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Final Program
9th JOINT MEETING
OF ICS-ISICR
CYTOKINES AND INTERFERONS:
FROM THE BENCH TO THE BEDSIDE
Florence, Italy
October 9-12, 2011
www.cytokines2011.it
SPONSORS
Platinum
www.interferonsource.com
Gold
www.spacesrl.com
www.RnDSystems.com
Silver
www.bdbiosciences.com/eu
www.lifetechnologies.com
Bronze
www.eBioscience.com
www.biolegend.com
www.gen-probe.com
www.nanoink.net
www.randox.com
Others
www.cellsignal.com/
www.elsevier.com/locate/cytokine
www.peprotech.com
2
www.merckmillipore.com
www.tevaitalia.it
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
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ORGANIZED BY
The International Cytokine Society (ICS)
The International Society for Interferon and Cytokine Research (ISICR)
CHAIRMAN: Santo Landolfo (Turin, Italy)
LOCAL ORGANIZING COMMITTEE:
Filippo Belardelli (Rome, Italy)
Ferdinando Dianzani (Rome, Italy)
Santo Landolfo (Turin, Italy)
Enrico Maggi (Florence, Italy)
SCIENTIFIC PROGRAM COMMITTEE:
Chair: Alberto Mantovani (Milan, Italy)
Santo Landolfo (Turin, Italy)
Nancy Reich (New York, USA)
Nancy Ruddle (Yale, USA)
John Schrader (Vancouver, Canada)
Michael Tovey (Villejuif, France)
Giorgio Trinchieri (Frederick, USA)
David Wallach (Rehovot, Israel)
Kathryn C. Zoon (Bethesda, USA)
INTERNATIONAL SCIENTIFIC COMMITTEE:
Chair: Alberto Mantovani (Milan, Italy)
Ahizuo Akira (Osaka, Japan)
Abul K. Abbas (San Francisco, USA)
Ernest Borden (Cleveland, USA)
Zhijian J. Chen (Dallas, USA)
Robert Coffman (Berkeley, USA)
Daniel Cua (Palo Alto, USA)
Charles A. Dinarello (Denver, USA)
Eleanor Fish (Toronto, Canada)
Richard Flavell (New Haven, USA)
Laurie Glimcher (Boston, USA)
Otto A. Haller (Freiburg, Germany)
John Hiscott (Montreal, Canada)
Christopher A. Hunter (Philadelphia, USA)
4
Allan Lau (Hong Kong, China)
Warren J. Leonard (Bethesda, USA)
David Levy (New York, USA)
Joe J. Oppenheim (Frederick, USA)
Keiko Ozato (Bethesda, USA)
Leonidas Platanias (Chicago, USA)
Andreas Radbruch (Berlin, Germany)
Stefan Rose-John (Kiel, Germany)
Alexander Rudensky (Seattle, USA)
Ganes Sen (Cleveland, USA)
Alan Sher (Bethesda, USA)
Bryan Williams (Victoria, Australia)
Thomas A. Waldmann (Bethesda, USA)
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
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October, 09th 2011
Hall A
17.30
Opening Remarks/Welcome
Santo Landolfo, Chair, Organizing Committee
Leonidas Platanias, President, ISICR
David Wallach, President, ICS
17.45
ISICR and ICS Awards Presentations
ISICR Awards:
Seymour and Vivian Milstein Award
Honorary Membership
Distinguished Service Award
Christina Fleischmann Award to Young Women Investigators
Seymour and Vivian Milstein Young Investigators Award
Sidney & Joan Pestka Graduate and Post-Graduate Awards
ISICR Herbert Tabor Award
ICS Awards:
Honorary Life Membership
Ed Leonard Prize Fund for Chemotaxis/Chemokine Research
ICS Young Investigator Award
Postdoctoral Investigator Award
Outstanding Scholar Award
ICS Herbert Tabor Young Investigator Award
18.30
6
Honorary Lecture
Negative Regulation of Cytokine Signal Transduction
Douglas Hilton, Australia
ISICR Seymour and Vivian Milstein Award
19.00
Keynote Lecture
Gut reactions: Immune pathways in the intestine in health
and disease
Fiona Powrie, UK
20.00
Welcome Reception
Complimentary event for all registered attendees
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
October, 10th 2011
Stabilisation of human interferon-α1 mRNA by its antisense RNA
T. Kimura, J. Shiwen, M. Nishizawa, E. Yoshigai, I. Hashimoto
Japan
Hall A - Plenary Session
MicroRNA expression in E6/E7 HPV-transformed human
keratinocytes. Effects of IFNβ treatment
G. Mangino, M.V.Chiantore, M. Iuliano, G. Fantasia, R. Accardi,
M. Tommasino, Z.A. Percario, E. Affabris, G. Fiorucci and G. Romeo
Italy
Innate and Adaptive Lymphoid Cells
Co-Chairs: Nancy Ruddle, USA - Katy Zoon, USA
08.30
09.00
Opening Lecture
IL-1 acts on T cells to enhance the magnitude of in vivo immune
responses
William E. Paul, USA
The role of inflammasome processed cytokines in driving Th17 cells and
IL-17 producing γδ T cells in infection and autoimmunity
Kingston Mills, Ireland
09.30
Regulation of Th17 responses during protective or pathological responses
Brigitta Stockinger, UK
10.00
IL-22 and immune pathway against fungal infections
Marco Colonna, USA
10.30
Coffee Break
11.00
Hall A - Concurrent Session
miRNA and post-Transcriptional Regulation
Chair: Massimo Locati, Italy
The biological relevance of non-coding RNAs
Irene Bozzoni, Italy
microRNAs positively regulate NFκB signalling
M.P. Gantier, H. James Stunden, C. E. McCoy and B. R.G. Williams
Australia
An Ancient Parallel RNA Helix Element in TNF-α Pre-mRNA
