S. No. Products /Processes Under Development Through BIPP Support Company/Collaborator(s) Product/Process Description Name Health Care 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. Drugs/Therapeutics ARA Healthcare Limited, Anti- TNF-alpha Antibody scFv for treatment of Gurgaon Inflammatory Diseases TCG Life Sciences Limited, Process for Asymmetric Synthesis of Kolkata Hexahydrobenzophenanthrenes, Dopamine D1 Agonists Technology development for implant based sustained Bharat Serums and Vaccines release formulations incorporating therapeutic peptides/ Limited, Mumbai recombinant proteins (i) Amrita Therapeutics Limited, Ahmedabad (ii) National Institute of Identification and Development of Promiscuous Anticancer Immunology, New Delhi Compounds from Microorganisms (iii) B.V. Patel PERD Centre, Ahmedabad Life Care Innovations Pvt. Production of poly (lactide-co-glycolide) nanoparticles Ltd., Gurgaon (PLG-NP )and poly (lactide-co-glycolide) nanoparticles encapsulating antitubercular drugs (rifampicin, isoniazid and pyrazinamide- PLG-NP-ATDs) in GMP facilities Incozen Therapeutics Pvt. Discovery and Development of potent, selective and novel Ltd., Hyderabad c-Met kinase inhibitors in cancer (i) Sphaera, Manesar (ii) Leadinvent, Delhi (iii) International Centre for Novel combination therapy for treatment of resistant and Genetic Engineering and non responsive cancers Biotechnology , New Delhi Rasayani Biologics Pvt. Ltd., Evaluation of Platinum Nano Particles for the Treatment of Pune Hormone Refractory Prostate Cancer Panacea Biotec Ltd., New Development of novel peptide based topical gel for the Delhi treatment of alopecia (i) Anthem Biosciences Pvt. Ketoreductases - Whole Cell Biotransformation for chiral Ltd., Bangalore chemistry (ii) Cellworks Research India Pvt Ltd., Bangalore (i) Mitra Biotech Pvt. Ltd., Development of PAT-1102, a novel HDAC inhibitor for the Bangalore treatment of cancer (ii) Anthem Biosciences Pvt. Ltd., Bangalore Crystalin Research Pvt. Ltd., Pre-Clinical studies of novel anticancer drug cocrystal Hyderabad Vitas Pharma Research Pvt. Novel inhibitors of fatty acid biosynthesis for the treatment of Ltd., Hyderabad drug resistant S.aureus bacterial infections 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. Orchid Chemicals & Pharmaceuticals Ltd., Shozhanganallur Phyto Biotech Pvt Ltd., Kolkata Natural Remedies Private limited, Bangalore Scale up and validation of technology for the manufacture of DAG using Deacetylcephalosporin C synthase Novel Technology for Microbial Production of Paclitaxel, an anticancer drug Scale-up facilities for the production of phytochemical reference substances from Indian medicinal plants of national relevance as a business model Excel Matrix Biological Novel Haemostasis Mechanisms Devices Pvt. Ltd., Hyderabad Yasham P2D Lifesciences Tumor necrosis factor - alpha (TNFa) inhibiting compound Pvt. Ltd., Mumbai as a first in class drug treatment for neuroinflammatory diseases (i) Enem Nostrum Remedies Discovery and Development of Novel Bone anabolic agents Pvt. Ltd., Mumbai for accelerated fracture healing (ii) CDRI, Lucknow Symmetrix Biotech, Development of Anti Thrombin-clot specific streptokinase Chandigarh (ACSSK), A Novel Thrombolytic with twin properties of clot dissolution and prevention of arterial re-occlusion during the treatment of Acute myocardial infarctio and Ischemic Stroke Usha Biotech Ltd., Rapid Production of Proteins Using CELL EXPRESS - 100 (a Hyderabad novel mammalian expression system PNB Vesper Life Science CLINICAL DEVELOPMENT OF NOVEL CCK PVT LTD, cochin, Kerala RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY PAIN Bugworks Research India Novel antibiotics for Gram negative bacteria: Structure based Pvt. Ltd., Bangalore strategy to Ameliorate antibiotic efflux and enhance compound efficacy (i) Unichem Labs Ltd., An integrated approach to develop recombinant selerotium Bardej rolfsii (SRL) antitumor tectins I E.coli as novel targeted (ii) Karnatak University, anticancer drug and drug delivery system for human colon and Dharwad breast cancer, providing affordaable health care to cancer patients Vaccines Virchow Biotech Private Development Of A Novel Mucosal Vaccine For Hpv Ltd., Hyderabad Gennova Biopharmaceuticals Development of a cost effective prophylactic and Limited, Pune Therapeutic Recombinant Human Papillomavirus vaccine (i) Serum Institute of India Limited, Pune (ii) Indian Institute of Design and evaluation of novel immunogens and Science, Bangalore monoclonal antibodies against pandemic H1N1 (iii) National Institute of Immunology, New Delhi Tergene Biotech Pvt. Ltd., Development of an Affordable, Asia specific 15 valent Secunderabad Pneumococcal Ploysaccharide - CRM 197 protein conjugate Vaccine 29. Tergene Biotech Pvt. Ltd., Secunderabad – Phase 2 30. Panacea Biotec Ltd., New Delhi 31. 32. 33. 34. 35. 36. 37. 38. Development of an Affordable, Asia specific 15 valent Pneumococcal Polysaccharide - CRM 197 Protein Conjugate Vaccine Development of safe and highly efficacious 13-valent pneumococcal conjugate vaccine against Streptococcus pneumoniae infections Serum Institute of India Ltd., Development of HPV Vaccine Pune Diagnostics/Devices/Implants Bigtec Private Limited, Point-of-Care detection of infectious disease using handheld Bangalore microPCR Amar Immunodiagnostics Immunodiagnostic kits for detection of autoimmune diseases Pvt. Ltd., Hyderabad Chromous Biotech Pvt. Ltd., Multiplex Fast-PCR based diagnosis and prognosis of Bangalore tuberclulosis (i) C-CAMP, Bangalore (ii) Indian Institute of Flow analyzer Technology, Madras Transasia Biomedical Ltd., To develop novel 3rd Generation HIV (Antibody) & 4th Mumbai generation (HIV Antigen and Antibody) immunoassay forma using flash type chemiluminiscence and magnetic particles as matrix (i) Design Innova, New Delhi (ii) International Centre for Design and development of an affordable fluorescence reader Genetic Engineering and for point-of-care diagnostics Biotechnology, New Delhi (i) Janacare Solutions Pvt. Ltd., New Delhi (ii) All India Institute of Medical Sciences, New Delhi DXPhone (iii)Narayana Hrudayalaya Hospital City, Bangalore 39. Optra Systems Pvt. Ltd., Pune ONCOSCAN – Digital Oncopathology slide Scanner 40. Perfint Healthcare Pvt. Ltd., Chennai Strand Life Science, Bangalore Frontier Lifeline Private Limited, Chennai (i) Vinvish Technologies Pvt. Ltd., Trivendrum (ii) Centre for Earth Sciences, Trivandrum 41. 42. 43. Solution for planning, execution and confirmation of targeted ablation therapy Hepatotoxicity prediction platform Porcine Pulmonary Xenograft Cardiovascular Surgery as a Conduit in Design and Development of photo dynamic therapy laser system (iii)Regional Cancer Centre, Thiruvananthapuram 44. 45. 46. 47. Agada Medical Technologies, Chennai Merkel Haptic Systems Pvt. Ltd., Chennai Panacea Medical Technologies Pvt. Ltd., Bangalore Achira Labs Pvt. Ltd., Bangalore Hi-fidelity affordable mannequin for effective CPR (Cardiopulmonary Resuscitation) Training Development of Flat Panel Computed Tomography (FPCT) machine Electrophoretic pre-concentration to enable the fluorescencebased detection of ultra-low concentrations of analytes in human sera at the point-of-care (i) 48. 49. 50. 51. Axxonet System Technologies, Bangalore (ii) NIMHANS, Bangalore Sahajanand Medical Technologies Pvt. Ltd., Surat Tuscano Equipments Private Limited, Chennai (i) DSS Imagetech Pvt. Ltd., New Delhi (ii) Dr. B. R. Ambedkar Center for Biomedical Research (ACBR), New Delhi Percutaneous Aortic Valve Technology Automated Portable Epilepsy-EEG system Development & building indigenous capability for Balloon Catheter Manufacturing Imaging device for monitoring breast tissue changes (iii) Validation, Field Trial, Scale-up and Commercialisation of Sensitive and Specific PCR based Diagnostic kit and Instruments for diagnosis of Chlamydia and Nisseria infection Clinical Trials 52. 53. 54. 