Optimizing Gastrointestinal Health How to maximize your

Optimizing
Gastrointestinal
Health
How to maximize your
health through a healthy gut
Dr Cameron McIntyre BSC, RTR, ND
AOR Medical Advisor
Notes
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8/13/2012
Optimizing Gastrointestinal Health:
How to maximize your health
through a healthy gut
Dr Cameron McIntyre BSC, RTR, ND
AOR Medical Advisor
Disclaimer
• These webinars have not been evaluated by the
Natural Health Product Directorate of Canada (NHPD).
Supplements mentioned are not intended to diagnose,
treat, cure, mitigate or prevent any medical
condition. The onlyy exceptions
p
are those health claims
approved by the NHPD, which are listed on the labels
of each product and on the NHPD website for products
with Natural Product Numbers (http://webprod3.hcsc.gc.ca/lnhpd-bdpsnh/index-eng.jsp).
Overview
•
•
•
•
•
•
•
•
•
•
Introductions
About me
Some GI numbers
Key concepts off the top – diet, stress, dental health
Clues your guts are not happy
Food Allergy 101
GI bugs – some common culprits
GI inflammation management – tying it all together
Q&A
Conclusion
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8/13/2012
About Me
• Naturopathic doctor – private practice North
Vancouver (www.lonsdalenaturopathic.com)
• AOR medical advisor
• DAN!! (defeat
(d f
autism
i now)) certified
ifi d
• IMMH (integrated medicine for mental health)
certified
Some GI Numbers
• Estimated over 20 million Canadians suffering
from gastrointestinal illness
• GI illness costs over 18 billion annually in
hospitalizations and lost productivity
• 30K Canadians
d
d
die each
h year ffrom GI related
l d
illness
• Highest incidence of GI ulcers and IBD in the
world!
Some GI Numbers
• Medical diagnosis of GI disease has doubled in
last decade
• Next to Lung cancer, GI cancers are Canada’s
biggest cancer killer
• Est. 10 million
ll
Canadians
d
with
h H. pylori
l
infections
• 5 million Canadians experience heartburn at
least once per week, estimated productivity
lost each year 2.1 billion
• Source: www.cdha.ca
2
8/13/2012
***http://www.cgtrader.com/3D-models/Characters-People/Digestive-System-in-a-Human-Body.html
Some Key Concepts For Long Term
GI Health
• Diet – “Let your food be your medicine and your
medicine be your food” – Hippocrates
• Diet themes – simple, clean, colorful,
grandmother test, chemistry test
• Stress management – as stress increases,
increases
digestive function decreases. The French Paradox
uncovered. Remember adaptogens!
• Dental health – mouth first stop on the GI train.
If poor oral and dental health – problems with GI
health will arise (30% of digestion happens in our
mouths!)
Divisions Of The Nervous
System - Sympathetic
Sympathetic (Stress)
Fight or flight/tend & befriend
Increased heart rate
Increased blood flow to skeletal muscles
Decreased blood flow to digestive tract, skin
and frontal lobe of brain
• Decreased immune function and quality of
sleep
•
•
•
•
•
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8/13/2012
Divisions Of The Nervous
System - Parasympathetic
Parasympathetic (non-stress)
Relaxation response
Decreased heart rate
Increased blood flow to digestive tract, skin
and frontal lobe of brain
• Increased immune function
• Increased quality of sleep
•
•
•
•
Stress Products
• Ortho Adapt
• Gandha 600
• Rhodiola
Ortho Adapt
• Contains glandular extracts which contain
peptides, minerals, lipids and nutrients which
are naturally present in the adrenal glands
• Combination formula with Adaptogens of
Licorice, Siberian Ginseng, Rhodiola and
Ashwagandha
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8/13/2012
Gandha 600
• In controlled human studies, better protection
against ulcers and adrenal exhaustion
• In animal studies, confirmed improved
immunity enhancing proliferation of immune
immunity,
cells and boosts immune cells’ ability to
destroy infected and foreign cells
Rhodiola
• Classic adaptogen balancing levels of
hormones and neurotransmitters normally
associated with stressors
• Demonstrated anti-fatigue
anti fatigue effect in human
trials
Clues Your Guts Are Not Happy
•
•
•
•
•
•
•
•
•
Stomach ulcers
GI Reflux (GERD)
Gas – the sniff test
Bloating
Diarrhea
Constipation
IBD/IBS – including Crohns and colitis
Skin concerns – eczema, psoriasis, fungal infections
Mental health – anxiety, depression, attention and
learning issues (children & adults)
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8/13/2012
Licorice
DGL 760
– Licorice stimulates the normal defense
mechanisms that prevent ulcer formation
• Rather than inhibit acid secretion (ie. Zantac & Tagamet)
– Flavonoids present in DGL inhibit the
growth of H. pylori in vitro
– Compared head to head against Tagamet &