Enables Highly Efficient Splicing by Activating PKR through an RNA
Pseudoknot
R. Kaempfer, L.S. Namer, F. Osman, Y. Banai, R. Jung and
B. Masquida Israel, France
Aryl hydrocarbon receptor involves in the expression of several
microRNAs in dendritic cells
N.T. Nguyen, T. Nakahama, H. Hanieh, I. Chinen, K. Masuda and
T. Kishimoto, Japan
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Influenza A Virus Infection of Human Respiratory Cells Induces
Primary MicroRNA Expression
C.M. Horvath, W. Buggele, K. Johnson, USA
11.00
Hall B - Concurrent Session
Cytokines in Lymphocyte Biology
Chair: John Schrader, USA
Immune regulation at barrier surfaces
David Artis, USA
Dichotomous consequences of IL-23 signaling in chemically induced
colitis in mice
J.H. Cox, N.M. Kljavin, L. Diehl, W. Ouyang and N. Ghilardi, USA
In vivo IL-7 exposure of CD4 T cells during HIV induced lymphopenia
leads to an enhanced Type-I IFN response
C. Le Saout, R. Hasley, L. Tcheung, H. Imamichi, J.H. Park, M. Sneller,
G. Roby, C. Rehm, C. Lane and M. Catalfamo, USA
Modulation of cytokine receptors by IL-2 broadly regulates differentiation
into helper T cell lineages
W. Liao, J.X. Lin, L. Wang, P. Li and W.J. Leonard, USA
Retinoic acid enhances IL-22 production by γδ T cells and protects against
colitis
L.A. Mielke, A. Misiak, C.E. Sutton, K.H.G. Mills, Ireland
Aberrant transcriptional program regulating naive CD4 T-cell
activation defines a progressive Multiple Sclerosis subgroup
E. Zastepa, E. Zastepa, L. Tao, L. Fitz-Gerald, M. Hallett, M. del Pilar
Cortes, J. Antel, J. Livingstone, A. Bar-Or, Y. Lapierre, D.G. Haegert
Canada
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
11.00
Firenze Fiera
Hall C - Concurrent Session
14.30
Firenze Fiera
Hall A - Concurrent Session
Host-Pathogen Interaction (I)
Chair: Santo Landolfo, Italy
Regulation of Interferon and Cytokine Signalling by
Transcription Factor PLZF
Bryan Williams, Australia
Systems Biology Approaches to Viral Pathogenesis and Immunity:
Where are Google and IBM?
Michael Katze, USA
SOCS1 selectively regulates type I IFN signaling
R. Piganis, N. de Weerd, J. Gould, B. Scott, S. Forster, S. Nicholson and
P. Hertzog, USA
TRIM proteins regulate the innate immune response
G.A. Versteeg, R. Rajsbaum, M.T. Sánchez-Aparicio, J. Valdiviezo,
M. Shi, K.S. Inn, J. J. and A. García-Sastre, USA
IRF-1 phosphorylation by I-kappa-B kinase epsilon impairs IFN beta
stimulation in activated CD4+ T cells
M. Sgarbanti, Giulia Marsili, Anna Lisa Remoli, Sun Qiang, E. Stellacci,
A. Mai, D. Rotili, E. Perrotti, R. Orsatti, A. Borsetti, M. Ferrari, N. Iraci,
J. Hiscott and A. Battistini, Italy, Canada
TLR9 and TLR7 mediate distinct type I IFN responses in humans and nonhuman primates
M. Puig, K.W. Tosh, L.M. Schramm, L.T. Grajkowska, K.D. Kirschman,
C. Tami, J. Beren, R.L. Rabin, D. Verthelyi, USA
Double-stranded RNA Adenosine Deaminase (ADAR) as a Modulator of Antiviral
Innate Immunity
C. Samuel, USA
The complex relationship between interferons and their receptors dictate
differential signaling
G. Schreiber, Israel
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Florence (Italy) October 9 -12, 2011
Interferons and Signal Transduction
Chair: Charles Samuel, USA
Differential negative regulation of type I and type III interferons by UBP43
underlies extended antiviral effects of interferon-lambdas in epithelial cells
S.V. Smirnov, C. Burkart, W. Li, A. Lewis-Antes, J. Durbin, D. Er Zhang
and S.V. Kotenko, USA
13.00
9th JOINT MEETING OF ICS-ISICR
Linear Ubiquitination Of Nemo Inhibits Rig-I Mediated Signalling By
Disrupting The Mavs-Traf3 Interaction
S.M. Belgnaoui, R. Lin, J. Hiscott, Canada, USA
Mechanism of IL-8 induction by HCMV UL76 protein
H. Costa, R. Nascimento, J. Sinclair, R.M.E. Parkhouse, Portugal, UK
Constitutively active Stat3 triggers autoimmune myocarditis by regulating
both innate and adaptive immunity
A. Camporeale, F. Marino, S. Fornero, R. Levi, V. Poli, Italy
Conditional ablation of Stat1 reveals the antagonistic role of interferons in
the clearance of the intracellular bacterial pathogen Listeria
monocytogenes
E. Kernbauer, A.M. Jamieson, C. Schneckenleithner, V. Sexl, U. Reichart,
B. Strobl, M. Müller and T. Decker, Austria
Features Of Influenza A Virus Non-Structural Protein 1 That Contribute To
Inhibiting An Interferon Response
B.X. Wang, D. Jia and E.N. Fish, Canada
Innate immune response modulators control inflammation and improve
survival in viral encephalitis
D. Verthelyi, J. Pedras-Vasconcelos, C. Butts, Y. Jones, M. Puig,
V. Wang, G. Trinchieri, C. Tami, USA
IL-1 signaling and the NLRP3 Inflammasome are required for CNS-specific
protective immunity against West Nile Virus
H.J. Ramos, M. Suthar, A. Negash, G. Blahnick, M. Brassil, M. Gale Jr.
