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March 2015 Volume 38, Number 3
In This Issue
341
412
In This Issue of Diabetes Care
R.R. Henry, J. Rosenstock, S. Edelman, S. Mudaliar,
A.-G. Chalamandaris, S. Kasichayanula, A. Bogle, N. Iqbal, J. List,
and S.C. Griffen
Commentaries
343
Responding to the Challenges of Primary Diabetes Care
Through the National Diabetes Education Program
420
K.A. Peterson, M.T. Brown, and E. Warren-Boulton
345
429
Profiles in Progress
347
Saul Genuth, MD: Clinical Researcher and Leader in
Developing Modern Diabetes Treatment
431
SGLT2 Inhibitors: The Latest “New Kids on the Block”!
Clinical Care/Education/Nutrition/Psychosocial Research
W.T. Cefalu and M.C. Riddle
439
Canagliflozin Provides Durable Glycemic Improvements and
Body Weight Reduction Over 104 Weeks Versus Glimepiride
in Patients With Type 2 Diabetes on Metformin: A
Randomized, Double-Blind, Phase 3 Study
Dapagliflozin Improves Glycemic Control and Reduces Body
Weight as Add-on Therapy to Metformin Plus Sulfonylurea:
A 24-Week Randomized, Double-Blind Clinical Trial
PCSK7 Genotype Modifies Effect of a Weight-Loss Diet on
2-Year Changes of Insulin Resistance: The POUNDS LOST Trial
T. Huang, J. Huang, Q. Qi, Y. Li, G.A. Bray, J. Rood, F.M. Sacks, and L. Qi
445
Mild Gestational Diabetes Mellitus and Long-Term Child Health
M.B. Landon, M.M. Rice, M.W. Varner, B.M. Casey, U.M. Reddy,
R.J. Wapner, D.J. Rouse, J.R. Biggio Jr., J.M. Thorp, E.K. Chien, G. Saade,
A.M. Peaceman, S.C. Blackwell, and J.P. VanDorsten, for the Eunice
Kennedy Shriver National Institute of Child Health and Human
Development Maternal-Fetal Medicine Units (MFMU) Network
L.A. Leiter, K.-H. Yoon, P. Arias, G. Langslet, J. Xie, D.A. Balis,
D. Millington, F. Vercruysse, W. Canovatchel, and G. Meininger
365
Greater Dose-Ranging Effects on A1C Levels Than on Glucosuria
With LX4211, a Dual Inhibitor of SGLT1 and SGLT2, in Patients
With Type 2 Diabetes on Metformin Monotherapy
J. Rosenstock, W.T. Cefalu, P. Lapuerta, B. Zambrowicz, I. Ogbaa,
P. Banks, and A. Sands
Evolving Tactics With Inhibition of Sodium–Glucose
Cotransporters
355
Blood Pressure Reduction: An Added Benefit of Sodium–
Glucose Cotransporter 2 Inhibitors in Patients With Type 2
Diabetes
C. Majewski and G.L. Bakris
A.M. Jacobson and D.M. Nathan
352
Empagliflozin Reduces Blood Pressure in Patients With Type 2
Diabetes and Hypertension
I. Tikkanen, K. Narko, C. Zeller, A. Green, A. Salsali, U.C. Broedl, and
H.J. Woerle, on behalf of the EMPA-REG BP Investigators
Gestational Diabetes Mellitus and the OffspringdJack and
Jill Are Different Still
H. Murphy and S. Finer
Exploring the Potential of the SGLT2 Inhibitor Dapagliflozin
in Type 1 Diabetes: A Randomized, Double-Blind, PlaceboControlled Pilot Study
453
S. Matthaei, K. Bowering, K. Rohwedder, A. Grohl, and S. Parikh,
for the Study 05 Group
Risks of Psychiatric Disorders and Suicide Attempts
in Children and Adolescents With Type 1 Diabetes:
A Population-Based Cohort Study
A. Butwicka, L. Frisén, C. Almqvist, B. Zethelius, and P. Lichtenstein
373
Where Does Combination Therapy With an SGLT2 Inhibitor
Plus a DPP-4 Inhibitor Fit in the Management of Type 2
Diabetes?
