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FEBRUARY 2015 • VOLUME 89 • NO. 4
TABLE OF CONTENTS
SPOTLIGHT
Articles of Significant Interest Selected from This Issue by the
Editors
1947
GEMS
What DNA Viral Genomic Rearrangements Tell Us about
Persistence
Michael J. Imperiale, Mengxi Jiang
1948 –1950
Expanding the Role of the Virome: Commensalism in the Gut
Ken Cadwell
1951–1953
Fang Li
1954 –1964
Functional Characterization of Nuclear Trafficking Signals in
Pseudorabies Virus pUL31
Lars Paßvogel, Barbara G. Klupp,
Harald Granzow, Walter Fuchs,
Thomas C. Mettenleiter
2002–2012
Human Noroviruses’ Fondness for Histo-Blood Group Antigens
Bishal K. Singh, Mila M. Leuthold,
Grant S. Hansman
2024 –2040
The Amphipathic Helix of Adenovirus Capsid Protein VI
Contributes to Penton Release and Postentry Sorting
Ruben Martinez, Pascale
Schellenberger, Daven Vasishtan, Cindy
Aknin, Sisley Austin, Denis Dacheux,
Fabienne Rayne, Alistair Siebert, Zsolt
Ruzsics, Kay Gruenewald, Harald
Wodrich
2121–2135
Structural Flexibility of a Conserved Antigenic Region in
Hepatitis C Virus Glycoprotein E2 Recognized by Broadly
Neutralizing Antibodies
Annalisa Meola, Alexander W. Tarr,
Patrick England, Luke W. Meredith,
C. Patrick McClure, Steven K. H.
Foung, Jane A. McKeating, Jonathan K.
Ball, Felix A. Rey, Thomas Krey
2170 –2181
Structure-Function Analysis of Vaccinia Virus H7 Protein
Reveals a Novel Phosphoinositide Binding Fold Essential for
Poxvirus Replication
Swapna Kolli, Xiangzhi Meng, Xiang
Wu, Djoshkun Shengjuler, Craig E.
Cameron, Yan Xiang, Junpeng Deng
2209 –2219
Herpes Simplex Virus 1 gN Partners with gM To Modulate the
Viral Fusion Machinery
Imane El Kasmi, Roger Lippé
2313–2323
Structural Analysis of a Rabbit Hemorrhagic Disease Virus
Binding to Histo-Blood Group Antigens
Mila M. Leuthold, Kevin P. Dalton,
Grant S. Hansman
2378 –2387
Analysis of Human T-Cell Leukemia Virus Type 1 Particles by
Using Cryo-Electron Tomography
Sheng Cao, José O. Maldonado, Iwen F.
Grigsby, Louis M. Mansky, Wei Zhang
2430 –2435
Deletion of the ORF9p Acidic Cluster Impairs the Nuclear
Egress of Varicella-Zoster Virus Capsids
Laura Riva, Marc Thiry, Marielle
Lebrun, Laurent L’homme, Jacques
Piette, Catherine Sadzot-Delvaux
2436 –2441
Amy L. Cherry, Caitriona A. Dennis,
Andrew Baron, Leslie E. Eisele, Pia A.
Thommes, Joachim Jaeger
2052–2063
MINIREVIEW
Receptor Recognition Mechanisms of Coronaviruses: a Decade
of Structural Studies
STRUCTURE AND ASSEMBLY
GENOME REPLICATION AND REGULATION OF VIRAL
GENE EXPRESSION
Hydrophobic and Charged Residues in the C-Terminal Arm of
Hepatitis C Virus RNA-Dependent RNA Polymerase Regulate
Initiation and Elongation
Instructions to Authors are available at http://journalitas.asm.org/t/49545.
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FEBRUARY 2015 • VOLUME 89 • NUMBER 4
Ayumi Taguchi, Kazunori Nagasaka,
Kei Kawana, Kosuke Hashimoto, Rika
Kusumoto-Matsuo, Charles Plessy,
Miranda Thomas, Hiroe Nakamura,
Alessandro Bonetti, Katsutoshi Oda,
Iwao Kukimoto, Piero Carninci,
Lawrence Banks, Yutaka Osuga,
Tomoyuki Fujii
2448 –2452
Identification and Functional Comparison of SevenTransmembrane G-Protein-Coupled BILF1 Receptors in
Recently Discovered Nonhuman Primate Lymphocryptoviruses
Katja Spiess, Suzan Fares, Alexander H.