USA
Lunch
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
Hall B - Concurrent Session
Firenze Fiera
Cytokines and Inflammation (I)
Chair: Nancy Reich, USA
Identification of RLR-activating compounds as novel antiviral therapeutics or
vaccine adjuvants
Y.M. Loo, K. Bedard, M. Wang, M.K. Muramatsu, S. Proll, R. Green,
R.C. Ireton, M.G. Katze, S.P. Iadonato and M. Gale Jr., USA
Interleukin-1beta in the modulation of the inflammatory process
Charles A. Dinarello, USA
The Role of Interferon Epsilon in the Immune Response in the Female
Reproductive Tract
N.E. Mangan, K.Y. Fung, S. Stifter, P.J. Hertzog, Australia
Genetic and functional analysis of a panel of truly human monoclonal
antibodies against GM-CSF generated from idiopathic pulmonary alveolar
proteinosis (IPAP) patients and potential therapeutic uses as an antiinflammatory agent
J.W. Schrader, Y.Wang, L. Allan, C. Thomson, L. Jackson, A. Turner,
G. Anderson, T. Waddell, J. Seymour, J. Hamilton, Canada, Australia
IFN-β limits Th17 induction and regulates dendritic cell activation in EAE
L.M. Pennell, C.L. Galligan and E.N. Fish, Canada
Human Alpha 1 Antitrypsin Modulates B lymphocyte Responses in Culture
and During Allogeneic Transplantation
M. Mizrahi, D. Ochayon and E.C. Lewis, Israel
Interleukin 37 exerts its anti-inflammatory functions by associating with
IL-18Rα and SIGIRR
M.F. Nold, C.A. Nold-Petry, J.A. Zepp, C. Lo, C, Garlanda, A. Mantovani,
P. Bufler, C.A. Dinarello, USA, Australia, Italy, Germany
The role of TGF-β as tolerogenic cytokine in regulating dendritic cell
function
M.L. Belladonna, F. Fallarino, M.T. Pallotta, C. Orabona, C. Volpi,
C. Bianchi, C. Vacca, U. Grohmann and P. Puccetti, Italy
Inflammatory Proteases Cleave and Activate IL-33, a novel alarmin from the
IL-1 Family
C. Cayrol, E. Lefrancais, S. Roga and J.P. Girard, France
Defective NOD2 Signaling And Innate Cytokine Production In Response To
Mdp In Experimental Crohn’s Disease (CD)
D. Corridoni, J. Marinis, D. Abbott and F. Cominelli, USA
Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17
Production by γδ and CD4 T Cells That Mediate Autoimmunity
L.S. Dungan, S.J. Lalor, C.E. Sutton, S.A. Basdeo, J.M. Fletcher,
K.H.G. Mills, Ireland
16.30
Coffee Break
17.00
Hall A - Special Symposium
Interferons and Multiple Sclerosis
17.00
Hall B - Special Symposium
TGF-beta - from bench to clinics
17.00
Hall C - Special Symposium
Interferons-lambda/IL-29
14.30
Hall C - Concurrent Session
Immunoregulation
Chair: John Hamilton, Australia
Manipulating human dendritic cells by STAT3 silencing to implement
their use in cancer immunotherapy
I. Sanseverino, C. Purificato, L. Conti, B. Varano, L. Beltrame, D. Cavalieri,
M.C. Gauzzi, S. Gessani, Italy
18.30
Hall A - Honorary Lecture
T-bet in Inflammatory Diseases
Laurie Glimcher, USA
ICS Honorary Life Membership Award
18.30
Poster Session
Activated Fibrocytes Contribute To The Pathogenesis of Rheumatoid
Arthritis
C.L. Galligan, E.N. Fish, Canada
12
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
October, 11th 2011
Loss of p53 increases unphosphorylated STAT1, which induces resistance
to DNA damage in cancer cells
H.J. Cheon, E. Holvey-Bates, D. Junk, M. Jackson, G. Stark, USA
Hall A - Plenary Session
Systems Biology and Gene Regulation
Co-Chairs: Scott Durum, USA - Alberto Mantovani, Italy
08.30
09.00
Opening Lecture
Bottom-up and Top-Down Systems Biology
Approaches to Understanding Immunity
Ronald N. Germain, USA
The innate immune interactome: Pathways leading to type I
interferon production
Martin E. Dorf, USA
Firenze Fiera
A Novel Requirement for Janus Kinases as Mediators of Drug Resistance
Induced by Fibroblast Growth Factor-2 in Human Cancer Cells
A.P. Costa-Pereira, C. Ramos do Carmo, J. Lyons-Lewis, M.J. Seckl and
A.P. Costa-Pereira, UK
11.00
Hall B - Concurrent Session
Interferons and Viral Infections
Chair: Eleanor Fish, Canada
Antiviral Actions of the IFIT Family of Interferon -Stimulated Genes
Ganes Sen, USA
09.30
Molecular Switch between Pro- and Anti-Inflammatory Cytokine Activities