55. (i) Bharat Biotech International Limited, Hyderabad (ii) Christian Medical College, Vellore (iii)KEM Hospital Research Centre, Pune (iv) Translational Health Science and Technology Institute, New Delhi Torrent Pharmaceuticals Limited, Gandhinagar Phase III Testing and Evaluation of Safety and Efficacy of Oral Rotavirus Vaccine Candidate 116E A strategy for the Development of Alternative treatment for Heart failure complicated with diabetes mellitus Clinical development of TRC150094, a novel Torrent Pharmaceuticals Diiodothyronine (T2) analogue, for the treatment of Limited, Gandhinagar cardiovascular (CV) risk factors defined by Metabolic Syndrome (MS). Safety and efficacy of TRC 150094 in treatment of cardioTorrent Pharmaceuticals metabolic risk inoverweight/obese diabetic and pre-diabetic Limited, Gandhinagar subjects with dyslipidemia - Phase II trials 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. Biocon Limited, Bangalore Panacea Biotec Limited, New Delhi V-Life Sciences Technology Pvt. Ltd., Pune A Multicenter, Randomized, Double-Blind, Placebo Control Study of IN-105 tablets [oral insulin] in Patients with Type 2 Diabetes Mellitus who have inadequate Glycemic Control on Optimal doses of Extended Release Metformin Tablets. Development of a H1N1 pandemic influenza vaccine Clinical Investigation of Galnobax for the treatment of Diabetic foot Ulcers To determine the safety, effective dose and frequency of V-Life Sciences Technology application of Galnobax TM in 50 subjects during Phase I Pvt. Ltd., Pune trial in the subjects suffering from diabetic foot ulcers – Phase 2 A Multicentric, Parallel Randomised (2:1) Open Label Phase III Clinical Study To Evaluate The Immunogenicity Biological E Limited., And Safety Of BE’s Inactivated JE Vaccine In Healthy ≥1 To <3 Year Old Indian Subjects In Comparison With Hyderabad Purified Inactivated JE Vaccine (IXIARO®) Of Intercell – An Non-Inferiority Study Cadila Pharmaceuticals Ltd., Clinical Development of Influenza Vaccines Ahmedabad Biogenerics/Biosimilars Sun Pharmaceutical Bevaciumab upto Pre-clinical studies Industries Ltd., Vadodra Gennova Biopharmaceuticals Bio-similar interferon beta 1a: process development Limited, Pune Clonz Biotech Pvt. Ltd., Production of ranibizumab a recombinant humanized AntiHyderabad VEGF monoclonal antibody fragment (recombinant huFab V2) expressed in Hansenula Ploymorpha` Navya Biologicals Pvt. Ltd., Development of novel intensified technology platform for Hubli, Karnataka production of low cost Mabs Development of animal component free biosimilar Wockhardt Limited, recombinant protein therapeutics using mammalian platform Aurangabad technology Serum Institute of India Clinical Development of Polysialylated Erythropoietin Limited, Pune IMGENEX India Pvt. LTd., Development of High Expression plasmid vectors for Bhubaneswar production of biosimilar herceptin and other recombinant proteins and antibodies IMGENEX India Pvt. LTd., Bio-process development for production of Biosimilar BhubaneswarTrastuzumab – Second Phase Intas Biopharmaceuticals Mucosal formulations of Parathyroid hormone (PTH) Pvt. Ltd., Ahemedabad Vivo Biotech Ltd., Hakimpet, Optimization of Scale-up/Purification and clinical grade Andhra Pradesh material generation of recombinant Urate Oxidase Inbiopro Solutions Pvt. Ltd., Interferon Beta 1b process development Bangalore 73. 74. 75. 76. (i) Bhat Biotech (I) Pvt. Ltd., Design and expression of humanied antibodies against soluble Bangalore Interleukin-6^ soluble gp130 in Bacterial and Animal Cell (ii) Manipal Life Sciences lines Centre, Manipal Apcegen Kanpur Technologies, Generation Of Proof Of Concept For Animal Studies of PEG Conjugated Fully Human Fab’ Antibody Fragment Expressed in E. Coli For the Treatment of Rheumatoid Arthritis Stemcells Stempeutics Research Pvt. A parallel group randomized open blinded end point Ltd., Bangalore evaluation, multicentric, dose escalation, phase –II study assessing the safety and efficacy of intra-arterial (hepatic) ex-vivo cultured adult allogenicmesenchymal stem cells in patients with alcoholic liver cirrhosis Ravindranath GE Medical Functional evaluation of autologous cell based therapy in Associates Pvt. Ltd., cardiovascular diseases - Molecular imaging (An innovative Hyderabad non-invasiv technology" Agriculture Transgenics 77. 