Zantac in short-term treatment and
maintenance therapy of peptic ulcers
– Increases the life span of intestinal cells,
and improves blood supply to the intestinal
lining
Mastic Gum
Mastica Chios
– In RCT study:
• 80% of Mastic Gum users experienced relief of
symptoms
• 70% healing of their ulcers
– Found to inhibit H. pylori in vitro
– May directly help the ulcerated stomach
wall to repair itself
– Mastic Tree (its source), is found almost
exclusively on the Greek Island of Chios,
birthplace of Hippocrates
Gastro Relief
Gastro Relief
– Potentiates NO (Nitric Oxide)
• Helps heal ulcers
• Inhibits H. pylori
– Zinc-Carnosine prevents gastric mucosal
injury and has anti-ulcer properties
– Contains Mastic Gum (previous slide)
– Alginic Acid helps prevent reflux
• Shown to be more effective than ranitidine and
omeprazole for reflux, during first hour after
dosing
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8/13/2012
Triphala
Triphlax 750
– Used in traditional Ayurvedic medicine for
colonic detoxification
– Stimulates bile secretion & detoxifies the
liver and other organs
– Helps digestion and assimilation &
stimulates the peristaltic action of the
intestinal lining
– Helps regulate CCK, a satiety hormone, to
inform the body it is full
Fiber!
SoluFibre
– SoluFibre: a highly soluble, easy to take,
digestion resistant form of fibre
– SoluFibre slows transit times in the
gastrointestinal system and stimulates the
growth of healthy bacteria
– Breakdown components or metabolites of
fiber stimulate the immune system.
• Fiber is known to activate our immune system
– Besides alleviating constipation:
• a high fiber diet may prevent stress induced diarrhea by
preventing the release of various hormones produced by the
body which normally quicken the passage in the intestines
which results in diarrhea
Food Allergy 101
• May be the key to the kingdom as to why your
guts are not happy
• IgE allergy – immediate, often serious, epi-pen
needed, hives, respiratory and GI issues.
Common foods – peanut, seafood, strawberries.
• IgG allergy – delayed over hours or days, more
mysterious, lower grade inflammation in guts and
beyond. Can affect all areas of the body.
Common foods- dairy, wheat, eggs, soy.
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8/13/2012
IgG Allergic Reaction
• IgG antibody – found in GI system
• Food component (usually undigested protein)
absorbed through intestinal wall to react with
y
in blood on other side
immune system
• Antigen-antibody complex formed, creating an
immune response
• Each time offending food eaten from here
after, immune system will be involved
Food Allergy Testing
• IgE allergy – using a “scratch” test
• IgG allergy – will not show up on scratch test
as it is a delayed reaction. Need to look in the
blood stream (i
(i.e.
e blood test required)
Fixing Delayed (IgG)
Food Allergies
The 4 “R”method
Remove – offending allergenic food
Rotate – existing foods in diet
Repair – digestive tissues with probiotics,
enzymes, glutamine, etc.
• Re-introduce – offending foods
•
•
•
•
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8/13/2012
Probiotics
• Described by Ilya (Elie) Metchnikoff in 19071965 Definition: “Substances secreted by one
or more microorganisms which stimulates the
growth of another”
another
• 1991 Definition: “ Viable microorganisms that
contribute to intestinal microbial balance and
have the potential to improve the health of
their human host”
Probiotics
Balance the immune system
Normal inflammatory response
Prevent infections
Show promise for reducing the likelihood of
developing allergies
• Essential for digestion
•
•
•
•
Probiotics- Mechanism of
Action
• Produce short chain fatty acids (which antagonize other
pathogenic microorganisms)
• Production of bacteriocin-like inhibitor
• Expression of cellular signaling molecules (cytokines) involved
in inflammatory pathways
• Genetic Level –up regulation of vast array of intestinal genes
that can affect nutrient absorption, metabolism, mucosal
barrier fortification, and angiogenesis
• Competition for binding sites on intestinal epithelial cells
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8/13/2012
Probiotics
Advanced Biotics
– Can help to mobilize and normalize the
immune system
– Reduces the incidence of diarrhea
associated with the use of antibiotics
– Improves intestinal habits in healthy adults
– Some of the carefully selected strains of probiotics:
• L. plantarum: Balances Th1:Th2 Immunity
• L. casei: Reduces colonization from other
pathogens
• Streptococcus thermophilus: Helps lower total
cholesterol & enhances intestinal mucosal
immunity
Probiotics
ProBIOTIC 3
–
–
–
–
Clinically studied for over 55 years!