Stefan Rose-John, Germany
IFN Regulation Of Metabolism Contributes To An Antiviral Response
D. Burke, N. Sonenberg, L.C. Platanias, E.N. Fish
Canada, USA
10.00
Regulation of innate immunity by KIR
Lorenzo Moretta, Italy
ISG54 protects mice against VSV pathogenesis
V. Fensterl, J.L. Rupert, S. Ramachandran, S.A. Stohlman,
C.C. Bergmann, M.S. Diamond, H.W. Virgin, G.C. Sen, USA
10.30
Coffee Break
11.00
Hall A - Concurrent Session
The viral nucleocapsid protein determines sensitivity of influenza A viruses
to MxA restriction
P. Zimmermann, B. Maenz, C. Patzina, M. Schwemmle, G. Kochs,
O. Haller, Germany
Cytokines and Carcinogenesis
Chair: David Levy, USA
Inflammatory cytokines and autocrine tumour-promoting networks
Frances Balkwill, UK
Identification of interferon-β producing cells in La Crosse virus-infected
mouse brains
C. Kallfass, A. Ackerman, S. Lienenklaus, B. Heimrich and P. Staeheli
Germany
Protein Kinase CK2 Functions as a Positive Regulator of the JAK/STAT
and NF-κB Pathways
E. Benveniste, Y. Zheng, USA
Role for RNase L in the Induction of IFN-β by Influenza A Virus
Lacking NS1
R.H. Silverman, S. Banerjee, A. Baum, A. García-Sastre, USA
STAT3-Driven Upregulation Of TLR2 Promotes Gastric Tumorigenesis
B.J. Jenkins, H. Tye, C.L. Kennedy, M. Najdovska, L. Mcleod, A. Dev,
W. Sievert, P. Tan, P.S. Bhathal, Australia, Singapore
Interferon and Acute Virus Infections: Knowledge to Action
Eleanor N. Fish, Canada
Gastritis and potent gastric epithelial alterations in mice following
exogenous administration of recombinant IL-33
L. Pastorelli, R.R. Garg, C. De Salvo, B. Mattioli, J.B. Meddings,
M. Vecchi and T.T. Pizarro, USA
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
11.00
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Hall C - Concurrent Session
Pattern Recognition and Innate Immunity
Chair: Filippo Belardelli, Italy
Overview of Pattern Recognition and Innate Immunity
John Hiscott, USA
The Regulation of Interleukin 10 and Interleukin 12 in Macrophages
A. Howes, X. Wu, J. Zhao, M. Saraiva, G.J. Bancroft, A. O’Garra
UK, China, Portugal
14-3-3 epsilon and TRIM25 regulate a RIG-I translocon that mediates
membrane-association and control of innate antiviral immunity
H.M. Liu, M. Gale Jr., USA
Molecular Mechanism Of Poxviral Antagonism Of The TLR4 Complex By
VACV Protein A46
J. Stack, T. Lysakova-Devine, A. Bowie, Ireland
DNA-dependent protein kinase is a DNA sensor for IRF-3-dependent innate
immunity
B. Ferguson, D. Mansur, N. Peters, G. Smith, UK
Hepatitis C Virus Reveals a Novel Early Control in Acute Immune
Response
N. Arnaud, S. Dabo, D. Akazawa, M. Fukasawa, F. Shinkai-Ouchi,
J. Hugon, T. Wakita and E.F. Meurs, France, Japan
Unraveling the complexity of the type I interferon antiviral response
J.W. Schoggins, S.J. Wilson, M. Panis, M.Y. Murphy, C.T. Jones,
P. Bieniasz, C.M. Rice, USA
A Systems Biology approach to defining the host immune response to
West Nile virus infection
M.S. Suthar, M. Brassil, S. Proll, S. Belisle, M.G. Katze, M. GaleJr
USA
13.00
16
Lunch
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
Firenze Fiera
Hall A - Concurrent Session
Cytokines and Inflammation (II)
Chair: Joost J. Oppenheim, USA
Regulation of the Immune Response in Tuberculosis: Lessons Learned
from Mouse Models and Human Disease
Anne O’Garra, UK
Thrombin mediates chemokinesis in human resting CD8 T cells through
specific interaction with thrombin receptor (PAR-1)
M. Smith, A. Hurley, T. Karpova, N. Belkina, S. Shaw, E. Nickel,
B. Packard, H. Imamichi, J. MacNally, M. Sneller, C. Lane and M. Catalfamo
USA
IKKi is required for interleukin 17-dependent signaling associated with
neutrophilia and pulmonary inflammation
K. Bulek, C. Liu, S. Swaidani, L. Wang, R.C. Page, M.F. Gulen, T. Herjan,
A. Abbadi, W. Qian, D. Sun, M. Lauer, V. Hascall, S. Misra, M. Chance,
M. Aronica, T. Hamilton and X. Li, USA
Function of SOCS3 on Macrophage Polarization and Inflammation
H. Qin, A.T. Holdbrooks, Y. Liu, S.L. Reynolds, L.L. Yanagisawa,
B.C. McFarland, W.I. Yeh, P. De Sarno, L.E. Harrington, C. Raman and