Sparre-Ulrich, Ellen Hilgenberg,
Michael A. Jarvis, Bernhard Ehlers,
Mette M. Rosenkilde
2253–2267
Adaptation of Pandemic H2N2 Influenza A Viruses in Humans
Udayan Joseph, Martin Linster, Yuka
Suzuki, Scott Krauss, Rebecca A.
Halpin, Dhanasekaran Vijaykrishna,
Thomas P. Fabrizio, Theo M.
Bestebroer, Sebastian Maurer-Stroh,
Richard J. Webby, David E.
Wentworth, Ron A. M. Fouchier, Justin
Bahl, Gavin J. D. Smith, members of
the CEIRS H2N2 Working Group
2442–2447
Influenza Virus M2 Protein Ion Channel Activity Helps To
Maintain Pandemic 2009 H1N1 Virus Hemagglutinin Fusion
Competence during Transport to the Cell Surface
Esmeralda Alvarado-Facundo, Yamei
Gao, Rosa María Ribas-Aparicio, Alicia
Jiménez-Alberto, Carol D. Weiss, Wei
Wang
1975–1985
Lentiviral Nef Proteins Manipulate T Cells in a Subset-Specific
Manner
Hangxing Yu, Mohammad Khalid,
Anke Heigele, Jan Schmökel, Shariq M.
Usmani, Johannes van der Merwe, Jan
Münch, Guido Silvestri, Frank
Kirchhoff
1986 –2001
Hepatitis B Virus Core Protein Sensitizes Hepatocytes to Tumor
Necrosis Factor-Induced Apoptosis by Suppression of the
Phosphorylation of Mitogen-Activated Protein Kinase Kinase 7
Baosen Jia, Minggao Guo, Gaiyun Li,
Demin Yu, Xinxin Zhang, Ke Lan,
Qiang Deng
2041–2051
Novel Mechanism of Regulation of Tomato Bushy Stunt Virus
Replication by Cellular WW-Domain Proteins
Daniel Barajas, Nikolay Kovalev, Jun
Qin, Peter D. Nagy
2064 –2079
Mutations across Murine Hepatitis Virus nsp4 Alter Virus
Fitness and Membrane Modifications
Dia C. Beachboard, Jordan M.
Anderson-Daniels, Mark R. Denison
2080 –2089
Model of the TVA Receptor Determinants Required for Efficient
Infection by Subgroup A Avian Sarcoma and Leukosis Viruses
Deborah C. Melder, Gennett M. Pike,
Matthew W. VanBrocklin, Mark J.
Federspiel
2136 –2148
Pseudorabies Virus Triggers Glycoprotein gE-Mediated ERK1/2
Activation and ERK1/2-Dependent Migratory Behavior in T
Cells
Maria Setas Pontes, Bert Devriendt,
Herman W. Favoreel
2149 –2156
Targeting Cellular Squalene Synthase, an Enzyme Essential for
Cholesterol Biosynthesis, Is a Potential Antiviral Strategy
against Hepatitis C Virus
Kyoko Saito, Yoshitaka Shirasago,
Tetsuro Suzuki, Hideki Aizaki, Kentaro
Hanada, Takaji Wakita, Masahiro
Nishijima, Masayoshi Fukasawa
2220 –2232
Kaposi’s Sarcoma-Associated Herpesvirus Induces Nrf2
Activation in Latently Infected Endothelial Cells through
SQSTM1 Phosphorylation and Interaction with
Polyubiquitinated Keap1
Olsi Gjyshi, Stephanie Flaherty,
Mohanan Valiya Veettil, Karen E.