Three Human species
Act synergistically as probiotic and prebiotic
PROVEN Health Benefits:
Reducing allergies
Improving immunity
Fighting colds and flu
Reducing intestinal symptoms of bloating,
constipation and reducing traveller’s and antibiotic
induced diarrhea
• Proven detoxifier
•
•
•
•
Enzymes
DPP Zyme
– DPP IV is an essential peptidase for antigen
presentation
• DPP IV promotes a normal cellular immune
response
– Lower peptidase levels (found in many GI
disorders) reduce the body's ability to
metabolize proteins
• Especially proteins containing proline (like
Gluten), because DPP IV is needed for their
assimilation
– Benefits those with autoimmune diseases
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8/13/2012
Enzymes
AOR Zymes
– Enzymes increase absorption and help in
the breakdown of food into nutrients
– Utilizes p
porcine p
pancreatic enzymes
y
because their composition is similar to
human digestive enzymes
• Superior to vegetable enzymes
– Full spectrum Enzyme support:
•
•
•
•
Amylase
Lipase
Protease
Alpha Galactosidase
Enzymes
Digestase
– Formulated with proteases that activate at
different pH ranges to guarantee protein
digestion
• As well as various amylases and lipases for the
breakdown of starch and fats
– Supplemental enzymes reduce
inflammation and speed up recovery
– Athletes show improved recovery times
when supplementing with enzymes
– Vegetarian Formula (Biological
fermentation)
L-Glutamine
L-Glutamine
– Consumed by epithelial cells, which convert
it into energy for use by the mucosa of the
small intestines
– Supports division of immune cells when
your body is challenged by pathogens
– Helps lymphocytes, marcophages and
neutrophils produce compounds that fight
bacteria and viruses
– High cortisol levels lower stored Lglutamine, impairing immune function
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8/13/2012
GI Bugs – Some Common
Culprits
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•
•
•
•
•
H. pylori
Candida
E. coli
Salmonella
C. difficile
Parasites – blastocystis, entamoeba
Probiotics
Advanced Biotics
– Reduces bacterial colonization and gastric
inflammation
• Ie. Candida, amongst other pathogens
– Enhanced immune response after intestinal
surgery
– Influence the immune response to
pathogens and other antigens
• Through cell signaling (cytokine production)
– Increases the proportion of:
• White blood cells
• NK cells and IgA
Yeast
Saccharomyces Boulardii
– Uses:
• Among the most effective probiotics in treating
symptoms of Traveler’s Diarrhea
• Efficacy in treating acute diarrhea in children
• Antibiotic-associated diarrhea
• Clostridium difficile infection
– Mechanisms:
• Interfering with the various pathogens that bind
to gastrointestinal cells
• Enhancing effect for certain protective proteins
of the immune system
• Competes with pathogens for receptor sites
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8/13/2012
Olive Leaf Extract
Olive Leaf Extract:
– Antibacterial, antiviral and antifungal:
• Ie. Bacillus cereus, E. Coli, Influenza A, etc.
– Enhanced immune p
properties
p
when
combined with NOx3,2,1 technology
• Stimulates T-helper cells, B cells and
macrophages
• Accelerates wound healing
• Helps prevent spread of infection
• Improves blood flow (oxygen and nutrients) to
damaged/infected area
Allium sativum
Garlic Alkalized:
– Patented product that reduces the unsocial
odour characteristic of allicin
– Wide spectrum
p
antimicrobial:
• Ie. E. coli, Candida, Entamoeba histolytica,
Giardia, etc.
– Stimulate lymphocytes, macrophages and
natural T killer cells
– Increases the production of several immune
activating chemicals such as cytokines,
interleukin-2 (IL-2) and tumor necrosis
factor-alpha (TNF-α)
GI Inflammation Management –
Tying It All Together
• For those interested in long term GI health, I
would recommend the following:
• Probiotic
• Enzyme
• Fiber
• Curcumin
• Adaptogen?
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8/13/2012
CurcuVIVA
Curcumin
• Isolated from Curcuma longa (turmeric) root
– Long history in Ayurveda
• Clinically demonstrated beneficial effects
– Anti-inflammatoryy
– Antioxidant
• Potential beneficial effects
– Anti-tumor
– Anti-amyloid (Alzheimer’s)
– Antibiotic
Questions??
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8/13/2012
Thank you!
Dr. Cameron McIntyre BSC, RTR, ND
AOR Medical Advisor
Facebook – Dr Cameron McIntyre ND
Twitter - @DrMcIntyreND
15
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For additional information contact:
[email protected]
Thank You
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