E.N. Benveniste, USA
Deficient IL-1 Receptor antagonist production by monocytes from patients
carrying mutations in the NLRP3 gene
A. Rubartelli, L. Delfino, A. Omenetti, M. Gattorno, S. Carta, Italy
Expression of Interleukin-37 in human pediatric inflammatory bowel
disease
S. Weidlich, A.M. Bulau, T. Schwerd, J. Helmbrecht, M. Lacher, D. Mayr,
S. Koletzko and P. Bufler, Germany
IL-32 promotes angiogenesis
C.A. Nold-Petry, M.F. Nold, J.A. Zepp, H. Dinkel, B.E. Palmer, C.D. Cool,
L. Taraseviciene-Stewart, S.H. Kim, C.A. Dinarello and N.F. Voelkel
USA, Australia, South Korea
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
Firenze Fiera
Hall B - Concurrent Session
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
Firenze Fiera
Hall C - Concurrent Session
Cytokines and Signal Transduction (I)
Chair: Dan Kalvakolanu, USA
Chemokines and their Receptors
Chair: Amanda Proudfoot, Switzerland
Role of the tyrosine Kinase FER in the activation of NFkappaB by mutated
growth factor receptors in cancer
George Stark, USA
Targeting CXCR4 in WHIM syndrome
Philip M. Murphy, USA
Macrophages from patients with atopic dermatitis show a reduced CXCL10
expression in response to staphylococcal α-toxin
S. Kasraie, M. Niebuhr, O. Dittrich-Breiholz, M. Kracht, T. Werfel
Germany
Signaling by the IL-17RA/IL-17RC Complex: Impact on oral mucosal
immunity
S. Gaffen, A.W. Ho, R. Onishi, F. Shen, A. Peterson,
N. Hernández-Santos, A. Garg, W. Ouyang, E.E. Childs, USA
CCR5 32 and CCR5-59029 Allele Frequency among Hepatitis C Virus
Infected and in Non-HCV Infected Saudi Population
F.M. Al-Sharif, O.H. Jiffri and E.I. Azhar, Saudi Arabia
Cish degradation of Htra1 regulates TGF-b signaling
D.C. Palmer, R.N. Reger, L.M. Garvin, D. Frasheri, Y. Ji, Z.J. Franco,
C.A. Klebanoff, L. Gattinoni and N.P. Restifo, USA
Understanding the WHIM syndrome: molecular analysis of CXCR4
functions in lymphocyte activation
M. Kallikourdis, A.E. Trovato, F. Anselmi, A. Sarukhan, L. Tassone,
R. Badolato and A. Viola, Italy
Inhibition of Interleukin 6 classic signaling is a novel function of soluble
gp130 which is controlled by the ratio of Interleukin 6 and soluble
Interleukin 6 receptor
C. Garbers, W. Thaiss, G.H. Waetzig, G.W. Jones, D.M. Floss,
I. Lorenzen, J. Grötzinger, S.A. Jones, S. Rose-John, J. Scheller
Germany, UK
Repression of Inflammatory Cytokine Genes by TNF- and IFNg-regulated
Signaling and Epigenetic Mechanisms
L. Ivashkiv, S.H. Park, J. Chen, USA
IFN-autophagy and tumor suppression: a novel IFN-γ induced signaling
cascade involving Activated transcription factor-6 (ATF-6) that collaborates
with C/EBP-beta and promotes tumor suppression
P. Gade, U.B. Machaani, D.V. Kalvakolanu, USA
Which chemokine receptor should we target in Rheumatoid Arthritis
A. Garin, A. Hermant, S. Krohn, C. Gabay and A. Proudfoot
Switzerland
16.30
Coffee Break
17.00
Hall A - Special Symposium
New Interferons
17.00
Hall B - Special Symposium
Cytokines and Autoimmunity
18.30
18
Poster Session
19
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
October, 12th 2011
Identification of NF-κB genes that contribute to reversible stimulation of
VSV oncolysis by histone deacetylase inhibitors (HDIs)
L. Shulak, T. Di Lenardo, T.L. Anh Nguyen and J. Hiscott
Canada, USA
Hall A - Plenary Session
Cell death and Cancer
Co-Chairs: Carl Ware, USA
09.00
Opening Lecture
Inhibitors of the NFkappaB Pathway and inflammation
Michael Karin, USA
09.30
Inflammation associated to cancer
Lisa Coussens, USA
10.00
STAT3 in cancer inflammation and as a target for cancer therapy
Hua Eleanor Yu, USA
Firenze Fiera
Loss ff IFN-G 3’untranslated Region Au-Rich Element Affects B220+ B Cell
and Plasmacytoid Dendritic Cell Populations in a Novel Murine Lupus Model
Deborah L. Hodge, Cyril Berthet, Vincenzo Coppola, Hidekazu Shirota,
Della Reynolds, Dennis M. Klinman, Howard A. Young, France, USA
11.00
Hall B - Concurrent Session
Cytokines and anti-tumor Immunity
Chair: Leonidas C. Platanias, USA
Mechanisms of mRNA Translation of ISGs in Malignant Cells.
