Optimizing Gastrointestinal Health How to maximize your health through a healthy gut Dr Cameron McIntyre BSC, RTR, ND AOR Medical Advisor Notes .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. ................................................................................. ................................................................................. ................................................................................. ................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. 8/13/2012 Optimizing Gastrointestinal Health: How to maximize your health through a healthy gut Dr Cameron McIntyre BSC, RTR, ND AOR Medical Advisor Disclaimer • These webinars have not been evaluated by the Natural Health Product Directorate of Canada (NHPD). Supplements mentioned are not intended to diagnose, treat, cure, mitigate or prevent any medical condition. The onlyy exceptions p are those health claims approved by the NHPD, which are listed on the labels of each product and on the NHPD website for products with Natural Product Numbers (http://webprod3.hcsc.gc.ca/lnhpd-bdpsnh/index-eng.jsp). Overview • • • • • • • • • • Introductions About me Some GI numbers Key concepts off the top – diet, stress, dental health Clues your guts are not happy Food Allergy 101 GI bugs – some common culprits GI inflammation management – tying it all together Q&A Conclusion 1 8/13/2012 About Me • Naturopathic doctor – private practice North Vancouver (www.lonsdalenaturopathic.com) • AOR medical advisor • DAN!! (defeat (d f autism i now)) certified ifi d • IMMH (integrated medicine for mental health) certified Some GI Numbers • Estimated over 20 million Canadians suffering from gastrointestinal illness • GI illness costs over 18 billion annually in hospitalizations and lost productivity • 30K Canadians d d die each h year ffrom GI related l d illness • Highest incidence of GI ulcers and IBD in the world! Some GI Numbers • Medical diagnosis of GI disease has doubled in last decade • Next to Lung cancer, GI cancers are Canada’s biggest cancer killer • Est. 10 million ll Canadians d with h H. pylori l infections • 5 million Canadians experience heartburn at least once per week, estimated productivity lost each year 2.1 billion • Source: www.cdha.ca 2 8/13/2012 ***http://www.cgtrader.com/3D-models/Characters-People/Digestive-System-in-a-Human-Body.html Some Key Concepts For Long Term GI Health • Diet – “Let your food be your medicine and your medicine be your food” – Hippocrates • Diet themes – simple, clean, colorful, grandmother test, chemistry test • Stress management – as stress increases, increases digestive function decreases. The French Paradox uncovered. Remember adaptogens! • Dental health – mouth first stop on the GI train. If poor oral and dental health – problems with GI health will arise (30% of digestion happens in our mouths!) Divisions Of The Nervous System - Sympathetic Sympathetic (Stress) Fight or flight/tend & befriend Increased heart rate Increased blood flow to skeletal muscles Decreased blood flow to digestive tract, skin and frontal lobe of brain • Decreased immune function and quality of sleep • • • • • 3 8/13/2012 Divisions Of The Nervous System - Parasympathetic Parasympathetic (non-stress) Relaxation response Decreased heart rate Increased blood flow to digestive tract, skin and frontal lobe of brain • Increased immune function • Increased quality of sleep • • • • Stress Products • Ortho Adapt • Gandha 600 • Rhodiola Ortho Adapt • Contains glandular extracts which contain peptides, minerals, lipids and nutrients which are naturally present in the adrenal glands • Combination formula with Adaptogens of Licorice, Siberian Ginseng, Rhodiola and Ashwagandha 4 8/13/2012 Gandha 600 • In controlled human studies, better protection against ulcers and adrenal exhaustion • In animal studies, confirmed improved immunity enhancing proliferation of immune immunity, cells and boosts immune cells’ ability to destroy infected and foreign cells Rhodiola • Classic adaptogen balancing levels of hormones and neurotransmitters normally associated with stressors • Demonstrated anti-fatigue anti fatigue effect in human trials Clues Your Guts Are Not Happy • • • • • • • • • Stomach ulcers GI Reflux (GERD) Gas – the sniff test Bloating Diarrhea Constipation IBD/IBS – including Crohns and colitis Skin concerns – eczema, psoriasis, fungal infections Mental health – anxiety, depression, attention and learning issues (children & adults) 5 8/13/2012 Licorice DGL 760 – Licorice stimulates the normal defense mechanisms that prevent ulcer formation • Rather than inhibit