M. Abdul-Ghani
376
Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled
With Metformin Monotherapy: A Randomized Double-Blind
Trial of Saxagliptin Plus Dapagliflozin Addition Versus Single
Addition of Saxagliptin or Dapagliflozin to Metformin
Epidemiology/Health Services Research
460
M.-Y.M. Leung, L.M. Pollack, G.A. Colditz, and S.-H. Chang
469
J. Rosenstock, L. Hansen, P. Zee, Y. Li, W. Cook, B. Hirshberg,
and N. Iqbal
384
Combination of Empagliflozin and Linagliptin as Second-Line
Therapy in Subjects With Type 2 Diabetes Inadequately
Controlled on Metformin
476
403
Efficacy and Safety of Canagliflozin, an Inhibitor of Sodium–
Glucose Cotransporter 2, When Used in Conjunction With
Insulin Therapy in Patients With Type 2 Diabetes
B. Neal, V. Perkovic, D. de Zeeuw, K.W. Mahaffey, G. Fulcher,
K. Ways, M. Desai, W. Shaw, G. Capuano, M. Alba, J. Jiang,
F. Vercruysse, G. Meininger, and D. Matthews, on behalf of the
CANVAS Trial Collaborative Group
Prevalence of Detectable C-Peptide According to Age at
Diagnosis and Duration of Type 1 Diabetes
A.K. Davis, S.N. DuBose, M.J. Haller, K.M. Miller, L.A. DiMeglio,
K.E. Bethin, R.S. Goland, E.M. Greenberg, D.R. Liljenquist, A.J. Ahmann,
S.M. Marcovina, A.L. Peters, R.W. Beck, and C.J. Greenbaum, for the
T1D Exchange Clinic Network
Initial Combination of Empagliflozin and Linagliptin in
Subjects With Type 2 Diabetes
A. Lewin, R.A. DeFronzo, S. Patel, D. Liu, R. Kaste, H.J. Woerle,
and U.C. Broedl
How Do People With Diabetes Describe Their Experiences in
Primary Care? Evidence From 85,760 Patients With Selfreported Diabetes From the English General Practice Patient
Survey
C.A.M. Paddison, C.L. Saunders, G.A. Abel, R.A. Payne, A.I. Adler,
J.P. Graffy, and M.O. Roland
R.A. DeFronzo, A. Lewin, S. Patel, D. Liu, R. Kaste, H.J. Woerle,
and U.C. Broedl
394
Life Years Lost and Lifetime Health Care Expenditures
Associated With Diabetes in the U.S., National Health
Interview Survey, 1997–2000
482
Trends in Diabetes Incidence: The Framingham Heart Study
T.M. Abraham, K.M. Pencina, M.J. Pencina, and C.S. Fox
488
Progression of Diabetes Retinal Status Within Community
Screening Programs and Potential Implications for Screening
Intervals
G.P. Leese, I.M. Stratton, M. Land, M.O. Bachmann, C. Jones,
P. Scanlon, H.C. Looker, and B. Ferguson, on behalf of the Four
Nations Diabetic Retinopathy Screening Study Group
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495
The Risk of Colorectal Cancer in Patients With Type 2
Diabetes: Associations With Treatment Stage and Obesity
e38
P.J.H.L. Peeters, M.T. Bazelier, H.G.M. Leufkens, F. de Vries, and
M.L. De Bruin
Emerging Technologies and Therapeutics
503
Pharmacokinetics and Pharmacodynamics of Insulin Glargine
Given in the Evening as Compared With in the Morning in
Type 2 Diabetes
Remission of Severe Neonatal Diabetes With Very Early
Sulfonylurea Treatment
B.A. Marshall, R.P. Green, J. Wambach, N.H. White, M.S. Remedi,
and C.G. Nichols
e-Letters – Comments and Responses
e40
F. Porcellati, P. Lucidi, P. Cioli, P. Candeloro, A. Marinelli Andreoli,
S. Marzotti, M. Ambrogi, G.B. Bolli, and C.G. Fanelli
Comment on Duran et al. Introduction of IADPSG Criteria for
the Screening and Diagnosis of Gestational Diabetes
Mellitus Results in Improved Pregnancy Outcomes at
a Lower Cost in a Large Cohort of Pregnant Women:
The St. Carlos Gestational Diabetes Study. Diabetes Care
2014;37:2442–2450
R. Rodrıguez-Gutiérrez and J.G. Gonz
alez-Gonz
alez
Pathophysiology/Complications
513
e41
Tyrosine Phosphatase–Related Islet Antigen 2(256–760)
Autoantibodies, the Only Marker of Islet Autoimmunity That
Increases by Increasing the Degree of BMI in Obese Subjects
With Type 2 Diabetes
R. Buzzetti, M. Spoletini, S. Zampetti, G. Campagna, L. Marandola,
F. Panimolle, F. Dotta, and C. Tiberti, for the NIRAD Study Group
(NIRAD 8)
A. Duran, M.J. Torrejón, I. Runkle, and A.L. Calle-Pascual
