1. No category

Supplementary appendix
This appendix formed part of the original submission and has been peer reviewed.
We post it as supplied by the authors.
Supplement to: Robidoux A, Tang G, Rastogi P, et al. Lapatinib as a component of
neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41):
an open-label, randomised phase 3 trial. Lancet Oncol 2013; published online October 4.
http://dx.doi.org/10.1016/S1470-2045(13)70411-X.
Supplementary Table S1: NSABP B-41 Patient Recruitment Site Accrual
Accrual
35
32
28
23
20
19
18
18
15
14
11
10
10
9
8
8
8
8
8
8
7
7
7
7
7
7
7
7
6
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
Institution
CCOP, Colorado Cancer Research Program, Inc., Denver, CO
CCOP, Southeast Cancer Control Consortium, Winston-Salem, NC
Kaiser Permanente, Northern CA Region, Vallejo, CA
Centre Hospitalier de l'Universite de Montréal (CHUM), Montréal, QC
MBCCOP, Virginia Commonwealth University, Richmond, VA
MBCCOP, San Juan, Puerto Rico
CCOP, Columbus, OH
Jewish General Hospital, Montréal, QC
Ohio State University, Columbus, OH
University of Pittsburgh, Pittsburgh, PA
Royal Victoria Hospital, Montréal, QC
CCOP, Ozark Health Ventures LLC, Springfield, MO
Kasier Permanente - San Diego Mission, CA
Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, PA
Aultman Hospital, Canton, OH
CCOP, Central Illinois, Springfield, IL
CCOP, Metro-Minnesota, Minneapolis, MN
CCOP, Sanford Research USD, Sioux Falls, SD
Centre Hospitalier Affilié Universitaire de Quebec (CHA), Quebec City, QC
Penn State Milton S Hershey Medical Center, Hershey, PA
CCOP, Dayton, OH
CCOP, Michigan Cancer Research Consortium, Ann Arbor, MI
CCOP, Northern Indiana Cancer Research Consortium, South Bend, IN
Greater Baltimore Medical Center, Baltimore, MD
Lehigh Valley Hospital, Allentown, PA
University of Iowa, Iowa City, IA
University of Kentucky, Lexington, KY
West Virginia University Hospitals, Inc., Morgantown, WV
CCOP, Missouri Valley Cancer Consortium, Omaha, NE
Hartford Hospital, Hartford, CT
Michigan State University, E. Lansing, MI
Odette Cancer Centre, Toronto, Ontario, ON
Case Western Reserve University/Univ Hospitals of Cleveland, Cleveland, OH
CCOP, Alton Ochsner Medical Foundation, New Orleans, LA
Desert Regional Medical Center, Palm Springs, CA
Kootenai Cancer Center, Coeur D'Alene, ID
MD Anderson Cancer Center, Orlando, FL
University of Missouri-Ellis Fischel, Columbia, MO
Alamance Regional Medical Center, Burlington, NC
CCOP, Heartland Cancer Research, St Louis, MO
Hennepin County Medical Center, Minneapolis, MN
MBCCOP, Boston Medical Center, Boston, MA
Norton Health Care Pavilion, Louisville, KY
Pacific Shores Medical Group, Long Beach, CA
Phoebe Putney Memorial Hospital, Albany, GA
University of Colorado Cancer Center, Denver, CO
University of Hawaii, Honolulu, HI
University of Texas, San Antonio, TX
Albert Einstein Healthcare Network, Philadelphia, PA
Cancer Institute of New Jersey, New Brunswick, NJ
CCOP, Benaroya Research Institute at Virginia Mason, Seattle, WA
CCOP, Geisinger Clinic, Danville, PA
CCOP, Upstate Carolina, Spartanburg, SC
Principal Investigator
Eduardo R. Pajon, MD
James N. Atkins, MD
