A*STAR scientists find way to boost body’s immune surveillance in...

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Posted: 10:09 am, September 19, 2013 by editor
SINGAPORE, Sept 19: Researchers at A*STAR’s Singapore Immunology Network (SIgN) have discovered a new mechanism involving p53, the famous tumour suppressor, to fight against
aggressive cancers.
It said the strategy works by sabotaging the ability of cancer cells to hide from the immune system.
A*STAR said the research opens a new avenue to improve targeted cancer therapy by harnessing the body’s own immune system to control and eliminate cancer cells.
Also known as the “Guardian of the Genome”, p53 fights cancer by causing damaged cells to die or by halting the growth of mutant cells before they become cancerous and spread to the rest
of the body.
The team leader, Associate Professor Ren Ee Chee from SIgN, said: “We were surprised to discover that p53 regulates MHC class I production by acting through ERAP1. This may explain
how cancer cells escape detection by our body’s immune system.
“More importantly, it opens up exciting avenues of research to explore how restoration of p53 with drugs such as those that target ERAP1 can help to harness the immune system to recognise
and destroy cancer cells.”
Acting executive director of SIgN, Associate Professor Laurent Rénia, said: “The team has uncovered a new door to manipulate one of the most studied yet enigmatic cancer-associated genes
of our time.
“I am confident that this work will pave the way for more targeted, efficient and cost-effective treatment for the millions of cancer patients globally.”
08-Nov-13 3:51 PM
A*STAR scientists find way to boost body’s immune surveillance in figh...
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08-Nov-13 3:51 PM