Sourcing Nature’s Best Ideas Natural Health Trading Garcinia Cambogia 1300 The supplement Dr Oz calls ‘the Holy Grail of weight loss’ What is Garcinia Cambogia? Garcinia Cambogia is a small, pumpkin-shaped fruit also known as Brindleberry or Malabar Tamarind. Though native to Indonesia, it is also grown in India, Southeast Asia, and West and Central Africa. It has long been used in traditional South Asian dishes, including curries and chutneys. Many also use the fruit for curing fish and preservation. It is also added as a spice on meals to make them more filling and help with the suppression of appetite. How does Garcinia Cambogia work? The weight loss benefits of the plant are due to a natural substance found in the nutrient rich rind of the fruit. The natural extract is known as Hydroxycitric acid (HCA), which has been found to dramatically hasten weight loss efforts by doing two things: It helps to block fat, and it suppresses your appetite. HCA is an active ingredient extracted from the rind of Garcinia. It inhibits an enzyme called Citrate Lyase. This enzyme is responsible for creating fat cells from carbohydrates and converting carbohydrates into cholesterol and triglycerides. When HCA inhibits Citrate Lyase, the fat-making process is halted and instead of converting sugar to fat, the liver will convert the sugar to glycogen – this glycogen is then used as energy. This prevents the formation of new fat cells in the body .The production of LDL (bad cholesterol) and triglycerides decreases when Citrate Lyase is inhibited. Additionally the plant aids emotional eaters, as it balances moods, increasing serotonin levels, which may improve temperament and enhance sleeping patterns. Key Benefits:  Supports healthy weight management – acts as a fat blocker  Supports appetite management – helps control overeating  Increases serotonin levels – supports better sleep and mood  Helps balance stress hormones  Contains 60% HCA  Supports healthy cholesterol and triglyceride levels  Supports digestive function  Contains calcium and potassium to help with metabolism  Free from artificial fillers and binders Ingredients:  Calcium 50mg  Chromium 200mcg  Potassium 50mg  Garcinia Cambogia (Fruit Rind) Extract 1000mg with 60% HCA Dose: Two capsules in total daily taken 30 minutes before a main meal Sourcing Nature’s Best Ideas Contraindications Garcinia Cambogia supplements have been shown repeatedly in multiple studies to be safe. However, We strongly advise your customers seek medical advice prior to use of Natural Health Trading Garcinia Cambogia 1300 from their General Practitioner if they have any concerns about the supplement. Cautions:  Dosage should not exceed 3000mg each day  Not recommended whilst pregnant or breastfeeding  Those with Alzheimer’s or other types of dementia should avoid taking this supplement, as it may aggravate their situation  Caution for patients on warfarin, medications for heart disease, high blood pressure or arrhythmias (product contains potassium and calcium)  Caution for patients on psychiatric medications (may be a potential serotonergic effect)  Caution for patients on statin medications (one case of rhabdomyolysis reported)  Diabetic patients taking medication should monitor blood sugar levels as Garcinia Cambogia may reduce intestinal glucose absorption after meals aciea.co.nz Natural Health Trading Limited Sourcing Nature’s Best Ideas Dr Oz’s interview with Dr Chen on Garcinia Cambogia “How can I burn fat without spending every waking moment exercising and diet?” asked Dr. Oz in a recent 2013 show. His answer? “Well, thanks to brand new scientific research, I can tell you about a revolutionary fat buster that you are hearing about here first”. His reference was to Garcinia Cambogia, the new scientific discovery in the latest weight loss research. Guest Dr. Julie Chen and Dr. Oz explained how this 100% natural ingredient is capable of suppressing the appetite and preventing fat accumulation. Dr. Oz: “How much weight would an average woman expect to lose if she uses this for a month for example?” Dr. Chen: “On average, about four pounds… but, I always recommend diet and exercise with it, so if people take the supplements with it, they actually will lose 2-3 times what they would normally lose with just diet and exercise alone.” Dr. Chen explained how Garcinia Cambogia not only suppresses appetite, but also has the ability to help those who consume too much food when they are emotionally challenged. It seems this fruit helps people go to sleep easier and their bodies no longer secrete cortisol, the fat building hormone. Also discussed was how HCA (the active ingredient) “locks” citrate lyase, the enzyme responsible with transforming carbs and sugars into fats that get stored in cells and cause weight gain. Additionaly,HCA is known to decrease