78. Maharashtra Hybrid Seeds Company Limited, Jalna Maharashtra Hybrid Seeds Company Limited, Jalna 79. Metahelix Life Sciences Private Limited, Bangalore 80. Metahelix Life Sciences Private Limited, Bangalore 81. (i) Bioseed Research India Ltd., Hyderabad (ii) International Centre for Genetic Engineering and Biotechnology , New Delhi 82. 83. 84. JK Agri Genetics Ltd., Hyderabad (i) Mother Dairy Fruit and Vegetable Private Limited, Noida (ii) University of Delhi, South Campus, New Delhi (i) Bejo Sheetal Seeds Private Limited, Jalna (ii) International Centre for Genetic Engineering and Stress tolerant rice Development of Sucking Insect Pest tolerant rice and cotton A proposal for funding of deregulation trials of transgenic rice events expressing Metahelix synthetic Cry1C, Cry1Ac and Cry1Ab genes for tolerance to rice yellow stem borer, Scirpophaga incertulas Deregul action trials phase I of transgenic maize events expressing Metahelix Synthetic Cry1C, Cry1Ac and Cry1Ab Genes for tolerance to stem and cob borers Development of rice hybrids with improved drought and salinity stress tolerance Development of Bt-rice with two cry genes To conduct confined field trials and biosafety studies on genetically engineered Brassica juncea (Male sterility and restorer lines as pollination control mechanism) for heterosis breeding and yield improvement Development of ‘Herbicide & Stress tolerant’ transgenic Onion 85. 86. 87. 88. 89. 90. 91. 92. 93. 94. 95. Biotechnology , New Delhi (i) GEO Biotechnologies Association mapping and whole genome marker assisted India Pvt. Ltd., recurrent selection for development of abiotic stress resilient Bangalore Maize (ii) CIMMYT, Hyderabad Marker Assisted Selection Advanta India Secunderabad Limited, Multistacking genes to develop engineered rice with enhanced drought and multiple disease and pest resistance Kaveri Seeds Company Ltd., Secunderabad Development of biotic stress resistant rice through conjunct use of bio-and hybrid technologies (i) Nirmal Seeds Pvt. Ltd., Jalgaon (ii) The Energy and Resources Institute, New Delhi Kaveri Seeds Company Ltd., Secunderabad (i) Krishidhan Seeds pvt. Ltd., Jalna (ii) ICRISAT, Andhra Pradesh Development of nutritionally improved mustard (Brassica juncea) varieties/hybrids having low erucic acid and low glucosinolate content using marker assisted selection (i) Advanta India Limited, Secunderabad (ii) Indian Agriculture Research Institute, New Delhi (i) Sri Biotech Laboratories India Ltd., Hyderabad (ii) University of Delhi South Campus, Delhi Ankur Seeds Pvt. Ltd., Nagpur Marker-assisted dissection of genetic basis of yield and improving yield potential under drought stress in Maize Genomics assisted accelerated product development of high yeilding pigeonpea hybrids RNAi RNAi and other cuting edge technological interventions to develop insect-pest diseases & viruses tolerant tomato hybrids for Indian & International markets Control of Shoot and Fruit Borer Insect Pest (Leucinodes orbonalis Guenée) in Brinjal Through RNA interference Third generation RNAi for engineering Tomato leaf curl (ToLCV) and tospovirus (GBNV) resistance in tomato (i) Nirmal Seeds Pvt. Ltd., Jalgaon (ii) University of Delhi, South Development of viral resistant okra using RNAi approached Campus, New Delhi Secondary Agriculture A P organics Ltd., Punjab Project on value addition including potential neutraceuticals from derivatives of rice Others 96. 97. 98. 