Implications for the Antitumor Effects of IFNS
10.30
Coffee Break
Leonidas C. Platanias, USA
11.00
Hall A - Concurrent Session
A cancer-protective role of inflammation
O.A. Werner Haabeth, K. Berg Lorvik, C. Hammarström, I.M. Donaldson,
G. Haraldsen, B. Bogen and A. Corthay, Norway
Gene Regulation
Chair: Howard Young, USA
SUMO Modification of IRF Family Proteins and Regulation of
Anti-Viral Innate Immunity
Keiko Ozato, USA
HDAC-sensitive transcriptional elongation checkpoint during interferonstimulated gene expression
I. Marie, H.M. Chang, L. Gnatovskiy and D.E. Levy, USA
Role of lysine methylation of NFkB in differential gene regulation
T. Lu, M. Yang, G.R. Stark, USA
Multi-layered cellular stochasticity and paracrine amplification shape the
interferon response
U. Rand, M. Rinas, J. Schwerk, H. Hauser, T. Höfer, M. Köster
Germany
Anti-inflammatory actions of glucocorticoids: the role of transcriptional
coregulator GRIP1 in shaping macrophage transcriptome and systemic
inflammation
I. Rogatsky, Y. Chinenov, R. Gupte, J.R. Flammer, J. Dobrovolna,
M.A. Kennedy, B. Liu, USA
20
Anti-tumor effect of a tumor cell vaccine expressing membrane-bound form
of IL-12 subunit p35
S.M. Park, S.A. Do, Y.S. Kim, South Korea
STAT1 independent cytokine responses in the immunosurveillance of
tumours
N.L. Messina, K.M. Banks, B.P. Martin, A. Uldrich, A.J. Christiansen,
M.J. Smyth, C.J.P. Clarke and R.W. Johnstone, Australia
Tumor cell induced immune evasion via loss of Type I IFN signalling
promotes breast cancer metastasis
B.S. Parker, C.Y. Slaney, B.N. Bidwell, S. Forster, R.L. Anderson,
P. Hertzog, Australia
Development of two IL15 immunocytokines targeting either GD2- or CD20tumoral bearing cells
M. Vincent, G. Teppaz, V. Solé, A. Bessard, S. Loisel, H. Watier,
B. Clémenceau, H. Vié, S. Birklé, L. Garrigue-Antar, A. Quéméner and
Y. Jacques, France
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
Firenze Fiera
Combination therapy with IFN-alpha plus IFN-gamma and monocytes
mediates synergistic antitumor effects against established human ovarian
and melanoma tumors in mouse models
K.C. Zoon, H. Nakashima, K. Miyake, C. Clark, J. Bekisz, S. Baron,
S.R. Husain and R. K. Puri, USA
11.00
Hall C - Concurrent Session
Immunopathology
Chair: Enrico Maggi, Italy
The Role of Cytokines in T-Cell Tolerance and Autoimmunity
Abul K. Abbas, USA
Mechanism of IRF5 constitutive activation in primary monocytes of SLE
patients is independent of type I IFNs
R.C. Stone, D. Feng, J. Deng, S. Singh, L. Yang, P. Fitzgerald-Bocarsly,
M.L. Eloranta, L. Rönnblom, Betsy J. Barnes, USA, Sweden
Basal Expression and Regulation by Pro-Inflammatory Cytokines of
Human Endogenous Retroviruses of the W Family in Bood Cell
Subpopulations and in Astrocytes
A. Mei, G. Mameli, L. Poddighe, E. Uleri, C. Serra, R. Manetti and
A. Dolei, Italy
Florence (Italy) October 9 -12, 2011
Firenze Fiera
13.00
Lunch
14.30
Hall A - Concurrent Session
Cytokines and Signal Transduction (II)
Chair: Alan Lau, Honk Kong
Interferon epsilon is a novel immune regulator that acts independently
of TLR activation
Paul Herzog, Australia
The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for
Human Cytomegalovirus Replication
V. Dell’Oste, G.R. Gariano, M. Bronzini, D. Gatti, A. Luganini,
M. De Andrea, G. Gribaudo, M. Gariglio and S. Landolfo, Italy
The extracellular domains of the IL-21 receptor are bridged by glycosylation
through conserved anchor points
O.J. Hamming, L. Kang, A. Svenson, J.L. Karlsen, H. Rahbek-Nielsen,
S.R. Paludan, S.A. Hjorth, K. Bondensgaard and R. Hartmann
Denmark
STAT3 transcriptional activity is controlled by regulated acetylation.