acid secretion (ie. Zantac & Tagamet) – Flavonoids present in DGL inhibit the growth of H. pylori in vitro – Compared head to head against Tagamet & Zantac in short-term treatment and maintenance therapy of peptic ulcers – Increases the life span of intestinal cells, and improves blood supply to the intestinal lining Mastic Gum Mastica Chios – In RCT study: • 80% of Mastic Gum users experienced relief of symptoms • 70% healing of their ulcers – Found to inhibit H. pylori in vitro – May directly help the ulcerated stomach wall to repair itself – Mastic Tree (its source), is found almost exclusively on the Greek Island of Chios, birthplace of Hippocrates Gastro Relief Gastro Relief – Potentiates NO (Nitric Oxide) • Helps heal ulcers • Inhibits H. pylori – Zinc-Carnosine prevents gastric mucosal injury and has anti-ulcer properties – Contains Mastic Gum (previous slide) – Alginic Acid helps prevent reflux • Shown to be more effective than ranitidine and omeprazole for reflux, during first hour after dosing 6 8/13/2012 Triphala Triphlax 750 – Used in traditional Ayurvedic medicine for colonic detoxification – Stimulates bile secretion & detoxifies the liver and other organs – Helps digestion and assimilation & stimulates the peristaltic action of the intestinal lining – Helps regulate CCK, a satiety hormone, to inform the body it is full Fiber! SoluFibre – SoluFibre: a highly soluble, easy to take, digestion resistant form of fibre – SoluFibre slows transit times in the gastrointestinal system and stimulates the growth of healthy bacteria – Breakdown components or metabolites of fiber stimulate the immune system. • Fiber is known to activate our immune system – Besides alleviating constipation: • a high fiber diet may prevent stress induced diarrhea by preventing the release of various hormones produced by the body which normally quicken the passage in the intestines which results in diarrhea Food Allergy 101 • May be the key to the kingdom as to why your guts are not happy • IgE allergy – immediate, often serious, epi-pen needed, hives, respiratory and GI issues. Common foods – peanut, seafood, strawberries. • IgG allergy – delayed over hours or days, more mysterious, lower grade inflammation in guts and beyond. Can affect all areas of the body. Common foods- dairy, wheat, eggs, soy. 7 8/13/2012 IgG Allergic Reaction • IgG antibody – found in GI system • Food component (usually undigested protein) absorbed through intestinal wall to react with y in blood on other side immune system • Antigen-antibody complex formed, creating an immune response • Each time offending food eaten from here after, immune system will be involved Food Allergy Testing • IgE allergy – using a “scratch” test • IgG allergy – will not show up on scratch test as it is a delayed reaction. Need to look in the blood stream (i (i.e. e blood test required) Fixing Delayed (IgG) Food Allergies The 4 “R”method Remove – offending allergenic food Rotate – existing foods in diet Repair – digestive tissues with probiotics, enzymes, glutamine, etc. • Re-introduce – offending foods • • • • 8 8/13/2012 Probiotics • Described by Ilya (Elie) Metchnikoff in 19071965 Definition: “Substances secreted by one or more microorganisms which stimulates the growth of another” another • 1991 Definition: “ Viable microorganisms that contribute to intestinal microbial balance and have the potential to improve the health of their human host” Probiotics Balance the immune system Normal inflammatory response Prevent infections Show promise for reducing the likelihood of developing allergies • Essential for digestion • • • • Probiotics- Mechanism of Action • Produce short chain fatty acids (which antagonize other pathogenic microorganisms) • Production of bacteriocin-like inhibitor • Expression of cellular signaling molecules (cytokines) involved in inflammatory pathways • Genetic Level –up regulation of vast array of intestinal genes that can affect nutrient absorption, metabolism, mucosal barrier fortification, and angiogenesis • Competition for binding sites on intestinal epithelial cells 9 8/13/2012 Probiotics Advanced Biotics – Can help to mobilize and normalize the immune system – Reduces the incidence of diarrhea associated with the use of antibiotics – Improves intestinal habits in healthy adults – Some of the carefully selected strains of probiotics: • L. plantarum: Balances Th1:Th2 Immunity • L. casei: Reduces colonization from other pathogens • Streptococcus thermophilus: Helps lower total cholesterol & enhances intestinal mucosal immunity Probiotics ProBIOTIC 3 – – – – Clinically studied for over 55 years! Three