1 ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Metastatic
Bone Tumors for the Palliation of Pain
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5.5.3 St. Jude Medical
5.5.3.1 AFMAZE-CABG Clinical Trial
5.5.4 US HIFU
5.5.4.1 Clinical Study of the Sonablate® 500 to Treat Localized (T1c/T2a) Prostate Cancer (SetPace)
5.5.4.2 A Multicenter Clinical Study of the Sonablate 500 for the Treatment of Locally Recurrent Prostate
Cancer With HIFU (STAR)
5.6 Cryotherapy
5.6.1 Boston Scientific
5.6.1.1 A Prospective Randomized Study Comparing Radiofrequency Energy with Cryoenergy
(CRYO-RF)
5.6.2 CSA Medical
5.6.2.1 Study of CryoSpray Ablation to Determine Treatment Effect, Depth of Injury, and Side Effects in
the Esophagus. (CSA Depth 3)
5.6.3 Medtronic
5.6.3.1 The STOP AF Clinical Trial
5.6.4 Sanarus Medical Technologies LLC
5.6.4.1 Z1072 Clinical Trial
5.6.5 Zeltiq Aesthetics
5.6.5.1 Non-Invasive Reduction of Abdominal Fat (JUNO)
5.7 Thermal
5.7.1 Ethicon
5.7.1.1 ThermaChoice III Under Local Sedation in the Office Setting
5.7.2 Uptake Medical
5.7.2.1 Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction (VAPOR)
5.8 Microwave
5.8.1 Boston Scientific
5.8.1.1 Prolieve Post-Marketing Study Treatment of Benign Prostatic Hyperplasia (BPH)
5.8.2 MedWaves
5.8.2.1 Microwave Ablation of Resectable Liver Tumors
5.9 Hydromechanical
5.9.1 Cook Medical
5.9.1.1 The StoneBreaker Trial
5.9.2 Smith & Nephew
5.9.2.1 Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
APPENDIX I: COMPANY DIRECTORY
APPENDIX II: RELEVANT ORGANIZATIONS
APPENDIX III: ABBREVIATIONS AND TERMS USED IN THIS REPORT
LIST OF EXHIBITS
Exhibit ES-1: Global Energy-based Ablation Devices Markets, 2009-2019
Exhibit ES-2: Percent USD Shares of Global Market by Modality, Energy-based Ablation Devices, 2009
Exhibit ES-3: Growth of the Global Energy-based Ablation Device Market, 2009-2019
Exhibit ES-4: Global Incidence and Prevalence (where known) for Conditions Treated with Energy-Based
Ablation Devices
Exhibit ES-5: Share of Energy-based Market by Clinical Market Segment, 2010
Exhibit ES-6: Global Market Leaders, Energy-based Ablation Devices, 2009
Exhibit ES-7: Leading Companies in Energy-based Ablation Device Market, 2010
Exhibit 1-1: Global Number of Selected Surgical Procedures, Electrical Ablation, 2009
Exhibit 1-2: Share of Energy-based Market by Clinical Market Segment, 2010
Exhibit 1-3: World Age-Standardized Cancer Incidence per 100,000 Population (All Ages), by Cancer Type
Exhibit 1-4: Global Incidence and Prevalence for Conditions Treated with Energy-Based Ablation Devices
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Exhibit 1-5: Staging of Prostate Cancer
Exhibit 1-6: Treatment Options for Clinically Localized Prostate Cancer
Exhibit 1-7: Estimated Total Cardiac Ablation Procedures, 2009 and 2019
Exhibit 1-8: Actual and Estimated RF Ablation Procedures, 2009-2010: US, EU, Japan
Exhibit 2-1: Energy-based Ablation Device Companies and Products
Exhibit 2-2: Electrical Ablation Device Companies, Products & Applications
Exhibit 2-3: Radiation Ablation Device Companies, Products & Applications
Exhibit 2-4: States Not Covered by Medicare for CyberKnife Treatment of Prostate Cancer
Exhibit 2-5: Light-based Ablation Device Companies, Products & Applications
Exhibit 2-6: Radiofrequency-based Ablation Device Companies, Products & Applications
Exhibit 2-7: Ultrasound-based Ablation Device Companies, Products & Applications
Exhibit 2-8: Cryotherapy Ablation Device Companies, Products & Applications
Exhibit 2-9: Thermal Ablation Device Companies, Products & Applications
Exhibit 2-10: Microwave Ablation Device Companies, Products & Applications
Exhibit 2-11: Hydromechanical Ablation Device Companies, Products & Applications
Exhibit 3-1: Percent USD Shares of Global Market by Modality, Energy-based Ablation Devices, 2009
Exhibit 3-2: 2009 Energy-based Ablation Modalities Global Market Size & CAGR (2010-2019)
Exhibit 3-3: Energy-Based Ablation Devices Global Market Sizes, 2009-2019 (USD millions)
Exhibit 3-4: Global Energy-based Ablation Device Market, by Product Type, 2009-2019
Exhibit 3-5: Global Electrical Ablation Market, 2009-2019
Exhibit 3-6: Market Shares of Leading Competitors, Electrical, 2009
Exhibit 3-7: Electrical Ablation Device Market, % per Region, 2009
Exhibit 3-8: Americas Market for Electrical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-9: EU Market for Electrical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-10: Asia-Pacific Market for Electrical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-11: Rest of World Market for Electrical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-12: Global Radiation Ablation Market, 2009-2019
Exhibit 3-13: Market Shares of Leading Competitors, Radiation Ablation Devices, 2009
Exhibit 3-14: Radiation Ablation Device Market, % per Region, 2009
Exhibit 3-15: Americas Market for Radiation Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-16: EU Market for Radiation Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-17: Asia-Pacific Market for Radiation Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-18: Rest of World Market for Radiation Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-19: Global Light-based Ablation Market, 2009-2019
Exhibit 3-20: Light-based Ablation Device Market, % per Region, 2009
Exhibit 3-21: Americas Market for Light-based Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-22: EU Market for Light-based Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-23: Asia-Pacific Market for Light-based Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-24: Rest of World Market for Light-based Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-25: Global Radiofrequency Ablation Market, 2009-2019