Louis Fehrenbacher, MD
André Robidoux, MD
Harry D. Bear, MD, PhD
Luis Baez-Diaz, MD
J. Philip Kuebler, MD PhD
Richard G. Margolese, MD
William B. Farrar, MD
Adam M. Brufsky, MD
Henry R. Shibata, MD
Robert R. Carolla, MD
Jonathan Polikoff, MD
Thomas B. Julian, MD
Shruti Trehan, MD
James L. Wade, III, MD
Patrick J. Flynn, MD
Miroslaw Mazurczak, MD
Louise Provencher, MD
J. Stanley Smith, MD
Howard M. Gross, MD
Philip J. Stella, MD
Bilal Ansari, MD
Madhu Chaudhry, MD
Lori Chapleskie Alfonso, DO
Alexandra Thomas, MD
Edward H. Romond, MD
Jame Abraham, MD
Gamini Soori, MD
Patricia A. DeFusco, MD
Deimante M. Tamkus, MD
Jean-Philippe Pignol, MD
Rosemary A. Leeming, MD FACS
Jyotsna Fuloria, MD
Elber S. Camacho, MD
Kevin T. Kim, MD
Mark S. Roh, MD
Rashmi Ramasubbaiah, MD
Janak K. Choksi, MD
Alan P. Lyss, MD
Richard T. Zera, MD
Maureen T. Kavanah, MD
John T. Hamm, MD
N. Simon Tchekmedyian, MD
Jose M. Tongol, MD
Nicole Kounalakis, MD
Kenneth N.M. Sumida, MD
Ismail Jatoi, MD
Ajit M. Desai, MD
Antoinette R. Tan, MD
Craig R. Nichols, MD
Victor G. Vogel, MD
James D. Bearden III, MD
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
CCOP, Wichita, KS
Glens Falls Hospital, Glens Falls, NY
MedStar Franklin Sq Med Ctr/Weinberg Cancer Institute, Baltimore, MD
Scripps Cancer Center, La Jolla, CA
St. Joseph Hospital, Orange, CA
St. Vincent Hospital and Health Services, Indianapolis, IN
Stanford University, Palo Alto, CA
University of California, Irvine Medical Center, Orange, CA
Akron City Hospital, Akron, OH
Cancer Institute at Alexian Brothers Hospital Network, Elk Grove Villiage, IL
CCOP, Marshfield Clinic, Marshfield, WI
Edward Hospital/Cancer Center, Naperville, IL
Henry Ford Health System, Detroit, MI
MBCCOP, Gulf Coast, Mobile, AL
New York Oncology Hematology PC, Albany, NY
Newark Beth Israel Medical Center, Newark, NJ
St. Mary's Hospital Center, Montréal, Canada
Wake Forest University School of Medicine, Winston-Salem, NC
CCOP, Des Moines, IA
CCOP, Kansas City, KS
CCOP, Main Line Health, Wynnewood, PA
CCOP, Montana Cancer Consortium, Billings, MT
Medical College of Wisconsin, Milwaukee, WI
Puget Sound Oncology Consortium, Seattle, WA
Reading Hospital, Reading, PA
Rush University Medical Center, Chicago, IL
Santa Rosa Memorial Hospital, Santa Rosa, CA
Thompson Cancer Survival Center, Knoxville, TN
Shaker R. Dakhil, MD
Robert W. Sponzo, MD FACP
John L. Zapas, MD
James R. Mason, MD
Lawrence D. Wagman, MD
Ruemu E. Birhiray, MD
Irene L. Wapnir, MD
Rita S. Mehta, MD
Jennifer E. Payne, MD
Kevin Patrick McKian, MD
Jessica A. Wernberg, MD
Alexander Hantel, MD
Thomas J. Doyle, MD
Thaddeus A. Beeker, MD
Regina Resta, MD
Lori Schleicher, MD
Jaroslav F. Prchal, MD FRCP
Edward A. Levine, MD
Robert J. Behrens, MD
Rakesh Gaur, MD
Thomas G. Frazier, MD
Benjamin T. Marchello, MD
Alonzo P. Walker, MD
Tanya Austin Wahl, MD
Terrence P. Cescon, MD
Melody A. Cobleigh, MD
Ian C. Anderson, MD
Daniel Ibach, MD
66
Mean LVEF (%)
64
62
60
58
AC
AC
AC
WP+T (N=143)
WP+L (N=134)
WP+TL (N=141)
56
Baseline
After AC
After paclitaxel
Time points
Nine months
after entry
Supplementary Figure S1. Left Ventricular Ejection Fraction (LVEF)