Human species Act synergistically as probiotic and prebiotic PROVEN Health Benefits: Reducing allergies Improving immunity Fighting colds and flu Reducing intestinal symptoms of bloating, constipation and reducing traveller’s and antibiotic induced diarrhea • Proven detoxifier • • • • Enzymes DPP Zyme – DPP IV is an essential peptidase for antigen presentation • DPP IV promotes a normal cellular immune response – Lower peptidase levels (found in many GI disorders) reduce the body's ability to metabolize proteins • Especially proteins containing proline (like Gluten), because DPP IV is needed for their assimilation – Benefits those with autoimmune diseases 10 8/13/2012 Enzymes AOR Zymes – Enzymes increase absorption and help in the breakdown of food into nutrients – Utilizes p porcine p pancreatic enzymes y because their composition is similar to human digestive enzymes • Superior to vegetable enzymes – Full spectrum Enzyme support: • • • • Amylase Lipase Protease Alpha Galactosidase Enzymes Digestase – Formulated with proteases that activate at different pH ranges to guarantee protein digestion • As well as various amylases and lipases for the breakdown of starch and fats – Supplemental enzymes reduce inflammation and speed up recovery – Athletes show improved recovery times when supplementing with enzymes – Vegetarian Formula (Biological fermentation) L-Glutamine L-Glutamine – Consumed by epithelial cells, which convert it into energy for use by the mucosa of the small intestines – Supports division of immune cells when your body is challenged by pathogens – Helps lymphocytes, marcophages and neutrophils produce compounds that fight bacteria and viruses – High cortisol levels lower stored Lglutamine, impairing immune function 11 8/13/2012 GI Bugs – Some Common Culprits • • • • • • H. pylori Candida E. coli Salmonella C. difficile Parasites – blastocystis, entamoeba Probiotics Advanced Biotics – Reduces bacterial colonization and gastric inflammation • Ie. Candida, amongst other pathogens – Enhanced immune response after intestinal surgery – Influence the immune response to pathogens and other antigens • Through cell signaling (cytokine production) – Increases the proportion of: • White blood cells • NK cells and IgA Yeast Saccharomyces Boulardii – Uses: • Among the most effective probiotics in treating symptoms of Traveler’s Diarrhea • Efficacy in treating acute diarrhea in children • Antibiotic-associated diarrhea • Clostridium difficile infection – Mechanisms: • Interfering with the various pathogens that bind to gastrointestinal cells • Enhancing effect for certain protective proteins of the immune system • Competes with pathogens for receptor sites 12 8/13/2012 Olive Leaf Extract Olive Leaf Extract: – Antibacterial, antiviral and antifungal: • Ie. Bacillus cereus, E. Coli, Influenza A, etc. – Enhanced immune p properties p when combined with NOx3,2,1 technology • Stimulates T-helper cells, B cells and macrophages • Accelerates wound healing • Helps prevent spread of infection • Improves blood flow (oxygen and nutrients) to damaged/infected area Allium sativum Garlic Alkalized: – Patented product that reduces the unsocial odour characteristic of allicin – Wide spectrum p antimicrobial: • Ie. E. coli, Candida, Entamoeba histolytica, Giardia, etc. – Stimulate lymphocytes, macrophages and natural T killer cells – Increases the production of several immune activating chemicals such as cytokines, interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-α) GI Inflammation Management – Tying It All Together • For those interested in long term GI health, I would recommend the following: • Probiotic • Enzyme • Fiber • Curcumin • Adaptogen? 13 8/13/2012 CurcuVIVA Curcumin • Isolated from Curcuma longa (turmeric) root – Long history in Ayurveda • Clinically demonstrated beneficial effects – Anti-inflammatoryy – Antioxidant • Potential beneficial effects – Anti-tumor – Anti-amyloid (Alzheimer’s) – Antibiotic Questions?? 14 8/13/2012 Thank you! Dr. Cameron McIntyre BSC, RTR, ND AOR Medical Advisor Facebook – Dr Cameron McIntyre ND Twitter - @DrMcIntyreND 15 Notes .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. ................................................................................. ................................................................................. ................................................................................. ................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. .................................................................................. 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