Melatonin More than a sleep hormone - Biotech-IgG
Neurodegeneration / Neurotransmitters Melatonin More than a sleep hormone IBL International is the only commercial supplier of a complete set of user friendly immunoassays for the reliable quantitative assessment of melatonin in serum as well as in saliva, and of its primary metabolite 6-sulfatoxymelatonin in urine. Products • The assays are calibrated to LC-MS/MS • The broad standard range allows application for therapeutic drug monitoring • Validated reference values for urinary 6-sulfatoxymelatonin (figure 1)1 • Successfully applied in diet research2-4, various species and cell culture supernatants* • Widely used and cited in multiple publications* Melatonin: a ubiquitously distributed and functionally diverse molecule Melatonin is an endogenous hormone synthesized and secreted primarily by the pineal gland. Its secretion is regulated by the suprachiasmatic nuclei and regulates the diurnal light-dark cycle with peak production at night and low level during the day time. Figure 1: Time and age dependent reference values of urinary 6-sulfatoxymelatonin measured with IBL International’s Melatonin-Sulfate Urine ELISA1 IBL International GmbH Flughafenstrasse 52 a Phone: +49 (0) 40 - 53 28 91 - 0 [email protected] D-22335 Hamburg Fax: +49 (0) 40 - 53 28 91 - 11 www.IBL-International.com Germany 2013_Melatonin-_EN_V01 Apart from its role in the regulation of sleep, multiple studies show its involvement in a wide variety of physiological processes (affecting circadian rhythm and mood, interacting with the immune system and acting as antioxidant, free radical scavenger and oncostatic agent). Moreover, it has been shown that melatonin performs these functions by a variety of mechanisms. Catalog # Sample Type Sample Size Range Sensitivity Melatonin ELISA RE54021 Serum, Plasma 500 μl 0 - 300 pg/mL 1.6 pg/mL Melatonin direct Saliva ELISA RE54041 Saliva 100 μl 0 - 050 pg/mL 0.3 pg/mL Melatonin RIA RE29301 Serum, Plasma 200 μl 0 - 750 pg/mL 0.9 pg/mL Saliva 500 μl 0 - 300 pg/mL 0.3 pg/mL RE54031 Urine 010 μl 0 - 420 ng/mL 0.1 ng/mL Catalog # Quantity Description MelatoninKEME761 Extraction columns 010 sets C18 reversed phase extraction columns for use with RE54021 Salicap Set 100 sets 500 sets Sampling tubes for collection of saliva samples to be used in the IBL Saliva Immunoassays Melatonin-Sulfate Urine ELISA RE69991 RE69995
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