Johnson, Bala Chandran, Virginie
Bottero
2268 –2286
Characterization of Novel Transcripts of Human
Papillomavirus Type 16 Using Cap Analysis Gene Expression
Technology
GENETIC DIVERSITY AND EVOLUTION
VIRUS-CELL INTERACTIONS
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FEBRUARY 2015 • VOLUME 89 • NUMBER 4
Hepatitis B Virus Polymerase Disrupts K63-Linked
Ubiquitination of STING To Block Innate Cytosolic
DNA-Sensing Pathways
Yinghui Liu, Jianhua Li, Jieliang Chen,
Yaming Li, Weixia Wang, Xiaoting Du,
Wuhui Song, Wen Zhang, Li Lin,
Zhenghong Yuan
2287–2300
Dengue Virus Induces and Requires Glycolysis for Optimal
Replication
Krystal A. Fontaine, Erica L. Sanchez,
Roman Camarda, Michael Lagunoff
2358 –2366
Phosphatidylserine-Specific Phospholipase A1 Involved in
Hepatitis C Virus Assembly through NS2 Complex Formation
Min Guo, Rongjuan Pei, Qi Yang,
Huang Cao, Yun Wang, Chunchen Wu,
Jizheng Chen, Yuan Zhou, Xue Hu,
Mengji Lu, Xinwen Chen
2367–2377
Lethal Coinfection of Influenza Virus and Streptococcus
pneumoniae Lowers Antibody Response to Influenza Virus
in Lung and Reduces Numbers of Germinal Center B Cells,
T Follicular Helper Cells, and Plasma Cells in Mediastinal
Lymph Node
Yuet Wu, Wenwei Tu, Kwok-Tai Lam,
Kin-Hung Chow, Pak-Leung Ho, Yi
Guan, Joseph S. Malik Peiris, Yu-Lung
Lau
2013–2023
Regulatory T Cells Resist Virus Infection-Induced Apoptosis
Jenny W. Che, Anke R. M. Kraft,
Liisa K. Selin, Raymond M. Welsh
2112–2120
The Inability of Wild-Type Rabies Virus To Activate Dendritic
Cells Is Dependent on the Glycoprotein and Correlates with Its
Low Level of the De Novo-Synthesized Leader RNA
Yang Yang, Ying Huang, Clement W.
Gnanadurai, Shengbo Cao, Xueqin Liu,
Min Cui, Zhen F. Fu
2157–2169
Induction of an Embryonic Mouse Innate Immune Response
following Inoculation In Utero with Minute Virus of Mice
Irina Rostovsky, Claytus Davis
2182–2191
Epstein-Barr Virus Type 2 Latently Infects T Cells, Inducing an
Atypical Activation Characterized by Expression of
Lymphotactic Cytokines
Carrie B. Coleman, Eric M. Wohlford,
Nicholas A. Smith, Christine A. King,
Julie A. Ritchie, Paul C. Baresel, Hiroshi
Kimura, Rosemary Rochford
2301–2312
Eleonora Forte, Archana N. Raja,
Priscilla Shamulailatpam, Mark
Manzano, Matthew J. Schipma, John L.
Casey, Eva Gottwein
2333–2341
James A. Carroll, James F. Striebel,
Brent Race, Katie Phillips, Bruce
Chesebro
2388 –2404
Generation and Evaluation of Clade C Simian-Human
Immunodeficiency Virus Challenge Stocks
Hui-Wen Chang, Lawrence J. Tartaglia,
James B. Whitney, So-Yon Lim,
Srisowmya Sanisetty, Christy L. Lavine,
Michael S. Seaman, Cecelia Rademeyer,
Carolyn Williamson, Katharine
Ellingson-Strouss, Leonidas Stamatatos,
James Kublin, Dan H. Barouch
1965–1974
Live-Attenuated Measles Virus Vaccine Targets Dendritic Cells
and Macrophages in Muscle of Nonhuman Primates
Linda J. Rennick, Rory D. de Vries,
Thomas J. Carsillo, Ken Lemon, Geert
van Amerongen, Martin Ludlow,
D. Tien Nguyen, Selma Yüksel, R. Joyce
Verburgh, Paula Haddock, Stephen
McQuaid, W. Paul Duprex, Rik L.
de Swart
2192–2200
CELLULAR RESPONSE TO INFECTION
TRANSFORMATION AND ONCOGENESIS
MicroRNA-Mediated Transformation by the Kaposi’s
Sarcoma-Associated Herpesvirus Kaposin Locus
PRIONS
Prion Infection of Mouse Brain Reveals Multiple New
Upregulated Genes Involved in Neuroinflammation or Signal
Transduction
VACCINES AND ANTIVIRAL AGENTS
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FEBRUARY 2015 • VOLUME 89 • NUMBER 4
PATHOGENESIS AND IMMUNITY
The P25 Protein of Potato Virus X (PVX) Is the Main
Pathogenicity Determinant Responsible for Systemic Necrosis
in PVX-Associated Synergisms
Emmanuel Aguilar, David Almendral,
Lucía Allende, Remedios Pacheco,
Bong Nam Chung, Tomás Canto,
Francisco Tenllado
2090 –2103
Host Genetic and Viral Determinants of HIV-1 RNA Set Point
among HIV-1 Seroconverters from Sub-Saharan Africa
Romel D. Mackelprang, Mary
Carrington, Katherine K. Thomas,
James P. Hughes, Jared M. Baeten,
Anna Wald, Carey Farquhar, Kenneth
Fife, Mary S. Campbell, Saida Kapiga,
Xiaojiang Gao, James I. Mullins,
Jairam R. Lingappa
2104 –2111
Thymic HIV-2 Infection Uncovers Posttranscriptional Control
of Viral Replication in Human Thymocytes
Helena Nunes-Cabaço, Paula Matoso,
Russell B. Foxall, Rita Tendeiro, Ana R.