the LDL (bad cholesterol) triglyceride levels. This fruit’s appetite suppressing qualities are known for increasing the serotonin levels. Low levels of serotonin induce depression and stress. This leads to emotional eating that causes too much weight gain. HCA increases the serotonin levels and causes the body to burn fats much easier. aciea.co.nz Natural Health Trading Limited Sourcing Nature’s Best Ideas Garcinia Cambogia Extract Research Scientific reviews report positive results in weight loss, especially when the supplement is being used in combination with a healthy diet and a regular exercise program. In one such 8-week scientific study of 60 obese patients, a control group was given HCA, while the other was given a placebo. By the end of the study, the HCA group met an approximate weight loss of 14 pounds, while the placebo one lost only 6 pounds. Both groups were on diet consuming only 1,200 calories per day. The study also revealed LDL, triglycerides and serum leptin levels were dramatically reduced, while HDL (good cholesterol), serotonin levels, and excretion of urinary fat metabolites (biomarkers of fat burning) were very much heightened. Dr. Oz’s final recommendations were to avoid Garcinia Cambogia supplements that are made with artificial ingredients, to take only the supplements that contain more than 50% HCA, to take 500-1000 mg capsules 30 minutes before each meal and avoid consumption in excess of 3000 mg per day. Research Much scientific research is available on Garcinia Cambogia. Some evidence suggests that it may be effective for weight loss and as an appetite suppressant. Mol Cell Biochem 2002 Sep;238(1-2):89-103. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). In a previous article it was shown that in the rat brain cortex a novel HCA extract (HCA-SX, Super CitriMax) increases the release/availability of radiolabeled 5-hydroxytryptamine or serotonin ([3H]-5-HT), a neurotransmitter implicated in the regulation of eating behavior and appetite control. The aim of the present study was 2-fold: (a) to determine the effect of HCA-SX on 5-HT uptake in rat brain cortex in vitro; and (b) to evaluate the safety of HCA-SX in vivo. Conclusions: HCA is a safe supplement, lethal dose in rats is greater than 5,000mg/kg. HCA also increased the levels of serotonin in the brain which may be beneficial in appetite control, depression, insomnia, migraine, among other serotonin deficient conditions. Diabetes Obes Metabol. 2004 May;6(3):171-80. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. HCA-SX has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. Hydroxycitric acid (HCA-SX) alone and in combination with niacin-bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. A randomized, double-blind, placebo-controlled human study was conducted in Elluru, India for 8 weeks in 60 moderately obese subjects (ages 21-50, BMI >26 kg/m(2)). Subjects were randomly divided into three groups. aciea.co.nz Natural Health Trading Limited Sourcing Nature’s Best Ideas Group A was administered HCA-SX 4667 mg, group B was administered a combination of HCA-SX 4667 mg, NBC 4 mg and GSE 400 mg, while group C was given placebo daily. Results: At the end of 8 weeks, body weight and BMI decreased by 5-6% in both groups A and B. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced in both groups. A non-significant effect was observed in all parameters in group C. J Med. 2004;35(1-6):33-48. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. This study was a 90-day toxicity study. The dose dependant effects of HCA-SX were assessed on body weight, selected organ weights, hepatic and testicular lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathology in male and female Sprague-Dawley rats. No toxicity was found after this trial. Furthermore, clinical studies to evaluate the safety and efficacy of HCA-SX over a period of eight weeks were conducted in 60 human volunteers. Subjects were given a 2,000 kcal diet/day, participated in a 30 min walking exercise program 5 days/week and given an oral dose of placebo or 4666.7 mg HCA-SX (providing 2,800 mg HCA) in three equally divided doses 30-60 min before meals, Body weight, BMI, lipid profiles, serum leptin, serotonin and excretion of urinary fat metabolites were determined at 0, 4 and 8 weeks of treatment. At the end of 8 weeks, body weight and BMI decreased by 5.4% and 5.2%, respectively. Food intake, total cholesterol, LDL, triglycerides and serum leptin levels were significantly reduced, while HDL and serotonin levels, and excretion of urinary fat metabolites (a biomarker of fat oxidation) significantly increased. No significant adverse effects were reported. Results: These results demonstrate the safety, bioavailability and efficacy of HCA-SX in weight management. aciea.co.nz Natural Health Trading Limited