J. Tavernier, L, Icardi, V. Gesellchen, R. Mori, S. Lievens, S. Eyckerman,
J. Bultynck, M. Boutros and K. De Bosscher, Belgium, Germany
Impairment of IFN-α production, peripheral plasmacytoid dendritic cell
number and susceptibility to MPO-ANCA-associated glomerulonephritis
and vasculitis
K. Uno, E. Muso, T. Ito-Ihara, K. Suzuki, Japan
IL-36R LIGANDS Are Potent Regulators Of Dendritic and T Cells
S. Vigne, G. Palmer, C. Lamacchia, P. Martin, D. Talabot-Ayer,
E. Rodriguez, F. Ronchi, F. Sallusto, H. Dinh, J.E. Sims, C. Gabay
Switzerland
Recruitment of bone marrow derived CD11c+ and c-Kit+ cells in pulmonary
fibrosis
S.H. Phan, T. Liu, L. Ding, T. Nakashima, M.R. Ullenbruch, USA
Plasmacytoid Dendritic Cells are infected by Epstein Barr virus and
induces TLR- dependent type I IFN production
M. Severa, E. Giacomini, E. Anastasiadou, V. Gafa, F. Rizzo,
M. Corazzari, A. Romagnoli, R. Feederle, H.J. Delecluse, P. Trivedi,
G.M. Fimia, E.M. Coccia, Italy, Germany
IFN-γ signaling intrinsically regulates expansion of effector
encephalitogenic Th1 cells in experimental autoimmune encephalomyelitis
(EAE)
C. Raman, C.M. Sestero, R. Naves, B.J. Baker, T.M. DeSilva and
P. De Sarno, USA, Chile
Decrease Of IL-17 and GM-CSF in Intestinal Mucosa of IBD Patients Is
Associated With Reduction Of CD68+ Macrophages And Clinical
Remission In Response To Anti-TNF Therapy
F. Bosè, F. Caprioli, R. Rossi, Palazzo, C. Viganò, L. Raeli, M. Moro,
G. Basilisco, S. Ferrero, M. Pagani, G. Altomare, S. Abrignani and
E. Reali, Italy
22
9th JOINT MEETING OF ICS-ISICR
A novel autosomal recessive and autosomal dominant deficiency in the
TLR3 pathway underlying susceptibility to Herpes Simplex Encephalitis
V. Sancho Shimizu, R. Perez, L. Lorenzo, R. Halwani, S. Fabrega,
A. Cardon, L. Abel, S.Y. Zhang, A. Puel, S. Al-Muhsen and J.L. Casanova
France, Saudi Arabia, USA
IKK603;-mediated STAT1 phosphorylation at S708 residue governs the
expression of Interferon-stimulated genes important for West Nile virus
control
O. Perwitasari, H. Cho, M.S. Diamond, M. Gale Jr., USA
23
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
Firenze Fiera
Hall B - Concurrent Session
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
14.30
Firenze Fiera
Hall C - Concurrent Session
Host-Pathogen Interaction (II)
Chair: Giorgio Trinchieri, USA
Cytokines and Cell Death
Chair: David Wallach, Israel
Cytokine pathways regulating the innate immune response to
mycobacteria
Alan Sher, USA
In vitro and in vivo regulation of TNF-induced necroptosis
Peter Vandenabeele, Belgium
Inhibition of Th17 differentiation and EAE development by tumor
suppressor death-associated protein kinase
M.Z. Lai, Y.T. Chuang, T.F. Chou, K.H. Lin, R.H. Chen, S.C. Miau,
A. Kimchi, Taiwan, Israel
Regulation of the Actin Modifier Gelsolin by Protein Kinase R Enforces
Basal Innate Immune Defense
A. Sadler, A.T. Irving, D. Wang, N. Kozer, A.H.A. Clayton, B.R.G. Williams
Australia
Modulation of apoptosis and pro-inflammatory signalling by vaccinia virus
protein N1
C. Maluquer de Motes, S. Cooray, H. Ren, G.M.F. Almeida, K. McGourty,
M.W. Bahar, D.I. Stuart, J.M. Grimes, S.C. Graham, G.L. Smith, UK
Vaccinia Virus Protein C6 is a Virulence Factor that Binds TBK1 Adaptor
Proteins and Inhibits Activation of IRF3
R.P. Sumner, H. Ren, L. Unterholzner, A.G. Bowie, G.L. Smith
UK, Ireland
Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in
the phagosome of human monocytes
J.L. Cervantes, Carson J. La Vake, and Juan C. Salazar (1,2,3)
USA
TWEAK/Fn14 Pathway in Colitis: Links to Interleukin-13-induced intestinal
epithelial cell injury and promotion of chronic colitis
L.C. Burkly, R. Kawashima, Y.I. Kawamura, T. Oshio, A. Son,
M. Yamazaki, T. Hagiwara, T. Okada, P. Wu, S. Szak, Y.J. Kawamura,
F. Konishi, O. Miyake, H. Yano, Y. Saito and T. Dohi, USA, Japan
Arteri- and nairovirus OTU domain-containing proteases target ubiquitinregulated factors in the RLR-mediated innate immune signaling pathway
M. Kikkert, P.B. van Kasteren, C. Beugeling, D. Ninaber, S. van Boheemen,
A. Garcia-Sastre, E.J. Snijder
The Netherlands
Bounding Interferon Alpha To Apolipoprotein A-I: A Strategy To Reduce
Hematological Toxicity While Enhancing Immunostimulatory Properties
J. Fioravanti, I. González, J. Medina-Echeverz, E. Larrea, N. Ardaiz,
G. González-Aseguinolaza, J. Prieto, P. Berraondo, Spain
Interferon stimulated gene 54 (ISG54) promotes apoptosis
M. Stawowczyk, S. Van Scoy, K. Prasanna Kumar, N.C. Reich, USA
A role for plasmacytoid dendritic cells in Th2 response induction against
helminths
R.J. Lundie, L.M. Webb, L. Boon, A.S. MacDonald, UK
NS3 of bluetongue virus interferes with the innate antiviral response
D. Vitour, E. Lara, E. Chauveau, M. Adam, C. Sailleau, E. Breard,
S. Zientara, France
Cytokines, cell death and tumor suppression:
a GRIM takes a central stage
D.V. Kalvakolanu, S. Kalakonda, S.C. Nallar, D.J. Lindner, USA
17.00
Hall A - Closing Honorary Lecture
T helper 17 cells
Sergio Romagnani, Italy
24
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
Firenze Fiera
GENERAL INFORMATION
9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
Firenze Fiera
FIRENZE FIERA - CONGRESS VENUE
Dates: 09-12 October 2011
Congress Venue: Palazzo dei Congressi, Palazzo degli Affari
Firenze, Italy (www.firenzefiera.it) - Piazza Adua 1 - 50123 Florence
REGISTRATION FEES
The registration fee for participants includes: congress bag, all congress materials,
abstract book, daily coffee/tea, welcome reception.