Pires, Tânia Carvalho, Ana I. Pinheiro,
Rui S. Soares, Ana E. Sousa
2201–2208
TRIM5␣ Restriction Affects Clinical Outcome and Disease
Progression in Simian Immunodeficiency Virus-Infected Rhesus
Macaques
Fan Wu, Ilnour Ourmanov, Nadeene
Riddick, Kenta Matsuda, Sonya
Whitted, Ronald J. Plishka, Alicia
Buckler-White, Matthew F. Starost,
Vanessa M. Hirsch
2233–2240
The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus
Harbors a Unique Motif Conferring Resistance to Antiviral
Human MxA
David Riegger, Rong Hai, Dominik
Dornfeld, Benjamin Mänz, Victor
Leyva-Grado, Maria T SánchezAparicio, Randy A. Albrecht, Peter
Palese, Otto Haller, Martin
Schwemmle, Adolfo García-Sastre,
Georg Kochs, Mirco Schmolke
2241–2252
The Progressive Adaptation of a Georgian Isolate of African
Swine Fever Virus to Vero Cells Leads to a Gradual Attenuation
of Virulence in Swine Corresponding to Major Modifications of
the Viral Genome
Peter W. Krug, Lauren G. Holinka,
Vivian O’Donnell, Bo Reese, Brenton
Sanford, Ignacio Fernandez-Sainz,
Douglas P. Gladue, Jonathan Arzt, Luis
Rodriguez, Guillermo R. Risatti,
Manuel V. Borca
2324 –2332
N-Linked Glycosylation Protects Gammaretroviruses against
Deamination by APOBEC3 Proteins
María Carla Rosales Gerpe, Tyler
Milston Renner, Kasandra Bélanger,
Cindy Lam, Halil Aydin, Marc-André
Langlois
2342–2357
MCL1 Enhances the Survival of CD8ⴙ Memory T Cells after
Viral Infection
Jingang Gui, Zhuting Hu, Ching-Yi
Tsai, Tian Ma, Yan Song, Amanda
Morales, Li-Hao Huang, Ethan
Dmitrovsky, Ruth W. Craig, Edward J.
Usherwood
2405–2414
Genetic Analysis of the Localization of APOBEC3F to Human
Immunodeficiency Virus Type 1 Virion Cores
John P. Donahue, Rebecca T. Levinson,
Jonathan H. Sheehan, Lorraine Sutton,
Harry E. Taylor, Jens Meiler, Richard T.
D’Aquila, Chisu Song
2415–2424
GB Virus C Coinfections in West African Ebola Patients
Michael Lauck, Adam L. Bailey,
Kristian G. Andersen, Tony L.
Goldberg, Pardis C. Sabeti, David H.
O’Connor
2425–2429
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FEBRUARY 2015 • VOLUME 89 • NUMBER 4
ERRATUM
Erratum for Tesfay et al., PEGylation of Vesicular Stomatitis
Virus Extends Virus Persistence in Blood Circulation of
Passively Immunized Mice
Mulu Z. Tesfay, Amber C. Kirk,
Elizabeth M. Hadac, Guy E. Griesmann,
Mark J. Federspiel, Glen N. Barber,
Stephen M. Henry, Kah-Whye Peng,
Stephen J. Russell
2453
Cover photograph (Copyright © 2015, American Society for Microbiology. All Rights Reserved.): Development of a robust henipavirus
reverse genetics system allows real-time monitoring of virus in vitro and in vivo. Microscopy analysis shows primary human endothelial cells
infected with recombinant Nipah virus expressing green fluorescent protein (left panel) and mCherry (right panel), respectively. The center
image shows a 3D reconstruction of bioluminescent signal detected from a live interferon alpha/beta receptor knockout mouse 6 days after
infection with recombinant Nipah virus (Malaysia strain) encoding firefly luciferase. The bioluminescent signal intensity is overlaid with the
IVIS mouse atlas and demonstrates infection of the brain. (See related article in February 2015, vol. 89, no. 2, p. 1242.)