e43
Cardiovascular and Metabolic Risk
521
Serum 25-Hydroxyvitamin D: A Predictor of Macrovascular and
Microvascular Complications in Patients With Type 2 Diabetes
M. Herrmann, D.R. Sullivan, A.-S. Veillard, T. McCorquodale,
I.R. Straub, R. Scott, M. Laakso, D. Topliss, A.J. Jenkins, S. Blankenberg,
A. Burton, and A.C. Keech, for the FIELD Study Investigators
e44
Sleep Duration and Risk of Type 2 Diabetes: A Meta-analysis
of Prospective Studies
Z. Shan, H. Ma, M. Xie, P. Yan, Y. Guo, W. Bao, Y. Rong, C.L. Jackson,
F.B. Hu, and L. Liu
Efficacy and Safety of Dulaglutide Versus Sitagliptin After 52
Weeks in Type 2 Diabetes in a Randomized Controlled Trial
(AWARD-5). Diabetes Care 2014;37:2149–2158
e45
e46
e47
e-Letters – Observations
e32
Effect of Bariatric Surgery Versus Intensive Medical
Management on Diabetic Ophthalmic Outcomes
R.P. Singh, R. Gans, S.R. Kashyap, R. Bedi, K. Wolski, S.A. Brethauer,
S.E. Nissen, D.L. Bhatt, and P. Schauer
e34
e36
Retinal Thinning as a Marker of Disease Progression in
Patients With Wolfram Syndrome
A. Zmyslowska, W. Fendler, A. Niwald, M. Ludwikowska-Pawlowska,
M. Borowiec, K. Antosik, A. Szadkowska, and W. Mlynarski
Comment on Steck et al. Early Hyperglycemia
Detected by Continuous Glucose Monitoring in Children
at Risk for Type 1 Diabetes. Diabetes Care
2014;37:2031–2033
D. Brancato and V. Provenzano
e48
Blinded Continuous Glucose Monitoring During Yom Kippur
Fasting in Patients With Type 1 Diabetes on Continuous
Subcutaneous Insulin Infusion Therapy
M. Metzger, L. Lederhendler, and A. Corcos
Response to Comment on O’Connor et al. Randomized Trial
of Telephone Outreach to Improve Medication Adherence
and Metabolic Control in Adults With Diabetes. Diabetes
Care 2014;37:3317–3324
P.J. O’Connor, J.A. Schmittdiel, R.D. Pathak, R.I. Harris, and
K.M. Newton
Issues and Events
Issues and Events
Comment on O’Connor et al. Randomized Trial of Telephone
Outreach to Improve Medication Adherence and Metabolic
Control in Adults With Diabetes. Diabetes Care
2014;37:3317–3324
I.D. Blackberry, J.S. Furler, J.D. Best, and D. Young
M. Nauck, R.S. Weinstock, G.E. Umpierrez, B. Guerci, Z. Skrivanek,
and Z. Milicevic
539
Response to Comment on Liu et al. Latent Autoimmune
Diabetes in Adults With Low-Titer GAD Antibodies: Similar
Disease Progression With Type 2 Diabetes: A Nationwide,
Multicenter Prospective Study (LADA China Study 3).
Diabetes Care 2015;38:16–21
X. Li, L. Liu, Y. Xiang, G. Huang, R.D. Leslie, and Z. Zhou
Erratum
538
Comment on Liu et al. Latent Autoimmune Diabetes in
Adults With Low-Titer GAD Antibodies: Similar Disease
Progression With Type 2 Diabetes: A Nationwide,
Multicenter Prospective Study (LADA China Study 3).
Diabetes Care 2015;38:16–21
V.N. Shah and L. Yu
Meta-analysis
529
Response to Comment on Duran et al. Introduction of
IADPSG Criteria for the Screening and Diagnosis of
Gestational Diabetes Mellitus Results in Improved
Pregnancy Outcomes at a Lower Cost in a Large Cohort of
Pregnant Women: The St. Carlos Gestational Diabetes Study.
Diabetes Care 2014;37:2442–2450
Response to Comment on Steck et al. Early Hyperglycemia
Detected by Continuous Glucose Monitoring in Children at
Risk for Type 1 Diabetes. Diabetes Care 2014;37:2031–2033
A.K. Steck, F. Dong, I. Taki, M. Hoffman, G.J. Klingensmith, and
M.J. Rewers
e49
Comment on Tovote et al. Individual Mindfulness-Based
Cognitive Therapy and Cognitive Behavior Therapy for
Treating Depressive Symptoms in Patients With Diabetes:
Results of a Randomized Controlled Trial. Diabetes Care
2014;37:2427–2434
V.Y. Womack and M.R. Carnethon
Cover: Angiogram of Kidneys. © Alain Pol, ISM/Science Photo Library. For more information, please visit sciencesource.com. This issue of Diabetes Care features
nine articles and three commentaries in a special section “Evolving Tactics With Inhibition of Sodium–Glucose Cotransporters” (pp. 352–438).