Exhibit 3-26: Market Shares of Leading Competitors, Radiofrequency Ablation Devices, 2009
Exhibit 3-27: Radiofrequency Ablation Device Market, % per Region, 2009
Exhibit 3-28: Americas Market for Radiofrequency Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-29: EU Market for Radiofrequency Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-30: Asia-Pacific Market for Radiofrequency Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-31: Rest of World Market for Radiofrequency Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-32: Global Market for Ultrasound Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-33: Market Shares of Leading Competitors, Ultrasound Ablation Devices, 2009
Exhibit 3-34: Ultrasound Ablation Device Market, % per Region, 2009
Exhibit 3-35: Americas Market for Ultrasound Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-36: EU Market for Ultrasound Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-37: Asia-Pacific Market for Ultrasound Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-38: Rest of World Market for Ultrasound Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-39: Global Market for Cryotherapy Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-40: Market Shares of Leading Competitors, Cryotherapy Ablation Devices, 2009
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Exhibit 3-41: Americas Market for Cryotherapy Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-42: EU Market for Cryotherapy Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-43: Asia-Pacific Market for Cryotherapy Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-44: Rest of World Market for Cryotherapy Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-45: Global Market for Thermal Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-46: Market Shares of Leading Competitors, Thermal Ablation Devices, 2009
Exhibit 3-47: Thermal Ablation Device Market, % per Region, 2009
Exhibit 3-48: Americas Market for Thermal Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-49: EU Market for Thermal Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-50: Asia-Pacific Market for Thermal Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-51: Rest of World Market for Thermal Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-52: Global Market for Microwave Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-53: Market Shares of Leading Competitors, Microwave Ablation Devices, 2009
Exhibit 3-54: Microwave Ablation Device Market, % per Region, 2009
Exhibit 3-55: Americas Market for Microwave Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-56: EU Market for Microwave Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-57: Asia-Pacific Market for Microwave Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-58: Rest of World Market for Microwave Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-59: Global Market for Hydromechanical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-60: Market Shares of Leading Competitors, Hydromechanical Ablation Devices, 2009
Exhibit 3-61: Americas Market for Hydromechanical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-62: EU Market for Hydromechanical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-63: Asia-Pacific Market for Hydromechanical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-64: Rest of World Market for Hydromechanical Ablation Devices, 2009-2019 (USD millions)
Exhibit 3-65: Leading Companies in the Global Energy-based Ablation Market, 2009
Exhibit 3-66: Global Market Leaders, Energy-based Ablation Devices, 2009
Exhibit 3-67: Energy-based Ablation Device Markets, USA, 2009-2019
Exhibit 3-68: Energy-based Ablation Device Markets, Canada, 2009-2019
Exhibit 3-69: Energy-based Ablation Device Markets, Mexico, 2009-2019
Exhibit 3-70: Energy-based Ablation Device Markets, Brazil, 2009-2019
Exhibit 3-71: Energy-based Ablation Device Markets, UK, 2009-2019
Exhibit 3-72: Energy-based Ablation Device Markets, Germany, 2009-2019
Exhibit 3-73: Energy-based Ablation Device Markets, France, 2009-2019
Exhibit 3-74: Energy-based Ablation Device Markets, Spain, 2009-2019
Exhibit 3-75: Energy-based Ablation Device Markets, Italy, 2009-2019
Exhibit 3-76: Energy-based Ablation Device Markets, BeNeLux, 2009-2019
Exhibit 3-77: Energy-based Ablation Device Markets, Japan, 2009-2019
Exhibit 3-78: Energy-based Ablation Device Markets, China, 2009-2019
Exhibit 3-79: Energy-based Ablation Device Markets, India, 2009-2019
Exhibit 3-80: Energy-based Ablation Device Markets, Australia, 2009-2019
Exhibit 3-81: Energy-based Ablation Device Markets, ROW, 2009-2019
Exhibit 4-1: Accuray, Inc. Financial Results for Year Ending June 27, 2009
Exhibit 4-2: AngioDynamics Consolidated Statement of Operations, July 2009
Exhibit 4-3: ArthroCare Financial Results
Exhibit 4-4: ATS Medical, Inc., Condensed Consolidated Statements of Operations
Exhibit 4-5: Boston Scientific Corporation Financials, 2007-2009
Exhibit 4-6: Covidien, Fiscal Years 2007-2009
Exhibit 4-7: Elekta Income Statements, 2006-2009
Exhibit 4-8: IBt-Bebig Financial Results, 2009
Exhibit 4-9: Medtronic’s Company & Product Line Acquisitions, 2008-2010
Exhibit 4-10: Medtronic Revenue by Operating Segment, 2008-2010
Exhibit 4-11: Medtronic Annual Income Statements, 2006-2010
Exhibit 4-12: SenoRx Financials, 2008-2009
Exhibit 4-13: Summary of St. Jude Medical’s Products for Atrial Fibrillation
Exhibit 4-14: Five-Year Summary Financial Data, St. Jude Medical
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Exhibit 4-15: Theragenics 2009 Annual Report: Net Income Statement
Exhibit 4-16: Varian Medical Systems Financials, 2008-2009
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16
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