COMBINED LIST OF DRUGS THAT PROLONG QT AND/OR CAUSE
COMBINED LIST OF DRUGS THAT PROLONG QT AND/OR CAUSE TORSADES DE POINTES (TDP) CredibleMeds® has reviewed available evidence for the drugs on this list and concluded that they either 1) have a Known Risk of TdP 2) prolong the QT interval and therefore have a Possible Risk of TdP or 3) have a Conditional Risk of TdP , that is, under certain conditions such as overdose, drug - drug interactions or when administered to certain high-risk individuals (e.g. congenital long QT syndrome). Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Alfuzosin Uroxatral® Dabrafenib Tafinlar® Grepafloxacin Raxar® Amantadine Symmetrel® and others Dasatinib Sprycel® Halofantrine Halfan® Amiodarone Cordarone® and others Degarelix Firmagon® Haloperidol Amisulpride Solian® and others Desipramine Pertofrane® and others Haldol® (US & UK) and others Elavil® (Discontinued 6/13) and others Dexmedetomidine Precedex® and others Hydrochlorothiazide Apo-Hydro® and others Amitriptyline Dihydroartemisinin+piperaquine Eurartesim® Hydroxychloroquine Plaquenil® and others Anagrelide Agrylin® and others Hydroxyzine Atarax® and others Apomorphine Apokyn® and others Ibutilide Corvert® Aripiprazole Abilify® and others Iloperidone Fanapt® and others Arsenic trioxide Trisenox® Imipramine (melipramine) Tofranil® Astemizole Hismanal® Indapamide Lozol® and others Atazanavir Reyataz® Isradipine Dynacirc® Atomoxetine Strattera® Itraconazole Sporanox® and others Azithromycin Zithromax® and others Ivabradine Procoralan® and others Bedaquiline Sirturo® Ketoconazole Nizoral® and others Bepridil Vascor® Lapatinib Tykerb® and others Bortezomib Velcade® and others Leuprolide (Leuprorelin) Lupron® and others Bosutinib Bosulif® Levofloxacin Levaquin® and others Ceritinib Zykadia® Levomethadyl Orlaam® Chloral hydrate Aquachloral® and others Lithium Eskalith® and others Chloroquine Aralen® Mesoridazine Serentil® Chlorpromazine Thorazine® and others Methadone Dolophine® and others Cilostazol Pletal® Metoclopramide Reglan® and others Ciprofloxacin Cipro® and others Metronidazole Flagyl® and many others Cisapride Propulsid® Mifepristone Korlym® and others Citalopram Celexa® and others Mirabegron Myrbetriq® Clarithromycin Biaxin® and others Mirtazapine Remeron Clomipramine Anafranil® Moexipril/HCTZ Uniretic® and others Clozapine Clozaril® and others Moxifloxacin Avelox® and others Cocaine Cocaine Nelfinavir Viracept® Crizotinib Xalkori® Nicardipine Cardene® Diphenhydramine Benadryl® and others Disopyramide Norpace® Dofetilide Tikosyn® Dolasetron Anzemet® Domperidone Motilium® and others Donepezil Aricept® Doxepin Sinequan® and others Dronedarone Multaq® Droperidol Inapsine® and others Eribulin Halaven® Erythromycin E.E.S.® and others Escitalopram Cipralex® and others Famotidine Pepcid® and others Felbamate Felbatol® Fingolimod Gilenya® Flecainide Tambocor® and others Fluconazole Diflucan® and others Fluoxetine Prozac® and others Foscarnet Foscavir® Furosemide (Frusemide) Lasix® and others Galantamine Reminyl® and others Gatifloxacin Tequin® Gemifloxacin Factive® Granisetron Kytril® and others If list is printed, check website for updates: www.crediblemeds.org •Please see Disclaimer and list continued Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Nilotinib Tasigna® Norfloxacin Noroxin® and others Nortriptyline Pamelor® and others Ofloxacin Floxin® Olanzapine Zyprexa® and others Ondansetron Zofran® and others Oxytocin Pitocin® and others Paliperidone Invega® and others Panobinostat Farydak® Pantoprazole Protonix® and others Paroxetine Paxil® and others Pasireotide Signifor® Pazopanib Votrient® Pentamidine Pentam® Perflutren lipid microspheres Definity® Pimozide Orap® Pipamperone Dipiperon (E.U) and others Posaconazole Noxafil® and others Probucol Lorelco® Procainamide Pronestyl® and others Promethazine Phenergan® Propofol Diprivan® and others Quetiapine Seroquel® Quinidine Quinaglute® and others Quinine sulfate Qualaquin® Ranolazine Ranexa® and others Rilpivirine Edurant® and others Risperidone Risperdal® Ritonavir Norvir® Roxithromycin Rulide® and others Saquinavir Invirase®(combo) Sertindole Serdolect® and others Sertraline Zoloft® and others Sevoflurane Ulane® and others Solifenacin VESIcare® Sorafenib Nexavar® Sotalol Betapace® and others Sparfloxacin Zagam® Sulpiride Dogmatil® and others Sunitinib Sutent® Tacrolimus Prograf® and others Tamoxifen Telaprevir Incivek® and others Telavancin Vibativ® Nolvadex®(discontinued 6/13) and others Terfenadine Seldane® Tetrabenazine Nitoman® and others Telithromycin Ketek® Thioridazine Mellaril® and others Toremifene Fareston® Trimipramine Surmontil® and others Tizanidine Zanaflex® and others Torsemide (Torasemide) Demadex® and others Tropisetron Tolterodine Detrol® and others Trazodone Desyrel® (discontinued 6/13) and others Vandetanib Caprelsa® Vardenafil Levitra® Venlafaxine Effexor® and others Voriconazole VFend® Ziprasidone Geodon® and others Navoban® and others Vemurafenib Zelboraf® Vorinostat Zolinza® Note: Medicines on this list are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. Because, the list changes regularly, we recommend always checking the website at crediblemeds.org for the most up-to-date information. Most drugs have multiple brand names and it is not practical to list them on this form. The CredibleMeds.org website provides a partial list of the more common brands. Disclaimer and Waiver: The information presented here is intended solely for the purpose of providing general information about health-related matters. It is not intended for any other purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users’ relationships with their own health care providers. To that extent, by use of this list and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any claims arising out of his/her use of this list. The Terms of Use Agreement for this list and the CredibleMeds website is available at https://www.crediblemeds.org/terms. The absence of drugs from these lists should not be considered an indication that they are free of risk of QT prolongation or torsades de pointes. Few medicines have been tested for this risk in patients, especially those with congenital long QT syndrome. This list and the CredibleMeds® website are intended for personal and professional use only and are protected by U.S. Copyright (title 17, U.S. Code). Unauthorized commercial use is prohibited. Generated: July 7, 2015. List last revised: July 3, 2015
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