99. (i) Sri Biotech Laboratories India Ltd., Hyderabad (ii) International Crops Research Institute for the Semi-Arid Tropics, Hyderabad (i) Chromous Biotech Pvt. Ltd., Bangalore (ii) IARI, New Delhi (i) Saveer Biotech, Greater Noida (ii) Indian Statistical Institute, Kolkata Tata Chemicals Limited, Pune Development of Actinomycetes based metabolites as delivery systems for soil health management in Groundnut Multiplexed Fast-PCR based detection kit for a group of viruses affecting potato in India Commercial Scale Production of Nanopesticides Nanofungicides for Indian Agro-industry and Inorganic and polymer nano-composites for micronutrient & pesticide delivery: Boosting crop health and yield. Industrial 100. 101. 102. Rossari Biotech Ltd., Mumbai Viable Enzymes production using Agro waste/produce as raw material of Industrial/Feed and health care use with large viable Market/demand Pvt., Single step extraction of cottonseed with miscella refining Abhay Cotex India Maharashtra (i) Anil Ltd., Ahmedabad Development of Value added Corn steep liquor and powder (ii) National Chemical suitable for food and fermentation industry upto pilot scale (1 TPD) Laboratory (NCL), Pune 103. Myko Tech Pvt. Ltd., Mapusa Enhanced production of extra-cellular melanin from various fungal sources for protection against UV and gamma radiations 104. Nagarjuna Fertilizers Pvt. Ltd., Hyderabad Kumar Organic Product Limited, Bangalore International Panacea Ltd., New Delhi Development of Technology Platform for Rare Sugar Production Sustainable and versatile microbial polymers: a bio-based prospect for India Developing Endosulphan degrading bacteria as a commercial product 105. 106. Energy 107 108 109 110 111 Avesthagen Limited, Bangalore Richcore Lifesciences Pvt Ltd., Bangalore Nagarjuna Fertilizers and Chemical Limited, Hyderabad Bharat Petroleum Corporation Limited, Greater Noida Thermax Limited, Pune Development of Self-glucogenic Pearl Millet adapted for marginal lands A process for Enhanced Ethanol Yield from Molasses Fermentation Transformational Technology Platform Development for Biological Hydrogen Butanol production from lignocellulosic biomass Anaerobic Membrane Bioreactor (AnMBR) for Waste to Energy Solutions India Glycols Limited, Kashipur India Glycols Limited, Kashipur 112 113 114 SPC Biotech, Hyderabad Sea6 Energy, chennai 115 Praj matrix, Pune 116 117 (i) Praj Matrix, Pune (ii) International Centre for Genetic Engineering and Biotechnology , New Delhi Setting up a 10 ton Lignocellulosic biomass/day processing plant to produce about 3000 Litre ethanol/day Setting up 10 ton Lignocellulosic biomass/day+C128 processing plant to produce about 3000 Litre ethanol/day (Phase – II: To run the plant in integrated continuous mode)+C390 Bioconversion of Agricultural Waste from Mango kernel, to Polylactic acid a bio-plastic Cost-effective offshore biomass production and bioconversion to fuel - Bioenergy Lignocellulosic Biomass to Ethanol Technology: Simultaneous Saccharification and Fermentation Development of novel cocktail of cellulolytic enzymes for Deconstruction of Lignocellulosic feedstocks Capacity Building through Infrastructure Support Span Surat 118 119 120 121 Diagnostics Limited, Establishment of cGMP compliant Bioprocess Facility for large-scale production of Microbial antigens and Monoclonal antibodies Intas Biopharmaceuticals Private Limited, Ahmedabad Gennova Biopharmaceuticals Limited, Pune Celestial Biologicals Ltd., Ahmedabad Facility for high end structural and functional characterization of protein therapeutics and peptides State of art cGMP prodution facility metting regulatory requirement for production of recombinant bio-therapeutics Scale-up of Plasma Fractionatin Facility for High Value Product Bio-informatics (i) Persistent Systems, Maharashtra (ii) Indian Institute of Technology (IIT), Mumbai SanGeniX: A comprehensive next generation sequence (NGS) (iii) Indian Institute of Science data analysis solution Education and Research (IISER), Pune (iv) National Bureau of Animal Genetic Resources (NBAGR), Haryana 122 SciGenome Labs Pvt. Ltd., Cochin 123 High performance Computing Infrastructure
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