General Registration On Site
MEMBER
Academic/Government
Euro 500
NON MEMBER
Academic/Government
Euro 700
Industry
Euro 750
PhD Students (under 35)*
Post-Doctarals (under 35)*
Euro 300
Accompanying Guests**
Euro 300
Registration Fees (Euro) VAT included
*Graduate students (up to 35 years old & students): An official document prooving this status
and their age must be present to Registration Desk
**Accompaning Guests fee includes: access to the Opening Ceremony and Welcome Reception at
the Palazzo dei Congressi, Palazzo degli Affari, Firenze, Italy
Opening Hours
Registration Desk
The Registration Desk is located in the Exhibition Area
Sunday
9 October 15:00-20:00
Monday
10 October 08:30-19:30
Tuesday
11 October 08:30-19:30
Wednesday
12 October 08:30-19:30
Exhibition Area
Sunday
Monday
Tuesday
Wednesday
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9 October 15:00-20:00
10 October 08:30-19:30
11 October 08:30-19:30
12 October 08:30-19:30
Conference Halls
Exhibition Area
Coffee Breaks
Conference Halls
Catering Area
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9th JOINT MEETING OF ICS-ISICR
Florence (Italy) October 9 -12, 2011
EXHIBITION AREA “PASSI PERDUTI”
Firenze Fiera
HOW TO REACH “FIRENZE FIERA”
BY PLANE - Florence International Airport “Amerigo
Vespucci” (connected to the main European cities) IATA
CODE: FLR www.aeroporto.firenze.it
It is located at 4 km (2.5 miles) from Florence and it
can be reached by taxi (20 minutes) or by the shuttle
bus “Vola in bus”, a special connection service from/to
the Vespucci Airport and the Santa Maria Novella train
station, jointly run by ATAF and SITA. For further
information call “Pronto Ataf” toll free no. from Italy 800
424500.
Pisa International Airport “Galileo Galilei” (connected
to the main European cities) IATA CODE: PSA
www.pisa-airport.it
It is located in Pisa, at 60 km (38 miles) from
Florence and it can be reached in 1 hour by train from the Santa Maria Novella train
station, in Florence: three trains every hour for Pisa C.le and Pisa Airport from 06.00
a.m. to 10.00 p.m.
BY CAR - An efficient motorway network connects Florence to the rest of Italy and
Europe. Firenze Fiera is just at 4 km (2.5 miles) from the main Italian motorway (the
A1: Autostrada del Sole - Exit Firenze Nord). Two large parking areas, respectively
for 600 and 800 cars, are just 100 meters away; another parking area for 400 cars
can be reached by bus.
BY TRAIN - There are 4 train stations in Florence:
• Santa Maria Novella Central Station: 80/100 meters from the “Palazzo dei
Congressi” and from the “Palazzo degli Affari”, 50 meters from the “Fortezza da Basso”
covering the access to railroad 16.
• Rifredi: approximately 2 km (1.2 miles) away
• Campo di Marte: 1,5 km ca.
• Statuto
PUBLIC TRANSPORTATION - All town busses stop at “Piazza della Stazione”
(Santa Maria Novella train station). Since they are just 50 meters far from the Santa
Maria Novella train station, Firenze Fiera’s venues are within walking distance of any
bus stop. In addition, a large number of bus services connect the centre of Florence
to its surroundings (Fiesole: ataf bus no. 7 - Settignano: Ataf bus no. 10).
The regional coach lines (Cap, Lazzi, Sita) connect Florence to the other wonderful
Tuscan cities such as San Gimignano, Pienza, Arezzo, Volterra, Forte dei Marmi,
etc.
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BD BIOSCIENCES
18, 19
BIOLEGEND
22
CELL SIGNALING TECHONOLOGY
31
EBIOSCIENCE
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GENPROBE
2
LIFETECHNOLOGY
8, 9
MERCK MILLIPORE
24
NANO INK
20
PBL INTERFERON SOURCE
30, 32
PEPROTECH
25
R&D SYSTEMS
27, 28
RANDOX
21
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ORGANIZING SECRETARIAT
M.A.F. SERVIZI SrL
Centro Direzionale Piero della Francesca - Corso Svizzera 185bis - 10149 Torino (Italy)
phone: ++ 39 011-505.900 fax: ++39 011-505.976
e-mail: [email protected] web site: www.mafservizi.it
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